|
|
| Id: | 13960
| | Author: | Krutzik, Stephan R; Ochoa, Maria Teresa; Sieling, Peter A; Uematsu, Satoshi; Ng, Yolanda W; Legaspi, Annaliza; Liu, Philip T; Cole, Stewart T; Godowski, Paul J; Maeda, Yumi; Sarno, Euzenir N; Norgard, Michael V; Brennan, Patrick J; Akira, Shizuo; Rea, Thomas H; Modlin, Robert L
| | Title: | Activation and regulation of toll-like receptors 2 and 1 in human leprosy
..-
| | Source: | s.l; s.n; 2003. 8 p. ilus, graf.
| | Abstract: | The expression and activation of Toll-like receptors (TLRs) was investigated in leprosy, a spectral disease in which clinical manifestations correlate with the type of immune response mounted toward Mycobacterium leprae. TLR2-TLR1 heterodimers mediated cell activation by killed M. leprae, indicating the presence of triacylated lipoproteins. A genome-wide scan of M. leprae detected 31 putative lipoproteins. Synthetic lipopeptides representing the 19-kD and 33-kD lipoproteins activated both monocytes and dendritic cells. Activation was enhanced by type-1 cytokines and inhibited by type-2 cytokines. In addition, interferon (IFN)-gamma and granulocyte-macrophage colony-stimulating factor (GM-CSF) enhanced TLR1 expression in monocytes and dendritic cells, respectively, whereas IL-4 downregulated TLR2 expression. TLR2 and TLR1 were more strongly expressed in lesions from the localized tuberculoid form (T-lep) as compared with the disseminated lepromatous form (L-lep) of the disease. These data provide evidence that regulated expression and activation of TLRs at the site of disease contribute to the host defense against microbial pathogens. (AU).
| | Descriptors: | CITOCINAS/fisiol
HANSENIASE/imunol
IMUNIDADE NATURAL
LIPOPROTEINAS/anal
GLICOPROTEINAS DE MEMBRANA/anal
GLICOPROTEINAS DE MEMBRANA/fisiol
RECEPTORES DA SUPERFICIE CELULAR/anal
RECEPTORES DA SUPERFICIE CELULAR/fisiol
| | Limits: | HUMANO
ANIMAL
CAMUNDONGOS
SUPPORT, NON-U.S. GOV'T
SUPPORT, U.S. GOV'T, P.H.S.
| | Electronic Medium: | http://www.ilsl.br
| | Location: | BR191.1; 09113/s |
|
