Base de dados : HANSEN Pesquisa : ELISA/NORMAS [Descritor de assunto] Referências encontradas : 2 [refinar] Mostrando: 1 .. 2   no formato [Detalhado]

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Id: 25761 Autor: Bakker, M. I; Hatta, M; Kwenang, A; Van Mosseveld, P; Faber, W. R; Klatser, P. R; Oskam, L. Título: Risk factores for developing leprosy -A population-based cohort study in Indonesia. Fonte: In: Bakker, Mirjam.Epidemiology and prevention of leprosy: a cohort study in Indonesia^ien. s.l, The Netherlands Leprosy Relief, 2005. p.106-124^btab, ^bgraf. Resumo: This study identified risk factors for developing leprosy through yearly incidence rates in five island populations. Personal factors, like age, sex, household size and the presence of M.leprae-specific antibodies as well as contact were studied. Of the 94 index patients (patients diagnosed in 2000) 43 (46%) were classified as multibacillary (MB), 17 (19%) were seropositive and 6 (7%) presented M.leprae DNA in nasal swabs as determined by polumerase chain reaction (PCR). All PCR positive patients were also seropositive. Forty-four of the 4903 persons initially without symptoms of leprosy developed leprosy in almost four years follow-up, giving an incidence rate of 2.98 per 1000 person-years. Men had a 2.2 times higher risk (95% Confidence Interval [CI]: 1.2-4.1) to developd leprosy than women. Persons living in households of more than 7 household members. Persons who were seropositive in 2000 had a 3.7 times higher risk (95% CI:1.1-12.4) than seronegative persons. Household contacts of MB patients had an adjusted hazard ratio (aHR) of 4.6 (95% CI:1.6-12.9) and household contacts of PCR positive patients an aHR of 9.36 (95% CI: 2.5-34.9) compared to non-contacts. Patients with PCR positive nasal swabs, suggesting nasal excretion of M.leprae, are probably the patients with the highest transmission patential. Since all index patients who were PCR positive were also seropositive, serology semms an adequate tool to identify these patients. Preventing seropositive persons to become seropositive patients and thus the main source of infection may break the chain of transmission (AU)^ien. Descritores: HANSENIASE/congen HANSENIASE/compl HANSENIASE/diag ELISA/normas ELISA/util REACAO EM CADEIA DA POLIMERASE/métodos REACAO EM CADEIA DA POLIMERASE/util ANALISE ESTATISTICA Limites: ESTUDO COMPARATIVO Humanos Localização: BR191.1; WC335.300, B179e

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Id: 25759 Autor: Bakker, M. I; Hatta, M; Kwenang, A; Faber, W. R; Van Beers, S. M; Klatser, P. R; Oskam, L. Título: Population survey to determine risk factors for Mycobacterium leprae transmission and infection. Fonte: In: Bakker, Mirjam.Epidemiology and prevention of leprosy: a cohort study in Indonesia^ien. s.l, The Netherlands Leprosy Relief, 2005. p.72-86^bmapas, ^btab. Resumo: Background: Not every leprosy patient is equally effective in transmitting Mycobacterium leprae. We studied the spatial distribution of infection (using seropositivity as a marker) in the population to identifity which disease characteristics of leprosy patients are important in transmission. Methods: Clinical data and blood samples for anti-M.leprae ELISA were collected during a cross-sectional survey on five Indonesian islands highly endemic for leprosy. A geographic information system (GIS) was used to define contacts of patients. We investigated spatial clustering of patients and seropositive people and used logist regression to determine risk factors for seropositivity. Results: Of the 3986 people examined for leprosy, 3271 gave blood. Seroprevalence varied between islands (1.7-8.7%) and correlated significantly with leprosy prevalence. Five clusters of patients and two clusters of seropositives were detected. In multivariate analysis, seropositivity significantly differed to be the best discriminator of contact groups with higher seroprevalence: contacts of seropositive patients had an adjusted odds ratio (aOR) of 1.75 (95% CI: 0.92-3,31). This increased seroprevalence was strongest for contact groups living _< 75 metres of two seropositive patients (aOR:3.07;95%CI:1.74-5.42). Conclusions: In this highly endemic area for leprosy, not only household contacts of seropositive patients, but also persons living in the vicinity of seropositive patient were more likely to harbour antibodies against M.leprae. Through measuring the serological status of patients and using a broader definition of contacts, higher risk groups can be more specifically identified (AU)^ien. Descritores: HANSENIASE/epidemiol MYCOBACTERIUM LEPRAE/cresc ELISA/normas ELISA/util MODELOS LOGISTICOS Limites: ESTUDO COMPARATIVO Humanos Localização: BR191.1; WC335.300, B179e

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