Database : HANSEN Search on : FITOHEMAGLUTININAS/FARMACOL [Subject descriptor] References found : 5 [refine] Displaying: 1 .. 5   in format [Detailed]

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Id: 13433 Author: Brown, Arthur E; Vithayasai, Vicharn; Scollard, David M; Nelson, Kenrad E; Moses, Vijai; Schauf, Victoria; Makonkawkeyoon, Sanit Title: Lymphocyte transformation in lepromatous leprosy: a study of the influence of disease activity and symptom duration ..- Source: s.l; s.n; mar. 1986. 7 p. tab, graf. Abstract: The lymphocyte hyporesponsiveness to M. leprae of patients with active lepromatous leprosy has been well described. This immune defect is less well understood in terms of its time of origin, possible reversibility and specificity. To further examine the persistence and specificity of this abnormality, lymphocyte transformation tests of 93 leprosy patients to lepromin, BCG and PHA were studied. Among lepromatous patients, a decreased response to M. leprae was seen, whether the disease was active or inactive. Decreased responses to BCG were found in lepromatous patients with active disease, but not in those with inactive disease. The duration of patient symptoms was not associated with differences in LTT responses among the active lepromatous patients.(AU). Descriptors: FITOHEMAGLUTININAS/farmacol TRANSFORMACAO LINFOCITICA HANSENIASE/imunol HANSENIASE/terap ANTIGENO DE MITSUDA VACINA BCG/farmacol Limits: HUMANO MASCULINO ADULTO MEIA-IDADE SUPPORT, NON-U.S. GOV'T SUPPORT, U.S. GOV'T, P.H.S. ADOLESCENTE Electronic Medium: http://www.ilsl.br Location: BR191.1; 01763/s

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Id: 13416 Author: Bjune, G Title: In vitro lymphocyte stimulation in leprosy; simultaneous stimulation with Mycobacterium leprae antigens and phytohaemagglutinin ..- Source: s.l; s.n; jun. 1979. 9 p. tab, graf. Abstract: Peripheral blood lymphocytes from 105 subjects with different forms of leprosy and healthy contacts of leprosy patients weere stimulated in vitro different preparations of mycobacterial antugens alone or in combination with a suboptimal dose of phytohaemagglutinin (PHA). In nearly all individuals sonicated leprosy bacilli and PHA together gave a lower 3H-thymidine incorporation than didi the same dose of PHA alone. There was no difference in the degree of inhibition seen in the different patient groups or the healthy contacts. High doses of whole, washed Mycobacterium leprae, combined with PHA led to an increased thymidine incorporation in borderline tuberculoid leprosy patients who had experienced a reversal reaction, and in healthy contacts with less than 6 months exposure did not show an augmentation of the PHA-induced thymidine incorporation. The inhibition exerted by sonicated M. leprae was dose-dependent, seen even with very low doses of antigen, and was not due to direct Cytotoxicity, M. bovis, strain BCG, was weakly suppressive effect. There was no correlation between the suppressive effective of M. leprae antigens and the other mtcobacteria neither was there any correlation with the responses to the mycobacterial antigens alone. Many lepromatous leprosy patients showed significant suppression of background incorporation with addition of M. leprae antigens. This paper discusses wheter the apparent `non-responsiveness` in lepromatous leprosy could be due to active suppressor mechanisms operative in vitro.(AU). Descriptors: ANTIGENOS DE BACTERIAS/imunol ANTIGENOS DE SUPERFÍCIE/imunol HANSENIASE/imunol HANSENIASE/metab TRANSFORMACAO LINFOCITICA TIMIDINA/metab FITOHEMAGLUTININAS/farmacol MYCOBACTERIUM LEPRAE/imunol RELACAO DOSE-RESPOSTA IMUNOLOGICA LINFOCITOS/metab Limits: HUMANO Electronic Medium: http://www.ilsl.br Location: BR191.1; 00020/s

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Id: 11478 Author: afutis-Morris, Mary; Guillén-Vargas, Cecilia M; Navarro-Fierros, Sérgio; Alfaro-Bustamante, Fernando; Zaitzeva-Petrovna, Galina; Daneri-Navarro, Adrian; Santoscoy-Tovar, Luis; Armendariz-Borunda, Juan Title: Addition of anti-CD28 antibodies restores PBMC proliferation and IFN-gamma production in lepromatous leprosy patients ..- Source: s.l; s.n; 1999. 7 p. graf. Descriptors: HANSENIASE LEPROMATOSA HANSENIASE LEPROMATOSA HANSENIASE LEPROMATOSA ANTICORPOS MONOCLONAIS ANTIGENOS CD28 ANTIGENOS CD80 LINFOCITOS B DIVISAO CELULAR INTERFERON TIPO II LEUCOCITOS MONONUCLEARES LEUCOCITOS MONONUCLEARES FITOHEMAGLUTININAS LINFOCITOS T Location: BR191.1; 08357/s

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Id: 10338 Author: Mesret, Yohannes; Reed, Allen H; Howe, Rawleigh Title: Proliferative responses of T cells from the skin and nerve lesions of leprosy patients ..- Source: s.l; s.n; 1995. 10 p. tab, graf. Descriptors: ANTIGENOS CD28 ANTIGENOS CD3 ANTIGENOS CD45 INTERFERON TIPO II RECEPTORES DA INTERLEUCINA 2 INTERLEUCINA-2 INTERLEUCINA-4 HANSENIASE HANSENIASE TRANSFORMAÇAO LINFOCITICA TRANSFORMAÇAO LINFOCITICA MITOGENOS NERVOS PERIFÉRICOS FITOHEMAGLUTININAS PELE LINFOCITOS T LINFOCITOS T CELULAS CULTIVADAS Location: BR191.1; 07189/s

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Id: 9869 Author: Bisht, Deepa; Mehrotra,, Jyoti; Dhindsa, M. S; Singh, N. B; Sinha, Sudhir Title: A major T-cell-inducing cytosolic 23 kDa protein antigen of the vaccine candidate Mycobacterium habana is superoxide dismutase ..- Source: s.l; s.n; 1996. 9 p. ilus, tab. Descriptors: MYCOBACTERIUM LEPRAE SEQUENCIA DE AMINOACIDOS ANTIGENOS DE BACTÉRIAS ANTIGENOS DE BACTÉRIAS PROTEINAS DE BACTÉRIAS PROTEINAS DE BACTÉRIAS VACINAS BACTERIANAS HANSENIASE TUBERCULOIDE TRANSFORMAÇAO LINFOCITICA CAMUNDONGOS ENDOGAMICOS BALB C DADOS DE SEQUENCIA MOLECULAR PESO MOLECULAR FITOHEMAGLUTININAS SUPEROXIDO DISMUTASE SUPEROXIDO DISMUTASE LINFOCITOS T Location: BR191.1; 06808/s

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