Database : HANSEN
Search on : SULFONAMIDAS [Subject descriptor]
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Id:17692
Author:Pesce, Carlo; Grattarola, Myriam; Menini, Stefano; Fiallo, Paolo
Title:Short report: Cyclooxygenase 2 expression in vessels and nerves in reversal reaction leprosy ..-
Source:s.l; s.n; 2006. 2 p. ilus.
Abstract:Tissue expression of cyclooxygenase (COX)2, an inducible enzyme synthesizing eicosanoids in inflammation, was studied in reversal reaction (RR) leprosy in comparison with nonreactionary leprosy. COX2 was consistently expressed in cells of the mononuclear-macrophage lineage across the leprosy spectrum. Only in RR, the following two additional sites showed COX2 expression in the dermis and subcutis: 1) microvessels and 2) nerve bundles and isolated nerve fibers. The same sites also express vascular endothelial growth factor (VEGF). This is in keeping with experimental models relating VEGF to COX2 expression, with VEGF enhancing prostaglandin production through COX2 stimulation and prostaglandin synthase expression. We postulate that selective COX2 inhibitors, which are currently used in several inflammatory conditions, could be considered for RR treatment to reduce acute symptoms caused by tissue edema and possibly prevent long-term nerve damage, the main complication of RR. (AU).
Descriptors:Vasos Sanguíneos/EN
Ciclooxigenase 2/*BI
Inibidores de Ciclooxigenase 2/PD
Edema/EN/MI
Endotélio/EN
Amarelo de Eosina-(ys)/ME
Regulação Enzimológica da Expressão Gênica/*
Granuloma/EN/MI/PA
Hematoxilina/ME
Imunoquímica/MT
Hanseníase/CL/*EN/PP
Mycobacterium leprae/IP
Neurônios/EN
Nitrobenzenos/PD
Pele/BS/*EN/IR/PA
Sulfonamidas/PD
Fator A de Crescimento do Endotélio Vascular/BI/DE
Limits:HUMANO
Location:BR191.1; 09360/S


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Id:13432
Author:Opromolla, Diltor Vladimir Araujo; Lopes, C. Ferreira; Sampaio, S. A
Title:The treatment of leprosy with a new long-acting sulfonamide ..-
Source:s.l; s.n; Apr.-Jun. 1968. 3 p. tab.
Abstract:The results obtained in 17 cases of lepromatous leprosy treated with a long-acting sulfonamide, Ro 4-4393, are reported. Clinically, two cases had marked improvement, four slight improvement, and one was unchanged. One patient became improved, and three did not change. Tolerance to the drug was excellent.(AU).
Descriptors:HANSENIASE/quimioter
MYCOBACTERIUM LEPRAE/ef drogas
PIRIMIDINAS/uso terap
SULFONAMIDAS/uso terap
Limits:HUMANO
Electronic Medium:http://www.ilsl.br
Location:BR191.1; 02375/s


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Id:13210
Author:Jopling, W. H
Title:The treatment of leprosy and its acute complications ..-
Source:s.l; s.n; jan. 1973. 4 p. tab.
Abstract:The first thing to be decided in treating a leprosy patient is whether to admit him to a leprosarium or to treat him on an out-patient basis. However, the question of admission does not arise if the leprosy is indeterminate, tuberculoid, or borderline, for these types of leprosy do not carry a public health risk as nasal scrapings are negative for leprosy bacilli.(AU).
Descriptors:DAPSONA/ef adv
DAPSONA/uso terap
EPISTAXE/etiol
EPISTAXE/terap
ANTIGENO DE MITSUDA
HANSENIASE/compl
HANSENIASE/imunol
HANSENIASE/terap
SULFONAMIDAS/uso terap
SULFONAS/uso terap
Limits:HUMANO
Electronic Medium:http://www.ilsl.br
Location:BR191.1; 02019/s


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Id:11894
Author:Flageul, B; Wagner, L; Cottenot, F
Title:Accidents immuno-allergiques à la rifampicine ..-
Source:s.l; s.n; 2002. 8 p. tab.
Descriptors:HANSENIASE
HANSENIASE DIMORFA
HANSENIASE LEPROMATOSA
HANSENIASE TUBERCULOIDE
RIFAMPINA
RIFAMPINA
RIFAMPINA
RIFAMPINA
SULFONAMIDAS
SULFONAMIDAS
TROMBOCITOPENIA
TROMBOCITOPENIA
ANTIBIOTICOS COMBINADOS
CLOFAZIMINA
CLOFAZIMINA
DAPSONA
DAPSONA
HIPERSENSIBILIDADE A DROGAS
LEPROSTATICOS
LEPROSTATICOS
LEPROSTATICOS
Location:BR191.1; 08568/s



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