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| Id: | 18273
| | Autor: | Gómez-Estrada, Hector; Morales-Ortiz, Roberto; González-Mendoza, Amado; Barba-Rubio, Jose; Ceja-Mendoza, Sagrario
| | Título: | Peroxidase deficiency in histiocytes of patients with nodular lepromatous leprosy
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| | Fonte: | s.l; s.n; Apr.-Jun. 1983. 11 p. ilus, tab.
| | Resumo: | The purpose of this study was to investigate the presence of peroxidase (PO) in the histiocytes which are found in the lepromatous lesions of patients with nodular lepromatous leprosy (NLL). We studied dermoepidermal biopsy specimens from lepromstous lesions and blood smears of 10 patients with NLL, eight males and twoo females 28 to 63 years age (average 45 + or - 6.2), of which nine coursed with the stable form of the disease and one was in lepromatous reaction. Six had received treatment with diaminodiphenylsulphone for more than six months, and the other four, none. As controls we studied the blood smears of 10 healthy controls and 10 rat liver sections. PO was investigated in histiocytes, Kupffer cells and polymorphonuclears by dichlorhydrate oxydation, according to the technique of Kaplow. By means of Fite-Faraco´s stain, all ten cases proved to have abundant phagocytized M. leprae. PO was not found in histiocytes of lepromatous lesions in nine cases of stable NLL in lepromatous reaction. PO was present in Kupffer cells, in polymorphonuclears of patients with NLL and in controls. No difference was found either in the PO or M. leprae contents between treated and untreated patients. The PO deficiency in histiocytes of patients with NLL may be related to an incapacity of these cells to destroy M. leprae.(AU).
| | Descritores: | PELE/enzimol
PELE/patol
FAGOCITOSE
PEROXIDASES/defic
HANSENIASE/enzimol
HANSENIASE/patol
HISTIOCITOS/enzimol
| | Limites: | HUMANO
ANIMAL
MASCULINO
FEMININO
ADULTO
MEIA-IDADE
IDOSO
RATOS
| | Meio Eletrônico: | - .
| | Localização: | BR191.1; 01309/s |
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