Base de dados : HANSEN Pesquisa : INTERLEUCINA-12/IMUNOL [Descritor de assunto] Referências encontradas : 7 [refinar] Mostrando: 1 .. 7   no formato [Detalhado]

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Id: 25086 Autor: Kang, Tae Jin; Yeum, Chung Eun; Kim, Byoung Chul; You, Eun-Young; Chae, Gue-Tae Título: Differential production of interleukin-10 and interleukin-12 mononuclear cells from leprosy patients with a Toll-like receptor 2 mutations ..- Fonte: s.l; s.n; 2004. 7 p. tab, graf. Resumo: Toll-like receptor 2 (TLR2) is a key mediator of the immune response to mycobacterial infections, and mutations in TLR2 have been shown to confer susceptibility to infections with mycobacteria. This study investigated the profiles of cytokines, such as interferon (IFN)-gamma, interleukin (IL)-10, IL-12 and tumour necrosis factor (TNF)-alpha in response to Mycobacterium leprae in peripheral blood mononuclear cells (PBMC) with the TLR2 mutation Argo677Trp, a recently reported polymorphism that is associated with lepromatous leprosy. In leprosy patients with the TLR2 mutation, production of IL-2, IL-12, IFN-gamma, and TNF-alpha by M. leprae-stimulated PBMC were significantly decreased compared with that in groups with wild-type TLR2. However, the cells from patients with the TLR2 mutation showed significantly increased production of IL-10. There was no significant difference in Il-4 production between the mutant and wild-type during stimulation. Yhus, these results suggest that the TLR2 signal pathway plays a critical role in the alteration of cytokine profiles in PBMC from leprosy pateints and the TLR2 mutation Arg677Trp provides a mechanism for the poor cellular immune response associated with lepromatous leprosy (AU). Descritores: HANSENIASE VIRCHOWIANA/sangue HANSENIASE VIRCHOWIANA/clas HANSENIASE VIRCHOWIANA/diag HANSENIASE VIRCHOWIANA/imunol HANSENIASE TUBERCULOIDE/sangue HANSENIASE TUBERCULOIDE/clas HANSENIASE TUBERCULOIDE/diag HANSENIASE TUBERCULOIDE/imunol INTERLEUCINA-10/anal INTERLEUCINA-10/sangue INTERLEUCINA-10/imunol INTERLEUCINA-12/anal INTERLEUCINA-12/sangue INTERLEUCINA-12/imunol - LEUCOCITOS MONONUCLEARES/imunol  IMUNOCOMPETÊNCIA/imunol Limites: ESTUDO COMPARATIVO HUMANO Localização: BR191.1; 09194/s

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Id: 18575 Autor: Cheadle, Eleanor J; Selby, Peter J; Jackson, Andrew M Título: Mycobacterium bovis bacillus Calmette-Guérin-infected dendritic cells potently activate autologous T cells via a B7 and interleukin-12-dependent mechanism ..- Fonte: s.l; s.n; 2003. 10 p. graf. Resumo: Mycobacteria are potent adjuvants, can survive intracellularly and have been safely used for many years as vaccines against tuberculosis and leprosy. They are thus important potential vectors for recombinant vaccines. Many of their adjuvant properties are mediated following phagocytosis by dendritic cells (DC), which are in turn critical for priming naïve T cells. Although the maturation of DC in response to mycobacteria, such as Mycobacterium bovis bacillus Calmette-Guérin (BCG), is well described the subsequent responses of autologous T cells to mycobacterium-infected DC remains uncharacterized. In our experiments DC infected with BCG expressed more co-stimulatory molecules than tumour-necrosis factor-alpha (TNF-alpha) -treated DC and stimulated more potent mixed leucocyte reactions. When autologous T cells were co-cultured with BCG-exposed DC they became highly activated, as determined by display of CD25, CD54 and CD71 on both CD4+ and CD8+ cells. In contrast, the response of T cells to TNF-alpha-matured DC was significantly less. Cytokine production from T cells cultured with BCG-exposed DC was enhanced with elevated secretion of interleukin-2 (IL-2), IL-10 and interferon-gamma (IFN-gamma) and was produced by both CD4+ and CD8+ lymphocytes as determined by intracellular staining. In particular, IFN-gamma secretion was increased from 50 pg/ml to 25 000 pg/ml and IL-10 secretion increased from 20 pg/ml to 300 pg/ml in BCG-exposed DC co-cultures. Blocking antibodies to B7.1 and B7.2 or IL-12 significantly reduced the secretion of IFN-gamma and reductions were also seen in the expression of CD25 and CD71 by CD4+ cells. These data demonstrate that mycobacterially infected DC are particularly potent activators of autologous T cells compared to TNF-alpha-exposed DC and that the resultant T cells are functionally superior. (AU). Descritores: ANTIGENOS CD/metab ANTIGENOS CD80/imunol ANTIGENOS DE DIFERENCIACAO DE LINFOCITOS B/metab LINFOCITOS T CD4-POSITIVOS/imunol LINFOCITOS T CD8-POSITIVOS/imunol CITOCINAS/bios CELULAS DENDRITICAS/imunol CELULAS DENDRITICAS/microbiol MOLECULA 1 DE ADESAO INTERCELULAR IMUNOFENOTIPAGEM INTERLEUCINA-12/imunol TRANSFORMACAO LINFOCITICA/imunol MYCOBACTERIUM BOVIS/imunol RECEPTORES DA INTERLEUCINA-2/metab LINFOCITOS T/imunol FATOR DE NECROSE TUMORAL/imunol REGULACAO PARA CIMA/imunol Limites: HUMANO SUPPORT, NON-U.S. GOV'T Meio Eletrônico: - . Localização: BR191.1; 08996/s

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Id: 15776 Autor: Aleman, M; Barrera, S. de la; Fink, S; Finiasz, M; Arinna, M. H; Pizzariello, G; Sasiain, M. del C Título: Interleukin-12 amplifies the M. leprae hsp65-cytotoxic responses in the presence of tumor necrosis factor-alpha and interferon-gamma generating CD56+ effector cells: interleukin-4 downregulates this effect ..- Fonte: s.l; s.n; 2000. 9 p. tab, graf. Descritores: HANSENIASE MYCOBACTERIUM LEPRAE ANTIGENOS CD56 CHAPERONINAS CITOTOXICIDADE IMUNOLOGICA SINERGISMO DE DROGAS SOROS IMUNES INTERFERON TIPO II INTERLEUCINA-10 INTERLEUCINA-12 INTERLEUCINA-12 INTERLEUCINA-12 INTERLEUCINA-4 INTERFASE LEUCOCITOS MONONUCLEARES LEUCOCITOS MONONUCLEARES TRANSFORMAÇAO LINFOCITICA COMPLEXO PRINCIPAL DE HISTOCOMPATIBILIDADE LIGAÇAO PROTÉICA LINFOCITOS T CITOTOXICOS LINFOCITOS T CITOTOXICOS FATOR DE NECROSE DE TUMOR FATOR DE NECROSE DE TUMOR FATOR DE NECROSE DE TUMOR Localização: BR191.1; 07463/s

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Id: 15557 Autor: García, Verónica E; Uyemura, Koichi; Sieling, Peter A; Ochoa, María T; Morita, Craig T; Okamura, Haruki; Kurimoto, Masashi; Rea, Thomas H; Modlin, Robert L Título: IL-18 promotes type 1 cytokine production from NK cells and T cells in human intracellular infection ..- Fonte: s.l; s.n; 1999. 8 p. graf. Descritores: HANSENIASE HANSENIASE CITOCINAS INTERFERON TIPO II INTERLEUCINA-12 CÉLULAS KILLER NATURAIS MONOCITOS LINFOCITOS T TUBERCULOSE PULMONAR Localização: BR191.1; 08399/s

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Id: 15093 Autor: Kobayashi, Kazuo; Kai, Masanori; Gidoh, Masa-ichi; Nakata, Noboru; Endoh, Masumi; Singh, Ram Pyare; Kasama, Tsuyoshi; Saito, Hajime Título: The possible role of interleukin (IL)-12 and interferon -gamma-inducing factor/IL-18 in protection against experimental mycobacterium leprae infection in mice ..- Fonte: s.l; s.n; sep. 1998. 6 p. ilus, graf. Descritores: HANSENIASE HANSENIASE HANSENIASE CITOCINAS CITOCINAS MYCOBACTERIUM LEPRAE INTERLEUCINA-12 INTERLEUCINA-12 INTERLEUCINA-12 RNA MENSAGEIRO CÉLULAS TH1 CÉLULAS TH1 Localização: BR191.1; 07371/s

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Id: 15085 Autor: Santos, D. O; Santos, S. L; Esquenazi, D; Nery, J. A; Defruyt, M; Lorre, K; van Heuverswyn, H Título: Evaluation of B7-1 (CD80) and B7-2 (CD86) costimulatory molecules and dendritic cells on the immune response in leprosy ..- Fonte: s.l; s.n; feb. 2001. 10 p. tab, graf. Descritores: HANSENIASE MYCOBACTERIUM LEPRAE ANTIGENOS CD ANTIGENOS CD80 IMUNIZAÇAO INTERLEUCINA-10 INTERLEUCINA-12 INTERLEUCINA-12 GLICOPROTEINAS DE MEMBRANAS MONOCITOS LINFOCITOS T Localização: BR191.1; 07363/s

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Id: 14188 Autor: De Jong, Rolien; Janson, Anneke A. M; Faber, William R; Naafs, Ben; Ottenhoff, Tom H. M Título: IL-2 and IL-12 act in synergy to overcome antigen-specific T cell unresponsiveness in mycobacterial disease ..- Fonte: s.l; s.n; 1997. 8 p. tab, graf. Descritores: SINERGISMO DE DROGAS IMUNIDADE CELULAR INTERLEUCINA-12 INTERLEUCINA-12 INTERLEUCINA-2 INTERLEUCINA-2 TRANSFORMAÇAO LINFOCITICA PROTEINAS RECOMBINANTES LINFOCITOS T Localização: BR191.1; 07102/s

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