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| Id: | 18204
| | Author: | Kang, Tae Jin; Yeum, Chung Eun; Kim, Byoung Chul; You, Eun-Young; Chae, Gue-Tae
| | Title: | Differential production of interleukin-10 and interleukin-12 mononuclear cells from leprosy patients with a Toll-like receptor 2 mutations
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| | Source: | s.l; s.n; 2004. 7 p. tab, graf.
| | Abstract: | Toll-like receptor 2 (TLR2) is a key mediator of the immune response to mycobacterial infections, and mutations in TLR2 have been shown to confer susceptibility to infections with mycobacteria. This study investigated the profiles of cytokines, such as interferon (IFN)-gamma, interleukin (IL)-10, IL-12 and tumour necrosis factor (TNF)-alpha in response to Mycobacterium leprae in peripheral blood mononuclear cells (PBMC) with the TLR2 mutation Argo677Trp, a recently reported polymorphism that is associated with lepromatous leprosy. In leprosy patients with the TLR2 mutation, production of IL-2, IL-12, IFN-gamma, and TNF-alpha by M. leprae-stimulated PBMC were significantly decreased compared with that in groups with wild-type TLR2. However, the cells from patients with the TLR2 mutation showed significantly increased production of IL-10. There was no significant difference in Il-4 production between the mutant and wild-type during stimulation. Yhus, these results suggest that the TLR2 signal pathway plays a critical role in the alteration of cytokine profiles in PBMC from leprosy pateints and the TLR2 mutation Arg677Trp provides a mechanism for the poor cellular immune response associated with lepromatous leprosy (AU).
| | Descriptors: | HANSENIASE VIRCHOWIANA/sangue
HANSENIASE VIRCHOWIANA/clas
HANSENIASE VIRCHOWIANA/diag
HANSENIASE VIRCHOWIANA/imunol
HANSENIASE TUBERCULOIDE/sangue
HANSENIASE TUBERCULOIDE/clas
HANSENIASE TUBERCULOIDE/diag
HANSENIASE TUBERCULOIDE/imunol
INTERLEUCINA-10/anal
INTERLEUCINA-10/sangue
INTERLEUCINA-10/imunol
INTERLEUCINA-12/anal
INTERLEUCINA-12/sangue
INTERLEUCINA-12/imunol
- LEUCOCITOS MONONUCLEARES/imunol
IMUNOCOMPETÊNCIA/imunol
| | Limits: | ESTUDO COMPARATIVO
HUMANO
| | Location: | BR191.1; 09194/s |
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