Database : HANSEN
Search on : CITOCINAS/FISIOL [Subject descriptor]
References found : 11 [refine]
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Id:17990
Author:Foss, Norma T.
Title:Cytokines profile in the serum and in the spernatant of cultures of PMNBC from the leprosy patients.
Source:Hansen. int;(n.esp):143-143, Jun. 1998. .
Conference:Present in: Congresso da Associação Brasileira de Hansenologia, IX, Foz do Iguaçu, 04-08 junho 1997.
Descriptors:CITOCINAS/anal
CITOCINAS/quim
CITOCINAS/farmacol
CITOCINAS/fisiol
HANSENIASE/quimioter
HANSENIASE/imunol
HANSENIASE/fisiopatol
Limits:RELATO DE CASO
ESTUDO COMPARATIVO
HUMANO
Location:BR 191.1


  2 / 11 HANSEN  
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Id:13960
Author:Krutzik, Stephan R; Ochoa, Maria Teresa; Sieling, Peter A; Uematsu, Satoshi; Ng, Yolanda W; Legaspi, Annaliza; Liu, Philip T; Cole, Stewart T; Godowski, Paul J; Maeda, Yumi; Sarno, Euzenir N; Norgard, Michael V; Brennan, Patrick J; Akira, Shizuo; Rea, Thomas H; Modlin, Robert L
Title:Activation and regulation of toll-like receptors 2 and 1 in human leprosy ..-
Source:s.l; s.n; 2003. 8 p. ilus, graf.
Abstract:The expression and activation of Toll-like receptors (TLRs) was investigated in leprosy, a spectral disease in which clinical manifestations correlate with the type of immune response mounted toward Mycobacterium leprae. TLR2-TLR1 heterodimers mediated cell activation by killed M. leprae, indicating the presence of triacylated lipoproteins. A genome-wide scan of M. leprae detected 31 putative lipoproteins. Synthetic lipopeptides representing the 19-kD and 33-kD lipoproteins activated both monocytes and dendritic cells. Activation was enhanced by type-1 cytokines and inhibited by type-2 cytokines. In addition, interferon (IFN)-gamma and granulocyte-macrophage colony-stimulating factor (GM-CSF) enhanced TLR1 expression in monocytes and dendritic cells, respectively, whereas IL-4 downregulated TLR2 expression. TLR2 and TLR1 were more strongly expressed in lesions from the localized tuberculoid form (T-lep) as compared with the disseminated lepromatous form (L-lep) of the disease. These data provide evidence that regulated expression and activation of TLRs at the site of disease contribute to the host defense against microbial pathogens. (AU).
Descriptors:CITOCINAS/fisiol
HANSENIASE/imunol
IMUNIDADE NATURAL
LIPOPROTEINAS/anal
GLICOPROTEINAS DE MEMBRANA/anal
GLICOPROTEINAS DE MEMBRANA/fisiol
RECEPTORES DA SUPERFICIE CELULAR/anal
RECEPTORES DA SUPERFICIE CELULAR/fisiol
Limits:HUMANO
ANIMAL
CAMUNDONGOS
SUPPORT, NON-U.S. GOV'T
SUPPORT, U.S. GOV'T, P.H.S.
Electronic Medium:http://www.ilsl.br
Location:BR191.1; 09113/s


  3 / 11 HANSEN  
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Id:11031
Author:Sieling, Peter A; Modlin, Robert L
Title:Regulation of cytokine patterns in leprosy ..-
Source:s.l; s.n; 1994. 11 p. .
Descriptors:RELAÇAO CD4-CD8
CITOCINAS
EXPRESSAO GENICA
INTERLEUCINA-10
INTERLEUCINA-12
INTERLEUCINA-7
INTERLEUCINAS
HANSENIASE
RNA MENSAGEIRO
RECEPTORES PARA ANTIGENOS DE CÉLULAS T ALFA-BETA
RECEPTORES PARA ANTIGENOS DE CÉLULAS T GAMA-DELTA
SUB-POPULAÇOES DE LINFOCITOS T
LINFOCITOS T AUXILIADORES-INDUTORES
LINFOCITOS T SUPRESSORES-EFETORES
Location:BR191.1; 07209/s


  4 / 11 HANSEN  
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Id:11006
Author:Griffin, George; Krishna, Sanjeev
Title:Infectious diseases ..-
Source:s.l; s.n; may-jun. 1998. 4 p. ilus, tab.
Descriptors:QUIMIOCINAS
QUIMIOCINAS
DOENÇAS TRANSMISSIVEIS
CITOCINAS
CITOCINAS
CITOCINAS
INTERLEUCINA-1
HANSENIASE
MALARIA
RECEPTORES, CITOCINA
LINFOCITOS T AUXILIADORES-INDUTORES
TUBERCULOSE
VIROSES
FATOR DE NECROSE TUMORAL/IM
Limits:ESTUDO COMPARATIVO
Location:BR191.1; 07296/s


  5 / 11 HANSEN  
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Id:10373
Author:Gupta, Anu; Sharma, V. K; Vohra, Harpreet; Ganguly, N. K
Title:Spontaneous apoptosis in peripheral blood mononuclear cells of leprosy patients: role of cytokines ..-
Source:s.l; s.n; 1999. 7 p. tab, graf.
Descriptors:ANTICORPOS
ESPECIFICIDADE DE ANTICORPOS
ANTIGENOS CD28
APOPTOSE
CITOCINAS
CITOCINAS
INTERLEUCINA-1
INTERLEUCINA-6
INTERLEUCINA-6
IONOMICINA
HANSENIASE
HANSENIASE
LEUCOCITOS MONONUCLEARES
LEUCOCITOS MONONUCLEARES
ZINCO
CELULAS CULTIVADAS
FATOR DE NECROSE TUMORAL/AI/PH
Location:BR191.1; 07501/s


  6 / 11 HANSEN  
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Id:10351
Author:Singh, Ram Pyare
Title:Immunoregulation of cytokines in infectious diseases (leprosy) future strategies ..-
Source:s.l; s.n; 1998. 6 p. ilus, tab.
Descriptors:FORMAÇAO DE ANTICORPOS
CITOCINAS
IMUNIDADE CELULAR
HANSENIASE
HANSENIASE
SUB-POPULAÇOES DE LINFOCITOS T
SUB-POPULAÇOES DE LINFOCITOS T
Limits:ANIMAL
Location:BR191.1; 07203/s


  7 / 11 HANSEN  
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Id:10168
Author:Kaplan, Gilla
Title:Cytokine regulation of disease progression in leprosy and tuberculosis ..-
Source:s.l; s.n; 1994. 5 p. .
Descriptors:HANSENIASE LEPROMATOSA
HANSENIASE LEPROMATOSA
INFECÇOES OPORTUNISTAS RELACIONADAS COM A AIDS
INFECÇOES OPORTUNISTAS RELACIONADAS COM A AIDS
CITOCINAS
ERITEMA NODOSO
ERITEMA NODOSO
HIV-1
IMUNIDADE CELULAR
INJEÇOES INTRADÉRMICAS
INTERFERON TIPO II
INTERFERON TIPO II
TALIDOMIDA
TUBERCULOSE
TUBERCULOSE
TUBERCULOSE
FATOR DE NECROSE DE TUMOR
FATOR DE NECROSE DE TUMOR
Location:BR191.1; 07081/s


  8 / 11 HANSEN  
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Id:9668
Author:Kaplan, Gilla; Cohn, Zanvil A
Title:Leprosy and cell-mediaded immunity ..-
Source:s.l; s.n; 1991. 6 p. ilus.
Descriptors:CITOCINAS
IMUNIDADE CELULAR
CÉLULAS KILLER NATURAIS
HANSENIASE
TRANSFORMAÇAO LINFOCITICA
LINFOCINAS
CAMUNDONGOS
FAGOCITOS
LINFOCITOS T
Location:BR191.1; 06505/s


  9 / 11 HANSEN  
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Id:9431
Author:Yamamura, Masahiro; Uyemura, Koichi; Deans, Robert J; Weinberg, Kenneth; Rea, Thomas H; Bloom, Barry R; Modlin, Robert L
Title:Definig protective responses to pathogens: cytokine profiles in leprosy lesions ..-
Source:s.l; s.n; 1991. 3 p. ilus.
Descriptors:SEQUENCIA DE BASES
CITOCINAS
CITOCINAS
IMUNIDADE NATURAL
INTERLEUCINA-10
INTERLEUCINA-2
INTERLEUCINA-4
INTERLEUCINA-5
HANSENIASE
RNA MENSAGEIRO
PELE
REAÇAO EM CADEIA POR POLIMERASE
Location:BR191.1; 06329/s


  10 / 11 HANSEN  
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Id:9390
Author:Yamamura, Masahiro; Wang, Xiao-Hong; Ohmen, Jeffrey D; Uyemura, Koichi; Rea, Thomas H; Bloom, Barry R; Modlin, Robert L
Title:Cytokine patterns of immunologically mediated tissue damage ..-
Source:s.l; s.n; 1992. 6 p. ilus, graf.
Descriptors:SEQUENCIA DE BASES
CITOCINAS
CITOTOXICIDADE IMUNOLOGICA
EXPRESSAO GENICA
HANSENIASE
HANSENIASE
DADOS DE SEQUENCIA MOLECULAR
OLIGODESOXIRRIBONUCLEOTIDIOS
REAÇAO EM CADEIA POR POLIMERASE
RNA MENSAGEIRO
Location:BR191.1; 06414/s


  11 / 11 HANSEN  
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Id:1032
Author:Walter, Joachim.
Title:The armadillo model in WHO global strategy for leprosy research.
Source:In: World Health Organization.The armadillo as an experimental model in biomedical research. Washington, Pan American Health Organization, 1978. p.79-80. (Scientific Publication, 366).
Descriptors:HANSENIASE
ANEXINAS
COLITE ULCERATIVA
COLITE ULCERATIVA
COLON
DOENÇA DE CROHN
DOENÇA DE CROHN
DOENÇA DE CROHN
CITOCINAS
CITOCINAS
Location:BR191.1; WC335.400, O14a



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