Base de dados : HANSEN Pesquisa : ELISA/UTIL [Descritor de assunto] Referências encontradas : 6 [refinar] Mostrando: 1 .. 6   no formato [Detalhado]

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Id: 25761 Autor: Bakker, M. I; Hatta, M; Kwenang, A; Van Mosseveld, P; Faber, W. R; Klatser, P. R; Oskam, L. Título: Risk factores for developing leprosy -A population-based cohort study in Indonesia. Fonte: In: Bakker, Mirjam.Epidemiology and prevention of leprosy: a cohort study in Indonesia^ien. s.l, The Netherlands Leprosy Relief, 2005. p.106-124^btab, ^bgraf. Resumo: This study identified risk factors for developing leprosy through yearly incidence rates in five island populations. Personal factors, like age, sex, household size and the presence of M.leprae-specific antibodies as well as contact were studied. Of the 94 index patients (patients diagnosed in 2000) 43 (46%) were classified as multibacillary (MB), 17 (19%) were seropositive and 6 (7%) presented M.leprae DNA in nasal swabs as determined by polumerase chain reaction (PCR). All PCR positive patients were also seropositive. Forty-four of the 4903 persons initially without symptoms of leprosy developed leprosy in almost four years follow-up, giving an incidence rate of 2.98 per 1000 person-years. Men had a 2.2 times higher risk (95% Confidence Interval [CI]: 1.2-4.1) to developd leprosy than women. Persons living in households of more than 7 household members. Persons who were seropositive in 2000 had a 3.7 times higher risk (95% CI:1.1-12.4) than seronegative persons. Household contacts of MB patients had an adjusted hazard ratio (aHR) of 4.6 (95% CI:1.6-12.9) and household contacts of PCR positive patients an aHR of 9.36 (95% CI: 2.5-34.9) compared to non-contacts. Patients with PCR positive nasal swabs, suggesting nasal excretion of M.leprae, are probably the patients with the highest transmission patential. Since all index patients who were PCR positive were also seropositive, serology semms an adequate tool to identify these patients. Preventing seropositive persons to become seropositive patients and thus the main source of infection may break the chain of transmission (AU)^ien. Descritores: HANSENIASE/congen HANSENIASE/compl HANSENIASE/diag ELISA/normas ELISA/util REACAO EM CADEIA DA POLIMERASE/métodos REACAO EM CADEIA DA POLIMERASE/util ANALISE ESTATISTICA Limites: ESTUDO COMPARATIVO Humanos Localização: BR191.1; WC335.300, B179e

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Id: 25759 Autor: Bakker, M. I; Hatta, M; Kwenang, A; Faber, W. R; Van Beers, S. M; Klatser, P. R; Oskam, L. Título: Population survey to determine risk factors for Mycobacterium leprae transmission and infection. Fonte: In: Bakker, Mirjam.Epidemiology and prevention of leprosy: a cohort study in Indonesia^ien. s.l, The Netherlands Leprosy Relief, 2005. p.72-86^bmapas, ^btab. Resumo: Background: Not every leprosy patient is equally effective in transmitting Mycobacterium leprae. We studied the spatial distribution of infection (using seropositivity as a marker) in the population to identifity which disease characteristics of leprosy patients are important in transmission. Methods: Clinical data and blood samples for anti-M.leprae ELISA were collected during a cross-sectional survey on five Indonesian islands highly endemic for leprosy. A geographic information system (GIS) was used to define contacts of patients. We investigated spatial clustering of patients and seropositive people and used logist regression to determine risk factors for seropositivity. Results: Of the 3986 people examined for leprosy, 3271 gave blood. Seroprevalence varied between islands (1.7-8.7%) and correlated significantly with leprosy prevalence. Five clusters of patients and two clusters of seropositives were detected. In multivariate analysis, seropositivity significantly differed to be the best discriminator of contact groups with higher seroprevalence: contacts of seropositive patients had an adjusted odds ratio (aOR) of 1.75 (95% CI: 0.92-3,31). This increased seroprevalence was strongest for contact groups living _< 75 metres of two seropositive patients (aOR:3.07;95%CI:1.74-5.42). Conclusions: In this highly endemic area for leprosy, not only household contacts of seropositive patients, but also persons living in the vicinity of seropositive patient were more likely to harbour antibodies against M.leprae. Through measuring the serological status of patients and using a broader definition of contacts, higher risk groups can be more specifically identified (AU)^ien. Descritores: HANSENIASE/epidemiol MYCOBACTERIUM LEPRAE/cresc ELISA/normas ELISA/util MODELOS LOGISTICOS Limites: ESTUDO COMPARATIVO Humanos Localização: BR191.1; WC335.300, B179e

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Id: 25144 Autor: Das, Pranab K; Rambukkan, Anura; Baas, J. G; Groothuuis, Dick G; Halperin, Moshe Título: Enzyme-linked immunosorbent assay for distinguishing serological responses of lepromatous and tuberculoid leprosies to the 29/33-kilodalton doublet and 64-kilodalton antigens of Mycobacterium tuberculosis ..- Fonte: s.l; s.n; Feb. 1990. 4 p. ilus, tab. Resumo: Immunoblot assays for the antibodies to Mycobacterium tuberculosis sonic extracts showed that all serum specimens of 40 lepromatous and 28 tuberculoid leprosy patient reacted in a significant amnner to 29/33-kilodalton (kDa) doublet and 64-kDa antigens, respectively. By using an enzyme-linked immunosorbent assay, we observed a significantly high immunoglobulin G antibody titer to the purified M. tuberculosis 29/33-kDa doublet and 64-kDa antigens in lepromatous and tuberculoid leprosy pateints, respectively, as compared with normal subjects and tuberculosis patients. This enzyme-linked immunosorbent assay serology may be useful for distinguihing two polar types of leprosy and for diagnosing leprosy in general (AU). Descritores: HANSENIASE VIRCHOWIANA/imunol HANSENIASE TUBERCULOIDE/imunol MYCOBACTERIUM TUBERCULOSIS/imunol ELISA/util IMUNOGLOBULINA G/imunol IMUNOGLOBULINA G/ultraest - HANSENIASE/imunol  MICOBACTERIOSE/imunol Limites: HUMANO Localização: BR191.1; 09295/s

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Id: 13549 Autor: Bonato, Vania Luiza Deperon Título: Correlacao dos anticorpos anti-PGL-I com indice baciloscopico, a reacao de Mitsuda, o tratamento poliquimioterapico e as interleucinas nas diferentes formas da hanseniase ?- Fonte: Ribeirao Preto; s.n; 1995. 98 p. tab, graf. Tese: Apresentada a Universidade de Sao Paulo. Faculdade de Medicina de Ribeirao Preto para obtenção do grau de Mestre. Resumo: Neste trabalho, nos quantificamos os niveis de anticorpos anti-PGL-I no soro de pacientes com hanseniase multibacilar (HV e HDV), paucibacilar (HT e HDT) e em comunicantes intra e extra domiciliares. A finalidade destas determinacoes visavam: 1- a implantacao de um teste sorologico de rotina laboratorial para o diagnostico precoce desta enfermidade; 2- a monitorizacao da resposta terapeutica e da reacao tipo I; 3- estabelecimento de correlacoes com os niveis sericos de interleucinas, com o indice baciloscopico e atividade da doenca, com a reacao de Mitsuda e com reacoes hansenicas. A quantificacao dos anticorpos foi feita pelo metodo de ELISA e foi altamente especifica para a hanseniase. Observou-se baixos niveis de anticorpos anti-PGL-I nos pacientes HT(AU). Descritores: ELISA HANSENIASE HANSENIASE HANSENIASE Localização: BR191.1; WC335.500.3, 64c

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Id: 13518 Autor: Repka, Joao Carlos D; Fabricio, Lincoln H; Brand, Luiz Renato; Lemos, Alberto L; Penteado Filho, Sergio R; Stahlke, Paulo H Título: Imunologia na hanseniase: (II) estudo sorologico pelo metodo imunoenzimatico (ELISA), contra o glicoconjugado sintetico do mycobacterium leprae em contactos profissionais com hansenianos Immunology in leprosy: (II) serologic study bu enzyme linked immune sorbent assay (ELISA) against yhe synthetic glycoconjugate of mycobacterium leprae in professional contacts with leprosy patients- Fonte: s.l; s.n; 1991. 8 p. tab, graf. Descritores: MYCOBACTERIUM LEPRAE HANSENIASE HANSENIASE HANSENIASE ELISA ELISA TESTES IMUNOLOGICOS TESTES IMUNOLOGICOS Localização: BR191.1; 06205/s

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Id: 13169 Autor: Repka, Joao Carlos D; Brand, Luiz R; Fabricio, Lincoln H; Lemos, Alberto L; Penteado Filho, Sergio R; Stahlke, Paulo Título: Imunologia na hanseniase; (I) aspectos da avaliacao imunologica no tratamento Immunology in leprosy: (I) some aspects in immunological evaluation in the treatment- Fonte: s.l; s.n; 1991. 8 p. tab. Descritores: HANSENIASE HANSENIASE HANSENIASE TÉCNICAS IMUNOLOGICAS ELISA TESTES IMUNOLOGICOS TESTES IMUNOLOGICOS Localização: BR191.1; 06170/s

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