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Id: 25256 Autor: Wallace, Chris; Clayton, David Título: Estimating the relative recurrence risk ratio using a global cross-ratio model ..- Fonte: s.l; s.n; 2003. 10 p. tab, graf. Resumo: The relative recurrence risk ratio lambdaR (and particularly the sibling recurrence risk ratio, lambdaS) is often of interest to those wanting to quantify the genetic contribution towards risk of disease or to discriminate between different genetic models. However, estimating lambdaR for complex diseases for which genetic and environmental risk factors are both involved is not straightforward. Ignoring environmental factors may lead to inflated estimates of lambdaR. We present a marginal model which uses a copula function to model the association in cumulative incidence rates between pairs of relatives. This model is applicable to present-state data and allows estimation of risk of disease in a pair of relatives (and hence lambdaR), given measured environmental covariates. We apply the model to leprosy among sibling pairs from the Karonga district, Malawi. If risk factors are ignored, the apparent lambdaS in this population is over 3. Accounting for known nongenetic risk factors reduces it to just under 2. (AU). Descritores: MODELOS TEORICOS MODELOS DE RISCOS PROPORCIONAIS MODELOS LOG-LINEARES (SAUDE PÚBLICA) MODELOS ESTATISTICOS HANSENIASE DIMORFA/imunol HANSENIASE DIMORFA/microbiol HANSENIASE DIMORFA/transm HANSENIASE VIRCHOWIANA/imunol HANSENIASE VIRCHOWIANA/microbiol HANSENIASE VIRCHOWIANA/transm HANSENIASE TUBERCULOIDE/imunol HANSENIASE TUBERCULOIDE/microbiol HANSENIASE TUBERCULOIDE/transm HANSENIASE/clas HANSENIASE/imunol HANSENIASE/microbiol HANSENIASE/transm - MODELOS MATEMATICOS  RAZAO DE DIFERENCA  RISCO RELATIVO (SAUDE PÚBLICA)  MEDICAO DE RISCO/estatíst  MEDICAO DE RISCO/tend  VACINA BCG/uso terap  COMUNICANTE/estatíst Limites: HUMANO Localização: BR191.1; 00723/s

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Id: 23201 Autor: Patrocinio, Lucas Gomes; Goulart, Isabela Maria Bernardes; Goulart, Luiz Ricardo; Patrocinio, Jose Aantonio; Ferreira, Frederico Rogerio; Fleury, Raul Negrao Título: Detection of Mycobacterium leprae in nasal mucosa biopsies by the polymerase chain reaction ..- Fonte: s.l; s.n; 2005. 6 p. ilus, tab. Resumo: Several discoveries about leprosy indicate that Mycobacterium leprae transmission mainly occurs by inhalation, and the nose is major port of entry and exit. The present study evaluated the clinical application of PCR for detection of M. leprae DNA in nasal mucosa biopsies in untreated leprosy patients (52) and their contacts (99) from the State Reference Center in Sanitary Dermatology and Leprosy, Uberlandia, MG, Brazil. PCR detection of a 372-base pair DNA fragment from M. leprae was accomplished in 36 (69.2%) patients, from which 34 (91.9%) of them were multibacillaries. Furthermore, PCR was positive in 3 (16.7%) of 18 slit-skin smear negative, 4 (25.0%) of 16 skin lesion BI negative, 8 (33.3%) of 24 nasal mucosa BI negative patients, and 10 of 99 contacts (10.1%). The presence of bacilli in 10.1% of the contacts may potentially reflect an occult leprosy, and these patients must be accompanied, followed by a chemoprophylaxy treatment. Considering all PCR results against clinical and BI classification of patients and controls, we have found a sensitivity of 69.2%, a specificity of 89.9%, and an accuracy of 82.8%. It has been demonstrated here through PCR of nasal biopsies that the bacillus invades the mucosa, passing through the nasal inferior turbinate to reach peripheral blood. Therefore, the molecular investigation of invasive nasal biopsies by PCR tests has proven to be useful in defining patients of higher risk of transmission and risk-group contacts, which is an important step to reach the World Health Organization objective towards the elimination of leprosy as a public health problem. (AU). Descritores: Biópsia Brasil/EP DNA Bacteriano/AN Hanseníase/*DI/EP/MI Mycobacterium leprae/GE/*IP Mucosa Nasal/*MI/PA Reação em Cadeia da Polimerase/* Fatores de Risco Sensibilidade e Especificidade Limites: Estudo Comparativo Humanos Localização: BR191.1; 09345/s

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Id: 18940 Autor: Boonpucknavig, Vijitr; Soontornniyomkij, Virawudh Título: Pathology of renal diseases in the tropics ..- Fonte: s.l; s.n; Jan. 2003. 19 p. ilus. Resumo: Renal diseases unique to the tropics are those that occur in association with infectious diseases including dengue hemorrhagic fever, typhoid fever, shigellosis, leptospirosis, lepromatous leprosy, malaria, opisthorchiasis, and schistosomiasis. These renal complications can be classified on the basis of their clinical and pathologic characteristics into acute transient reversible glomerulonephritis, chronic progressive irreversible glomerulonephritis, amyloidosis, and acute renal failure (ARF) resulting from acute tubular necrosis, acute tubulointerstitial nephritis, and thrombotic microangiopathy. Certain primary glomerular diseases including immunoglobulin (Ig) M nephropathy and focal segmental and global glomerulosclerosis are prevalent in some tropical countries. Renal complications of venomous snakebites also are common in the tropics. This article discusses and summarizes important works in the literature in respect to the clinical syndromes, pathologic features, and pathogenesis of tropical renal diseases both in humans and experimental animal models. (AU). Descritores: DOENCAS TRANSMISSIVEIS/compl DOENCAS TRANSMISSIVEIS/diag GLOMERULOSCLEROSE FOCAL/etiol GLOMERULOSCLEROSE FOCAL/patol IMUNOHISTOQUIMICA NEFROPATIAS/epidemiol NEFROPATIAS/etiol NEFROPATIAS/patol NECROSE TUBULAR AGUDA/etiol NECROSE TUBULAR AGUDA/patol BIOPSIA POR AGULHA NEFRITE INTERSTICIAL/etiol NEFRITE INTERSTICIAL/patol PREVALÊNCIA PROGNOSTICO INDICE DE GRAVIDADE DE DOENCA TAXA DE SOBREVIVÊNCIA FATORES DE RISCO CLIMA TROPICAL/ef adv Limites: HUMANO MASCULINO FEMININO Meio Eletrônico: - . Localização: BR191.1; 09109/s

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Id: 18938 Autor: Dolo, A; Diane, K; Coulibaly, I; Sow, S; Diawara, H. Konare; Fomba, A; Thera, M. A; Diallo, A; Keita, S; Doumbo, O Título: Recherche systematique de parasites chez les lepreux au Mali Systematic search for parasites among patients with leprosy in Mali- Fonte: s.l; s.n; 2002. 4 p. tab. Resumo: Practice of multidrug therapy in leprosy (combination Dapsone + Rifampicine + Clofazimine) established since 1981, has significantly reduced the incidence of the disease. However, immunosuppression due to treatment of multi-drugs therapy induced adverse reactions with glucocorticoid and the change in host immune response due to the leprosy itself, might increase the risk of parasitic infections. To test this hypothesis, we carried out a case-control study at the "Institut Marchoux" in Bamako. Stool and urine samples from all patients included in the study were examined for parasites identification. In addition, we performed thick and thin blood film to identify malaria infection and skin biopsy (snip) to detect onchocerciasis. A total of 121 cases of leprosy and 219 controls aged 10-84 years old were included in the study from March 1999 to February 2000. Sixty two percent (n = 121) of cases were treated with glucocorticoid. The prevalence of infection due to Entamoeba coli and Entamoeba histolytica were higher in cases than in controls (p = 0.02). The prevalence of infection due to hookworms was higher in cases than in controls. There was no difference of the infections to the other intestinal parasites. Three cases of cryptosporidiosis and one case of isosporosis were observed in leprosy group vs none in the control group. There was no significant difference between cases and controls with regard to prevalence of Schistosoma haematobium, Trichomonas vaginalis and Onchocera volvulus. The prevalence of Plasmodium falciparum was 4.9% (6/121) in the leprosy case and 7.8% (17/219) in the control group. In conclusion, despite the corticotherapy and immunosuppression due to leprosy, there was no difference in prevalence of pathogenic parasites. Entomoeba coli, Entamoeba histolytica which have significantly higher prevalence among the cases were not pathogen therefore there was no higher risk of severe intestinal parasitosis among the cases of leprosy. Treatment with glycocorticoid in patients with leprosy did not suggest any impact on the prevalence of this parasitic infections. In addition, multidrug therapy did not show any effect on the carriage of Plasmodium falciparum. (AU). Descritores: HANSENIASE/compl MALI/epidemiol DOENCAS PARASITARIAS/epidemiol DOENCAS PARASITARIAS/etiol INCIDÊNCIA PREVALÊNCIA FATORES DE RISCO HOSPEDEIRO IMUNOCOMPROMETIDO ESTUDOS DE CASOS E CONTROLES RESISTÊNCIA A MULTIPLAS DROGAS Limites: HUMANO MASCULINO FEMININO CRIANÇA ADULTO MEIA-IDADE IDOSO SUPPORT, NON-U.S. GOV'T ADOLESCENTE RESUMO EM INGLES Meio Eletrônico: - . Localização: BR191.1; 09107/s

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Id: 18579 Autor: Kumagai, Masaru; Yokota, Kimagai; Endoh, Toshiya; Takemoto, Hitoshi; Nagata, Kensei Título: Charcot joint-like changes following ankle fracture in a patient with no underlyng disease: report of a rare case ..- Fonte: s.l; s.n; 2002. 4 p. ilus. Resumo: Charcot joint is a disease that often occurs in patients with diabetes mellitus, tabes dorsalis, syringomyelia, chronic alcoholism, leprosy, trauma, or infection after fractures and dislocations. The treatment for Charcot joint has various complications, such as skin lesions, infections, and delayed union. We present our experience with a male patient who developed Charcot joint-like changes without diabetes mellitus or any other disease after an ankle fracture due to minor trauma. (AU). Descritores: ACIDENTES POR QUEDAS RESULTADO DE TRATAMENTO MEDICAO DE RISCO AMPLITUDE DE MOVIMENTO ARTICULAR/fisiol SEGUIMENTOS ARTROPATIA NEUROGÊNICA/etiol ARTROPATIA NEUROGÊNICA/patol ARTROPATIA NEUROGÊNICA/cirurg FRATURAS/compl FRATURAS/radiogr FRATURAS/reabil TRAUMATISMOS DO TORNOZELO/compl TRAUMATISMOS DO TORNOZELO/radiogr TRAUMATISMOS DO TORNOZELO/reabil PROCEDIMENTOS ORTOPEDICOS/métodos APARELHOS ORTOPEDICOS - ESCALA DE GRAVIDADE DO FERIMENTO  IMAGEM POR RESSONÂNCIA MAGNETICA  RECUPERACAO DE FUNÇÃO FISIOLOGICA Limites: RELATO DE CASO HUMANO MASCULINO ADULTO Meio Eletrônico: - . Localização: BR191.1; 09025/s

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Id: 18505 Autor: Seedat, Yackoob K Título: Glomerular disease in the tropics ..- Fonte: s.l; s.n; Jan. 2003. 9 p. . Resumo: Glomerular disease in the tropics differs considerably from that in temperate climates and between the developed and the developing world. The prevalence and pattern of glomerular disease in the tropics in turn varies widely in different geographic regions and is influenced by environmental, nutritional, and socioeconomic factors. Among the infective agents that have been identified as contributing to an increased prevalence of glomerular disease in the tropics are Plasmodium malaria, Schistsomiasis mansoni, Mycobacterium leprosy, and hepatitis B virus (HBV). A decline in the prevalence can only be expected with the eradication of infections. Accurate knowledge of the prevalence, histologic features, and causes is essential to achieve prevention and management of glomerular diseases in the tropics. (AU). Descritores: GLOMERULONEFRITE/diag GLOMERULONEFRITE/epidemiol GLOMERULONEFRITE POR IGA/diag GLOMERULONEFRITE POR IGA/epidemiol GLOMERULONEFRITE MEMBRANOSA/diag GLOMERULONEFRITE MEMBRANOSA/epidemiol NEFRITE LUPICA/diag NEFRITE LUPICA/epidemiol SISTEMAS DE MEDICACAO CLIMA TROPICAL/ef adv FATORES DE RISCO INDICE DE GRAVIDADE DE DOENCA PREVALÊNCIA - PROGNOSTICO Limites: HUMANO MASCULINO FEMININO Meio Eletrônico: - . Localização: BR191.1; 09140/s

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Id: 18470 Autor: Hegazy, Aly A; Abdel-Hamid, Ibrahim A; Ahmed, El-Shahat F; Hammad, Sabry M; Hawas, Samia A Título: Leprosy in a high-prevalence Egyptian village: epidemiology and risk factors ..- Fonte: s.l; s.n; 2002. 6 p. ilus, tab. Resumo: BACKGROUND: The epidemiology of leprosy in rural Egypt is unknown. This prospective household survey was conducted in a high-prevalence Egyptian village in order to explore the epidemiologic characteristics of the disease and to determine the possible socioeconomic and HLA genotype risk factors. METHODS: The subjects of the study were the residents of Kafr-Tambul village in the Dakahlia governorate, Egypt. There were 10,503 inhabitants of the village, of whom 9643 (91.8 per cent) had a complete visual skin examination, and suspected leprosy patients were subjected to histopathological examination and slit skin smears. Each household was interviewed to record personal data on family members, family size, education, occupation, crowding index at sleep, social score and source of water supply. Human leukocyte antigen (HLA) class II genotypes were analyzed in all leprosy patients and in a number of both household (N = 124) and non-household (N = 30) contacts. RESULTS: The overall prevalence of clinical leprosy in the village studied was 24.9/10,000 (95 per cent CI = 16.3-37.6). Individuals above the age of 40 years were 4 times more likely to develop leprosy (OR = 4, P= 0.01). The degree of education, crowding index at sleep, social score and source of water supply were found to be unlikely to increase the risk of leprosy (P > 0.05). The frequencies of HLA-DR2 and -DQ1 were significantly associated with leprosy (OR = 3.33 and 5.4; CI = 0.95-12.07 and 1.08-30.19, respectively, all P < 0.05). CONCLUSIONS: Our study provides the first picture of the epidemiology of leprosy in a high-prevalence village in rural Egypt. Leprosy detection campaigns should be initiated and directed towards high-prevalence villages. Provision of leprosy control activities in rural health units is necessary in order to detect new cases. The risk for leprosy is associated with HLA-DR2 and -DQ1 markers, and these markers appear to increase personal susceptibility to leprosy in this village. (AU). Descritores: FATORES ETARIOS EGITO/epidemiol PREDISPOSICAO GENETICA PARA DOENÇA/genet GENOTIPO ANTIGENOS HLA/genet LEVANTAMENTOS EPIDEMIOLOGICOS HANSENIASE/epidemiol HANSENIASE/etiol HANSENIASE/genet PREVALÊNCIA ESTUDOS PROSPECTIVOS FATORES DE RISCO POPULACAO RURAL/estatíst FATORES SOCIOECONÔMICOS Limites: HUMANO MASCULINO FEMININO ADULTO MEIA-IDADE SUPPORT, NON-U.S. GOV'T Meio Eletrônico: - . Localização: BR191.1; 09012/s

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Id: 17503 Autor: Brunet, Robert C; Struchiner, Claudio J; Loinaz, Arik Título: A method for estimating time depedent intervention benefits under arbitrarily varying age and exogenous components of hazard ..- Fonte: s.l; s.n; 2001. 16 p. ilus, tab, graf. Descritores: MEDIÇÃO DE RISCO FATORES DE RISCO FATORES DE TEMPO METODOLOGIA - RISCO  COMPORTAMENTO DE REDUÇÃO DO RISCO  RESULTADO DE TRATAMENTO Localização: BR191.1; 08969/s

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Id: 16370 Autor: Fine, P. E. M; Floyd, S; Stanford, J. L; Nkhosa, P; Kasunga, A; Chaguluka, S; Warndorff, D. K; Jenkins, P. A; Yates, M; Ponnighaus, J. M Título: Environmental mycobacteria in northern Malawi: implications for the epidemiology of tuberculosis and leprosy ..- Fonte: s.l; s.n; 2001. 9 p. tab, graf. Descritores: ADOLESCENCIA DISTRIBUIÇAO POR IDADE ANTIGENOS DE BACTÉRIAS CRIANÇA EXPOSIÇAO AMBIENTAL SEGUIMENTOS INCIDENCIA HANSENIASE HANSENIASE HANSENIASE MALAUI MYCOBACTERIUM MYCOBACTERIUM MYCOBACTERIUM MYCOBACTERIUM VIGILANCIA DA POPULAÇAO QUESTIONARIOS FATORES DE RISCO SAUDE RURAL DISTRIBUIÇAO POR SEXO PELE MICROBIOLOGIA DO SOLO TESTE TUBERCULINICO TUBERCULOSE TUBERCULOSE TUBERCULOSE MICROBIOLOGIA DA AGUA Localização: BR191.1; 08629/s

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Id: 15752 Autor: Smith, C. M; Smith, W. C. S Título: Chemoprophylaxis is effective in the prevention of leprosy in endemic countries: a systematic review and meta-analysis ..- Fonte: s.l; s.n; 2000. 6 p. tab. Descritores: HANSENIASE HANSENIASE LEPROSTATICOS LEPROSTATICOS ACEDAPSONA ENSAIOS CLINICOS ANALISE CUSTO-BENEFICIO DAPSONA RIFAMPINA FATORES DE RISCO Localização: BR191.1; 08489/s

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Id: 15668 Autor: Lapa, Tiago; Ximenes, Ricardo; Silva, Nilza Nunes; Souza, Wayner; Albuquerque, Maria de Fátima Militão; Campozana, Gisele Título: Vigilância da hanseníase em Olinda. Brasil, utilizando técnicas de análise espacial Leprosy surveillance in Olinda, Brazil, Using spatial analysis techniques- Fonte: Rio de Janeiro; s.n; set-out., 2001. 10 p. tab, graf, mapas. Descritores: HANSENIASE HANSENIASE ANALISE DE VARIANCIA FATORES DE RISCO FATORES SOCIO-ECONOMICOS POPULAÇAO URBANA ANALISE POR CONGLOMERADOS Localização: BR191.1; 08443/s; BR191.1; 08685/s

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Id: 15537 Autor: Fine, P. E. M; Floyd, S; Stanford, J. L; Nkhosa, P; Kasunga, A; Chaguluka, S; Warndorff, D. K; Jenkins, P. A; Yates, M; Ponnighaus, J. M Título: Environmental mycobacteria in northern Malawi: implications for the epidemiology of tuberculosis and leprosy ..- Fonte: s.l; s.n; 2001. 9 p. tab, graf. Descritores: HANSENIASE HANSENIASE HANSENIASE MYCOBACTERIUM MYCOBACTERIUM MYCOBACTERIUM MYCOBACTERIUM INCIDENCIA MALAUI VIGILANCIA DA POPULAÇAO FATORES DE RISCO SAUDE RURAL DISTRIBUIÇAO POR SEXO PELE MICROBIOLOGIA DO SOLO TESTE TUBERCULINICO TUBERCULOSE TUBERCULOSE TUBERCULOSE MICROBIOLOGIA DA AGUA ANTIGENOS DE BACTÉRIAS Localização: BR191.1; 08359/s

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Id: 15478 Autor: Archibald, Helen; Fitzpatrick, Peter F; Rée, G. Hugo Título: Locally acquired Hansen's disease in North Queensland ..- Fonte: s.l; s.n; jan. 1999. 2 p. ilus. Descritores: BIOPSIA DIAGNOSTICO DIFERENCIAL FAMILIA HANSENIASE DIMORFA HANSENIASE DIMORFA HANSENIASE DIMORFA HANSENIASE DIMORFA QUEENSLAND DISTRIBUIÇAO ESPACIAL FATORES DE RISCO Limites: RELATO DE CASO Localização: BR191.1; 08333/s

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Id: 15461 Autor: Jacob, Shanti; Patil, Mothiram K Título: Three-dimensional foot modeling and analysis of stresses in normal and early stage Hansen's disease with muscle paralysis ..- Fonte: s.l; s.n; 1999. 12 p. ilus, tab. Descritores: BIOMECANICA ESTUDOS DE CASOS E CONTROLES SIMULAÇAO POR COMPUTADOR AVANÇO DA DOENÇA PÉ HANSENIASE MODELOS ANATOMICOS PARALISIA PARALISIA PARALISIA DOENÇAS DO SISTEMA NERVOSO PERIFÉRICO DOENÇAS DO SISTEMA NERVOSO PERIFÉRICO DOENÇAS DO SISTEMA NERVOSO PERIFÉRICO REPRODUTIBILIDADE DE RESULTADOS FATORES DE RISCO ESTRESSE MECANICO CAMINHADA ANALISE DE ELEMENTO FINITO Localização: BR191.1; 08316/s

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Id: 15335 Autor: Whitty, C. J. M; Lockwood, D. N. J Título: Leprosy - new perspectives on an old disease ..- Fonte: s.l; s.n; 1999. 4 p. . Descritores: HANSENIASE HANSENIASE HANSENIASE HANSENIASE FATORES DE RISCO Localização: BR191.1; 07256/s

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Id: 15331 Autor: John, Deepa; Daniel, Ebenezer Título: Infectious keratitis in leprosy ..- Fonte: s.l; s.n; 1999. 4 p. tab. Descritores: ANTIINFECCIOSOS CIPROFLOXACINA ULCERA DA CORNEA ULCERA DA CORNEA KETOCONAZOL HANSENIASE LEPROMATOSA HANSENIASE TUBERCULOIDE FATORES DE RISCO ACUIDADE VISUAL Localização: BR191.1; 07252/s

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Id: 15285 Autor: Judd, Margaret A; Roberts, Charlotte A Título: Fracture ppatterns at the medieval leper Hospital in Chichester ..- Fonte: s.l; s.n; 1998. 13 p. ilus, tab. Descritores: ANTROPOLOGIA FISICA OSSO E OSSOS INGLATERRA FRATURAS HISTORIA DA MEDICINA MEDIEVAL HOSPITAIS HANSENIASE ESTILO DE VIDA FATORES DE RISCO Localização: BR191.1; 07302/s

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Id: 15161 Autor: Anon Título: Leprosy elimination campaigns (LECs): progress during 1997-1998 ..- Fonte: s.l; s.n; 1998. 6 p. tab, graf. Descritores: HANSENIASE HANSENIASE INCIDENCIA INDIA MADAGASCAR MIANMA SAUDE PUBLICA FATORES DE RISCO ORGANIZAÇAO MUNDIAL DA SAUDE Localização: BR191.1; 07322/s

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Id: 15039 Autor: Anon Título: Elimination of leprosy as a public health problem (update) ..- Fonte: s.l; s.n; oct. 1998. 5 p. tab. Descritores: LEPROSTATICOS HANSENIASE HANSENIASE PREVALENCIA PROGNOSTICO SAUDE PUBLICA FATORES DE RISCO SAUDE MUNDIAL ORGANIZAÇAO MUNDIAL DA SAUDE Localização: BR191.1; 07281/s

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Id: 15033 Autor: Arain, Ghazala Moihyuddin Título: Socio-economic status of leprosy patients ..- Fonte: s.l; s.n; 1996. 1 p. . Descritores: HANSENIASE AGLOMERAÇAO POBREZA FATORES DE RISCO FATORES SOCIO-ECONOMICOS Localização: BR191.1; 07287/s

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