Database : HANSEN Search on : TRANSDUCAO DE SINAL/IMUNOL [Subject descriptor] References found : 5 [refine] Displaying: 1 .. 5   in format [Detailed]

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Id: 13944 Author: Bochud, Pierre-Yves; Hawn, Thomas R; Aderem, Alan Title: Cutting edge: a toll-like receptor 2 polymorphism that is associated with lepromatous leprosy is unable to mediate mycobacterial signaling ..- Source: s.l; s.n; 2003. 4 p. graf. Abstract: Toll-like receptors (TLRs) are key mediators of the innate immune response to microbial pathogens. We investigated the role of TLRs in the recognition of Mycobacterium leprae and the significance of TLR2Arg(677)Trp, a recently discovered human polymorphism that is associated with lepromatous leprosy. In mice, TNF-alpha production in response to M. leprae was essentially absent in TLR2-deficient macrophages. Similarly, human TLR2 mediated M. leprae-dependent activation of NF-kappaB in transfected Chinese hamster ovary and human embryonic kidney 293 cells, with enhancement of this signaling in the presence of CD14. In contrast, activation of NF-kappaB by human TLR2Arg(677)Trp was abolished in response to M. leprae and Mycobacterium tuberculosis. The impaired function of this TLR2 variant provides a molecular mechanism for the poor cellular immune response associated with lepromatous leprosy and may have important implications for understanding the pathogenesis of other mycobacterial infections. (AU). Descriptors: CELULAS CHO LINHAGEM CELULAR IMUNIDADE NATURAL/genet ARGININA/genet HANSENIASE VIRCHOWIANA/genet HANSENIASE VIRCHOWIANA/imunol HANSENIASE VIRCHOWIANA/microbiol GLICOPROTEINAS DE MEMBRANA/defic GLICOPROTEINAS DE MEMBRANA/genet GLICOPROTEINAS DE MEMBRANA/fisiol CAMUNDONGOS ENDOGÂMICOS C57BL CAMUNDONGOS KNOCKOUT MYCOBACTERIUM LEPRAE/imunol MYCOBACTERIUM TUBERCULOSIS/imunol POLIMORFISMO DE UM UNICO NUCLEOTIDIO/imunol TRANSDUCAO DE SINAL/imunol TRIPTOFANO/genet RECEPTORES DA SUPERFICIE CELULAR/defic RECEPTORES DA SUPERFICIE CELULAR/genet RECEPTORES DA SUPERFICIE CELULAR/fisiol Limits: HUMANO ANIMAL HAMSTERS CAMUNDONGOS SUPPORT, NON-U.S. GOV'T SUPPORT, U.S. GOV'T, P.H.S. Electronic Medium: http://www.ilsl.br Location: BR191.1; 09085/s

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Id: 12551 Author: Seitzer, Ulrike; Kayser, Klaus; Höhn, Hanni; Entzian, Peter; Wacker, Hans-Heinrich; Ploetz, Sabine; Flad, Hans-Dieter; Gerdes, Johannes; maeurer, Markus J Title: Reduced T-cell receptor CD3zeta-chain protein and sustained CD3epsilon expression at the site of mycobacterial infection ..- Source: s.l; s.n; 2001. 9 p. ilus. Descriptors: IMUNOFLUORESCENCIA GRANULOMA TÉCNICAS IMUNOENZIMATICAS INTERLEUCINA-2 HANSENIASE LEPROMATOSA PROTEINA-TIROSINA QUINASE PROTEINAS DA MEMBRANA MICOBACTERIOSE PROTEINAS PROTO-ONCOGENICAS RECEPTORES DE ANTIGENO DA CÉLULA-T SARCOIDOSE PULMONAR TRANSDUÇAO DE SINAL TONSILA TUBERCULOSE PULMONAR Location: BR191.1; 08657/s

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Id: 12279 Author: Kim, Jenny; Uyemura, Koichi; Van Dyke, Melissa K; Legaspi, Annaliza J; Rea, Thomas H; Shuai, Ke; Modlin, Robert L Title: A role for IL-12 receptor expression and signal transduction in host defense in leprosy ..- Source: s.l; s.n; 2001. 8 p. graf. Descriptors: ANTIGENOS DE BACTÉRIAS PROTEINAS DE LIGAÇAO DE DNA TOLERANCIA IMUNOLOGICA IMUNIDADE CELULAR INTERFERON TIPO II INTERLEUCINA-12 INTERLEUCINA-12 HANSENIASE LEPROMATOSA HANSENIASE TUBERCULOIDE TRANSFORMAÇAO LINFOCITICA MYCOBACTERIUM LEPRAE FOSFORILAÇAO RECEPTORES DA INTERLEUCINA RECEPTORES DA INTERLEUCINA TRANSDUÇAO DE SINAL LINFOCITOS T TRANSATIVADORES CELULAS CULTIVADAS Limits: ESTUDO COMPARATIVO Location: BR191.1; 08631/s

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Id: 11692 Author: Sharma, Nidhi; Sharma, V. K; Gupta, Anu; Kaur, Inderjeet; Ganguly, N. K Title: Immunological defect in leprosy patients: altered T-lymphocyte signals ..- Source: s.l; s.n; 1999. 8 p. graf. Descriptors: HANSENIASE CALCIO DIVISAO CELULAR FOSFATOS DE INOSITOL LIQUIDO INTRACELULAR TRANSDUÇAO DE SINAL LINFOCITOS T LINFOCITOS T Location: BR191.1; 08484/s

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Id: 11001 Author: Schlienger, Katia; Uyemura, Koichi; Jullien, Denis; Sieling, Peter A; Rea, Thomas H; Linsley, Peter S; Modlin, Robert L Title: B7-1, but not CD28, is crucial for the maintenance of the CD4+ T cell responses in human leprosy ..- Source: s.l; s.n; 1998. 7 p. tab, graf. Descriptors: HANSENIASE LEPROMATOSA HANSENIASE LEPROMATOSA HANSENIASE TUBERCULOIDE HANSENIASE TUBERCULOIDE MYCOBACTERIUM LEPRAE ANTICORPOS BLOQUEADORES ANTIGENOS CD ANTIGENOS CD28 ANTIGENOS CD28 ANTIGENOS DE DIFERENCIAÇAO ANTIGENOS CD80 ANTIGENOS CD80 ANTIGENOS CD80 LINFOCITOS T CD4-POSITIVOS LINFOCITOS T CD4-POSITIVOS CÉLULAS CLONAIS SOROS IMUNES LEUCOCITOS MONONUCLEARES TRANSFORMAÇAO LINFOCITICA GLICOPROTEINAS DE MEMBRANAS TRANSDUÇAO DE SINAL PELE PELE Location: BR191.1; 07275/s

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