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Id: 18457 Autor: Meyers, Wayne M; Walsh, Gerald P; Brown, Harriett L; Rees, R. J. W; Convit, Jacinto Título: Naturally acquired leprosy-like disease in the nine-banded armadillo (Dasypus novemcinctus): reactions in leprosy patients to lepromins prepared from naturally infected armadillos ..- Fonte: s.l; s.n; oct. 1977. 7 p. tab. Resumo: Lepromins prepared from 6 armadillos with a naturally acquired leprosy-like disease in Louisiana were assayed in 146 leprosy patients with lepromatous and nonlepromatous leprosy. The patients resided in Ethiopia, Malaysia, Venezuela and Zaire. The classic pattern of mitsuda reactiona was observed. Whereas patients with lepromatous leprosy gave weak or negative reactions, those with nonlepromatous leprosy gave positive reactions. Because Mycobacterium leprae is the only micoorganism known to give this pattern of repsonse, these data indicate that the organism reponsible for the naturally acquired leprosy-like disease of armadillos in Louisiana is closely related to, if not identical with, M. leprae.(AU). Descritores: REPUBLICA DEMOCRATICA DO CONGO ETIOPIA ANTIGENO DE MITSUDA HANSENIASE/etiol HANSENIASE/vet LOUISIANA MALASIA MYCOBACTERIUM LEPRAE VENEZUELA XENARTROS Limites: ANIMAL SUPPORT, U.S. GOV'T, P.H.S. TATUS Meio Eletrônico: - . Localização: BR191.1; 00569/s

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Id: 18427 Autor: Storrs, Eleanor E; Binford, Chapman H; Migaki, George Título: Animal model of human disease: lepromatous leprosy ..- Fonte: s.l; s.n; sep. 1978. 4 p. ilus. Resumo: The nine-banded armadillo (Dasypus novemcicnctus Linn)(Figure 1) is one of approximately 20 species of armadillos comprising several genera. They belong to the Edentata. D novemcinctus ranges from Central Argentina through Central America, Mexico, the Gulf States, and north-ward into Oklahoma, Arkansas, and Georgia. Among the characteristics which make this animal a useful research model for lepromatous leprosy a) low body temperature (32 to 35C), b) regular production of monozygotic quadruplet young, and c) a long life-spain (estimated to be 15 years). Other biologic characteristics are a) delayed (14 to 16 weeks) implantation period of the blastocyst, b) gestation period of approximately 9 months, c) ability to build up an oxygen debt, and d) occasional variability in band numbers.(AU). Descritores: HANSENIASE XENARTROS MODELOS ANIMAIS DE DOENCAS TATUS Limites: ANIMAL SUPPORT, U.S. GOV'T, NON-P.H.S. SUPPORT, U.S. GOV'T, P.H.S. Meio Eletrônico: - . Localização: BR191.1; 00212/s

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Id: 18416 Autor: Storrs, Eleanor E; Walsh, G. P; Burchfield, H. P Título: Development of leprosy in another species of armadillo Dasypus hybridus (L): genetic and immunologic implications ..- Fonte: s.l; s.n; Oct-Nov. 1975. 3 p. ilus. Resumo: The leprosy bacillus (Mycobacterium leprae) was discovered in 1873 and was the first bacterium to be associated with a human disease; yet leprosy is one of the least understood of all bacterial diseases.(AU). Descritores: XENARTROS/microbiol TEMPERATURA CORPORAL IMUNIDADE CELULAR TATUS/microbiol HANSENIASE/imunol HANSENIASE/microbiol HANSENIASE/vet MYCOBACTERIUM LEPRAE/cresc MYCOBACTERIUM LEPRAE/imunol Limites: ANIMAL Meio Eletrônico: - . Localização: BR191.1; 01408/s

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Id: 18382 Autor: Purtilo, David T; Walsh, Gerald P; Storrs, Eleanor E; Banks, Isaac S Título: Impact of cool temperatures on transformation of human and armadilio lymphocytes ( Dasypus novemcinctus, Linn. ) as related to leprosy ..- Fonte: s.l; s.n; March 29, 1974. 3 p. tab, graf. Resumo: A CENTURY-LONG search for an unaltered animal in which to study leprosy in humans culminated in the finding that the nine-banded armadillo (Dasypus novemcinctus, Linn.) a primitive mammal native to the southern Western Hemisphere, develops disseminated lepromstous leprosy following inocuation with Mycobacterium leprae isolated from human tissue.(AU). Descritores: TRANSFORMACAO LINFOCITICA/ef drogas MYCOBACTERIUM LEPRAE/imunol XENARTROS/imunol HANSENIASE/imunol LECTINAS MODELOS ANIMAIS DE DOENCAS ANTIGENOS DE BACTERIAS FRIO Limites: HUMANO ANIMAL MASCULINO FEMININO Meio Eletrônico: - . Localização: BR191.1; 00494/s

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Id: 18371 Autor: Marchiondo Alan A; Smith, Jerome H; File, Sharon K Título: Naturally occurring leprosy-like disease of wild armadillos: ultrastructure of lepromatous lesions ..- Fonte: s.l; s.n; mar. 1980. 15 p. ilus. Resumo: An idependent survey of leprosy-like disease in wild armadillos was undertaken in the French Acadiana section of Louisiana in roder to arbitrate the controversy over the existence of this entity(21). As part of this study, material from lepromas was prepared for electron microscopy. Bacilli were concentrated in macrophages and were also found in capillary endothelial cells and fibroblasts, but tjey were not observed in lymphocytes or plasma cells. Bacilli consisted of electron-dense fibrillogranular material limited by a pentalaminar membrane (inner trilaminate plasma membrane and outer bilaminate cell wall). Bacillary division was common and was manifested as irregularly coiled nuclear strands and transverse septation by ingrowth of the plasma membrane. Degenerating bacilli were numerous in large multinucleate macrophages. The host inflammatory infiltrate was comprised of active plasma cells, untransformed lymphocytes, and macrophages originating from circulating monocytes. Monocytes recently emerging from capillaries were small and had a relative paucity of bacilli and lysosomes. These monocytes increased in size, plasma membrane complexity, bacillary burden, numbers and varieties of heterophagic and autophagic lysosomes, numbers of nuclei and nucleolar activity. Replicating, interphase and degenerating bacilli were found within macrophage phagolysosomes or free in the cytoplasmic matrix often aggreated in ranks forming "cigar bundles". Bacilli were variably surrounded by an eletronlucent substance comparable to the "gloae" or "schleim layer" described in human leprosy. Aggregates of bacilli in "gloae" formed "foamy bodies" and rarely observed opaqe droplets. thus, the ultrastructural features of this disease in wild armadillos are identical to those seen in human leprosy and armadillos experimentally infected with Mycobacterium leprae from human lesions. The findings suggest that B lymphocyte-macrophage interaction may be the predominant mechanism of leproma formation.(AU). Descritores: TATUS/microbiol FIBROBLASTOS/microbiol HANSENIASE/microbiol HANSENIASE/patol HANSENIASE/vet MACROFAGOS/microbiol MACROFAGOS/ultraest MYCOBACTERIUM LEPRAE/ultraest XENARTROS/microbiol Limites: ANIMAL Meio Eletrônico: - . Localização: BR191.1; 00937/s

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Id: 18364 Autor: Khanolkar, Saroj R; Ambrose, E. J; Mahadevan, P. R Título: Uptake of 3, 4-dihydroxy(3H)phenylalanine by Mycobacterium leprae isolated from frozen (-80 degrees C) armadillo tissue ..- Fonte: s.l; s.n; dec. 1981. 5 p. tab, graf. Resumo: Mycobacterium leprae separated from armadillo tissues stored at -80 degrees C is similar to that from human sources in its ability to take up 3H-labelled 3,4-dihydroxyphenylalanine (DOPA). Several inhibitors were studied which showed complete or partial inhibition of [3H]DOPA uptake. These findings suggest that M. leprae isolated from frozen tissue possesses an active uptake system for [3H]DOPA.(AU). Descritores: TATUS/microbiol ACIDO ASCORBICO/farmacol QUELANTES/farmacol DIIDROXIFENILALANINA/metab MYCOBACTERIUM LEPRAE/metab BACO/microbiol TEMPERATURA AMBIENTE XENARTROS/microbiol Limites: ANIMAL SUPPORT, NON-U.S. GOV'T Meio Eletrônico: - . Localização: BR191.1; 00902/s

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Id: 18269 Autor: Kirchheimer, W. F; Sanchez, R. M Título: Intraspecies differences of resistance against leprosy in nine-banded armadillos ..- Fonte: s.l; s.n; oct. 1981. 6 p. tab. Resumo: Infection of nine-banded armadillos with decreasing doses of armadillo-passaged leprosy bacilli show that most individuals of this species are susceptible and only about 20 percent are resistant regardless of the size of the infecting bacterial dose. It is pointed out that the intraspecies distribution of resistance to leprosy in human beings and in nine-banded armadillos differs because most individuals of the former species are resistant. Attention is drawn to the possibility that the results of anti-leprosy vaccination in armadillos might not apply to vaccination of human beings because the differences in distribution of resistant individuals might also reflect different mechanisms of susceptibility in the two species.(AU). Descritores: IMUNIDADE NATURAL HANSENIASE/imunol TATUS/imunol ESPECIFICIDADE DE ESPECIES XENARTROS/imunol Limites: ANIMAL MASCULINO FEMININO Meio Eletrônico: - . Localização: BR191.1; 00326/s

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Id: 18262 Autor: Hobbs, H. E; Harman, D. J; Rees, J. W; McDougall, A. C Título: Ocular histopathology in animals experimentally infected with Mycobacterium leprae and M. lepraemurium ..- Fonte: s.l; s.n; aug. 1978. 9 p. ilus, tab. Resumo: At varying periods of time following the successful establishment of systemic infections with Mycobacterium leprae or M. lepraemurium in the mouse and the nine-banded armadillo eyes were examined by light microscopy. Inoculation of bacilli was by the intravenous or intraperitoneal route or directly into the hind footpads; eyes were not directly inoculated in this study. During periods of up to 3 years under laboratory conditions no animal showed evidence of impaired vision or blindness, and the external appearance of both eyes was normal. The ocular histopathology and the sites of accumulation of bacilli are described. In immunologically normal mice infected with M. lepraemurium bacilli were much commoner in extraorbital tissues, but they were, nevertheless, found in various tissues within the orbit, including the ciliary body and sclera. In immunologically normal mice (and one rat) injected with M. leprae of human origin no bacilli were found in the eye, but in mice immunologically depressed by thymectomy and total body irradiation considerable numbers of bacilli were present in the iris and ciliary body and also in the limbal cornea. In the armadillo bacilli were found in large numbers in virtually all tissues except the lens, retina, optic nerve, and aqueous and vitreous humours, but the uveal tract was heavily involved. Findings are discussed in relation to the great frequency of ocular involvement and the importance of immune-complex disease in patients with lepromatous leprosy, and to factors wihch may favour the localisation and multiplication of Mycobacterium leprae in the eye.(AU). Descritores: TIMECTOMIA MICOBACTERIOSE/patol HANSENIASE/patol OLHO/microbiol OLHO/patol TATUS XENARTROS MYCOBACTERIUM LEPRAEMURIUM/isol Limites: ANIMAL CAMUNDONGOS RATOS Meio Eletrônico: - . Localização: BR191.1; 00338/s

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Id: 18231 Autor: Smith, Jerome H; File, Sharon K; Nagy, Barbara A; Folse, Dean S; Buckner, James A; Webb, Lew J; Beverding, Anne Marie Título: Leprosy-like disease of wild armadillos in French Acadiana, Louisiana ..- Fonte: s.l; s.n; dec. 1978. 15 p. ilus, tab. Resumo: An independent survy of wild armadillos in the French Acadiana section of Louisiana revelead that approximately 10% of trapped armadillos had a leprosy-like disease indistinguishable from experimentally produced infections of armadillos with Mycobacterium leprae from human sources. Detailed description of pathologic findings in 2 afflicted animals and proposed model of the pathogenesis are reported.(AU). Descritores: TATUS/imunol LOUISIANA MACROFAGOS/patol MYCOBACTERIUM LEPRAE XENARTROS/imunol HANSENIASE/diag HANSENIASE/patol HANSENIASE/vet Limites: ANIMAL Meio Eletrônico: - . Localização: BR191.1; 01441/s

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Id: 18230 Autor: Hayes, Thomas G Título: Structure of the ellipsoid sheath in the spleen of the armadillo (Dasypus novemcinctus). A light and electron microscopic study ..- Fonte: s.l; s.n; oct. 1970. 17 p. ilus. Resumo: The spleen of the armadillo is invested by a capsule composed predominantly of smooth muscle. Inward extensions from the capsule contribute to an extensive system of trabeculae of the non-vascular type. The white pulp presents series of venous sinsuses. The capillary segment of the penicillar artery is invested by an ellipsoid sheath. The spleen of the armadillo may be included in the class of mammalian spleens characterized as sinusal in nature and possessing ellipsoid sheaths. Electron micrographs of thin sections of the sheathed capillaries demonstrate a high-type of endothelium. A characteristic feature of this endothelium is the presence of a distinct intracytoplasmic fibrous component. The reticular cells comprising the sheath proper exhibit various sized vacuoles and inclusion bodies suggestive of their potentially phagocytic nature. In both light and electron microscopy, venous sinuses lie in close proximity to the paripheral cells of the ellipsoid sheaths. Within the wall of the venous sinuses, patent openings are apparent between the lining cells. If such an arrangement exists in the functional state of the organ, it could provide for an additional means of exposure of both plasma and cellular elements to the adjacent phagocytic cells of the sheath proper.(AU). Descritores: COLORACAO E ROTULAGEM MICROSCOPIA ELETRÔNICA TECNICAS HISTOLOGICAS GRÂNULOS CITOPLASMATICOS CAPILARES/citol RETICULOCITOS/citol XENARTROS/anat BACO/anat BACO/irrig BACO/citol Limites: ANIMAL Meio Eletrônico: - . Localização: BR191.1; 01435/s

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Id: 18229 Autor: Storrs, Eleanor E; Walsh, G. P; Burchfield, H. P; Binford, C. H Título: Leprosy in the armadillo: new model for biomedical research ..- Fonte: s.l; s.n; March 01, 1974. 3 p. tab. Resumo: Eight of twenty armadillos (Dasypus novemcinctus L.) developed severe lepromatous leprosy 3 to 3.5 years after inoculation with viable Mycobacterium leprae. A total of 988 grams of lepromas containing and estimated 15 to 20 grams of leprosy bacilli ahs been harvested from these animals. The large amounts of material now available will permit in-depth studies of the biochemistry and metabolism of the leprosy bacillus, and the animal model should make possible definitive studies on the immunology, chemotherapy, and epidemiology of the disease.(AU). Descritores: FATORES DE TEMPO XENARTROS MODELOS ANIMAIS DE DOENCAS HANSENIASE/etiol HANSENIASE/mortal MYCOBACTERIUM LEPRAE/cresc Limites: HUMANO ANIMAL CAMUNDONGOS Meio Eletrônico: - . Localização: BR191.1; 00210/s

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Id: 18216 Autor: Anderson, J. M; Benirschke, K Título: The armadillo, Dasypus novemcinctus, in experimental biology ..- Fonte: s.l; s.n; jun. 1966. 15 p. ilus. Resumo: A general account of the armadillo, including historical references and laboratory maintenance is given. Some of the commonly encountered diseases and details of useful surgical procedures are described. Important studies utilizing the armadillo in various biological fields are reviewed, and the wide potential of this animal as an experimental model in studies of genetics, immunology and reproductive physiology is stressed.(AU). Descritores: ANIMAIS DE LABORATORIO XENARTROS Limites: ANIMAL Meio Eletrônico: - . Localização: BR191.1; 01410/s

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Id: 18150 Autor: Purtilo, David T; Walsh, Gerald P; Storrs, Eleanor E; Gannon, Carman Título: The immune system of the nine-banded armadillo (Dasypus novemcinctus, Linn) ..- Fonte: s.l; s.n; apr. 1975. 9 p. ilus, tab. Resumo: The armadillo is rapidly emerging as an animal for biomedical research. A morphological study of the immune system of the armadillo was undertaken to try to demonstrate a possible defect in the morphogenesis of the lymphoid organs that could account for their susceptibility to leprosy. Blood from 20 domesticated adult armadillos revealed lymphocytes predominated among circulating leukocytes in the majority of animals, whereas in wild animals neutrophils predominated. Necropsies revealed well-developed thymus glands and the thymus-dependent areas in lymph nodes and spleens contained abundant lymphoid cells. Hence, we conclude that the susceptibility of the armadillo to leprosy cannot be explained on a morphological basis.(AU). Descritores: HANSENIASE/imunol LINFOCITOS/citol LEUCOCITOS/citol MYCOBACTERIUM LEPRAE/patogen HISTIOCITOS/citol NEUTROFILOS/citol TECIDO LINFOIDE/anat LINFONODOS/anat XENARTROS/anat XENARTROS/imunol Limites: ANIMAL Meio Eletrônico: - . Localização: BR191.1; 00495/s

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Id: 18143 Autor: Binford, Chapman H; Meyers, Wayne M; Walsh, Gerald P; Storrs, Eleanor E; Brown, Harriet L Título: Naturally acquired leprosy-like disease in the nine-banded armadillo (Dasypus novemcinctus): histopathologic and microbiologic studies of tissues ..- Fonte: s.l; s.n; oct. 1977. 12 p. ilus, tab. Resumo: Histopathologic studies were conducted on tissues from necropsies on 41 nine-banded armadillos from Louisiana with a natural disease resembling lepromatous leprosy, hereafter often referred to as the natural disease. The lesions were composed of macrophages (histiocytes) containing numerous acid-fast bacilli and were similar to those seen in armadillos experimentally inoculated with Mycobacterium leprae. Invasion of small and large nerves by phagocytes containing acid-fast bacilli was characteristic feature of the standard mycobacterial media; however, mycobacteria belonging to the M. avium-intracellulare group were cultivated from lymph nodes of 8 and the spleen of 1 of 32 of the diseased armadillos but not from other organs. Cultures of lymph node specimens and other organs from each of the remaining 24 diseased armadillos were negative. Acid-fastness of the bacilli in all tissues was abolished on exposure to pyridine. The bacilli were DOPA oxidase positive, but interpretation of this finding is difficult because some tissues from normal armadillos also gave positive reactions in the spot test employed. Histopathologic studies from 32 of the animals provided evidence indicating that the cause of the natural disease in armadillos may be M. leprae.(AU). Descritores: MYCOBACTERIUM/isol PELE/microbiol PELE/patol XENARTROS/microbiol LINFONODOS/microbiol SISTEMA NERVOSO/microbiol HANSENIASE/microbiol HANSENIASE/patol HANSENIASE/vet Limites: ESTUDO COMPARATIVO ANIMAL SUPPORT, U.S. GOV'T, P.H.S. Meio Eletrônico: - . Localização: BR191.1; 00571/s

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Id: 18037 Autor: Filice, Gregory A; Greenberg, Richard N; Fraser, David W Título: Lack of observed association between armadillo contact and leprosy in humans ..- Fonte: s.l; s.n; jan. 1977. 3 p. tab. Resumo: In 1971 it was discovered that the nine-banded armadillo (Dasypus novemcinctus) could be infected in the laboratory with Mycobacterium leprae, and would manifest disease similar to the lepromatous form of leprosy in man. In 1975 several wild armadillos captured in Louisiana were found to have a disease identical to the M. laprae infection in laboratory animals. To determine if there is a significant association between contact with armadillos and presence of leprosy in humans, the armadillo contact of persons with indigenous leprosy in Louisiana was compared to the contact of matched controls. No difference in the nature or frequency of contact was found. If this infection of wild armadillos is of recent onset, an association with human leprosy in enzootic areas may not be detectable for several years.(AU). Descritores: TATUS VETORES DE DOENCAS LOUISIANA XENARTROS HANSENIASE/epidemiol HANSENIASE/transm Limites: HUMANO ANIMAL ADULTO MEIA-IDADE Meio Eletrônico: - . Localização: BR191.1; 01642/s

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Id: 18025 Autor: Convit, Jacinto; Pinardi, M. E Título: Leprosy: confirmation in the armadillo ..- Fonte: s.l; s.n; Jun. 14, 1974. 2 p. . Resumo: Bacteria isolated from lesions of lepromatoid leprosy in the armadillo were studied in comparison...(AU). Descritores: HANSENIASE/diag HANSENIASE/imunol HANSENIASE/vet ANTIGENO DE MITSUDA MYCOBACTERIUM LEPRAE/clas MYCOBACTERIUM LEPRAE/isol XENARTROS PIRIDINAS MODELOS ANIMAIS DE DOENCAS - TESTES CUTÂNEOS  COLORACAO E ROTULAGEM Limites: HUMANO ANIMAL Meio Eletrônico: - . Localização: BR191.1; 01052/s

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Id: 18016 Autor: Hobbs, H. E; Harman, D. J; Rees, J. W; McDougall, A. C Título: Ocular histopathology in animals experimentally infected with Mycobacterium leprae and M. lepraemurium ..- Fonte: s.l; s.n; aug. 1978. 9 p. ilus, tab. Resumo: At varying periods of time following the successful establishment of systemic infections with Mycobacterium leprae or M. lepraemurium in the mouse and the nine-banded armadillo eyes were examined by light microscopy. Inoculation of bacilli was by the intravenous or intraperitoneal route or directly into the hind footpads; eyes were not directly inoculated in this study. During periods of up to 3 years under laboratory conditions no animal showed evidence of impaired vision or blindness, and the external appearance of both eyes was normal. The ocular histopathology and the sites of accumulation of bacilli are described. In immunologically normal mice infected with M. lepraemurium bacilli were much commoner in extraorbital tissues, but they were, nevertheless, found in various tissues within the orbit, including the ciliary body and sclera. In immunologically normal mice (and one rat) injected with M. leprae of human origin no bacilli were found in the eye, but in mice immunologically depressed by thymectomy and total body irradiation considerable numbers of bacilli were present in the iris and ciliary body and also in the limbal cornea. In the armadillo bacilli were found in large numbers in virtually all tissues except the lens, retina, optic nerve, and aqueous and vitreous humours, but the uveal tract was heavily involved. Findings are discussed in relation to the great frequency of ocular involvement and the importance of immune-complex disease in patients with lepromatous leprosy, and to factors wihch may favour the localisation and multiplication of Mycobacterium leprae in the eye.(AU). Descritores: TATUS HANSENIASE/patol MICOBACTERIOSE/patol MYCOBACTERIUM LEPRAEMURIUM/isol TIMECTOMIA XENARTROS - OLHO/microbiol  OLHO/patol Limites: ANIMAL CAMUNDONGOS RATOS Meio Eletrônico: - . Localização: BR191.1; 00991

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Id: 17908 Autor: Smith, Jerome H; Folse, Dean S; Long, Earl G; Christie, John D; Crouse, Dennis T; Tewes, Michael E; Gatson, Alice M; Lynn Ehrhardt, R; File, Sharon K; Kelly, Michael T Título: Leprosy in wild armadillos (Dasypus novemcinctus) of the Texas Gulf Coast: epidemiology and mycobacteriology ..- Fonte: s.l; s.n; aug. 1983. 4 p. mapas, tab. Resumo: A significant prevalence of leprosy has been demonstrated in wild Louisiana armadillos. The Texas Gulf Coast still has endemic human leprosy, and recent mores in Texas have markedly increased armadillo-human contact. Armadillos were screened by physical examination, and by ear-snip and slit-scrape technique. Animals that screened positive were sacrificed and necropsied under aseptic conditions. Liver, spleen, gross lesions, and four groups of lymph nodes were cultured for mycobacteria and were studied histologically. Base ratios and DNA homology with Mycobacterium leprae were determined on mycobacteria from two armadillos (and two tissues from one of these); these studies indicate that the organism found in Texas armadillos is M leprae. Twenty-one of the armadillos were leprous--4.66%. The local prevalence varied from 1.0% to 15.4%. Epidemiologic implications of these findings and the occurrence of other concomitant mycobacterial infections are discussed.(AU). Descritores: DOENCAS DOS ANIMAIS/epidemiol TATUS/microbiol HANSENIASE/epidemiol HANSENIASE/patol HANSENIASE/vet LINFONODOS/microbiol TRIAGEM DE MASSA/vet MYCOBACTERIUM/isol MYCOBACTERIUM LEPRAE/isol XENARTROS/microbiol - TEXAS Limites: ANIMAL MASCULINO FEMININO SUPPORT, NON-U.S. GOV'T Meio Eletrônico: - . Localização: BR191.1; 01640/s

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Id: 17863 Autor: Portaels, F; Francken, A; Pattyn, S. R Título: Bacteriological studies of armadillo livers infected with Mycobacterium leprae ..- Fonte: s.l; s.n; 1982. 13 p. tab. Resumo: Non mycobacterial contaminants and in vitro cultivable mycobacteria have been isolated in large numbers from two out four armadillo livers infected with human derived Mycobacterium leprae. The organisms were difficult to grow mycobacteria and their in vitro multiplication was only successful if the following three conditions were fulfilled: (1) inocula should contain high numbers of viable organisms(10(5)); (2) suspensions should be pretreated with NaOH or HCl; (3) acid media, with a very precise pH(5.4-5.7) and containing autoclaved mycobacterial suspensions should be used.The presence of these mycobacteria in armadillo livers may influence the results of studies performed on M. leprae purified from such organs. The relationship of these mycobacteria with M. leprae remains to be elucidated.(AU). Descritores: HANSENIASE/vet HANSENIASE/microbiol MYCOBACTERIUM/isol TATUS/microbiol FIGADO/microbiol XENARTROS/microbiol Limites: ANIMAL SUPPORT, NON-U.S. GOV'T Meio Eletrônico: - . Localização: BR191.1; 02181/s

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Id: 17762 Autor: Convit, Jacinto Título: Indigenous leprosy in the armadillo Dasypus novemcinctus ..- Fonte: s.l; s.n; dec. 1978. 3 p. . Resumo: The publication of the unusual. Descritores: XENARTROS/imunol IMUNIDADE NATURAL HANSENIASE/imunol - MEXICO  ESTADOS UNIDOS Limites: ANIMAL Meio Eletrônico: - . Localização: BR191.1

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