Database : HANSEN Search on : PLASMIDEOS [Subject descriptor] References found : 4 [refine] Displaying: 1 .. 4   in format [Detailed]

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Id: 17560 Author: Honore, N Title: Le genome de Mycobacterium leprae: de l'analyse de la sequence aux enjeux therapeutiques The Mycobacterium leprae genome: from sequence analysis to therapeutic implications- Source: s.l; s.n; 2002. 7 p. ilus, tab. Abstract: The genome of Mycobacterium leprae, the causative agent of leprosy, was analyzed by rapid sequencing of cosmids and plasmids prepared from DNA isolated from one patient's strain. Results showed that the bacillus possesses a single circular chromosome that differs from other known mycobacterium chromosomes with regard to size (3.2 Mb) and G + C content (57.8%). Computer analysis demonstrated that only half of the sequence contains protein-coding genes. The other half contains pseudogenes and non-coding sequences. These findings indicate that M. leprae has undergone a major reductive evolution leaving a minimal set of functional genes for survival. Study of the coding region of the sequence provides evidence accounting for the particular pathogenic properties of M. leprae which is an obligate intracellular parasite. Disappearance of numerous enzymatic pathways in comparison with M. tuberculosis, an intracellular pathogen comparable to M. leprae, could explain the differences observed between the two organisms. Genomic analysis of the leprosy bacillus also provided insight into the molecular basis for resistance to various antibiotics and allowed identification of several potential targets for new drug treatments. (AU). Descriptors: Cromossomos Bacterianos/*GE Cosmídeos/GE DNA Bacteriano/*AN Genoma Hanseníase/DT/*PP Mycobacterium leprae/*GE/*PY/PH Plasmídeos Research Support, Non-U.S. Gov't Análise de Sequência de DNA/* Limits: Humanos Location: BR191.1; 09339/s

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Id: 13931 Author: Honore, N Title: Le genome de Mycobacterium leprae: de l'analyse de la sequence aux enjeux therapeutiques The Mycobacterium leprae genome: from sequence analysis to therapeutic implications- Source: s.l; s.n; 2002. 7 p. ilus, tab. Abstract: L'analyse génomique de Mycobacterium leprae, l'agent pathogène de la lèpre, a été réalisée grâce au séquençage à haut débit des cosmides et plasmides préparés à partir de l'ADN d´une souche isolée d'un patient. Elle a montré que ce bacille possède un seul chromosome circulaire, dont la taille (3,2Mb) et la composition en G+C (57,8%) sont réduits par rapport aux austres chromosomes mycobactériens connus. L'analyse informatique de la séquence a mis en évidence que seule la moitié de la séquences est codante. L'autre moitié contient des pseudogènes et des séquences non codantes. Le génome de M. leprae a donc subi une évolution réductive très importante qui ne lui a laissé qu'un set minimun de gènes fonctionnels pour vivre. Les informations déduites de la partie codante de la séquence permettent d'appréhender les propriétés biologiques particulières de cet agent infectieux à développement intra-cellulaire obligatoire. De plus, la disparition de nombreuses voies enzymatiques par rapport à M. tuberculosis, autre pathogène intra-cellulaire en certains points semblable à M. leprae, explique les différences observées entre les deux organismes. Enfin, l'analyse génomique du bacille lépreux permet de comprendre les bases moléculaires de sa résistance à différents antibiotiques et d'identifier des cibles potentielles pour la mise au point de nouveaux traitements. (AU). Descriptors: DNA BACTERIANO/anal CROMOSSOMOS BACTERIANOS/genet COSMIDIOS/genet HANSENIASE/quimioter HANSENIASE/fisiopatol MYCOBACTERIUM LEPRAE/genet MYCOBACTERIUM LEPRAE/fisiol MYCOBACTERIUM LEPRAE/patogen GENOMA PLASMIDEOS ANALISE DE SEQUÊNCIA DE DNA Limits: HUMANO SUPPORT, NON-U.S. GOV'T RESUMO EM INGLES Location: BR191.1; 09108/s

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Id: 11686 Author: Ohara, Naoya; Matsuoka, Masanori; Nomaguchi, Hiroko; Naito, Mariko; Yamada, Takeshi Title: Protective responses against experimental Mycobacterium leprae infection in mice induced by recombinant Bacillus Calmette-Guérin over-producing three putative protective antigen candidates ..- Source: s.l; s.n; 2001. 5 p. ilus, graf. Descriptors: MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE MYCOBACTERIUM BOVIS MYCOBACTERIUM BOVIS HANSENIASE HANSENIASE ANTIGENOS DE BACTÉRIAS VACINA BCG VACINA BCG VACINA BCG SEQUENCIA DE BASES PRIMERS DO DNA CAMUNDONGOS ENDOGAMICOS BALB C CAMUNDONGOS ENDOGAMICOS C57BL PLASMIDEOS BAÇO Limits: ANIMAL MASCULINO CAMUNDONGOS Location: BR191.1; 08478/s

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Id: 9486 Author: Eiglmeier, K; Honore, N; Cole, S. T Title: Towards the integration of foreign DNA into the chromosome of Mycobacterium leprae ..- Source: s.l; s.n; 1991. 6 p. ilus. Descriptors: ASPARTATO-SEMIALDEIDO DESIDROGENASE SEQUENCIA DE BASES DNA BACTERIANO ELETROFORESE EM GEL DE AGAR VETORES GENÉTICOS DADOS DE SEQUENCIA MOLECULAR MYCOBACTERIACEAE MYCOBACTERIUM LEPRAE PLASMIDEOS RNA DE TRANSFERENCIA DE PROLINA MAPEAMENTO POR RESTRIÇAO Limits: IN VITRO Location: BR191.1; 06342/s

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