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Id: 18821 Author: Almeida, José Oliveira de. Title: Preparo, padronizado e comparação de antígenos em reações quantitativas de fixação de complemento com soros de doentes de lepra. Source: Rev. bras. Leprol;26(3/4):181-271, jul.-dez. 1958. ^btab, ^bgraf. Abstract: A reação de fixação do complemento em sôro de lepra com antígenos preparados de bacilos da tuberculose se deve à atividade haptênica dos fosfatídeos  ácidos complexos ligados a carboidratos e solúveis em piridina. O efeito anticomplementar dos ant¡genos solúveis em piridina ‚ corrigido pela lecitina; efeito semelhante se observa nos antígenos aquosos do bacilo da tuberculose. As reações entre antígeno, anticorpo e complemento, podem ser melhor estudadas por meio das "curvas de isofixação" obtidas por projeção de antígeno contra sôro, o complemento sendo mantido constante. A curva de isofixação em seu ramo vertical permite determinar as condições necessárias para a titulagem de antígenos e também a influência da quantidade de sôro presente na reação sôbre os parâmetros de linha de regressão: antígeno-complemento. O ramo horizontal da curva de isofixação indica as condições nas quais se deve processar a titulagem do sôro. A influência da dose de antígeno empregada sôbre os parâmetros da linha de regressão sôro-complemento pôde ser apreciada e dada uma correta interpretação. A dose de antígeno a ser usada numa titulagem de sôro é aquela que não afeta o relativo paralelismo das curvas de isofixação. Então, complemento fixado ser  função linear da quantidade de sôro presente. A parte da curva de isofixação que liga os dois ramos assintóticos, traduz a suplência observada entre sôro e antìgeno e indica as condições em que a fixação do complemento depende tanto da quantidade de sôro presente, como da quantidade de antígeno usado. Nesse caso, a titulagem de qualquer um dêsses elementos nâo poder  ser feita. Para a titulagem de sôros, por método simplificado, fatôres de conversão são utilizados. Êsses fatores foram determinados para o sistema lepra onde os valores de h sofrem marcada influência da quantidade de complemento necessário para 50% de hemólise, pois há  estreita dependência entre a percentagem de complemento fixado e a...(AU)^ipt. Descriptors: Hanseníase/genet Hanseníase/imunol Antígenos/genet Antígenos/imunol Tuberculose/genet Tuberculose/imunol Limits: Humanos Masculino Feminino Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/brasleprol/1958/PDF/v26n3-4/v26n3-4a06.pdf / pt Location: BR191.1

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Id: 18388 Author: Jamieson, S. E; Miller, E. N; Black, G. F; Peacock, C. S; Cordel, H. J; Howson, J. M. M; Shaw, M. A; Burgner, D; Xu, W; Lins-Lainson, Z; Shaw, J. J; Ramos, F; Silveira, F; Blackwell, J. M Title: Evidence for cluster of genes on chromosome 17q11-q21 controlling susceptibility to tuberculosis and leprosy in Brazilians ..- Source: s.l; s.n; 2004. 12 p. ilus, tab. Abstract: The region of conserved synteny on mouse chromosome 11/human 17q11-q21 is known to carry a susceptibility gene(s) for intramacrophage pathogens. The region is rich in candidates including NOS2A, CCL2/MCP-1, CCL3/MIP-1x, CCL4/mip-1b, CCL5/RANTES, CCR7, STAT3 and STAT5A/5B. To examine the region in man, we studied 92 multicase tuberculosis (627 individuals) and 72 multicase leprosy (372 individuals) families from Brazil. Multipoint nonparametric analysis (ALLEGRO) using 16 microsatallites shows two peaks of linkage for leprosy at D17S250 (Z score 2.34; P=0.01) and D17S1795 (Z 2.67; P=0.004) and a single peak for tuberculosis at D17S250 (Z 2.04; P=0.02). Combined analysis shows significant linkage genes contribute, 49 informative single nucleotide polymorphisms were typed in candidate genes. Family-based allelic associationtesting that was robust to family clustering demonstrated siginificant associations with tuberculosis susceptibility at four loci separated by intervals (NOS2A-8.4Mb-CCL18-32.3kb-CCL4-6.04 Mb-STAT5B) up to several Mb. Stepwise conditional logistic regression analysis using a case/pseudo-control data set showed that the four genes contributed separate main effects, consistent with a cluster of susceptibility genes across 17q11.2 (AU). Descriptors: CROMOSSOMOS HUMANOS PAR 17/genet CROMOSSOMOS HUMANOS PAR 17/imunol PREDISPOSICAO GENETICA PARA DOENÇA MYCOBACTERIUM LEPRAE/imunol MYCOBACTERIUM LEPRAE/metab MYCOBACTERIUM TUBERCULOSIS/genet MYCOBACTERIUM TUBERCULOSIS/imunol MYCOBACTERIUM TUBERCULOSIS/metab - HANSENIASE/genet  TUBERCULOSE/genet  BRASIL/etnol  BRASIL/epidemiol Limits: HUMANO ANIMAL Location: BR191.1; 09314/s

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Id: 18387 Author: Miller, E. N; Jamieson, S. E; Jobert, C; Fakiola, M; Peacock, C. S; Cordell, H. J; Shaw, M. A; Lins-Lainson, Z; Shaw, J. J; Ramos, F; Silveira, F; Blackwell, J. M Title: Genome-wide scans for leprosy and tuberculosis susceptibility genes in Brazilians ..- Source: s.l; s.n; 2004. 5 p. tab, graf. Abstract: Genome-wide scans were conducted for tuberculosis and leprosy per se in Brazil. At stage 1,405 markers (10 cM map) were typed in 16 (178 individuals) tuberculosis and 21 (173 individuals) leprosy families. Nonparametric multipoint analysis detected 8 and 9 chromosomal regions respectively with provisional evidence (P<0.05) for linkage. A stage 2, 58 markers from positive regions were typed in a second set of 22 (176 individuals) tuberculosis families, with 22 additional markers types in all families; 42 positive markers in 50 (192 individuals) new leprosy families, and 30 additional markers in all families. Three regions (10q26.13, 11q12.3, 20p12.1) retained suggestive evidence (peak LOD scores 1.31, 1.78, 1.78; P=0.007, 0.0018, 0.0021) for linkage to tuberculosis, 3 regions (6p21.32, 17q22, 20p13) to leprosy (HLA-DQA, 3.23, P=5.8 x 10-5; D17S1868.2.38, P=0.0005; D20S889, 1.51, P=0.004). The peak at D20S889 for leprosy is 3.5 Mb distal to that reported at D20S115 for leprosy in India (AU). Descriptors: PREDISPOSICAO GENETICA PARA DOENÇA MYCOBACTERIUM LEPRAE MYCOBACTERIUM TUBERCULOSIS HANSENIASE/genet TUBERCULOSE/genet - MYCOBACTERIUM LEPRAE/imunol  MYCOBACTERIUM LEPRAE/metab  MYCOBACTERIUM TUBERCULOSIS/imunol  MYCOBACTERIUM TUBERCULOSIS/metab Location: BR191.1; 09313/s

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Id: 18217 Author: Jamieson, S. E; Miller, E. N; Black, G. F; Peacock, C. S; Cordell, H. J; Howson, J. M. M; Shaw, M. A; Burgner, D; Xu, W; Lins-Lainson, Z; Shaw, J. J; Ramos, F; Silveira, F; Blackwell, J. M Title: Evidence for a cluster of genes on chromosome 17q11-q21 controlling susceptibility to tuberculosis and leprosy in Brazilians ..- Source: s.l; s.n; 2004. 12 p. tab, graf. Abstract: The region of conserved synteny on mouse chromosome 11/human 17q11-q21 is known to carry a susceptibility gene(s) for intramacrophage pathogens. The region is rich in candidates including NOS2A, CCL2/MCP-1, CCL3/MIP-1 alpha, CCL4/MIP-1 beta, CCL5/RANTES, CCR7, STAT5A/5B. To examine the region in man, we studied 92 multicase tuberculosis (627 individuals) and 72 multicase leprosy (372 indiciduals) families from Brazil. Multipoint nonparametric analysis (ALLEGRO) using 16 microsatellites shows two peaks of linkage for leprosy at D17S250 (Zir score 2.34; P=0.01) and D17S1795 (Zir 2.67; P=O.004) and a single peack for tuberculosis at D17S250 (Zir 2.04; P=0.02). Combined analysis shows significant linkage (peak Zir 3.38) at D17S250, equivalent to an allele sharing LOD score 2.48 (P=0.0004). To determine whether one or multiple genes contribute, 49 informative single nucleotide polymorphisms were typed in candidate genes. Family-based allelic association testing that was robust to family clustering demonstrated significant associations with tuberculosis susceptibility at four loci separated by intervals (NOS2A-8.4 Mb-CCL 18-32.3 kb-CCL4-6.04 Mb-STAT5B) up to several Mb. Stepwise conditional logistic regression analysis using a case/pseudo-control data set showed that the four genes contributed separate main effects, consistent with a cluster of susceptibilitty genes acros 17q11.2 (AU). Descriptors: HANSENIASE/genet HANSENIASE/imunol TUBERCULOSE/genet TUBERCULOSE/imunol CROMOSSOMOS HUMANOS PAR 17/imunol CROMOSSOMOS HUMANOS PAR 21/imunol - GENETICA POPULACIONAL Limits: HUMANO Location: BR191.1; 09196/s

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Id: 13965 Author: Hoal, Eileen G Title: Human genetic susceptibility to tuberculosis and other mycobacterial diseases ..- Source: s.l; s.n; 2002. 5 p. . Abstract: The existence of a genetic component in mycobacterial disease susceptibility is no longer in doubt and the investigations now being conducted aim to determine which genes are involved, to what extent, and in which disease phenotype they are relevant. In certain rare instances of susceptibility to poorly pathogenic mycobacteria, the genetic component is clear. The approaches employed to elucidate common disease susceptibility include linkage studies, particularly genome-wide linkage analysis of both tuberculosis and leprosy, and association studies. A number of candidate genes have shown association with tuberculosis, and in many cases, on replication of the study, association has been confirmed in a disparate population, indicating the wider importance of the gene in the disease process. In other instances, associations appear to be particular to a population or a subtype of disease. (AU). Descriptors: PREDISPOSICAO GENETICA PARA DOENÇA LIGACAO (GENETICA) GENOTIPO MYCOBACTERIUM TUBERCULOSIS/patogen TUBERCULOSE/epidemiol TUBERCULOSE/genet FENOTIPO Limits: HUMANO SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 09058/s

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Id: 13635 Author: Hoal, Eileen G Title: Human genetic susceptibility to tuberculosis and other mycobacterial diseases ..- Source: s.l; s.n; 2002. 5 p. . Abstract: The existence of a genetic component in mycobacterial disease susceptibility is no longer in doubt and the investigations now being conducted aim to determine which genes are involved, to what extent, and in which disease phenotype they are relevant. In certain rare instances of susceptibility to poorly pathogenic mycobacteria, the genetic component is clear. The approaches employed to elucidate common disease susceptibility include linkage studies, particularly genome-wide linkage analysis of both tuberculosis and leprosy, and association studies. A number of candidate genes have shown association with tuberculosis, and in many cases, on replication of the study, association has been confirmed in a disparate population, indicating the wider importance of the gene in the disease process. In other instances, associations appear to be particular to a population or a subtype of disease.(AU). Descriptors: PREDISPOSICAO GENETICA PARA DOENÇA GENOTIPO LIGACAO (GENETICA) MYCOBACTERIUM TUBERCULOSIS/patogen FENOTIPO TUBERCULOSE/epidemiol TUBERCULOSE/genet Limits: HUMANO SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 09044/s

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Id: 12271 Author: Marquet, Sandrine; Schurr, Erwin Title: Genetics of susceptibility to infectious diseases: tuberculosis and leprosy as examples ..- Source: s.l; s.n; 2001. 5 p. tab. Descriptors: MODELOS ANIMAIS DE DOENÇAS HANSENIASE POLIOVIRUS MURINO CAMUNDONGOS TUBERCULOSE Limits: ANIMAL Location: BR191.1; 08674/s

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Id: 11600 Author: Marquet, Sandrine; Schurr, Erwin Title: Genetics of susceptibility to infectious diseases: tuberculosis and leprosy as examples ..- Source: s.l; s.n; 2001. 5 p. tab. Descriptors: MODELOS ANIMAIS DE DOENÇAS HANSENIASE CAMUNDONGOS TUBERCULOSE PREDISPOSICAO GENETICA PARA DOENCA/* Limits: ANIMAL Location: BR191.1; 08419/s

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Id: 11455 Author: Skamene, Emil; Schurr, Erwin; Gros, Philippe Title: Infection genomics: Nramp1 as a major determinant of natural resistance to intracellular infections ..- Source: s.l; s.n; 1998. 13 p. . Descriptors: ALELOS ANTITUBERCULOSOS INFECÇOES BACTERIANAS INFECÇOES BACTERIANAS INFECÇOES BACTERIANAS INFECÇOES BACTERIANAS PROTEINAS DE TRANSPORTE SURTOS DE DOENÇAS SUSCETIBILIDADE A DOENÇA GENOMA BACTERIANO GENOMA HUMANO GENOMA DE PROTOZOARIO LEISHMANIOSE LEISHMANIOSE IMUNIDADE NATURAL LEPROSTATICOS HANSENIASE HANSENIASE HANSENIASE HANSENIASE LIGAÇAO (GENÉTICA) MACROFAGOS PROTEINAS DA MEMBRANA CAMUNDONGOS MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE MYCOBACTERIUM TUBERCULOSIS MYCOBACTERIUM TUBERCULOSIS INFECÇOES POR SALMONELLA INFECÇOES POR SALMONELLA TUBERCULOSE TUBERCULOSE TUBERCULOSE TUBERCULOSE Predisposição Genética para Doença Limits: ESTUDO COMPARATIVO ANIMAL Location: BR191.1; 08338/s

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Id: 10357 Author: Levin, Michael; Newport, Melanie Title: Understanding the genetic basis of susceptibility to mycobacterial infection ..- Source: s.l; s.n; 1999. 5 p. . Descriptors: CRIANÇA GAMBIA IMUNIDADE NATURAL HANSENIASE MALTA CAMUNDONGOS MICOBACTERIOSE RECEPTORES DE INTERFERON TUBERCULOSE PREDISPOSICAO GENETICA PARA DOENCA/*GE Location: BR191.1; 07474/s

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Id: 10099 Author: Blackwell, J. M; Black, G. F; Peacock, C. S; Miller, E. N; Sibthorpe, D; Gnananandha, D; Shaw, J. J; Silveira, F; Lins-Lainson, Z; Ramos, F; Collins, A; Shaw, M. A Title: Immunogenetics of leishmanial and mycobacterial infections: the Belem Family Study ..- Source: s.l; s.n; 1997. 15 p. ilus, tab. Descriptors: ANTIGENOS DE BACTÉRIAS DOENÇAS AUTO-IMUNES BRASIL PROTEINAS DE TRANSPORTE CROMOSSOMOS HUMANOS PAR 17 ANTIGENOS HLA INTERLEUCINA-4 LEISHMANIOSE CUTANEA LEISHMANIOSE CUTANEA HANSENIASE HANSENIASE LIGAÇAO (GENÉTICA) PROTEINAS DA MEMBRANA CAMUNDONGOS MICOBACTERIOSE MICOBACTERIOSE LINHAGEM POLIMORFISMO (GENÉTICA) SOFTWARE TUBERCULOSE TUBERCULOSE Limits: ANIMAL Location: BR191.1; 07158/s

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Id: 10073 Author: Blackwell, Jenefer M Title: Genetics of host resistance and susceptibility to intramacrophage pathogens: a study of multicase families of tuberculosis, leprosy and leishmaniasis in north-eastern Brazil ..- Source: s.l; s.n; 1998. 8 p. ilus. Descriptors: HANSENIASE HANSENIASE LEISHMANIOSE LEISHMANIOSE IMUNIDADE NATURAL LIGAÇAO (GENÉTICA) FENOTIPO TUBERCULOSE TUBERCULOSE Location: BR191.1; 07133/s

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Id: 9979 Author: Young, Douglas B; Cole, Stewart T Title: Leprosy, tuberculosis, and the new genetics ..- Source: s.l; s.n; 1993. 6 p. tab. Descriptors: RESISTENCIA MICROBIANA A DROGAS GENOMA BACTERIANO HANSENIASE HANSENIASE HANSENIASE MYCOBACTERIUM LEPRAE MYCOBACTERIUM TUBERCULOSIS TUBERCULOSE TUBERCULOSE TUBERCULOSE VIRULENCIA Location: BR191.1; 06623/s

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Id: 9961 Author: Schurr, Erwin; Malo, Danielle; Radzioch, Danuta; Buschman, Ellen; Morgan, Kenneth; Gros, Philippe; Skamene, Emil Title: Genetic control of innate resistance to mycobacterial infections ..- Source: s.l; s.n; 1991. 4 p. ilus, graf. Descriptors: MAPEAMENTO CROMOSSOMICO REGULAÇAO DA EXPRESSAO GENICA NO DESENVOLVIMENTO MARCADORES GENÉTICOS IMUNIDADE NATURAL ATIVAÇAO DE MACROFAGOS MACROFAGOS CAMUNDONGOS CAMUNDONGOS CAMUNDONGOS MICOBACTERIOSE MICOBACTERIOSE FENOTIPO TUBERCULOSE TUBERCULOSE Location: BR191.1; 06539/s

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Id: 9744 Author: Blackwell, Jenefer M; Barton, C. Howard; White, Jacqueline K; Roach, Tamara I. A; Shaw, Marie-Anne; Whitehead, Simon H; Mock, Beverly A; Searle, Susan; Williams, Hazel; Baker, Anne-Marie Title: Genetic regulation of leismanial and mycobacterial infections: the Lsh / Ity / Bcg gene story continues ..- Source: s.l; s.n; 1994. 9 p. ilus, graf. Descriptors: SEQUENCIA DE AMINOACIDOS PROTEINAS DE TRANSPORTE PROTEINAS DE TRANSPORTE SUSCETIBILIDADE A DOENÇA LEISHMANIOSE HANSENIASE ATIVAÇAO DE MACROFAGOS PROTEINAS DA MEMBRANA PROTEINAS DA MEMBRANA CAMUNDONGOS DADOS DE SEQUENCIA MOLECULAR MICOBACTERIOSE TUBERCULOSE Limits: ANIMAL Location: BR191.1. 6705/s

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Id: 9637 Author: Shaw, M. A; Atkinson, S; Dockrell, H; Hussain, R; Lins-Lainson, Z; Shaw, J; Ramos, F; Silveira, F; Mehdi, S. Q; Kaukab, F; Khaliq, S; Chiang, T; Blackwell, J Title: An RFLP map for 2q33-q37 from multicase mycobacterial and leishmanial disease families: no evidence for an Lsh/Ity/Bcg gene homologue influencing susceptibility to leprosy ..- Source: s.l; s.n; 1993. 21 p. tab, graf. Descriptors: LINFOCITOS B SEQUENCIA DE BASES BRASIL LINHA CELULAR TRANSFORMADA SUSCETIBILIDADE A DOENÇA FREQUENCIA DOS GENES GENES MARCADORES GENÉTICOS LEISHMANIOSE LEISHMANIOSE HANSENIASE ESCORE LOD CAMUNDONGOS DADOS DE SEQUENCIA MOLECULAR LINHAGEM POLIMORFISMO DE FRAGMENTO DE RESTRIÇAO HOMOLOGIA DE SEQUENCIA DO ACIDO NUCLÉICO ESPECIFICIDADE DE ESPÉCIES TUBERCULOSE TUBERCULOSE Limits: ESTUDO COMPARATIVO ANIMAL Location: BR191.1; 06555/s

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Id: 9458 Author: Terpstra, W. J Title: Mycobacterial research at the N.H. Swellengrebel Laboratory of Tropical Hygiene ..- Source: s.l; s.n; 1991. 2 p. . Descriptors: ACADEMIAS E INSTITUTOS ANTICORPOS MONOCLONAIS GENÉTICA BIOQUIMICA GENÉTICA BIOQUIMICA HANSENIASE HANSENIASE HANSENIASE PESQUISA MEDICINA TROPICAL TUBERCULOSE TUBERCULOSE TUBERCULOSE Location: BR191.1; 06302/s

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