|
|
| Id: | 20441
| | Autor: | Emmerson, George A; Anderson, Hamiilton H. | | Título: | Toxicity of certain proposed antileprosy dyes: fluorescein, eosin, erythrosin, and others.
| | Fonte: | Int. J. Lepr;2(3):257-263, Aug.-Oct. 1934. tab.
| | Resumo: | Fluorescein, eosin, erythrosin and methylene green were found to be lethal at 300, 350, 200 and 150 mgm. per kilogram, respectively when administered intravenously to rabbits, and at 600, 500, 300 and 125 mgm. per kilogram intraperitoneally in rats. Methylene green is lethal for anesthetized cats in doses of 50 to 75 mgm. per kilogram. Orally in rats these dyes are tolerated in doses of 1.0 gm. per kilogram with the exception of methylene green, which killed 2 of 5 rats at 500 mgm. per kilogram. Data are presented on the chronic toxicity of trypan blue, gentian violet, brillant green and mercurochrome. Three of 6 rabbits dying under repeated intravenous administrations of trypan blue had received a total cumulative dose, approximately equivalent to but one acute lethal dose, i.e., 120 to 150 mgm. per kilogram. The dangers of repeatedly using high doses in human lepers, the superiority of oral administration over intravenous, and the danger of certain synergizing agents, including photodynamic effects, are discussed. (AU).
| | Descritores: | HANSENIASE/quimioter
HANSENOSTATICOS/admin
HANSENOSTATICOS/ef adv
HANSENOSTATICOS/tox
| | Limites: | ANIMAL
| | Localização: | BR191.1 |
|
