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| Id: | 15488
| | Author: | Ermakóva, Nína. | | Title: | Studies on leprosy. II. Formation, distribution and diagnostic significance of pigment.
| | Source: | Int. J. Lepr;4(4):445-454, Oct.-Dec. 1936. ilus.
| | Abstract: | An iron-containing blood pigment was found in the affected organs and tissues of all cases of leprosy that I examined. In the nodular form of the disease this pigment is deposited in strikingly large quantities, while in the maculo-neural and tuberculoid forms the quantity is very small. The cause of the pigment formation may be (a)erythrocyte destruction in the general blood stream, or (b) some process of local character. The generally accepted view that the leprosy bacillus does not excrete toxic substances that may act on the cells of the organisms seems to be against the first of these theories. However, this view is based entirely on clinical data and not on experimental immuno-biological studies. It seems quite possible that products of bacillary activity may be fixed by the lipoid membrane of the erythrocyte and destroy them. In favor of the second theory, that the pigment is of local origin, is my observation that erythrophagocytosis is found with some constancy in the lesions. It is true that in cases of the nodular form phagocytosis is demonstrated with great difficulty, though the pigment is deposited in large quantities. However, in some of the cases in which there were lesser quantities of pigment, that did not interfere with the clearness of the picture, phagocytosis could be observed. At any rate, the question must be regarded as an open one, requiring further study... (AU).
| | Descriptors: | HANSENIASE/clas
HANSENIASE/diag
HANSENIASE/patol
HANSENIASE VIRCHOWIANA/sangue
HANSENIASE VIRCHOWIANA/patol
HANSENIASE TUBERCULOIDE/sangue
HANSENIASE TUBERCULOIDE/patol
HANSENIASE/sangue
HANSENIASE/compl
- PELE
NERVOS PERIFERICOS/patol
BACO/patol
FIGADO/patol
GÔNADAS/patol
LINFONODOS/patol
HEMOSSIDERINA
| | Limits: | HUMANO
necropsia
biopsia
| | Location: | BR191.1 |
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