Database : HANSEN Search on : RATOS/MICROBIOL [Subject descriptor] References found : 3 [refine] Displaying: 1 .. 3   in format [Detailed]

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Id: 19733 Author: Kurz, Xavier M; Declercq, Etienne E; Vellut, Claire M. Title: Rate and time distribution of relapses in multibacillary leprosy. Source: Int J Lep;57(3):599-606, sept. 1989. ^bgraf, ^btab. Abstract: Of the 47,068 patients registered in the Polambakkam Leprosy Center between 1955 and 1982, we selected 1886 cases having shown bacteriological positivity at any time during this period, whatever their classifications at registration, and subsequently found bacteriologically negative. After an average follow-up period of 10 years, 243 relapses were observed, giving a crude relapse rate of 12.8 per person-years of observation and a cumulative probability of relapse of 18.9%. Relapse rates were found to be dependent on regularity during smear-positive and -negative periods; a regularity greater than 75% in the smear-positive period proved to be particularly important. The results show no evidence that relapses occurring after 3 years of negativity could be reinfections, and that the relapse rate was still affected by regularity 7 years after negativation. The median delay of relapses was found to be 4.4 years and was not affected by the regularity of treatment. Descriptors: Hanseníase/microbiol Hanseníase/fisiopatol Ratos/microbiol Limits: Animais Ratos Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1989/pdf/v57n3/v57n3a01.pdf / en Location: Br191.1

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Id: 19714 Author: Yogi, Yasuko; Banba, Tomoko; Kobayashi, Masanori; Katoh, Hideki; Jahan, Nilufar; Endoh, Masumi; Nomaguchi, Hiroko. Title: Leprosy in hypertensive nude rats (SHR/NCrj-rnu). Source: Int. J. Lepr;67(4):435-445, Dec., 1999. ilus, tab, graf. Abstract: Since more than a decade ago, we have attempted to develop spontaneously hypertensive rats carrying the nude gene that permits high multiplication of Mycobacterium leprae. A congenic strain carrying nude (rnu) and hypertensive genes was produced using SHR/NCrj females and F344/NJcl-rnu males. Cross-intercross was carried out 12 times to establish the hypertensive nude rat congenic strain. As a result of the genetic monitoring test with NE12F2 generation rats, the genetic profile of the SHR/NCrj-rnu rats was the same as that of the SHR/NCrj rats except for the rnu gene. We have successfully developed a hypertensive congenic nude rat strain (SHR.F344Hfh11; SHR/NCrj-rnu). An increase in the blood pressure in nude rats was found to begin at a slightly delayed age when compared with their hairy litter mates. Both female and male rats showed the highest blood pressure at approximately 20 weeks of age--166 +/- 1.4 and 197 +/- 11 mm Hg in nude rats and 175 +/- 11 and 193 +/- 3.2 mm Hg in their hairy litter mates in female and male rats, respectively. In the present study, comparisons were made on the susceptibility to M. leprae in hypertensive SHR/NCrj-rnu and normotensive F344/NJcl-rnu rats. We have reconfirmed that hypertensive SHR/NCrj-rnu rats of the NE12F3 generation were highly susceptible to M. leprae. In the SHR/NCrj-rnu rats of both sexes excellent massive swelling due to multiplication of M. leprae was observed and, also, nodular lesions were produced in uninoculated fore feet and lips while those sites in the F344/NJcl-rnu rats showed only a slight swelling of the inoculated feet with mild nodular lesions. Although mild lymphocyte proliferation was seen only in the M. leprae-inoculated site with numerous bacilli and partial necrosis in the SHR/NCrj-rnu rats, at noninoculated sites, multiplication of M. leprae was only observed in the cells of the mononuclear phagocyte system. However, in F344/NJcl-rnu rats, lymphocyte proliferation with a few neutrophils was seen at the site of inoculated hind foot pads and everywhere at the site of multiplication of M. leprae. There was a wide difference in the susceptibility to M. leprae between the SHR/NCrj-rnu and the F344/NJcl-rnu rats. (AU)^ien. Descriptors: Hanseníase/compl Hanseníase/diag - Ratos/microbiol Limits: Ratos Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1999/pdf/v67n4/v67n4a10.pdf / en Location: BR191.1

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Id: 18318 Author: Singhi, M. K; Ghiya, B. C; Gupta, Dhruv; Kachhawa, Dilip Title: Disability rates in leprosy ..- Source: s.l; s.n; 2004. 2 p. . Descriptors: HANSENIASE/parasitol RATOS/genet RATOS/microbiol RATOS/parasitol RATOS/virol Limits: ESTUDO COMPARATIVO Location: BR191.1; 09353/S

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