| Id: | 13537
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| Author: | Wahba, Asher; Cohen, Haim; Sheskin, Jacob
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| Title: | Neutrophil chemotactic response in lepromatous leprosy: an in vitro study of 52 patients
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| Source: | s.l; s.n; 1980. 6 p. ilus, tab, graf.
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| Abstract: | The chemotactic responses of neutrophils derived from 52 patients with lepromatous leprosy and 24 healthy controls were assessed in vitro by a modification of the Boyden chamber method using lipopolysaccharide-activated serum as a chemotactic factor. Highly bacilliferous patients with active disease of long-standing duration had significantly reduced chemotactic responses, while patients with burnt-out lepromatous leprosy as well as those with recently acquired disease showed normal chemotactic responses. Preincubation of normal human blood group O leukocytes in plasma from patients with active disease of long-standing duration markedly reduced their chemotactic responses whereas preincubation in plasma derived from patients belonging to the other two subgroups of patients did not affect much leokotaxis. These findings suggest that the diminished chemotactic capacities among certain plasma factors sucha as immunoglobulins or antigen - antibody complexes that may-by attachment to the cell membrane-block the receptors required for interaction with the chemotactic factor. (AU).
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| Descriptors: | NEUTROFILOS
FATORES DE TEMPO
HANSENIASE/imunol
QUIMIOTAXIA DE LEUCOCITO
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| Limits: | HUMANO
MASCULINO
FEMININO
ADULTO
MEIA-IDADE
IDOSO
SUPPORT, NON-U.S. GOV'T
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| Location: | BR191.1; 08987/s |
