Database : HANSEN Search on : RNA MENSAGEIRO/METAB [Subject descriptor] References found : 6 [refine] Displaying: 1 .. 6   in format [Detailed]

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Id: 13937 Author: Teles, Rosane M. B; Moraes, Milton O; Geraldo, Natasha T. R; Salles, Ana M; Sarno, Euzenir N; Sampaio, Elizabeth P Title: Differential TNFalpha mRNA regulation detected in the epidermis of leprosy patients ..- Source: s.l; s.n; 2002. 8 p. ilus, tab, graf. Abstract: The epidermis is an important site of the immunoinflammatory response in the skin. In the present study, the expression of cytokine and ICAM-1 (intercellular adhesion molecule-1) genes was evaluated by RT-PCR in the epidermis isolated from biopsies from 25 reactional leprosy patients. TNFalpha and IL-6 mRNAs were detected in all individuals during the reactional state (reversal reaction or erythema nodosum leprosum), IL-8 message was detected in 66.6 per cent and 62.5 per cent of the patients, IL-12 mRNA was present in 91.6 per cent and 62.5 per cent and ICAM-1 in 100 per cent and 71.4 per cent, respectively. In addition, when skin biopsies were obtained from the same patients before and during the reactional episode, an enhancement in cytokine mRNA, but not in ICAM-1 mRNA, was observed. Seven patients were also evaluated at the onset of reaction and during antiinflammatory treatment. In contrast to a preferential decrease in the TNFalpha gene detected in the dermis, during the treatment phase, persistent/enhanced TNFalpha mRNA expression was detected in the epidermis in six out of the seven patients assessed. This peculiar pattern of expression might reflect a differential impact that in vivo antiinflammatory therapy has on the epidermis. The present findings indicate that the epidermis plays an important role in the local inflammatory response in leprosy and that the profile of response detected in the epidermis during the reactions may be regulated differently from that in the dermis. (AU). Descriptors: CITOCINAS/genet CITOCINAS/metab ANTIINFLAMATORIOS ESTERÓIDES/uso terap DERME/metab HANSENOSTATICOS/uso terap EPIDERME/metab MOLECULA 1 DE ADESAO INTERCELULAR/genet MOLECULA 1 DE ADESAO INTERCELULAR/metab HANSENIASE/quimioter HANSENIASE/metab PENTOXIFILINA/uso terap ANTIINFLAMATORIOS/uso terap RNA MENSAGEIRO/metab TALIDOMIDA/uso terap PREDNISONA/uso terap FATOR DE NECROSE TUMORAL/genet FATOR DE NECROSE TUMORAL/metab Limits: HUMANO MASCULINO FEMININO ADULTO MEIA-IDADE IDOSO SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 09157/s

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Id: 12226 Author: Sampaio, E. P; Hernandez, M. O; Carvalho, D. S; Sarno, E. N Title: Management of erythema nodosum leprosum by thalidomide: thalidomide analogues inhibit M. leprae-induced TNFalpha production in vitro ..- Source: s.l; s.n; 2002. 7 p. ilus, graf. Descriptors: APOPTOSE CITOCINAS CITOCINAS ERITEMA NODOSO IMUNOSSUPRESSORES IMUNOSSUPRESSORES INTERLEUCINA-12 MONOCITOS MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE RNA MENSAGEIRO RNA MENSAGEIRO RNA MENSAGEIRO TALIDOMIDA TALIDOMIDA TALIDOMIDA FATOR DE NECROSE TUMORAL/AI/GE Location: BR191.1; 08709/s

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Id: 11299 Author: Moraes, M. O; Sarno, E. N; Almeida, A. S; Saraiva, B. C. C; Nery, J. A. C; Martins, R. C. L; Sampaio, E. P Title: Cytokine mRNA expression in leprosy: a possible role for interferon-gamma and interleukin-12 in reactions (RR and ENL) ..- Source: s.l; s.n; 1999. 9 p. ilus, tab, graf. Descriptors: SEQUENCIA DE AMINOACIDOS SEQUENCIA DE BASES ESTUDOS DE CASOS E CONTROLES CITOCINAS PRIMERS DO DNA EXPRESSAO GENICA FATOR ESTIMULADOR DE COLONIAS DE GRANULOCITOS-MACROFAGOS INTERFERON TIPO II INTERLEUCINA-12 HANSENIASE HANSENIASE GLICOPROTEINAS DE MEMBRANAS REAÇAO EM CADEIA POR POLIMERASE RNA MENSAGEIRO RNA MENSAGEIRO RNA MENSAGEIRO Location: BR191.1; 07238/s

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Id: 11075 Author: Kobayashi, Kazuo; Kai, Masanori; Gidoh, Masa-ichi; Nakata, Noboru; Endoh, Masumi; Singh, Ram Pyare; Kasama, Tsuyoshi; Saito, Hajime Title: The possible role of interleukin (IL)-12 and interferon -gamma-inducing factor/IL-18 in protection against experimental mycobacterium leprae infection in mice ..- Source: s.l; s.n; sep. 1998. 6 p. ilus, graf. Descriptors: HANSENIASE HANSENIASE HANSENIASE CITOCINAS CITOCINAS MYCOBACTERIUM LEPRAE INTERLEUCINA-12 INTERLEUCINA-12 INTERLEUCINA-12 RNA MENSAGEIRO CÉLULAS TH1 CÉLULAS TH1 Location: BR191.1; 07371/s

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Id: 10170 Author: Sieling, Peter A; Modlin, Robert L Title: Cytokine patterns at the site of mycobacterial infection ..- Source: s.l; s.n; 1994. 10 p. ilus, graf. Descriptors: HANSENIASE LINFOCITOS T CD4-POSITIVOS LINFOCITOS T CD8-POSITIVOS CITOCINAS CITOCINAS ATIVAÇAO DE MACROFAGOS MODELOS BIOLOGICOS RNA MENSAGEIRO RNA MENSAGEIRO Limits: ANIMAL CAMUNDONGOS Location: BR191.1; 07083/s

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Id: 10036 Author: Sampaio, E. P; Moraes, M. O; Nery, J. A. C; Santos, A. R; Matos, H. C; Sarno, E. N Title: Pentoxifylline decreases in vivo and in vitro tumour necrosis factor-alpha (TNF-a) production in lepromatous leprosy patients with erythema nodosum leprosum (ENL) ..- Source: s.l; s.n; 1998. 9 p. tab, graf. Descriptors: HANSENIASE LEPROMATOSA HANSENIASE LEPROMATOSA ERITEMA NODOSO ERITEMA NODOSO PENTOXIFILINA INIBIDORES DE FOSFODIESTERASE REAÇAO EM CADEIA POR POLIMERASE RNA MENSAGEIRO FATOR DE NECROSE DE TUMOR Location: BR191.1; 07001/s

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