Database : HANSEN Search on : SULFONAS/SANGUE [Subject descriptor] References found : 4 [refine] Displaying: 1 .. 4   in format [Detailed]

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Id: 17194 Author: Anon. Title: Reports: Annual report for 1950 of the Hind Kusht Nivaran Sangh (Indian Leprosy Association). Part 1 - Report of the Chairman. Part 2 - Research activities. Source: Lepr Ind;23(3):169-79, july. 1951. . Descriptors: HANSENIASE/prev HANSENIASE/psicol HANSENIASE/reabil HANSENIASE/quimioter SULFONAS/admin SULFONAS/ef adv SULFONAS/sangue SULFONAS/uso terap Location: BR191.1

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Id: 17075 Author: Fernandez, Jose M. M; Carboni, Eduardo A. Title: The action of diasone in the treatment of leprosy: preliminary report. Source: Int. J. Lepr;14(n.esp):19-29, Dec. 1946. tab, ilus. Abstract: The action of the oral administration of diasone has been studied in a group of advanced cases of leprosy of whom almost all had previously been treated with chaulmoogra oil. The drug was given for periods of 8 weeks with a daily dosage varying between 1 and 3 Grams according to individual tolerance; between each period or course of treatment there was a 4 weeks' interval. Anemia (82 per cent), asthenia and depression (88 per cent), headache (74 per cent) were noted as signs of intolerance. There were no grave consequences and intolerance was readily treated with liver extract, iron, and vitamin B complex. Activity of the drug was shown by softening, ulceration, and re-absorption of leprous nodules, healing of ulcers, and re-absorption of deep lepromatous infiltrations. Bacteriologically, granulation of the bacilli was observed but in no case had bacilli completely disappeared from the lesions. The improvement noted was greater the longer and more concentrated the treatment. The results found after 8 months trial were the following: in 5 cases treated for 3 periods, 100 per cent improved; in 11 cases treated for 2 periods, 63.6 per cent improved; in 26 cases after only 1 period of treatment, 50 per cent improved. Thus of 42 patients who had completed 1 to 3 periods of treatment, 59.5 per cent showed improvement. Finally it may be stated that diasone has proved to be effective in the treatment of leprosy in a series of 42 patients observed for 8 months. Further experimental treatment should be carried out so that definite conclusions based on greater experience can be obtained. (AU). Descriptors: HANSENIASE/quimioter HANSENOSTATICOS/hist SULFONAS/admin SULFONAS/ef adv SULFONAS/sangue SULFONAS/sint quim SULFONAS/farmacol SULFONAS/uso terap Limits: HUMANO Location: BR191.1

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Id: 6858 Author: Beiguelman, Bernardo; Pisani, R. C. B. Title: Chromosomal aberrations in leucocyte metaphases of leprosy patients under dapsone therapy. Source: Hansen. Int;1(1):53-60, 1976. tab. Abstract: Chromosome analyses were made on leukocyte metaphases of 18 leprosy patients who were ingesting daily doses of 50 mg or 100 mg of DDS and of 40 healthy individuals used for control. These analyses have shown that the proportion of numerical chromosomal aberrations in the leukocyte metaphases of the leprosy patients did not differ significantly from that observed in the cells of the controls. In contrast, the frequency of cells with chromatid or chromosome breaks and gaps was significantly increased in the leukocytesof leprosy patients. Multiple regression analysis applied to the data recorded has shown that the increase of breaks and gaps in the chromosomes of leprosy patients can not be attributed to age, years under sulfonetherapy or to concentration of DDS in blood.. Descriptors: HANSENIASE HANSENIASE HANSENIASE - SULFONAS  SULFONAS  SULFONAS  SULFONAS  SULFONAS  SULFONAS  SULFONAS  ABERRAÇOES CROMOSSOMICAS Electronic Medium: http://hansen.bvs.ilsl.br/textoc/hansenint/v01aov20/1976/PDF/v1n1/v1n1a05.pdf / pt Location: BR191.1

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Id: 414 Author: Gordon, G. R; Murray Junior, J. F; Peters, J. H. Title: Measurement of N, N'-diacetyldiaminodiphenyl sulfone (DAAS) in the plasma of leprosy patients treated with DADDS. Source: In: Annual Leprosy Research Conference, 6.Annual Leprosy Research Conference, 6/Abstracts. Atlanta, Center for Disease Control, 1971. p.16. Conference: Present in: Annual Leprosy Research Conference, 6, Atlanta, 10-12 March 1971. Descriptors: SULFONAS SULFONAS SULFONAS SULFONAS ANALISE MICROBIOLOGICA Location: BR191.1; WC335.3, A78a

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