Database : HANSEN Search on : NEOPLASIAS/QUIMIOTER [Subject descriptor] References found : 8 [refine] Displaying: 1 .. 8   in format [Detailed]

page 1 de 1

1 / 8

HANSEN

select to print

Id: 18054 Author: União Internacional Contra o Câncer*. Title: Manual de oncologia clinica Manual of clinical neoplasms- Source: Sao Paulo; FOSP; 2006. xix,919 p. ilus, tab. Descriptors: NEOPLASIAS/sangue NEOPLASIAS/quim NEOPLASIAS/compl NEOPLASIAS/diag NEOPLASIAS/quimioter NEOPLASIAS/epidemiol NEOPLASIAS/genet NEOPLASIAS/metab NEOPLASIAS/microbiol NEOPLASIAS/mortal NEOPLASIAS/patol NEOPLASIAS/fisiopatol NEOPLASIAS/reabil NEOPLASIAS/cirurg NEOPLASIAS/terap Limits: ESTUDO COMPARATIVO HUMANO Location: BR191.1; , U3m

2 / 8

HANSEN

select to print

Id: 13938 Author: Dredge, Keith; Marriott, J. Blake; Dalgleish, Angus G Title: Immunological effects of thalidomide and its chemical and functional analogs ..- Source: s.l; s.n; 2002. 13 p. ilus, tab. Abstract: Thalidomide has recently shown considerable promise in the treatment of a number of conditions, such as leprosy and cancer. Its effectiveness in the clinic has been ascribed to wide-ranging properties, including anti-TNF-alpha, T-cell costimulatory and antiangiogenic activity. Novel compounds with improved immunomodulatory activity and side effect profiles are also being evaluated. These include selective cytokine inhibitory drugs (SelCIDs), with greatly improved TNF-alpha inhibitory activity, and immunomodulatory drugs (IMiDs) that are structural analogs of thalidomide, with improved properties. A third group recently identified within the SelCID group, with phosphodiesterase type 4-independent activity, is in the process of being characterized in laboratory studies. This review describes the emerging immunological properties of thalidomide, from a historical context to present-day clinical applications, most notably in multiple myeloma but also in other cancers, inflammatory disease, and HIV. We also describe the laboratory studies that have led to the characterization and development of SelCIDs and IMiDs into potentially clinically relevant drugs. Early trial data suggest that these novel immunomodulatory compounds may supercede thalidomide to become established therapies, particularly in certain cancers. Further evidence is required, however, to correlate the clinical efficacy of these compounds with their known immunomodulatory, antiangiogenic, and antitumor properties. (AU). Descriptors: TALIDOMIDA/analog TALIDOMIDA/imunol TALIDOMIDA/farmacol SISTEMA IMUNE/ef drogas NEOPLASIAS/quimioter NEOPLASIAS/imunol INFECCOES POR HIV/quimioter INFECCOES POR HIV/imunol ADJUVANTES IMUNOLOGICOS/farmacol INIBIDORES DE ANGIOGÊNESE/imunol INIBIDORES DE ANGIOGÊNESE/farmacol ANTIVIRAIS/imunol ANTIVIRAIS/farmacol Limits: HUMANO Electronic Medium: http://www.ilsl.br Location: BR191.1; 04731/s

3 / 8

HANSEN

select to print

Id: 12227 Author: Mathé, G Title: Thalidomide, a drug which may protect the organism against some agressive effects of the immunologic system ..- Source: s.l; s.n; 2002. 3 p. . Descriptors: SINDROME DE IMUNODEFICIENCIA ADQUIRIDA SINDROME DE IMUNODEFICIENCIA ADQUIRIDA ERITEMA NODOSO REAÇAO ENXERTO-HOSPEDEIRO IMUNOSSUPRESSORES IMUNOSSUPRESSORES INTERFERON ALFA FATOR DE NECROSE TUMORAL/AI FATOR DE NECROSE TUMORAL/AI - INTERLEUCINA-1  INTERLEUCINA-6  HANSENIASE LEPROMATOSA  NEOPLASIAS  TALIDOMIDA Location: BR191.1; 08710/s

4 / 8

HANSEN

select to print

Id: 11936 Author: Mujagic, Hamza; Chabner, Bruce A; Mujagic, Zlata Title: Mechanisms of action and potential therapeutic uses of thalidomide ..- Source: s.l; s.n; 2002. 12 p. tab. Descriptors: MIELOMA MULTIPLO MIELOMA MULTIPLO NEOPLASIAS NEOPLASIAS DEFEITOS DO TUBO NEURAL DEFEITOS DO TUBO NEURAL SENSIBILIDADE E ESPECIFICIDADE RELAÇAO ESTRUTURA-ATIVIDADE TALIDOMIDA TALIDOMIDA TALIDOMIDA RESULTADO DE TRATAMENTO Location: BR191.1; 08595/s

5 / 8

HANSEN

select to print

Id: 11824 Author: Mujagic, Hamza; Chabner, Bruce A; Mujagic, Zlata Title: Mechanisms of action and potential therapeutic uses of thalidomide ..- Source: s.l; s.n; 2002. 12 p. ilus, tab. Descriptors: ENSAIOS CLINICOS MIELOMA MULTIPLO MIELOMA MULTIPLO NEOPLASIAS NEOPLASIAS SENSIBILIDADE E ESPECIFICIDADE TALIDOMIDA TALIDOMIDA TALIDOMIDA Location: BR191.1; 08562/s

6 / 8

HANSEN

select to print

Id: 11644 Author: Mujagic, Hamza; Chabner, Bruce A; Mujagic, Zlata Title: Mechanisms of action and potential therapeutic uses of thalidomide ..- Source: s.l; s.n; 2002. 12 p. tab. Descriptors: TALIDOMIDA TALIDOMIDA TALIDOMIDA ENSAIOS CLINICOS MIELOMA MULTIPLO MIELOMA MULTIPLO NEOPLASIAS NEOPLASIAS DEFEITOS DO TUBO NEURAL DEFEITOS DO TUBO NEURAL SENSIBILIDADE E ESPECIFICIDADE RELAÇAO ESTRUTURA-ATIVIDADE RESULTADO DE TRATAMENTO Location: BR191.1; 08505/s

7 / 8

HANSEN

select to print

Id: 10963 Author: Calabrese, Leonard; Fleischer, Alan B Title: Thalidomide: current and potential clinical applications ..- Source: s.l; s.n; 2000. 9 p. tab. Descriptors: HANSENIASE LEPROMATOSA LEPROSTATICOS LEPROSTATICOS LEPROSTATICOS ARTRITE REUMATOIDE SINDROME DE BEHCET AGENTES DERMATOLOGICOS AGENTES DERMATOLOGICOS AGENTES DERMATOLOGICOS ECTROMELIA ERITEMA NODOSO DOENÇA ENXERTO-HOSPEDEIRO INFECÇOES POR HIV IMUNOSSUPRESSORES IMUNOSSUPRESSORES IMUNOSSUPRESSORES LUPUS ERITEMATOSO CUTANEO NEOPLASIAS DOENÇAS DO SISTEMA NERVOSO PERIFÉRICO ESTOMATITE AFTOSA TERATOGENIOS TALIDOMIDA TALIDOMIDA TALIDOMIDA Location: BR191.1; 07430/s

8 / 8

HANSEN

select to print

Id: 10080 Author: Anon Title: The problem with thalidomide's new incarnation (Editorial) ..- Source: s.l; s.n; 1998. 1 p. . Descriptors: SINDROME DE IMUNODEFICIENCIA ADQUIRIDA HANSENIASE APROVAÇAO DE DROGAS NEOPLASIAS TALIDOMIDA Location: BR191.1; 07139/s

---

page 1 de 1

Refine the search

Database : HANSEN

Advanced form

Search for : Free form

		Search	in field
1			WordsTitle wordsAbstract wordsAuthorInstitutional authorSubject descriptorLimitsLanguageCountry, year publicationJournalType of literatureBibliographic levelMonography in seriesPublication typeConferenceUnique identifierLocationElectronic supportEntry dateRecord type
2	and or and not		WordsTitle wordsAbstract wordsAuthorInstitutional authorSubject descriptorLimitsLanguageCountry, year publicationJournalType of literatureBibliographic levelMonography in seriesPublication typeConferenceUnique identifierLocationElectronic supportEntry dateRecord type
3	and or and not		WordsTitle wordsAbstract wordsAuthorInstitutional authorSubject descriptorLimitsLanguageCountry, year publicationJournalType of literatureBibliographic levelMonography in seriesPublication typeConferenceUnique identifierLocationElectronic supportEntry dateRecord type

Search engine: iAH powered by WWWISIS

IAH - © BIREME/PAHO/WHO Latin American and Caribbean Center on Health Sciences Information