Database : HANSEN Search on : ANIMAIS [Subject descriptor] References found : 73 [refine] Displaying: 1 .. 20   in format [Detailed]

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Id: 19095 Author: Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde. Departamento de Vigilância Epidemiológica. Title: Caderno 14 - Acidentes por Animais Peçonhentos / Book 14 - Envenomations Source: In: Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde. Departamento de Vigilância Epidemiológica.Guia de Vigilância Epidemiológica^ipt. Brasília, Ministério da Saúde, 2009. p.1-24ilus, tab, graf. Descriptors: Animais Venenosos/microbiol Animais Venenosos/fisiol Location: BR191.1, B736g, pt.3

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Id: 18274 Author: Burchfield, H. P; Storrs, Eleanor E; Walsh, G. P; Vidrine, M. F Title: Improved caging for nine-banded armadillos ..- Source: s.l; s.n; 1976. 3 p. ilus. Descriptors: TATUS/clas TATUS/les TATUS/psicol ANIMAIS DE LABORATORIO/clas ANIMAIS DE LABORATORIO/les - ANIMAIS SILVESTRES/les  ANIMAIS SILVESTRES/psicol Limits: ANIMAL Electronic Medium: 00211/s Location: BR191.1; 00211/s

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Id: 18272 Author: Job, Charles K Title: Nine-banded armadillo and leprosy research ..- Source: s.l; s.n; 2003. 10 p. ilus. Abstract: In this presentation an attempt has been made to describe the nine-banded armadillo as an animal model, probably the only one in which lepromatous leprosy similar to that found in humans can be experimentally produced. Some unique features of the physiology of the animal are mentioned. The pathology and the microbiology of leprosy in the armadillo are described in detail. The discovery of lepromatous leprosy in the wild armadillos in the southern parts of United States, the transmission of disease among them through trauma and thorn pricks and the pathogenesis of the disease are presented. The impact of leprosy in the wild animals may have on human leprosy is discussed. (AU). Descriptors: HANSENIASE VIRCHOWIANA/epidemiol HANSENIASE VIRCHOWIANA/etiol HANSENIASE VIRCHOWIANA/patol HANSENIASE VIRCHOWIANA/transm HANSENIASE VIRCHOWIANA/vet TATUS/imunol TATUS/microbiol - MODELOS ANIMAIS  VETERINARIA DE SAUDE PÚBLICA Limits: ANIMAL Location: BR191.1; 00279/s

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Id: 18236 Author: Caparo, Alberto Cuba; Takano, Juan Title: El armadillo de 7-bandas Dasypus hybridus, como animal de laboratorio en el estudio experimental de la lepra ..- Source: s.l; s.n; 1985. 10 p. ilus, tab. Abstract: El armadillo de 7-bandas, Dasypus hybridus, ha sido utilizado en estudios de lepra experimental en un reducido numero de animales. Con el proposito de conocer la susceptibilidad de esta especie frente al Mycobacterium leprae y de llevar a cabo estudios patologicos con microscopia de luz y microscopia electronica se inoculo cinco armadillos con germenes provenientes de lesiones lepromatosas de dos enfermos sin tratamiento. Se encontro lesiones lepromatosas disemidas en uno solo de los cinco armadillos inoculados las que morfologicamente son similares a las previamente descritas por otros autores en esta misma especie, en D. novemcinctus y D. sabanicola. Se describe aspectos ultraestructurales del granuloma lepromatoso y del M. leprae. Se describe tambiem lesiones degenerativas de fibras miocardicas y de fibras musculares esqueleticas en el armadillo que presento lesiones lepromatosas, asi como en los cuatro armadillos en los que esta no se desarrollaron y se discute la natureza de estas lesiones y de otras de tipo granulomatoso inespecifico en la serosa pleural y peritoneal (AU). Descriptors: HANSENIASE/genet MYCOBACTERIUM LEPRAE/ef drogas MYCOBACTERIUM LEPRAE/genet MYCOBACTERIUM LEPRAE/isol MYCOBACTERIUM LEPRAE/patogen GRANULOMA/fisiopatol - ANIMAIS DE LABORATORIO/genet Limits: ESTUDO COMPARATIVO HUMANO Location: BR191.1; 09271/s

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Id: 18119 Author: Binford, C. H Title: Histiocytic granulomatous mycobacterial lesions produced in the golden hamster (cricetus auratus) inoculated with human leprosy: negative results in experiments using other animals ?- Source: s.l; s.n; 1959. 24p p. ilus. Abstract: 1- During the past three years 35 experiments in inoculation with Mycobacterium leprae were undertaken on approximately 1500 animals. Total body irradiation and/or cortisone were used, in the hope of reducing host resistance. Because M. leprae in man grows best where the temperature is lower, the cooler parts of animals were inoculated. In all experiments, heat-treated inoculum was given to control animals. Histopathologic studies of the inoculation sites were made regularly. 2- Thirteen completed experiments on albino hamsters, white mice, white rats, hairless mice, and white guinea pigs have given negative results. 3- The histiocytic granulomatous lesions, in the testes and ears of the golden hamster approximately 18 months post inoculation, resembled human lepromatous leprosy in their histologic pattern, their number of intracellular acid-fast bacilli, and the presence of bacilli within nerves...AU. Descriptors: HANSENIASE/microbiol HANSENIASE/patol HANSENIASE/transm HANSENIASE/vet ANIMAIS DE LABORATORIO/imunol ANIMAIS DE LABORATORIO/microbiol - MODELOS ANIMAIS/imunol  MESOCRICETUS/microbiol Limits: HAMSTERS Location: BR191.1; 00538/s

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Id: 18118 Author: Collier, D. R Title: Inoculation of monkeys with leprosy, following a diet of puak (colocasia) ?- Source: s.l; s.n; 1940. 6p p. . Abstract: A number of monkeys have been fed on a diet of colocasia, and then inoculated with material from lepers. All four female monkeys, so treated six or more months ago, have developed symptoms similar to those seen in leprosy in humans. There have been positive bacteriological findings in nodules and changes in pigmentation of the skin. One animal developed thickening of the ulnar nerves. One male monkey has developed abcesses containing acid-fast bacilli as well as other sympstoms after being injected with a solution of sapotoxin in addition to the diet of colocasia. Descriptors: MYCOBACTERIUM LEPRAE/isol MYCOBACTERIUM LEPRAE/patogen HANSENIASE/microbiol HANSENIASE/patol HANSENIASE/transm HANSENIASE/vet ANIMAIS DE LABORATORIO/imunol ANIMAIS DE LABORATORIO/microbiol - MODELOS ANIMAIS  MESOCRICETUS  MACACO  cachorro  coelho  porquinho da índia  porco Limits: ANIMAL Location: BR191.1; 00536/s

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Id: 18117 Author: Soule, M. H; McKinley, E. B Title: Cultivation of b. leprae with experimental lesions in monkeys ?- Source: s.l; s.n; 1932. 36p p. ilus, tab. Abstract: The experiments described include (1) the experimental production of granulomatous lesions suggestive of early lesions of leprosy in two species of monkeys by intradermal inoculation of human leprosy material; (2) the cultivation of acid-fast (presumably B. leprae) bacilli from human leprosy nodules on several artificial mediums in various gaseous environments; and (3) the experimental production of granulomatous lesions, suggestive of early leprosy, in two species of monkeys by the intradermal inoculation of cultures of acid-fast bacilli from human leprosy material grown on artificial mediums. We believe the experiments indicate a step forward in the fulfillment of Koch's postulates for the causative agent in the disease of leprosy. Descriptors: HANSENIASE/microbiol HANSENIASE/patol HANSENIASE/transm HANSENIASE/vet MODELOS ANIMAIS ANIMAIS DE LABORATORIO/imunol ANIMAIS DE LABORATORIO/microbiol Limits: ANIMAL Location: BR191.1; 00565/s

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Id: 18102 Author: Fernández, J. M. M Title: The early reaction induced by lepromin ?- Source: Rosario; s.n; 1940. 13p p. . Abstract: The intradermal reaction to lepromin has been studied in a total of 563 persons, cases of leprosy and contacts. Observation of its clinical and histopathologic development has shown the following facts:a- In allergic cases intradermal injection of lepromin induces an "early" reaction which is well defined, both clinically and histologically, beginning a few hours after injection and reaching its maximum between 48 and 72 hours, thereafter decreasing until it disappears completely during the first week. b- This early reaction, which is manifested clinically by an erythematous halo, usually infiltrated, is not of nonspecific character since it has the histologic structure common to allergic reactions and is only seen in those cases which offer resistance to the infection (i.e., neural forms of the disease, particularly the tuberculoid form) and does not occur in cases which are considered anergic, as in the lepromatous type...AU. Descriptors: ANTIGENO DE MITSUDA/admin ANTIGENO DE MITSUDA/ef drogas ANTIGENO DE MITSUDA/uso diag - MODELOS ANIMAIS  MYCOBACTERIUM LEPRAE/cresc  MYCOBACTERIUM LEPRAE/patogen Limits: ANIMAL Location: BR191.1; 00716/s

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Id: 18094 Author: Garfield, Eugene Title: Leprosy: down not out ..- Source: s.l; s.n; 1980. 8 p. . Descriptors: HANSENIASE/compl HANSENIASE/hist MYCOBACTERIUM LEPRAE/cresc - ANIMAIS DE LABORATORIO/les  DAPSONA/uso terap Limits: HUMANO Location: BR191.1; 00261/s

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Id: 18086 Author: Gunders, A. E Title: Progressive experimental infection with mycobacterium leprae in a chimpanzee ?- Source: s.l; s.n; 1958. 3p p. ilus. Descriptors: MYCOBACTERIUM LEPRAE/cresc MYCOBACTERIUM LEPRAE/isol MYCOBACTERIUM LEPRAE/patogen - MODELOS ANIMAIS Location: BR191.1; 00567/s

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Id: 17691 Author: Scollard, D. M; Adams, L. B; Gillis, T. P; Krahenbuhl, J. L; Truman, R. W; Williams, D. L Title: The continuing challenges of leprosy ..- Source: s.l; s.n; 2006. 44 p. ilus, tab. Abstract: Leprosy is best understood as two conjoined diseases. The first is a chronic mycobacterial infection that elicits an extraordinary range of cellular immune responses in humans. The second is a peripheral neuropathy that is initiated by the infection and the accompanying immunological events. The infection is curable but not preventable, and leprosy remains a major global health problem, especially in the developing world, publicity to the contrary notwithstanding. Mycobacterium leprae remains noncultivable, and for over a century leprosy has presented major challenges in the fields of microbiology, pathology, immunology, and genetics; it continues to do so today. This review focuses on recent advances in our understanding of M. leprae and the host response to it, especially concerning molecular identification of M. leprae, knowledge of its genome, transcriptome, and proteome, its mechanisms of microbial resistance, and recognition of strains by variable-number tandem repeat analysis. Advances in experimental models include studies in gene knockout mice and the development of molecular techniques to explore the armadillo model. In clinical studies, notable progress has been made concerning the immunology and immunopathology of leprosy, the genetics of human resistance, mechanisms of nerve injury, and chemotherapy. In nearly all of these areas, however, leprosy remains poorly understood compared to other major bacterial diseases. (AU). Descriptors: Antiinfecciosos/TU Proteínas de Bactérias/ME Vacinas Bacterianas Modelos Animais de Doenças Suscetibilidade à Doença/IM Resistência Bacteriana a Drogas Genes Bacterianos/GE Predisposição Genética para Doença Genoma Bacteriano Imunidade Celular Imunidade Natural/GE Hansenostáticos/PD/TU Hanseníase/*/DI/MI/TH Mycobacterium leprae/*/CH/DE/IP/PH Nervos Periféricos/MI Doenças do Sistema Nervoso Periférico/MI/PA Reação em Cadeia da Polimerase Research Support, N.I.H., Extramural Células de Schwann/IM/MI Limits: HUMANO ANIMAL CAMUNDONGOS SUPPORT, NON-U.S. GOV'T Location: BR191.1; 09365/S

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Id: 17623 Author: Rosa, Patricia Sammarco; Bolone, Andrea de Faria Fernandes; Silva, Eliane Aparecida. Title: Mitsuda reaction in armadillos Dasypus novemcinctus using human and armadillo derived antigens. Source: Hansen. int;30(2):180-184, Jul-Dez. 2005. tab. Abstract: The armadillo has been an important experimental model for leprosy, besides it is still an important resource for bacilli. Despite the innumerous studies about armadillos of the Genus Dasypus, little is known about the real susceptibility of this species to the Hansen’s bacillus after experimental infection with M. leprae. Many authors have reported that 80 per cent of the inoculated animal will develop the disease. In Brazil, positive inoculation of this species was obtained only twice, being raised the hypothesis that these animals are more resistant to experimental infection. In the present study the response to the Mitsuda antigen was used as an indicative of cellular immune response to M. leprae in armadillos. Twenty one animals were tested with two Mitsuda antigen preparations, human derived (4,2 x 109 bacilli/ml) and armadillo derived (1,6 x 108 bacilli/ml) antigens. Response after 28 days of intradermal testing showed that most of the animals presented an infiltrate composed by grouped macrophages with vacuolated cytoplasm and rare lymphocytes. This response resembles lepromatous leprosy in humans and suggests that these animals would be susceptible to development of disseminated leprosy when successfully inoculated. Bacilloscopy in these animals varied from 3+ to 4+ according to Ridley’s scale (1966). Two animals developed a granulomatous reaction with borderline pattern and bacilloscopy varying from 1+ to 3+.AU. Descriptors: ANTIGENO DE MITSUDA MODELOS ANIMAIS HANSENIASE/vet Electronic Medium: Internet Location: BR191.1

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Id: 17622 Author: Rosa, Patricia Sammarco; Belone, Andrea de Faria Fernandes; Silva, Eliane Aparecida. Title: A reaçao de mitsuda em tatus Dasypus novemcinctus utilizando antigeno humano e antigeno derivado de tatus / Mitsuda reaction in armadillos Dasypus novemcinctus using human and armadillo derived antigens Source: Hansen. int;30(2):174-179, Jul-Dez. 2005. ilus, tab. Abstract: O tatu foi um modelo experimental importante para o estudo da hanseniase, alem de ser ainda uma importante fonte para coleta de bacilos. Apesar dos inumeros relatos de estudos em tatus de especie Dasypus novemcinctus, pouco se sabe sobre a real susceptibilidade desta especie ao bacilo de Hansen apos inoculaçao experimental com M. leprae. Alguns autores relatam que cerca de 80 por cento dos animais desenvolveriam a doença quando infectados. No Brasil, a inoculaçao experimental desta especie resultou em inoculaçoes positiva em apenas dois momento, tendo ate sido levantada a hipotese de estes animais serem mais resistentes a infecçao experimental. No presente estudo, utilizou-se a resposta ao nantigeno de Mitsuda como um indicador de resposta imune celular de tatus ao M. leprae...AU. Descriptors: ANTIGENO DE MITSUDA MODELOS ANIMAIS HANSENIASE/vet Electronic Medium: Internet Location: BR191.1

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Id: 17616 Author: Lopez-Hurtado, Marcela; Flores-Medina, Saul; Díaz-García, Francisco J; Guerra-Infante, Fernando M Title: Partial characterization of phagocytic activity in neutrophils of the nine-banded armadillo Dasypus novemcinctus ..- Source: s.l; s.n; 2005. [7] p. tab. Descriptors: Animais Tatus/*IM Atividade Bactericida do Sangue Quimiotaxia de Leucócito/DE Endocitose Escherichia coli/IM Humanos In Vitro Cinética Hanseníase/IM Monócitos/IM N-Formilmetionina Leucil-Fenilalanina/PD Neutrófilos/DE/*IM Proteínas Opsonizantes/IM Fagocitose/* Location: BR191.1; 09349/S

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Id: 17546 Author: Diorio, Suzana Madeira; Manini, Marli Izabel Penteado; Trino, Lazara Moreira; Sartori, Beatriz Gomes Carreira; Opromolla, Diltor Vladimir Araujo. Title: Resistance to dapsone and rifampin in Mycobacterium leprae isolated from leprosy patients of Sao Paulo State. Source: Hansen. int;30(1):15-18, Jan-Jun 2005. tab. Abstract: In 1981, reports of resistance to dapsone and rifampin led WHO to recommend multidrugtherapy in leprosy treatment. One of its main goals is preventing the selection of drug-resistant strains of mutant bacteria. Dapsone was the first drug which was experimentally proved to induce resistance; this became possible only after the mouse footpad inoculation technique was standardized, in 1960. There are some important criteria to suspect the existence of resistance, such as: relapses in multibacillary patients already treated or undergoing treatment or unsatisfactory clinical response. Our study aimed at detection of dapsone and rifampin resistant strains among 40 treated patients with clinical signs of relapse, from different cities of São Paulo State and its capital, employing the mouse footpad inoculation. We detected dapsone resistant bacilli in 11 cases. Among them, 5 showed total resistance, 1 intermediary resistance and 5 partial resistance. Rifampin resistant bacilli were detected in only two cases. We did not detect any case of multiple...(AU). Descriptors: HANSENIASE/quimioter HANSENOSTATICOS/uso terap MYCOBACTERIUM LEPRAE/ef drogas - HANSENIASE/PATOL  MODELOS ANIMAIS Electronic Medium: Internet Location: BR191.1

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Id: 17541 Author: Diorio, Suzana Madeira; Manini, Marli Izabel Penteado; Trino, Lazara Moreira; Sartori, Beatriz Gomes Carreira; Opromolla, Diltor Vladimir Araujo. Title: Resistencia a dapsona e rifampicina em Mycobacterium leprae isolado de pacientes portadores de hanseniase no Estado de Sao paulo / Resistance to dapsone and rifampin in Mycobacterium leprae isolated from leprosy patients of Sao Paulo Source: Hansen. int;30(1):09-14, Jan-Jun 2005. tab. Abstract: Os relatos de resistencia e rifampicina fizeram com que a Organizaçao Mundial de Saude preconizasse, 1981, a poliquimioterapia para o tratamento da hanseniase. A prevençao da seleçao de cepas mutantes resistentes as drogas e um de seus principais objetivos. A dpsona foi a primeira droga a ter comprovação experimental de resistencia e isto so foi possivel depois que a tecnica de inoculaçao do bacilo em coxim plantar de camundongos foi padronizado em 1960. Criterios importantes a serem considerados para se suspeitar de resistencia seriam recidivas em pacientes multibacilares ja tratado, ou em tratamento, ou resposta clinica insatisfatoria. Nosso estudo teve por objetivo detectar cepas resistentes a dapsona e rifampicina entre 40 pacientes tratados com sinais clinicos de recidiva, procedentes de cidades do Estado de Sao paulo e capital, utilizando a tecnica de inoculaçao do em coxim plantar de camundongos. Foram observados bacilos resistentes a dapsona em 11 casos, sendo 05 de resistencia total, 01 intermediario e 05 parcial. Bacilos resistente a rifampicina foram observados em apenas 02 casos. Nao se observou nenhum caso de resistencia multipla. O alto indice obtido de resistencia a dapsona, provavelmente e decorrencia de muitos anos de monoterapia sulfonica ou de seus derivados. No caso da rifampicina, provavelmente a droga foi utilizada de forma irregular, em monoterapia ou aind, o paciente pode ter utilizado-a previamente para tratar outra molestia....(AU). Descriptors: HANSENIASE/quimioter HANSENOSTATICOS/uso terap MYCOBACTERIUM LEPRAE/ef drogas - HANSENIASE/patol  MODELOS ANIMAIS Electronic Medium: Internet Location: BR191.1

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Id: 17540 Author: Paschoal, Vania Del'Arco; Rossit, Andrea Batista; Bizutti, Luiz O; Azoubel, Reinaldo. Title: Volume dos nucleos das celulas do testiculo de ratos sob efeitos da ofloxacina / Study of nuclear volume of testicular cells in rats after the use of ofloxacin Source: Hansen. int;30(1):03-08, Jan-Jun 2005. tab. Abstract: A ofloxacina possui amplo aspectro de açao antimicrobiana, inclusive no combate ao Mycobacterium leprae, sendo atualmente empregada em substituiçao, quando da impossibilidade do uso da rifampicina. O objetivo deste foi estudar alteraçoes nos nucleos das celulas do testiculo de ratos puberes e respectivos grupos controle, submetidos a aplicaçao oral de ofloxacina. O metodo utilizado foi a morfometria, pela tecnica cariometrica. As principais estruturas observadas nas preparaçoes histologicas dos testiculos foram: as celulas de Leydig, as espermatogonias e as celulas de Setoli. Foram utilizados 09 ratos (Wistar), cinco tratados e quatro controles, aos quais foram administrados diariamente 12 mg/kg/peso de ofloxacina, do 34º ao 48º dia apos o nascimento. No 49º dia de vida, os ratos foram sacrificados. O estudo cariometrico das celulas de Leydig, das espermatogonias e das celulas de Sertoli de testiculos dos animais tratados nao evidenciou mudanças significativas na forma de seus nucleos (p>0,05), quando comparados aos controles. Conclui-se que a oflocaxina na dose e periodo empregados nao promoveu alteraçoes nos constituintes celulares de testiculos de ratos pubers. (AU). Descriptors: HANSENIASE HANSENOSTATICOS MODELOS ANIMAIS Electronic Medium: Internet Location: BR191.1

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Id: 13605 Author: Binford, Chapman H; Meyers, Wayne M; Walsh, Gerald P Title: Leprosy ..- Source: s.l; s.n; April 23, 1982. 10 p. ilus, mapas, graf. Abstract: TODAY, leprosy impairs the physical, social, and economic well-being of millions. Those who live in Third World countries suffer most, because living conditions are marginal and health care provision systems are undeveloped or disrupted by political ferment.(AU). Descriptors: CERCOPITHECIDAE CLOFAZIMINA/uso terap MODELOS ANIMAIS DE DOENCAS HANSENIASE/epidemiol HANSENIASE/terap HANSENIASE/transm MYCOBACTERIUM LEPRAE/isol PAN TROGLODYTES PELE/microbiol SULFONAS/uso terap - TEMPERATURA AMBIENTE  ESTADOS UNIDOS Limits: ANIMAL HAMSTERS CAMUNDONGOS RATOS TATUS Electronic Medium: http://www.ilsl.br Location: BR191.1; 00560/s

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Id: 13584 Author: Storrs, Eleanor E; Binford, Chapman H; Migaki, George Title: Animal model of human disease: lepromatous leprosy ..- Source: s.l; s.n; sep. 1978. 4 p. ilus. Abstract: The nine-banded armadillo (Dasypus novemcicnctus Linn)(Figure 1) is one of approximately 20 species of armadillos comprising several genera. They belong to the Edentata. D novemcinctus ranges from Central Argentina through Central America, Mexico, the Gulf States, and north-ward into Oklahoma, Arkansas, and Georgia. Among the characteristics which make this animal a useful research model for lepromatous leprosy a) low body temperature (32 to 35C), b) regular production of monozygotic quadruplet young, and c) a long life-spain (estimated to be 15 years). Other biologic characteristics are a) delayed (14 to 16 weeks) implantation period of the blastocyst, b) gestation period of approximately 9 months, c) ability to build up an oxygen debt, and d) occasional variability in band numbers.(AU). Descriptors: HANSENIASE XENARTROS MODELOS ANIMAIS DE DOENCAS TATUS Limits: ANIMAL SUPPORT, U.S. GOV'T, NON-P.H.S. SUPPORT, U.S. GOV'T, P.H.S. Electronic Medium: http://www.ilsl.br Location: BR191.1; 00212/s

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Id: 13560 Author: Purtilo, David T; Walsh, Gerald P; Storrs, Eleanor E; Banks, Isaac S Title: Impact of cool temperatures on transformation of human and armadilio lymphocytes ( Dasypus novemcinctus, Linn. ) as related to leprosy ..- Source: s.l; s.n; March 29, 1974. 3 p. tab, graf. Abstract: A CENTURY-LONG search for an unaltered animal in which to study leprosy in humans culminated in the finding that the nine-banded armadillo (Dasypus novemcinctus, Linn.) a primitive mammal native to the southern Western Hemisphere, develops disseminated lepromstous leprosy following inocuation with Mycobacterium leprae isolated from human tissue.(AU). Descriptors: TRANSFORMACAO LINFOCITICA/ef drogas MYCOBACTERIUM LEPRAE/imunol XENARTROS/imunol HANSENIASE/imunol LECTINAS MODELOS ANIMAIS DE DOENCAS ANTIGENOS DE BACTERIAS FRIO Limits: HUMANO ANIMAL MASCULINO FEMININO Electronic Medium: http://www.ilsl.br Location: BR191.1; 00494/s

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