Database : HANSEN Search on : LINFOCITOS/EF DROGAS [Subject descriptor] References found : 5 [refine] Displaying: 1 .. 5   in format [Detailed]

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Id: 13663 Author: Kalaiselvi, K; Rajaguru, P; Palanivel, M; Usharani, M. V; Ramu, G Title: Chromosomal aberration, micronucleus and Comet assays on peripheral blood lymphocytes of leprosy patients undergoing multidrug treatment. (Mutagenesis, 17, 309-312, 2002) ..- Source: s.l; s.n; 2003. 1 p. tab. Abstract: To evaluate the genetic damage in leprosy patients, we carried out the alkaline Comet assay and chromosomal aberration (CA) and micronucleus (MN) tests in peripheral blood lymphocytes of 50 leprosy patients receiving multidrug treatment (MDT) and 50 healthy individuals. The Comet assay showed statistically higher mean values for length to width ratios of DNA mass (P < 0.01) and for mean frequencies of tailed cells (P < 0.001) in cells of leprosy patients than in those of controls. Similarly, the mean frequencies of micronucleated cells (per 1000 cytochalasin B-induced binucleated cells) were significantly greater (P < 0.001) in leprosy patients (19.92 +/- 2.564) than in controls (1.6 +/- 0.231). A statistically significant 10-fold increase in the frequency of CAs (11.16 +/- 0.411) was observed in leprosy patients compared with controls (1.28 +/- 0.242). In multiple regression analyses, when patients and controls were considered together, disease factor alone significantly influenced the genotoxicity markers. In the control group, age and alcohol consumption significantly influenced MN and length to width ratios and CA frequency, respectively. However, in MDT-treated leprosy patients none of the other confounding factors (sex, age, smoking and alcohol drinking) significantly affected the extent of genetic damage.(AU). Descriptors: ENSAIO EM COMETA CONSUMO DE BEBIDAS ALCOOLICAS ABERRACOES CROMOSSÔMICAS HANSENIASE/sangue HANSENIASE/quimioter LINFOCITOS/ef drogas LINFOCITOS/fisiol TESTES PARA MICRONUCLEOS FATORES SEXUAIS TABAGISMO Limits: MASCULINO FEMININO ADULTO HUMANO Electronic Medium: http://www.ilsl.br Location: BR191.1; 09120/s

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Id: 13634 Author: Kalaiselvi, K; Rajaguru, P; Palanivel, M; Usharani, M. V; Ramu, G Title: Chromosomal aberration, micronucleus and Comet assays on peripheral blood lymphocytes of leprosy patients undergoing multidrug treatment ..- Source: s.l; s.n; 2002. 4 p. ilus, tab. Abstract: To evaluate the genetic damage in leprosy patients, we carried out the alkaline Comet assay and chromosomal aberration (CA) and micronucleus (MN) tests in peripheral blood lymphocytes of 50 leprosy patients receiving multidrug treatment (MDT) and 50 healthy individuals. The Comet assay showed statistically higher mean values for length to width ratios of DNA mass (P < 0.01) and for mean frequencies of tailed cells (P < 0.001) in cells of leprosy patients than in those of controls. Similarly, the mean frequencies of micronucleated cells (per 1000 cytochalasin B-induced binucleated cells) were significantly greater (P < 0.001) in leprosy patients (19.92 +/- 2.564) than in controls (1.6 +/- 0.231). A statistically significant 10-fold increase in the frequency of CAs (11.16 +/- 0.411) was observed in leprosy patients compared with controls (1.28 +/- 0.242). In multiple regression analyses, when patients and controls were considered together, disease factor alone significantly influenced the genotoxicity markers. In the control group, age and alcohol consumption significantly influenced MN and length to width ratios and CA frequency, respectively. However, in MDT-treated leprosy patients none of the other confounding factors (sex, age, smoking and alcohol drinking) significantly affected the extent of genetic damage. (AU). Descriptors: CONSUMO DE BEBIDAS ALCOOLICAS ABERRACOES CROMOSSÔMICAS ENSAIO EM COMETA HANSENIASE/sangue HANSENIASE/quimioter LINFOCITOS/ef drogas LINFOCITOS/fisiol TESTES PARA MICRONUCLEOS FATORES SEXUAIS TABAGISMO Limits: HUMANO MASCULINO FEMININO ADULTO Electronic Medium: http://www.ilsl.br Location: BR191.1; 09045/s

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Id: 13260 Author: Anderson, R; Gatner, E. M. S; van Rensburg, C. E; Grabow, G; Imkamp, F. M. G. H; Kok, S. K; van Rensburg, A. J Title: In vitro and in vivo effects of dapsone on neutrophil and lymphocyte functions in normal individuals and patients with lepromatous leprosy ..- Source: s.l; s.n; apr. 1981. 9 p. tab, graf. Abstract: The effects of dapsone on polymorphonuclear leukocyte functions and lymphocyte mitogen-induced transformation were assessed in vitro and in vivo in normal individuals and in newly diagnosed untreated patients with lepromatous leprosy. The effects of dapsone on the cell-free generation of superoxide by the xanthine: xanthine oxidase system and iodination of bovine serum albumin by horseradish peroxidase were also investigated. In normal individuals dapsone mediated stimulation of polymorphonuclear leukocyte migration in vitro and vivo. Dapsone had no effect on postphagocytic hexose monophosphate shunt activity in vivo. Similar effects were found in patients with lepromatous leprosy. Dapsone also decreased the inhibitory activity of serum from patients with lepromatous leprosy on normal polymorphonuclear leukocyte migration in vitro. Progressive loss of serum-mediated inhibition of migration was observed after ingestion of dapsone by the patients. Further experiments showed that stimulation of polymorphonuclear leukocyte motility was related to inhibition of lymphocyte transformation at high concentrations in vitro, but had slight stimulatory activity on phytohemagglutinin-induced transformation in controls and patients in vivo.(AU). Descriptors: PEROXIDASE/metab SUPEROXIDOS/metab HANSENIASE/sangue PEROXIDO DE HIDROGÊNIO/metab TRANSFORMACAO LINFOCITICA/ef drogas LINFOCITOS/ef drogas NEUTROFILOS/ef drogas FAGOCITOSE/ef drogas MOVIMENTO CELULAR/ef drogas DAPSONA/farmacol Limits: HUMANO IN VITRO Electronic Medium: http://www.ilsl.br Location: BR191.1; 00756/s

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Id: 9872 Author: Fernandez, Luis P; Schlegel, Paul G; Baker, Jeanette; Chen, Yanfei; Chao, Nelson J Title: Does thalidomide affect IL-2 response and production? ..- Source: s.l; s.n; 1995. 8 p. tab, graf. Descriptors: TALIDOMIDA CÉLULAS CLONAIS RELAÇAO DOSE-RESPOSTA A DROGA ELEMENTOS DE FACILITAÇAO (GENÉTICA) ELISA RECEPTORES DA INTERLEUCINA 2 RECEPTORES DA INTERLEUCINA 2 LINFOCITOS LINFOCITOS TRANSFORMAÇAO LINFOCITICA TRANSFECÇAO CÉLULAS CULTIVADAS DE TUMOR BETA-GALACTOSIDASE BETA-GALACTOSIDASE Location: BR191.1; 06805/s

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Id: 7059 Author: Ghei, S. K; Sengupta, U; Desikan, K. V. Title: In vitro effect of DDS on phytohaemagglutinin (PHA) induced linphocyte transformation. Source: Hansen. Int;5(2):112-118, dez. 1980. tab. Abstract: Estudou-se o efeito do DDS, sobre a transformaçao linfocitaria estimulada pela PHA, in vitro, utilisando-se concentraçoes variaveis de DDS. Os linfocitos foram doados por voluntarios, divididos em tres gupos, e o estudo foi desenvolvido em tres fases. Foram empregadas 4 concentraçoes diferentes de DDS para 10 a sexta de linfocitos em cultura de tecidos alem de 0,02 ml de PHA. Foi observada uma diminuiçao estatisticamente significativa (P<0,05) no percentual de formaçao de celulas blasticas induzida pela PHA com todas as concentraçoes de DDS, exceto com a concentraçao mais baixa (0,01 ug de DDS). Enquanto que a diminuiçao observada na primeira e na terceira fases mostrou-se dependente de dose de DDS, na segunda fase nao se encontrou correlaçao significativa entre a concentraçao de DDS e a depressao da blastogenese induzida pela PHA. Discute-se a significancia destas observaçoes.(AU). Descriptors: SULFONAS SULFONAS - FITOHEMAGLUTININAS  LINFOCITOS Electronic Medium: http://hansen.bvs.ilsl.br/textoc/hansenint/v01aov20/1980/PDF/v5n2/v5n2a02.pdf / En Location: BR191.1

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