|
|
| Id: | 27003
| | Autor: | Sachdeva, Geetanjali; Kaur, Gurvinder; Bhutani, L. K; Bamezai, R. N. K. | | Título: | Lymphoproliferative responses of leprosy patients and healthy controls to nitrocellulose-bound M. leprae antigens.
| | Fonte: | Int. J. Lepr;67(2):133-142, Jun., 1999. tab, graf.
| | Resumo: | The lymphoproliferative responses of 51 leprosy patients and 11 healthy contacts were analyzed using the nitrocellulose-bound specific antigen fractions from the cell-free extract of Mycobacterium leprae. The main proliferation-inducing fraction for peripheral blood mononuclear cells of the healthy contacts was found to be the Fraction II, bearing antigens in the range of 66-45 kDa. However, this fraction failed to induce lymphoproliferation in the leprosy patients, unlike healthy contacts (p < 0.032). The number of responders as well as the strength of the responses to 66-45 kDa proteins were found to be low in the leprosy patients compared to the healthy contacts. Further, preliminary analysis with the subfractions of Fraction II produced a similar pattern, suggesting that the immune response to the antigens in the range of 66-45 kDa M. leprae proteins remains suppressed in subjects with clinical signs and symptoms of the disease. (AU)^ien.
| | Descritores: | Hanseníase/genet
Hanseníase/imunol
Colódio/anal
Colódio/uso diag
Mycobacterium leprae/genet
Mycobacterium leprae/imunol
| | Meio Eletrônico: | http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1999/pdf/v67n2/v67n2a03.pdf - en.
| | Localização: | BR191.1 |
|
