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| Id: | 18466
| | Autor: | Reichart, P. A; Samaranayake, L. P; Samaranayake, Y. H; Grote, M; Pow, E; Cheung, B
| | Título: | High oral prevalence of Candida krusei in leprosy patients in northern Thailand
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| | Fonte: | s.l; s.n; Dec.2002. 7 p. tab, graf.
| | Resumo: | Although Candida albicans is the most common human yeast pathogen, other Candida species such as C. krusei are now recognized as emerging agents, especially in patients with human immunodeficiency virus (HIV) disease. C. krusei is inherently resistant to the widely used triazole antifungal fluconazole and poses therapeutic problems, especially in systemic candidiasis. In a surveillance study of leprosy patients (with arrested or burnt-out disease) in a leprosarium in northern Thailand, we found a rate of oral carriage of C. krusei (36 per cent) significantly (P smaller 0.05) higher than that for a healthy control group (10 per cent). Among the Candida-positive patients, 16 of 35 (46 per cent) carried C. krusei, while C. albicans was the second most common isolate (12 of 35 patients; 34 per cent). The corresponding figures for the control group were 2 of 13 (15 per cent) and 6 of 13 (46 per cent), respectively. Studies of the antifungal resistance of the C. krusei isolates from patients indicated that all except one of the isolates were resistant to fluconazole, two isolates were resistant to ketoconazole, and all isolates were sensitive to amphotericin B. Evaluation of their genetic profiles by randomly amplified polymorphic DNA analysis with three different primers and subsequent analysis of the gel profiles by computerized cluster-derived dendrograms revealed that the C. krusei isolates from patients belonged to 10 disparate clusters, despite the origin from a single locale. These nascent findings indicate an alarmingly high prevalence of a Candida species resistant to a widely used antifungal in a part of the world where HIV disease is endemic. (AU).
| | Descritores: | ANTIMICOTICOS/farmacol
CANDIDA/clas
CANDIDA/ef drogas
CANDIDA/genet
CANDIDA/isol
CANDIDIASE BUCAL/compl
CANDIDIASE BUCAL/epidemiol
CANDIDIASE BUCAL/microbiol
PORTADOR/epidemiol
PORTADOR/microbiol
Resistência Fúngica a Múltiplas Drogas
HANSENIASE/compl
TESTES DE SENSIBILIDADE MICROBIANA
BOCA/microbiol
PREVALÊNCIA
TECNICA DE AMPLIFICACAO AO ACASO DE DNA POLIMORFICO
TAILÂNDIA/epidemiol
| | Limites: | HUMANO
MASCULINO
FEMININO
MEIA-IDADE
IDOSO
IDOSO DE 80 ANOS OU MAIS
| | Localização: | BR191.1; 09003/s |
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