Database : HANSEN Search on : TIMECTOMIA [Subject descriptor] References found : 8 [refine] Displaying: 1 .. 8   in format [Detailed]

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Id: 13564 Author: Rees, R. J; Waters, M. F; Weddell, A. G; Palmer, E Title: Experimental lepromatous leprosy ..- Source: s.l; s.n; August 5, 1967. 4 p. ilus, tab, graf. Abstract: LEPROSY is the result of infection by Mycobacterium leprae-bacilli which are closely realted to those responsible for tuberculosis. Myco. leprae, however, unlike Myco. tuberculosis, cannot as yet gown in vitro, and to such a limited extent in vivo that progress in the aetiology and treatment of the disease is making little headway.(AU). Descriptors: HANSENIASE/patol IMUNIDADE/ef rad MYCOBACTERIUM LEPRAE/cresc TIMECTOMIA Limits: ANIMAL FEMININO CAMUNDONGOS Electronic Medium: http://www.ilsl.br Location: BR191.1; 00492/s

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Id: 13480 Author: Hobbs, H. E; Harman, D. J; Rees, J. W; McDougall, A. C Title: Ocular histopathology in animals experimentally infected with Mycobacterium leprae and M. lepraemurium ..- Source: s.l; s.n; aug. 1978. 9 p. ilus, tab. Abstract: At varying periods of time following the successful establishment of systemic infections with Mycobacterium leprae or M. lepraemurium in the mouse and the nine-banded armadillo eyes were examined by light microscopy. Inoculation of bacilli was by the intravenous or intraperitoneal route or directly into the hind footpads; eyes were not directly inoculated in this study. During periods of up to 3 years under laboratory conditions no animal showed evidence of impaired vision or blindness, and the external appearance of both eyes was normal. The ocular histopathology and the sites of accumulation of bacilli are described. In immunologically normal mice infected with M. lepraemurium bacilli were much commoner in extraorbital tissues, but they were, nevertheless, found in various tissues within the orbit, including the ciliary body and sclera. In immunologically normal mice (and one rat) injected with M. leprae of human origin no bacilli were found in the eye, but in mice immunologically depressed by thymectomy and total body irradiation considerable numbers of bacilli were present in the iris and ciliary body and also in the limbal cornea. In the armadillo bacilli were found in large numbers in virtually all tissues except the lens, retina, optic nerve, and aqueous and vitreous humours, but the uveal tract was heavily involved. Findings are discussed in relation to the great frequency of ocular involvement and the importance of immune-complex disease in patients with lepromatous leprosy, and to factors wihch may favour the localisation and multiplication of Mycobacterium leprae in the eye.(AU). Descriptors: TIMECTOMIA MICOBACTERIOSE/patol HANSENIASE/patol OLHO/microbiol OLHO/patol TATUS XENARTROS MYCOBACTERIUM LEPRAEMURIUM/isol Limits: ANIMAL CAMUNDONGOS RATOS Electronic Medium: http://www.ilsl.br Location: BR191.1; 00338/s

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Id: 13421 Author: Fieldsteel, A. Howard; McIntosh, Arthur H Title: Effect of neonatal thymectomy and antithymocytic serum on susceptibility of rats to mycobacterium leprae infection ..- Source: s.l; s.n; nov. 1971. 6 p. tab, graf. Abstract: Neonatal thymectomy and neonatal thymectomy plus ATS resulted in a merked increase in susceptibility of both Buffalo and Lewis rats to infection with M. leprae. In Buffalo rats, increase in susceptibility was limited to footpad infection. In Lewis rats, this was extended to include testis infection where the organisms in thymectomized-ATS-treated rats were found to be still in the logarithmic phase of growth 15 months after inoculation.(AU). Descriptors: MICOBACTERIOSE/imunol MYCOBACTERIUM LEPRAE/isol RATOS DE CEPAS ENDOGÂMICAS TESTICULO/microbiol TIMECTOMIA TIMO/imunol TIMO/fisiol Limits: ANIMAL MASCULINO FEMININO CAMUNDONGOS COELHOS RATOS Electronic Medium: http://www.ilsl.br Location: BR191.1; 00497/s

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Id: 13339 Author: Hobbs, H. E; Harman, D. J; Rees, J. W; McDougall, A. C Title: Ocular histopathology in animals experimentally infected with Mycobacterium leprae and M. lepraemurium ..- Source: s.l; s.n; aug. 1978. 9 p. ilus, tab. Abstract: At varying periods of time following the successful establishment of systemic infections with Mycobacterium leprae or M. lepraemurium in the mouse and the nine-banded armadillo eyes were examined by light microscopy. Inoculation of bacilli was by the intravenous or intraperitoneal route or directly into the hind footpads; eyes were not directly inoculated in this study. During periods of up to 3 years under laboratory conditions no animal showed evidence of impaired vision or blindness, and the external appearance of both eyes was normal. The ocular histopathology and the sites of accumulation of bacilli are described. In immunologically normal mice infected with M. lepraemurium bacilli were much commoner in extraorbital tissues, but they were, nevertheless, found in various tissues within the orbit, including the ciliary body and sclera. In immunologically normal mice (and one rat) injected with M. leprae of human origin no bacilli were found in the eye, but in mice immunologically depressed by thymectomy and total body irradiation considerable numbers of bacilli were present in the iris and ciliary body and also in the limbal cornea. In the armadillo bacilli were found in large numbers in virtually all tissues except the lens, retina, optic nerve, and aqueous and vitreous humours, but the uveal tract was heavily involved. Findings are discussed in relation to the great frequency of ocular involvement and the importance of immune-complex disease in patients with lepromatous leprosy, and to factors wihch may favour the localisation and multiplication of Mycobacterium leprae in the eye.(AU). Descriptors: TATUS HANSENIASE/patol MICOBACTERIOSE/patol MYCOBACTERIUM LEPRAEMURIUM/isol TIMECTOMIA XENARTROS - OLHO/microbiol  OLHO/patol Limits: ANIMAL CAMUNDONGOS RATOS Electronic Medium: http://www.ilsl.br Location: BR191.1; 00991

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Id: 13279 Author: Fieldsteel, A. Howard; Levy, Louis Title: Dapsone chemotherapy of Mycobacterium leprae infection of the neonatally thymectomized Lewis rat ..- Source: s.l; s.n; nov. 1976. 6 p. tab. Abstract: In order to learn whether the neonatally thymectomized Lewis rat (NTLR) infected with Mycobacterium leprae could serve as a model for chemotherapeutic studies in a situation resembling that found in human lepromatous leprosy, NTLR inoculated with M. leprae either locally or intravenously 9 to 16 months earlier were treated for from 1.5 to 8.5 months with dapsone (4,4´-diaminodiphenylsulfone, DDS) incorporated in the rat chow in the concentration providing the minimal inhibitory concentration of the drug for M. leprae and in the 100-fold larger concentration. NTLR were killed at intervals; the M. leprae were counted and passed to mice. Treatment with the smaller dosage of dapsone neither killed M. leprae nor reduced the number of organisms in the bacterial populations, whereas treatment with the larger dosage both killed M. leprae and reduced their numbers. The rate at which the organisms were killed (i.e., rendered noninfective for mice) was much the same as that in patients treated with dapsone in comparable dosage. The dead organisms were removed from the rat tissues at a faster rate than encountered in patients. The NTLR may indeed be suitable for chemotherapeutic studies relevant to man. In addition, the more rapid diappearance of dead M. leprae from the rat tissues may facilitate the study of treatment regimens designed to eradicate persisting viable organisms.(AU). Descriptors: ANIMAIS RECEM-NASCIDOS DAPSONA/admin MODELOS ANIMAIS DE DOENCAS HANSENIASE/quimioter HANSENIASE/parasitol CAMUNDONGOS ENDOGÂMICOS BALB C MYCOBACTERIUM LEPRAE RATOS ENDOGÂMICOS LEW RATOS DE CEPAS ENDOGÂMICAS TIMECTOMIA Limits: ANIMAL MASCULINO FEMININO CAMUNDONGOS RATOS SUPPORT, U.S. GOV'T, P.H.S. Electronic Medium: http://www.ilsl.br Location: BR191.1; 00545/s

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Id: 13220 Author: Rees, R. J; McDougall, A. C;; Weddell, A. G Title: The testis in mice infected with Mycobacterium leprae ..- Source: s.l; s.n; feb. 1975. 7 p. ilus, tab. Abstract: Following inoculation either locally or intravenously with Mycobact. leprae of human origin, the histopathology and bacteriology of the testis in experimental mice is described. Normal mice, and mice rendered immunologically deficient by thymectomy and whole-body irradiation, were studied. Attention is drawn to a heavy bacillation of the testis in mice from both groups. Bacilli were found in and beneath the tunica albuginea, but mainly in interstitial cells and in macrophages surrounding the tubules. The percentage of solidly staining bacilli was high, and globi were frequent. The study showed that the testis in mice is particularly favourable for the lodgement and multiplication of Mycobact. laprae following either local or intravenous inoculation. The significance of this in relation to the metabolism of the leprosy bacillus and to the frequent occurrence of testicular damage in the lepromatous male patient is discussed. This work was supported by grants to A. G. M. Weddell and A. C. McDougall from the Medical Research Council and the British Leprosy Relief Association (LEPRA).(AU). Descriptors: HANSENIASE/microbiol HANSENIASE/patol IMUNOSSUPRESSAO CAMUNDONGOS ENDOGÂMICOS CBA CAMUNDONGOS NUS MYCOBACTERIUM LEPRAE/isol TESTICULO/microbiol TESTICULO/patol TIMECTOMIA IMUNIDADE/ef rad Limits: ANIMAL MASCULINO CAMUNDONGOS Electronic Medium: http://www.ilsl.br Location: BR191.1; 01582/s

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Id: 6773 Author: Fieldsteel, A. Howard; Gartner, Suzanne Title: Effect of thymectomy and antilymphocyte serum on Mycobacterium Leprae infection in mice ..- Source: s.l; s.n; 1975. 4 p. tab, graf. Descriptors: TIMECTOMIA - MYCOBACTERIUM LEPRAE Location: BR191.1; 03921/s

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Id: 421 Author: Congdon, C. C; Payne, H; Gengozian, N. Title: Immune status of thymectomized chimeras. Source: In: Annual Leprosy Research Conference, 6.Annual Leprosy Research Conference, 6/Abstracts. Atlanta, Center for Disease Control, 1971. p.23. Conference: Present in: Annual Leprosy Research Conference, 6, Atlanta, 10-12 March 1971. Descriptors: HANSENIASE HANSENIASE TIMECTOMIA Location: BR191.1; WC335.3, A78a

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