Database : HANSEN Search on : BRASIL/ETNOL [Subject descriptor] References found : 4 [refine] Displaying: 1 .. 4   in format [Detailed]

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Id: 18388 Author: Jamieson, S. E; Miller, E. N; Black, G. F; Peacock, C. S; Cordel, H. J; Howson, J. M. M; Shaw, M. A; Burgner, D; Xu, W; Lins-Lainson, Z; Shaw, J. J; Ramos, F; Silveira, F; Blackwell, J. M Title: Evidence for cluster of genes on chromosome 17q11-q21 controlling susceptibility to tuberculosis and leprosy in Brazilians ..- Source: s.l; s.n; 2004. 12 p. ilus, tab. Abstract: The region of conserved synteny on mouse chromosome 11/human 17q11-q21 is known to carry a susceptibility gene(s) for intramacrophage pathogens. The region is rich in candidates including NOS2A, CCL2/MCP-1, CCL3/MIP-1x, CCL4/mip-1b, CCL5/RANTES, CCR7, STAT3 and STAT5A/5B. To examine the region in man, we studied 92 multicase tuberculosis (627 individuals) and 72 multicase leprosy (372 individuals) families from Brazil. Multipoint nonparametric analysis (ALLEGRO) using 16 microsatallites shows two peaks of linkage for leprosy at D17S250 (Z score 2.34; P=0.01) and D17S1795 (Z 2.67; P=0.004) and a single peak for tuberculosis at D17S250 (Z 2.04; P=0.02). Combined analysis shows significant linkage genes contribute, 49 informative single nucleotide polymorphisms were typed in candidate genes. Family-based allelic associationtesting that was robust to family clustering demonstrated siginificant associations with tuberculosis susceptibility at four loci separated by intervals (NOS2A-8.4Mb-CCL18-32.3kb-CCL4-6.04 Mb-STAT5B) up to several Mb. Stepwise conditional logistic regression analysis using a case/pseudo-control data set showed that the four genes contributed separate main effects, consistent with a cluster of susceptibility genes across 17q11.2 (AU). Descriptors: CROMOSSOMOS HUMANOS PAR 17/genet CROMOSSOMOS HUMANOS PAR 17/imunol PREDISPOSICAO GENETICA PARA DOENÇA MYCOBACTERIUM LEPRAE/imunol MYCOBACTERIUM LEPRAE/metab MYCOBACTERIUM TUBERCULOSIS/genet MYCOBACTERIUM TUBERCULOSIS/imunol MYCOBACTERIUM TUBERCULOSIS/metab - HANSENIASE/genet  TUBERCULOSE/genet  BRASIL/etnol  BRASIL/epidemiol Limits: HUMANO ANIMAL Location: BR191.1; 09314/s

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Id: 18179 Author: Sociedade de assistencia aos lazaros*. Title: O problema da lepra no Brasil The problem of the Leprosy in Brazil- Source: Sao Paulo; s.n; 1926. 63 p. . Descriptors: HANSENIASE/clas HANSENIASE/etnol HANSENIASE/hist ASSISTÊNCIA AO PACIENTE/hist ASSISTÊNCIA AO PACIENTE/estatíst HOSPITAIS DE DERMATOLOGIA SANITARIA DE PATOLOGIA TROPICAL/hist HOSPITAIS DE DERMATOLOGIA SANITARIA DE PATOLOGIA TROPICAL/estatíst - BRASIL/etnol  BRASIL/epidemiol Limits: RELATO DE CASO ESTUDO COMPARATIVO HUMANO Location: Br191.1; WC335.300.10, S13p

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Id: 13984 Author: Lombardi, Clovis; Ramírez, Rolando; Suárez, Gil; Eugenio, Reinaldo. Title: Tendencia temporal de la detección de la lepra en el Estado de São Paulo (Brasil) 1934-1983. Source: Fontilles - Revista de Leprología;19(4):369-386, Ene.-Abr. 1994. tab. Abstract: A partir de una muestra de casos de lepra detectados en el Estado de São Paulo, Brasil, entre 1943 y 1983, se describe y se avalúa la tendencia temporal de la endemis en el Estado. La tendencia de las tasas de detección ha sido estudiada por sexo y grupo de edad,. así como también las proporciones de las distintas formas clínicas, incluso por comparación con otros países de tendencia secular parecida. En el período estudiado, la tendencia global de las tasas de detección es decreciente; sin embargo, solamente las dos décadas subsiguientes a la introdución de la sulfonoterapia podrían considerarse como de caída real la incidencia. Dado que el lapso abarcado incluye límites importantes en la terapéutica y el enfoque de las políticas de control de la lepra, se intenta una interpretación del fenómeno epidemiológico observado en función de las características organizativas y estratégicas del programa de control en las diferentes etapas consideradas. (AU). Descriptors: HANSENIASE/etnol HANSENIASE/hist DETERMINACAO BRASIL/etnol Electronic Medium: http://www.ilsl.br Location: BR191.1

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Id: 9748 Author: Ishii, Norihisa; Sugita, Yasuyuki; Nakajima, Hiroshi Title: Two sister with leprosy ..- Source: s.l; s.n; 1993. 5 p. ilus, tab. Descriptors: BRASIL ANTIGENOS HLA ANTIGENOS HLA-DR JAPAO CÉLULAS DE LANGERHANS HANSENIASE HANSENIASE HANSENIASE RECEPTORES PARA ANTIGENOS DE CÉLULAS T ALFA-BETA LINFOCITOS T AUXILIADORES-INDUTORES Limits: RELATO DE CASO Location: BR191.1; 06701/s

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