Database : HANSEN Search on : INTERLEUCINA-12/SANGUE [Subject descriptor] References found : 2 [refine] Displaying: 1 .. 2   in format [Detailed]

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Id: 18204 Author: Kang, Tae Jin; Yeum, Chung Eun; Kim, Byoung Chul; You, Eun-Young; Chae, Gue-Tae Title: Differential production of interleukin-10 and interleukin-12 mononuclear cells from leprosy patients with a Toll-like receptor 2 mutations ..- Source: s.l; s.n; 2004. 7 p. tab, graf. Abstract: Toll-like receptor 2 (TLR2) is a key mediator of the immune response to mycobacterial infections, and mutations in TLR2 have been shown to confer susceptibility to infections with mycobacteria. This study investigated the profiles of cytokines, such as interferon (IFN)-gamma, interleukin (IL)-10, IL-12 and tumour necrosis factor (TNF)-alpha in response to Mycobacterium leprae in peripheral blood mononuclear cells (PBMC) with the TLR2 mutation Argo677Trp, a recently reported polymorphism that is associated with lepromatous leprosy. In leprosy patients with the TLR2 mutation, production of IL-2, IL-12, IFN-gamma, and TNF-alpha by M. leprae-stimulated PBMC were significantly decreased compared with that in groups with wild-type TLR2. However, the cells from patients with the TLR2 mutation showed significantly increased production of IL-10. There was no significant difference in Il-4 production between the mutant and wild-type during stimulation. Yhus, these results suggest that the TLR2 signal pathway plays a critical role in the alteration of cytokine profiles in PBMC from leprosy pateints and the TLR2 mutation Arg677Trp provides a mechanism for the poor cellular immune response associated with lepromatous leprosy (AU). Descriptors: HANSENIASE VIRCHOWIANA/sangue HANSENIASE VIRCHOWIANA/clas HANSENIASE VIRCHOWIANA/diag HANSENIASE VIRCHOWIANA/imunol HANSENIASE TUBERCULOIDE/sangue HANSENIASE TUBERCULOIDE/clas HANSENIASE TUBERCULOIDE/diag HANSENIASE TUBERCULOIDE/imunol INTERLEUCINA-10/anal INTERLEUCINA-10/sangue INTERLEUCINA-10/imunol INTERLEUCINA-12/anal INTERLEUCINA-12/sangue INTERLEUCINA-12/imunol - LEUCOCITOS MONONUCLEARES/imunol  IMUNOCOMPETÊNCIA/imunol Limits: ESTUDO COMPARATIVO HUMANO Location: BR191.1; 09194/s

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Id: 11751 Author: Oliver, Stephen J; Kikuch, Toyoko; Krueger, James G; Kaplan, Gilla Title: Thalidomide induces granuloma differentiation in sarcoid skin lesions associated with disease improvement ..- Source: s.l; s.n; 2002. 11 p. ilus, tab, graf. Descriptors: ANTIGENOS CD CÉLULAS DENDRITICAS AGENTES DERMATOLOGICOS AGENTES DERMATOLOGICOS CITOMETRIA DE FLUXO ANTIGENOS HLA-DR IMUNOHISTOQUIMICA IMUNOSSUPRESSORES INTERLEUCINA-12 INTERLEUCINA-2 CÉLULAS DE LANGERHANS SARCOIDOSE SARCOIDOSE SARCOIDOSE DERMATOPATIAS DERMATOPATIAS DERMATOPATIAS LINFOCITOS T TALIDOMIDA TALIDOMIDA RESULTADO DE TRATAMENTO FATOR DE NECROSE DE TUMOR Location: BR191.1; 08523/s

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