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Id: | 22351
| Autor: | S, B. B. M. Dharmendra; Chatterjee, K. R. | Título: | Thiosemicarbazone in the treatment of leprosy.
| Fonte: | Lepr Ind;24(3):93-, july, 1952. tab.
| Resumo: | (I) The previous work with thiosemicarbazone in the treatment of leprosy is summarised. (2) Siocarbazone brand of thiosemicarbazone has been used in 52 cases of leprosy, 9 untraeded neural cases, 27 untreated lepromatous cases and 16 previously treated lepromatous cases, 15 with sulphones, and I with hydnocarpus oil. The duration of treatment has from 2 months to 16 months with an average of I0 months. (3) The patients have stood the drug well and there has been satisfactory clinical and bacteriological response. In addition to usual therapeutic affects, special features with thiosemicarbazone treatment have been the complete or partial restoration of sensation in the anaesthetic patches and in the limbs with polyneuritic type of anaesthesia, replacement of deseased nails by new ones, and growth of new hair in depilated areas. Considering the short period of treatment those features are rather remarkable. (4) In the toxicity of thiosemicarbazone seems to be less than that of the sulphones specially in relation to its effect on the haemopoietic system. However, the thiosemicarbazone is not as free from toxicity as described by some workers eho have used it in leprosy. A special kind of toxicity which indicates specific intolerance has been noticed and this has been manifested by sudden rise of temperature even after small doses of the drug (AU).
| Descritores: | HANSENIASE/quimioter HANSENOSTATICOS/admin HANSENOSTATICOS/ef adv HANSENOSTATICOS/farmacol HANSENOSTATICOS/tox HANSENOSTATICOS/uso terap
| Localização: | BR191.1 |
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