Database : HANSEN
Search on : RECEPTORES IMUNOLOGICOS [Subject descriptor]
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Id:13656
Author:Bleharski, Joshua R; Li, Huiying; Meinken, Christoph; Graeber, Thomas G; Ochoa, Maria-Teresa; Yamamura, Masahiro; Burdick, Anne; Sarno, Euzenir N; Wagner, Manfred; Röllinghoff, Martin; Rea, Thomas H; Colonna, Marco; Stenger, Steffen; Bloom, Barry R; Eisenberg, David; Modlin, Robert L
Title:Use of genetic profiling in leprosy to discriminate clinical forms of the disease ..-
Source:s.l; s.n; Sep. 2003. 4 p. graf.
Abstract:Leprosy presents as a clinical and immunological spectrum of disease. With the use of gene expression profiling, we observed that a distinction in gene expression correlates with and accurately classifies the clinical form of the disease. Genes belonging to the leukocyte immunoglobulin-like receptor (LIR) family were significantly up-regulated in lesions of lepromatous patients suffering from the disseminated form of the infection. In functional studies, LIR-7 suppressed innate host defense mechanisms by shifting monocyte production from interleukin-12 toward interleukin-10 and by blocking antimicrobial activity triggered by Toll-like receptors. Gene expression profiles may be useful in defining clinical forms of disease and providing insights into the regulation of immune responses to pathogens. (AU).
Descriptors:HANSENIASE VIRCHOWIANA/clas
HANSENIASE VIRCHOWIANA/genet
HANSENIASE VIRCHOWIANA/imunol
HANSENIASE VIRCHOWIANA/fisiopatol
HANSENIASE TUBERCULOIDE/clas
HANSENIASE TUBERCULOIDE/genet
HANSENIASE TUBERCULOIDE/imunol
HANSENIASE TUBERCULOIDE/fisiopatol
CITOCINAS/genet
CITOCINAS/metab
PERFILACAO DA EXPRESSÃO GÊNICA
ANALISE POR CONGLOMERADOS
CONTAGEM DE COLÔNIA MICROBIANA
REGULACAO DA EXPRESSÃO GÊNICA
IMUNIDADE CELULAR
IMUNIDADE NATURAL
MACROFAGOS ALVEOLARES/microbiol
GLICOPROTEINAS DE MEMBRANA/imunol
MYCOBACTERIUM TUBERCULOSIS/cresc
MYCOBACTERIUM TUBERCULOSIS/imunol
REACAO EM CADEIA DA POLIMERASE
RECEPTORES IMUNOLOGICOS/genet
RECEPTORES IMUNOLOGICOS/metab
RECEPTORES DA SUPERFICIE CELULAR/imunol
REGULACAO PARA CIMA
 Análise de Componente Principal
 ALGORITMOS
 GENES DE IMUNOGLOBULINAS
 ANALISE DE SEQUÊNCIA COM SERIES DE OLIGONUCLEOTIDIOS
Limits:SUPPORT, NON-U.S. GOV'T
HUMANO
SUPPORT, U.S. GOV'T, P.H.S.
Electronic Medium:http://www.ilsl.br
Location:BR191.1; 09142/s; BR191.1; 09145/s


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Id:11040
Author:Sieling, Peter A; Ochoa, Maria Teresa; Jullien, Denis; Leslie, David S; Sabet, Shereen; Rosat, Jean-Pierre; Burdick, Anne E; Rea, Thomas H; Brenner, Michael B; Porcelli, Steven A; Modlin, Robert L
Title:Evidence for human CD4+ T cells in the CD1-restricted repertoire: derivation of mycobacteria-reactive T cells from leprosy lesions ..-
Source:s.l; s.n; 2000. 7 p. graf.
Descriptors:HANSENIASE
HANSENIASE
MYCOBACTERIUM LEPRAE
ANTIGENOS
ANTIGENOS DE BACTÉRIAS
ANTIGENOS DE BACTÉRIAS
ANTIGENOS CD1
ANTIGENOS CD1
GLICOLIPIDIOS
GLICOLIPIDIOS
ACIDOS MICOLICOS
ACIDOS MICOLICOS
PROTEINAS
RECEPTORES IMUNOLOGICOS
Location:BR191.1; 07447/s


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Id:10049
Author:Khare, Sangeeta; Bhutani, Lalit K; Rao, D. Nageswara
Title:Quantitative assessement of tuftsin receptor expression and second messenger during in vitro differentiation of peripheral blood derived monocytes of leprosy patients ..-
Source:s.l; s.n; 1997. 10 p. ilus, tab, graf.
Descriptors:CALCIO
CALCIO
AMP CICLICO
GMP CICLICO
HANSENIASE
HANSENIASE
MACROFAGOS
MACROFAGOS
MONOCITOS
MONOCITOS
RECEPTORES IMUNOLOGICOS
SISTEMAS DO SEGUNDO MENSAGEIRO
TRANSDUÇAO DE SINAL
TUFTSINA
TUFTSINA
Location:BR191.1; 07014/s


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Id:9308
Author:Sullivan, Laura; Sano, Shigetoshi; Pirmez, Claude; Salgame, Padmini; Mueller, Christoph; Hofaman, Florence; Uyemura, Koichi; Rea, Thomas H; Bloom, Barry R; Modlin, Robert L
Title:Expression of adhesion molecules in leprosy lesions ..-
Source:s.l; s.n; 1991. 7 p. ilus, tab, graf.
Descriptors:ANTIGENOS CD2
ANTIGENOS CD58
ANTIGENOS DE DIFERENCIAÇAO DE LINFOCITOS T
ANTIGENOS DE SUPERFICIE
MOLÉCULAS DE ADESAO CELULAR
EPIDERME
EPIDERME
EXPRESSAO GENICA
MOLÉCULA 1 DE ADESAO INTERCELULAR
INTERFERON TIPO II
HANSENIASE
HANSENIASE
HANSENIASE
ANTIGENO-1 LINFOCITARIO ASSOCIADO A FUNÇAO
HIBRIDIZAÇAO DE ACIDO NUCLÉICO
RECEPTORES IMUNOLOGICOS
LINFOCITOS T
LINFOTOXINA
Location:BR191.1; 06211/s


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Id:9269
Author:Longo, Ieda M; Moura, Nayla C; Opromolla, Diltor Vladimir Araujo; Mendes, N. F
Title:Quantitation of the soluble e-receptor of human T lymphocytes by rocket electrophoresis in the serum of patients with lepromatous and tuberculoid leprosy ..-
Source:Buenos Aires; s.n; 1991. 4 p. ilus, tab.
Descriptors:ELETROFORESE
IMUNIDADE CELULAR
HANSENIASE LEPROMATOSA
HANSENIASE TUBERCULOIDE
RECEPTORES IMUNOLOGICOS
LINFOCITOS T
Location:BR191.1; 06246/s



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