Base de dados : HANSEN Pesquisa : HANSENIASE/GENET [Descritor de assunto] Referências encontradas : 182 [refinar] Mostrando: 1 .. 20   no formato [Detalhado]

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Id: 27301 Autor: Roger, Michel; Levee, Geraldine; Chanteau, Suzanne; Gicquel, Brigitte; Schurr, Erwin. Título: No evidence for linkage between leprosy susceptibility and the human natural resistance-associated macrophage protein 1 (NRAMP1) gene in French Polynesia. Fonte: Int. J. Lepr;65(2):197-202, Jun. 1997. tab. Resumo: In order to determine whether a human homolog (NRAMP1) to a murine candidate gene for resistance to mycobacteria influences susceptibility to human disease, we analyzed data from seven multicase leprosy families (84 individuals) from French Polynesia for linkage markers within the NRAMP1 gene and leprosy per se. Individual family members were typed at nine polymorphic loci within NRAMP1. In addition, three physically linked, polymorphic microsatellite markers-D2S104, D2S173 and D2S1471-were also typed. Linkage analyses were done using affected sibpair and LOD score methods employing different modes of inheritance with full and reduced penetrance. The results of this study strongly suggest that NRAMP1 is not linked to leprosy susceptibility in the French Polynesian families tested. (AU)^ien. Descritores: Hanseníase/epidemiol Hanseníase/genet Proteínas de Transporte/genet Proteínas de Membrana/genet Limites: Humanos Masculino Feminino Localização: BR191.1

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Id: 27167 Autor: Yogi, Yasuko; Endoh, Masumi; Banba, Tomoko; Okamura, Haruki; Nomaguchi, Hiroko. Título: Susceptibility to Mycobacterium leprae of ALY (Alymphoplasia) mice and IFN-gamma induction in the culture supernatant of spleen cells. Fonte: Int. J. Lepr;66(4):464-474, Dec. 1998. ilus, graf. Resumo: The aly/aly (alymphoplasia) mice from a mutation of a colony of the C57BL/6J mouse strain, which has a systemic absence of lymph nodes and Peyer's patches, are deficient in both T- and B-cell-mediated immune functions. We have undertaken a comparison of susceptibility to Mycobacterium leprae of ALY (aly/aly, aly/+) mice with C57BL/6J mice. The aly/aly mouse was found to have an excellent high susceptibility to M. leprae with no distinction between female and male. The aly/+ mouse also was more susceptible to M. leprae at an earlier stage than the C57BL/6J mouse. Therefore, we examined and compared the cytokine gene expression and gamma interferon (IFN-gamma) induction in the splenocytes of ALY mice. The expression of interleukin 4 (IL-4), IL-10 and IL-12 mRNA was weakly stimulated with ML-lysate in inoculated aly/aly mice but IL-2, IL-6, IGIF/IL-18 and IFN-gamma mRNA were not observed. None of the cytokine genes used appeared, except the mRNA for IL-1-alpha, when uninfected cultured spleen cells were stimulated with ML-lysate. Also, IFN-gamma production was not induced. However, the appearance of these cytokine genes was observed when stimulated with concanavalin A (ConA), and IFN-gamma production was also induced in the culture supernatant by aly/+ and even aly/aly mice stimulated with ConA. To examine the reason why IFN-gamma cannot be produced by splenocytes of ALY mice inoculated with M. leprae, we detected cytokine gene expression and IFN-gamma induction in the presence of recombinant murine IL-12 or IGIF/IL-18. IL-2 mRNA expression was detected in all of the mice tested in the presence of IL-12 but not in aly/aly mice under IGIF/IL-18, and iNOS mRNA expression was not observed in aly/aly mice under IL-12 or IGIF/IL-18. IL-4 and IL-10 mRNA were detected by aly/aly mice only by exposure to IGIF/IL-18. In culture, the supernatant with ML antigens of the aly/aly mice did not produce IFN-gamma in spite of the presence of IL-12 and IGIF/IL-18, while IFN-gamma was weakly induced in aly/+ mice stimulated with ML-lysate and in the presence of IGIF/IL-18. Nevertheless, IFN-gamma production was observed in splenocytes of the aly/aly mice stimulated with ConA and also with IGIF/IL-18 plus anti-CD3 antibody. Our results suggest that ALY mice might be showing a high susceptibility to M. leprae because of deficient priming for activation of T cells with the leprosy bacilli infection. Moreover, it is possible that the phagocytic activities of the macrophages of ALY mice are also impaired. (AU)^ien. Descritores: Hanseníase/genet Hanseníase/imunol Mycobacterium leprae/genet Mycobacterium leprae/imunol Limites: Animais Camundongos Meio Eletrônico: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1998/pdf/v66n4/v66n4a04.pdf - en. Localização: BR191.1

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Id: 27157 Autor: Ishaque, M. Título: Investigations into cultivation of M. leprae under low oxygen tension. Fonte: Int J Lep;57(1):115-116, Mar. 1989. . Descritores: Hanseníase/genet Hanseníase/microbiol Meio Eletrônico: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1989/pdf/v57n1/v57n1cor05.pdf - en. Localização: Br191.1

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Id: 27150 Autor: Ramos, Teresa; Zalcberg-Quintana, Ilana; Appelberg, Rui; Sarno, Euzenir N; Silva, Manuel T. Título: T-helper cell subpopulations and the immune spectrum of leprosy. Fonte: Int J Lep;57(1):73-81, Mar. 1989. . Descritores: Hanseníase/genet Hanseníase/imunol Linfócitos T Auxiliares-Indutores/clas Linfócitos T Auxiliares-Indutores/imunol Limites: Humanos Meio Eletrônico: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1989/pdf/v57n1/v57n1edt01.pdf - en. Localização: Br191.1

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Id: 27121 Autor: Abel, Laurent; Demenais, Florence; Baule, Marie-Sophie; Blanc, Madeleine; Muller, Anne; Raffoux, Colette; Millan, Jacques; Bois, Etienne; Babron, Marie-Claude; Feingold, Nicole. Título: Genetic susceptibility to leprosy on a Caribbean Island: linkage analysis with five markers. Fonte: Int J Lepr;57(2):465-471, June 1989. ^btab. Descritores: Alótipos da Imunoglobulina Gm/genet Alótipos de Imunoglobulina/genet Hanseníase/genet Hanseníase Virchowiana/genet Limites: Humanos Meio Eletrônico: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1989/pdf/v57n2/v57n2a02.pdf - en. Localização: Br191.1

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Id: 27078 Autor: Jayaseelan, Elizabeth; Shariff, Shameem; Rout, Pritilata. Título: Cytodiagnosis of primary neuritic leprosy. Fonte: Int. J. Lepr;67(4):429-434, Dec., 1999. ilus, tab. Resumo: The diagnosis of primary neuritic leprosy (PNL) and its differentiation from other causes of peripheral neuropathy is difficult since acid-fast bacilli (AFB) smears and skin biopsy are negative from anesthetic areas. A biopsy of the involved nerve is the only conclusive method of diagnosis. Such a biopsy may not necessarily be free of complications when a large nerve is involved. However, fine needle aspiration has in this study proved to be a simple technique to demonstrate inflammation granulomas and AFB from these involved nerves in 18 of the 27 cases suspected to have PNL. The validity of the cytological classification into morphological subtypes may have to be supplemented by a large series of studies. (AU)^ien. Descritores: Hanseníase/genet Hanseníase/patol Hanseníase Tuberculóide/genet Hanseníase Tuberculóide/patol Meio Eletrônico: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1999/pdf/v67n4/v67n4a09.pdf - en. Localização: BR191.1

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Id: 27077 Autor: Beuria, Mihir K; Mohanty, Keshar K; Katoch, Kiran; Sengupta, U. Título: Determination of circulating IgG subclasses against lipoarabinomannan in the leprosy spectrum and reactions. Fonte: Int. J. Lepr;67(4):422-428, Dec., 1999. tab. Resumo: IgG subclasses against lipoarabinomannan of mycobacteria were analyzed in the sera of leprosy patients. Patients with active leprosy [tuberculoid and lepromatous, patients undergoing erythema nodosum leprosum (ENL) and reversal reactions] and inactive cases (tuberculoid and lepromatous who were cured after chemotherapy) were included in this study. Active lepromatous patients had higher levels of IgG subclasses, except IgG4, compared to active tuberculoid patients. Some of the inactive cases (lepromatous patients cured after chemotherapy) were positive for the IgG1, IgG2 and IgG3 subclasses. However, their levels are lower than active lepromatous cases. On the other hand, no difference in the subclass levels between the active and inactive tuberculoid groups could be observed. While a significant fall in the level of IgG3 in ENL was observed as compared to lepromatous leprosy without ENL, higher levels of IgG1 and IgG2 were found in patients with reversal reactions compared to their active counterparts without reactions. (AU)^ien. Descritores: Hanseníase/genet Hanseníase/imunol Meio Eletrônico: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1999/pdf/v67n4/v67n4a08.pdf - en. Localização: BR191.1

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Id: 27074 Autor: Wang, Li-Man; Kimura, Akinori; Satoh, Manatsu; Mineshita, Satoru. Título: HLA linked with leprosy in Southern China; HLA-linked resistance alleles to leprosy. Fonte: Int. J. Lepr;67(4):403-408, Dec., 1999. . Resumo: According to the World Health Organization recommended multidrug therapy (WHO/MDT), we have carried out this study to investigate the presence of HLA-linked susceptibility or resistance to leprosy in a southern Chinese population. Sixty-nine leprosy patients and 112 healthy controls participated in the study. HLA-DR2 subtypes, HLA-B and MHC Class I chain-related A (MICA) alleles were typed at the DNA level using the polymerase chain reaction-single strand conformation polymorphism method. The frequencies of HLA-DR2-DRB1 alleles did not show any significant differences between the patient and the control groups, suggesting that the disease susceptibility was not associated with the DR2 subtypes in this southern Chinese population. On the other hand, in the multibacillary (MB) patients significantly decreased allele frequencies of HLA-B46 (0.040 in MB patients vs 0.129 in controls) and MICA-A5 (0.200 vs 0.380) were observed compared with the healthy controls. The calculated relative risk (RR) for B46 was 0.28; for MICA-A5, 0.52. In addition, on haplotype analysis the frequency of the HLA-B46/MICA-A5 haplotype was significantly decreased in the MB patients compared to controls (0.060 vs 0.233, RR = 0.22, p < 0.01). These results suggest that an HLA-linked disease-resistant gene to MB leprosy in southern China is in strong linkage disequilibrium with the HLA-B46/MICA-A5 haplotype. In other words, the resistant gene may be located near the HLA-B/MICA region and not in the HLA-DR locus. (AU)^ien. Descritores: Antígenos HLA/anal Antígenos HLA/imunol Hanseníase/genet Meio Eletrônico: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1999/pdf/v67n4/v67n4a05.pdf - en. Localização: BR191.1

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Id: 27073 Autor: Soto, Carlos Y; Moreno, Pedro A; Valencia, James T; Bernal, Maria M; Guzman, Fanny; Patarroyo, Manuel E; Murillo, Luis A. Título: Isolation, characterization, molecular cloning and amplification of a species-specific M. leprae antigen. Fonte: Int. J. Lepr;67(4):392-402, Dec., 1999. ilus, tab, graf. Resumo: A polyclonal serum sample from a lepromatous leprosy (LL) patient, which presented a specific recognition pattern for leprosin, was used to screen a Mycobacterium leprae genomic library constructed with DNA isolated from human lepromas. One clone, designated ML4-1, which expressed a specific antigenic determinant of M. leprae as part of a beta-galactosidase fusion protein, was isolated. The 1.932 bp M. leprae-derived genomic fragment was sequenced, and it had an incomplete open-reading frame shown to code for a 644 amino-acid polypeptide (72.3 kDa). Some partial nucleotide homology to the M. tuberculosis MTCY9C4 cosmid and the M. leprae B1913 cosmid were found. Southern blot assays using the 584 bp Eco RI-Bam HI fragment excised from the ML4-1 clone revealed that this sequence is present only in the M. leprae genome and not in the 24 different mycobacterial DNA tested. Two oligonucleotides based on the genomic sequence were also synthesized and used as amplifiers for a polymerase chain reaction (PCR) test, giving a positive signal exclusively in M. leprae DNA. Furthermore, 32 sequential synthetic peptides, 20 amino-acids long, spanning the entire protein corresponding to the hypothetical ML4-1 clone sequence, were synthesized and evaluated by ELISA. A peptide included in the 221-240 region was significantly recognized by either lepromatous leprosy or healthy tuberculosis contact patient sera. Thus, PCR amplification of this fragment, along with the recognition of its protein sequence by leprosy patient sera, could be a useful tool for a potential diagnostic method in the detection of M. leprae infection in the future. (AU)^ien. Descritores: Mycobacterium leprae/genet Mycobacterium leprae/isol Hanseníase Hanseníase/genet Meio Eletrônico: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1999/pdf/v67n4/v67n4a04.pdf - en. Localização: Br191.1

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Id: 27046 Autor: Rafi, Abdolnasser; Donoghue, Helen D; Stanford, John L. Título: Application of Polymerase Chain Reaction for the Detection of Mycobacterium leprae DNA in Specimens from Treated Leprosy Patients. Fonte: Int. J. Lepr;63(1):42-47, 1995. ^btab. Resumo: Resumo: In this study of leprosy patients apparently cured by dapsone monotherapy, the polymerase chain reaction (PCR), one of the most reliable and sensitive DNA-based assays, was used for the specific detection of Mycobacterium leprae DNA. Sputum and slit-skin samples from 44 such patients at Baba Baghi Leprosy Sanatorium in Iran were examined. Primers for a 530-base-pair fragment of the gene encoding the 36-kDa antigen of M. leprae were used for the study. The PCR results were compared with microscopy for acid-fast bacilli. Of the 44 sputum samples, 2 were positive by PCR (4.5%) and of the 44 slit-skin swabs taken from the same patients, 10 were PCR positive (22.7%). Only one patient was PCR positive for both sputum and slit-skin specimens (2.3%). No positive results were found by acid-fast microscopy. In total, 11 of 44 (25%) patients in this study were found to be PCR positive for M. leprae, and it was thought probable that this indicated the presence of live organisms. Particularly interesting was the statistically significant association of positive results from slit-skin swabs with paucibacillary rather than multibacillary leprosy. It is suggested that whereas relapse or immunological reaction in paucibacillary disease may result from surviving organisms, in multibacillary leprosy this may be due to re-infection. Descritores: Reação em Cadeia da Polimerase/métodos DNA/genet Hanseníase/genet Hanseníase/fisiopatol Meio Eletrônico: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1995/pdf/v63n1/v63n1a07.pdf - en. Localização: BR191.1

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Id: 27044 Autor: Nakamura, Masahiro. Título: Optimal pH for Preserving the Activity of Mycobacterium leprae During Incubation of Cells in a Cell-Free Liquid Medium. Fonte: Int. J. Lepr;63(1):28-34, 1995. ^bgraf. Resumo: Resumo: The effect of the pH of a cell-free liquid medium on the activity of Mycobacterium leprae during incubation of the cells was investigated. As a parameter for evaluating the activity, the amount of adenosine triphosphate (ATP) extracted from the incubated cells collected by centrifugation was measured. The results demonstrate that the activity of M. leprae cells was maintained at a significant level for approximately 4 weeks at 30 degrees C in 0.05 M phosphate buffer containing 10% fetal calf serum at pH 7.0 compared to cells at other pHs tested, but activity was not preserved in phosphate buffer at pH 7.0 without serum and incubated at 37 degrees C. The maintenance of the activity under these conditions was prolonged somewhat by the addition of glycerin (2%) to the medium, and was definitely inhibited by rifampin but not by either penicillin or isoniazid. From the results reported here, it could be postulated that the optimal pH of cell-free media for the study of cultivation of M. leprae is 7.0. Descritores: Mycobacterium leprae/genet Mycobacterium leprae/imunol Hanseníase/genet Meio Eletrônico: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1995/pdf/v63n1/v63n1a05.pdf - en. Localização: BR191.1

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Id: 27023 Autor: Sharma, Pankaj; Kar, Hemant K; Misra, Radhey S; Mukherjee, Ashok; Kaur, Harvinder; Mukherjee, Rama; Rani, Rajni. Título: Induction of lepromin positivity following immuno-chemotherapy with mycobacterium w vaccine and multidrug therapy and its impact on bacteriological clearance in multibacillary leprosy: report on a hospital-based clinical trial with the candidate antileprosy vaccine. Fonte: Int. J. Lepr;67(3):259-269, Sept., 1999. tab, graf. Resumo: A vaccine based on autoclaved Mycobacterium w was administered, in addition to standard multidrug therapy (MDT), to 157 bacteriologically positive, lepromin-negative, multibacillary (LL, BL and BB) leprosy patients. The vaccinees were supported by a well-matched control group of 147 patients with similar type of disease who received a placebo injection in addition to MDT. The MDT was given for a minimum period of 2 years and continued until skin-smear negativity, while the vaccine was given at 3-month intervals up to a maximum of 8 doses. The lepromin response evaluated in terms of percentage of subjects converting to positivity status, measurement in millimeters, and duration of lepromin positivity sustained, reflected a statistically significant better outcome in the vaccine group patients (especially LL and BL leprosy) in comparison to those in the placebo group. The data indicate that lepromin-positivity status seems to have an impact on accelerating the bacteriological clearance, as is evident by the statistically significant accelerated decline in the BI of those patients who converted to lepromin positivity as compared to those remaining lepromin negative throughout therapy and post-therapy follow up. To conclude, the addition of the Mycobacterium w vaccine to standard MDT induces a lepromin response of a statistically significant higher magnitude than that observed with MDT alone. (AU)^ien. Descritores: Mycobacterium leprae/genet Mycobacterium leprae/imunol Hanseníase/genet Hanseníase/imunol Antígeno de Mitsuda/imunol Meio Eletrônico: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1999/pdf/v67n3/v67n3a05.pdf - en. Localização: BR191.1

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Id: 27011 Autor: Rada-Schlaefli, Elsa; Santaella, Carlos; Aranzazu, Nacarid; Convit, Jacinto. Título: Detection of antibodies toward secreted mycobacterial antigen 85 in untreated leprosy patients' Sera. Fonte: Int. J. Lepr;67(2):168-170, Jun., 1999. ilus, tab. Descritores: Hanseníase/genet Hanseníase/imunol Meio Eletrônico: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1999/pdf/v67n2/v67n2cor04.pdf - en. Localização: BR191.1

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Id: 27003 Autor: Sachdeva, Geetanjali; Kaur, Gurvinder; Bhutani, L. K; Bamezai, R. N. K. Título: Lymphoproliferative responses of leprosy patients and healthy controls to nitrocellulose-bound M. leprae antigens. Fonte: Int. J. Lepr;67(2):133-142, Jun., 1999. tab, graf. Resumo: The lymphoproliferative responses of 51 leprosy patients and 11 healthy contacts were analyzed using the nitrocellulose-bound specific antigen fractions from the cell-free extract of Mycobacterium leprae. The main proliferation-inducing fraction for peripheral blood mononuclear cells of the healthy contacts was found to be the Fraction II, bearing antigens in the range of 66-45 kDa. However, this fraction failed to induce lymphoproliferation in the leprosy patients, unlike healthy contacts (p < 0.032). The number of responders as well as the strength of the responses to 66-45 kDa proteins were found to be low in the leprosy patients compared to the healthy contacts. Further, preliminary analysis with the subfractions of Fraction II produced a similar pattern, suggesting that the immune response to the antigens in the range of 66-45 kDa M. leprae proteins remains suppressed in subjects with clinical signs and symptoms of the disease. (AU)^ien. Descritores: Hanseníase/genet Hanseníase/imunol Colódio/anal Colódio/uso diag Mycobacterium leprae/genet Mycobacterium leprae/imunol Meio Eletrônico: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1999/pdf/v67n2/v67n2a03.pdf - en. Localização: BR191.1

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Id: 26918 Autor: Yushin, M. Yu. Título: A study of the biology of M. lufu and prospects for using it in leprosy investigations. Fonte: Int. J. Lepr;68(2):179-182, Jun., 2000. . Descritores: Hanseníase/genet Hanseníase/imunol Hanseníase/microbiol Hanseníase/fisiopatol Meio Eletrônico: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/2000/pdf/v68n2/v68n2cor04.pdf - en. Localização: BR191.1

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Id: 26894 Autor: Manandhar, Rakesh; LeMaster, Joseph W; Butlin, C. Ruth; Brennan, Patrick J; Roche, Paul W. Título: Interferon-Gamma responses to candidate leprosy skin-test reagents detect exposure to leprosy in an endemic population. Fonte: Int. J. Lepr;68(1):40-48, Mar., 2000. tab, graf. Resumo: New tools for the detection of leprosy exposure in a community will be necessary for the eradication of leprosy. Candidate leprosy skin-test antigens derived from the fractionation of the leprosy bacillus into cytoplasmic and cell-wall proteins free of immuno-inhibitory mycobacterial lipoglycans and carbohydrates were used in an overnight blood test to determine whether exposure to leprosy can be detected by the production of the cytokine interferon gamma (IFN-gamma). Strong IFN-gamma responses were detected in leprosy contacts to both skin-test antigens compared with control subjects from the same endemic communities. There was little response in patients with tuberculosis. Responses were greatest in contacts with recent leprosy exposure. The implications of these findings for the application of these reagents in a field trial as skin tests to detect exposure to leprosy are discussed in light of the strong association between overnight IFN-gamma to PPD and the tuberculin skin-test responses previously reported. (AU)^ien. Descritores: Interferon Tipo II/farmacol Interferon Tipo II/uso terap Hanseníase/genet Hanseníase/imunol Meio Eletrônico: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/2000/pdf/v68n1/v68n1a06.pdf - en. Localização: BR191.1

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Id: 26865 Autor: Curtiss III, Roy; Blower, Sally; Cooper, Kevin; Russell, David; Silverstein, Samuel; Young, Lowell. Título: Leprosy Workshop: Leprosy research in the post-genome era. Fonte: Int. J. Lepr;68(4):492-503, Dec., 2000. . Conferência: Apresentado em: Leprosy Workshop, Washington, 21-22 November 1999. Descritores: Hanseníase/genet Hanseníase/fisiopatol Meio Eletrônico: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/2000/pdf/v68n4/v68n4wor.pdf - en. Localização: BR191.1

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Id: 26702 Autor: Anon. Título: Microbiology & molecular biology. Fonte: Int. J. Lepr;70(4):243A-257A, Dec., 2002. . Conferência: Apresentado em: International Leprosy Congress, 16, Salvador, 4-9 Aug., 2002. Descritores: Hanseníase/genet Hanseníase/microbiol Meio Eletrônico: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/2002/pdf/v70n4/v70n4abs16.pdf - en. Localização: BR191.1

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Id: 26692 Autor: Anon. Título: Microbiology & Molecular biology. Fonte: Int. J. Lepr;70(4):49A-61A, Dec., 2002. . Conferência: Apresentado em: International Leprosy Congress, 16, Salvador, 4-9 Aug., 2002. Descritores: Hanseníase/genet Hanseníase/microbiol Hanseníase/patol Meio Eletrônico: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/2002/pdf/v70n4/v70n4abs06.pdf - en. Localização: BR191.1

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Id: 26611 Autor: Rojas-Espinosa, Oscar; Wek-Rodríguez, Kendy; Arce-Paredes, Patricia; Aguilar-Torrentera, Fabiola; Truyens, Carine; Carlier, Yves. Título: Contrary to BCG, MLM fails to induce the production of TNFx and NO by macrophages. Fonte: Int. J. Lepr;70(2):111-118, Jun. 2002. ilus, tab, graf. Resumo: Pathogenic mycobacteria must possess efficient survival mechanisms to resist the harsh conditions of the intraphagosomal milieu. In this sense, Mycobacterium lepraemurium (MLM) is one of the most evolved intracellular parasites of murine macrophages; this microorganism has developed a series of properties that allows it not only to resist, but also to multiply within the inhospitable environment of the phagolysosome. Inside the macrophages, MLM appears surrounded by a thick lipid-envelope that protects the microorganism from the digestive effect of the phagosomal hydrolases and the acid pH. MLM produces a disease in which the loss of specific cell-mediated immunity ensues, thus preventing activation of macrophages. In vitro, and possibly also in vivo, MLM infects macrophages without triggering the oxidative (respiratory burst) response of these cells, thus preventing the production of the toxic reactive oxygen intermediaries (ROI). Supporting the idea that MLM is within the most evolved pathogenic microorganisms, in the present study we found, that contrary to BCG, M. lepraemurium infects macrophages without stimulating these cells to produce meaningful levels of tumor necrosis factor alpha (TNF alpha) or nitric oxide (NO). Thus, the ability of the microorganisms to stimulate in their cellular hosts, the production of ROI and RNI (reactive nitrogen intermediates), seems to be an inverse correlate of their pathogenicity; the lesser their ability, the greater their pathogenicity. (AU)^ien. Descritores: Hanseníase/genet Hanseníase/imunol Vacina BCG/imunol Vacina BCG/uso terap Receptores de Fatores de Necrose Tumoral/imunol Meio Eletrônico: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/2002/pdf/v70n2/v70n2a03.pdf - en. Localização: BR191.1

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