Database : HANSEN Search on : EXPRESSAO GENICA [Subject descriptor] References found : 13 [refine] Displaying: 1 .. 13   in format [Detailed]

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Id: 17284 Author: Moraes, M. O; Sarno, E. N; Almeida, A. S; Saraiva, B. C. C; Nery, J. A. C; Martins, R. C. L; Sampaio, E. P Title: Cytokine mRNA expression in leprosy; a possible role for interferon-gamma and interleukin-12 in reaction (RR and ENL) ..- Source: s.l; s.n; 1999. 9 p. tab, graf, ilus. Abstract: Leprosy patients during the natural course of the disease may develop reactional episodes, namely reversal reaction (RR) and erythema nodosum leprosum (ENL). Immunological events described as occurring during RR indicate up-regulation of the immune response, whereas in ENL the events are not fully understood. The aim of this study was to analyse the in vivo pattern of cytokine gene expression in the reactional states of leprosy. Peripheral blood mononuclear cells (PBMC, n = 14) and tissue samples (n = 17) obtained from patients with ENL and RR were obtained and assayed by RT-PCR. PBMC obtained from unreactional patients (n = 15) and normal individuals (n = 5) were also assessed. Expression of interferon (IFN)gamma, granulocyte-macrophage colony stimulating factor (GM-CSF), interleukin (IL)-2Rp55, perforin and IL-1beta mRNA in PBMC were detected mostly in ENL/RR patients, but not in unreactional patients. Likewise, cytokines such as IL-6, IL-8, tumour necrosis factor (TNF)alpha and TNFbeta were also present in reactional and tuberculoid patients as opposed to lepromatous leprosy (BL/LL). Interestingly, the majority of ENL/RR patients showed messages for IL-6, IL-10, IL-12 and TNFalpha in the skin. IFNgamma was detected in 84.6% (ENL) and 100% (RR) of the patients, whereas IL-4 was detected only in few individuals (38.5 and 25%, respectively). Although mRNA expression and protein levels may be different, the data reported in this study suggest a cytokine mRNA profile that seems to be indistinguishable for RR and ENL. In addition, it shows up-regulation of immuno-inflammatory cytokines in the blood and tissue of the same patient examined before and during reaction. Furthermore, it is suggested that this pattern of response results from an immunological reactivation that might lead to an acute inflammatory response in both reactional episodes. (AU). Descriptors: Sequência de Bases Estudos de Casos e Controles Citocinas/*GE Primers do DNA/GE Expressão Gênica Fator Estimulador de Colônias de Granulócitos-Macrófagos/GE Interferon Tipo II/*GE Interleucina-12/*GE Hanseníase/*GE/*IM Glicoproteínas de Membrana/GE Reação em Cadeia da Polimerase RNA Mensageiro/BL/*GE/*ME Limits: Humano Support, Non-U.S. Gov't Location: BR191.1; 09183/s

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Id: 13722 Author: Maeda, Yumi; Makino, Masahiko; Crick, Dean C; Mahapatra, Sebabrata; Srisungnam, Sopa; Takii, Takemasa; Kashiwabara, Yoshiko; Brennan, Patrick J Title: Novel 33-kilodalton lipoprotein from Mycobacterium leprae ..- Source: s.l; s.n; 2002. 6 p. tab, graf. Abstract: A novel Mycobacterium leprae lipoprotein LpK (accession no. ML0603) was identified from the genomic database. The 1,116-bp open reading frame encodes a 371-amino-acid precursor protein with an N-terminal signal sequence and a consensus motif for lipid conjugation. Expression of the protein, LpK, in Escherichia coli revealed a 33-kDa protein, and metabolic labeling experiments and globomycin treatment proved that the protein was lipidated. Fractionation of M. leprae demonstrated that this lipoprotein was a membrane protein of M. leprae. The purified lipoprotein was found to induce production of interleukin-12 in human peripheral blood monocytes. The studies imply that M. leprae LpK is involved in protective immunity against leprosy and may be a candidate for vaccine design. (AU). Descriptors: SEQUENCIA DE AMINOACIDOS ANTIGENOS DE BACTERIAS/GE/*IM/IP PROTEINAS DE BACTERIAS/GE/*IM/IP CLONAGEM MOLECULAR ESCHERICHIA COLI EXPRESSAO GENICA GENES BACTERIANOS INTERLEUCINA-12/*BI LIPOPROTEINAS/GE/*IM/IP PROTEINAS DE MEMBRANA/GE/*IM/IP DADOS DE SEQUENCIA MOLECULAR PESO MOLECULAR MONOCITOS/IM MYCOBACTERIUM LEPRAE/GE/*IM/IP PRECURSORES DE PROTEINAS/GE/*IM/IP ANALISE DE SEQUENCIA DE DNA Limits: HUMANO SUPPORT, NON-U.S. GOV'T SUPPORT, U.S. GOV'T, P.H.S. Location: BR191.1; 09059/s

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Id: 11939 Author: Meada, Yumi; Makino, Masahiko; Crick, Dean C; Mahapatra, Sebabrata; Srisungnam, Sopa; Takii, Takemasa; Kashiwabara, Yoshiko; Brennan, Partrick J Title: Novel 33-kilodalton lipoprotein from Mycobacterium leprae ..- Source: s.l; s.n; 2002. 6 p. ilus, graf. Descriptors: MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE MONOCITOS ANTIGENOS DE BACTÉRIAS ANTIGENOS DE BACTÉRIAS ANTIGENOS DE BACTÉRIAS PROTEINAS DE BACTÉRIAS PROTEINAS DE BACTÉRIAS PROTEINAS DE BACTÉRIAS CLONAGEM MOLECULAR ESCHERICHIA COLI EXPRESSAO GENICA GENES BACTERIANOS INTERLEUCINA-12 PESO MOLECULAR ANALISE SEQUENCIAL PRECURSORES DE PROTEINAS PRECURSORES DE PROTEINAS PRECURSORES DE PROTEINAS Location: BR191.1; 08605/s

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Id: 11725 Author: Moraes, M. O; Sampaio, E. P; Nery, J. A. C; Saraiva, B. C. C; Alvarenga, F. B. F; Sarna, E. N Title: Sequential erythema nodosum leprosum and reversal reaction with similar lesional cytokine mRNA pattern in a borderline leprosy patient ..- Source: s.l; s.n; 2001. 7 p. ilus, tab, graf. Descriptors: HANSENIASE LEPROMATOSA HANSENIASE LEPROMATOSA CITOCINAS CITOCINAS ERITEMA NODOSO ERITEMA NODOSO EXPRESSAO GENICA RNA MENSAGEIRO REAÇAO EM CADEIA POR POLIMERASE DNA POLIMERASE DIRIGIDO POR RNA FATOR DE NECROSE DE TUMOR Limits: RELATO DE CASO HUMANO MASCULINO Location: BR191.1; 07353/s

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Id: 11703 Author: Moraes, Milton O; Sarno, Euzenir N; Teles, Rosane M. B; Almeida, Alexandre S; Saraiva, Bruno C. C; Nery, José A. C; Sampaio, Elizabeth P Title: Anti-inflammatory drugs block cytokine mRNA accumulation in the skin and improve the clinical condition of reactional leprosy patients ..- Source: s.l; s.n; 2000. 6 p. tab. Descriptors: HANSENIASE LEPROMATOSA HANSENIASE LEPROMATOSA ANTIINFLAMATORIOS ANTIINFLAMATORIOS BIOPSIA CITOCINAS CITOCINAS ERITEMA NODOSO ERITEMA NODOSO EXPRESSAO GENICA INTERFERON TIPO II INTERLEUCINA-4 REAÇAO EM CADEIA POR POLIMERASE PELE PELE FATOR DE NECROSE DE TUMOR Location: BR191.1; 08424/s

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Id: 11651 Author: Nakanga, Kazue; Nomaguchi, Hiroko; Matsuoka, Masanori Title: Establishment of mouse cell lines expressing Micobacterium leprae 65KDa heat shock protein gene ..- Source: s.l; s.n; 1996. 8 p. graf. Descriptors: HANSENIASE MYCOBACTERIUM LEPRAE LINHAGEM CELULAR CHAPERONINAS CHAPERONINAS EXPRESSAO GENICA CAMUNDONGOS ENDOGAMICOS BALB C RNA MENSAGEIRO LINFOCITOS T CITOTOXICOS TRANSFECÇAO Location: BR191.1; 08462/s

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Id: 11299 Author: Moraes, M. O; Sarno, E. N; Almeida, A. S; Saraiva, B. C. C; Nery, J. A. C; Martins, R. C. L; Sampaio, E. P Title: Cytokine mRNA expression in leprosy: a possible role for interferon-gamma and interleukin-12 in reactions (RR and ENL) ..- Source: s.l; s.n; 1999. 9 p. ilus, tab, graf. Descriptors: SEQUENCIA DE AMINOACIDOS SEQUENCIA DE BASES ESTUDOS DE CASOS E CONTROLES CITOCINAS PRIMERS DO DNA EXPRESSAO GENICA FATOR ESTIMULADOR DE COLONIAS DE GRANULOCITOS-MACROFAGOS INTERFERON TIPO II INTERLEUCINA-12 HANSENIASE HANSENIASE GLICOPROTEINAS DE MEMBRANAS REAÇAO EM CADEIA POR POLIMERASE RNA MENSAGEIRO RNA MENSAGEIRO RNA MENSAGEIRO Location: BR191.1; 07238/s

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Id: 11031 Author: Sieling, Peter A; Modlin, Robert L Title: Regulation of cytokine patterns in leprosy ..- Source: s.l; s.n; 1994. 11 p. . Descriptors: RELAÇAO CD4-CD8 CITOCINAS EXPRESSAO GENICA INTERLEUCINA-10 INTERLEUCINA-12 INTERLEUCINA-7 INTERLEUCINAS HANSENIASE RNA MENSAGEIRO RECEPTORES PARA ANTIGENOS DE CÉLULAS T ALFA-BETA RECEPTORES PARA ANTIGENOS DE CÉLULAS T GAMA-DELTA SUB-POPULAÇOES DE LINFOCITOS T LINFOCITOS T AUXILIADORES-INDUTORES LINFOCITOS T SUPRESSORES-EFETORES Location: BR191.1; 07209/s

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Id: 10245 Author: Sieling, Peter A; Wang, Xiao-Hong; Gately, Maurice K; Oliveros, Jennifer L; McHugh, Teresa; Barnes, Peter F; Wolf, Stanley F; Golkar, Linda; Yamamura, Masahiro; Yogi, Yasuko; Uyemura, Koichi; Rea, Thomas H; Modlin, Robert L Title: IL-12 regulates T helper type 1 cytokine responses in human infectious disease ..- Source: s.l; s.n; 1994. 9 p. ilus, graf. Descriptors: SEQUENCIA DE BASES LINFOCITOS T CD8-POSITIVOS PRIMERS DO DNA EXPRESSAO GENICA INTERFERON TIPO II INTERLEUCINA-10 INTERLEUCINA-12 INTERLEUCINA-4 INTERLEUCINA-4 HANSENIASE TRANSFORMAÇAO LINFOCITICA DADOS DE SEQUENCIA MOLECULAR MYCOBACTERIUM LEPRAE RNA MENSAGEIRO SUB-POPULAÇOES DE LINFOCITOS T CÉLULAS TH1 Location: BR191.1; 06955/s

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Id: 9774 Author: Sampaio, Elizabeth P; Caneshi, Jaqueline R. T; Nery, Jose A. C; Duppre, Nadia C; Pereira, Geraldo M. B; Vieira, Leila M. M; Moreira, Andre L; Kaplan, Gilla; Sarno, Euzenir N Title: Cellular immune response to Mycobacterium leprae infection in human immunodeficiency virus-infected individuals ..- Source: s.l; s.n; 1995. 7 p. ilus, tab, graf. Descriptors: CITOCINAS CITOCINAS EXPRESSAO GENICA INFECÇOES POR HIV INFECÇOES POR HIV HIV-1 ANTIGENO DE MITSUDA LEUCOCITOS MONONUCLEARES TRANSFORMAÇAO LINFOCITICA RNA MENSAGEIRO PELE Location: BR191.1. 6774/s

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Id: 9421 Author: Uyemura, Koichi; Ohmen, Jeffrey D; Grisso, Cara L; Sieling, Peter A; Wyzykowski, Richard; Reisenger, Diane M; Rea, Thomas H; Modlin, Robert L Title: Limited T-cell receptor B-chain diversity of a T-helper cell type 1-like response to Mycobacterium leprae ..- Source: s.l; s.n; 1992. 7 p. ilus, tab, graf. Descriptors: ANTIGENOS DE BACTÉRIAS ANTIGENOS DE BACTÉRIAS EXPRESSAO GENICA REORDENAMENTO GENICO DO LINFOCITO T REORDENAMENTO GENICO DO RECEPTOR PARA CADEIA BETA DO ANTIGENO DE CÉLULAS T HANSENIASE TUBERCULOIDE LINFOCINAS PESO MOLECULAR MYCOBACTERIUM LEPRAE REAÇAO EM CADEIA POR POLIMERASE RNA MENSAGEIRO RECEPTORES PARA ANTIGENOS DE CÉLULAS T ALFA-BETA LINFOCITOS T AUXILIADORES-INDUTORES Location: BR191.1; 06381/s

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Id: 9390 Author: Yamamura, Masahiro; Wang, Xiao-Hong; Ohmen, Jeffrey D; Uyemura, Koichi; Rea, Thomas H; Bloom, Barry R; Modlin, Robert L Title: Cytokine patterns of immunologically mediated tissue damage ..- Source: s.l; s.n; 1992. 6 p. ilus, graf. Descriptors: SEQUENCIA DE BASES CITOCINAS CITOTOXICIDADE IMUNOLOGICA EXPRESSAO GENICA HANSENIASE HANSENIASE DADOS DE SEQUENCIA MOLECULAR OLIGODESOXIRRIBONUCLEOTIDIOS REAÇAO EM CADEIA POR POLIMERASE RNA MENSAGEIRO Location: BR191.1; 06414/s

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Id: 9308 Author: Sullivan, Laura; Sano, Shigetoshi; Pirmez, Claude; Salgame, Padmini; Mueller, Christoph; Hofaman, Florence; Uyemura, Koichi; Rea, Thomas H; Bloom, Barry R; Modlin, Robert L Title: Expression of adhesion molecules in leprosy lesions ..- Source: s.l; s.n; 1991. 7 p. ilus, tab, graf. Descriptors: ANTIGENOS CD2 ANTIGENOS CD58 ANTIGENOS DE DIFERENCIAÇAO DE LINFOCITOS T ANTIGENOS DE SUPERFICIE MOLÉCULAS DE ADESAO CELULAR EPIDERME EPIDERME EXPRESSAO GENICA MOLÉCULA 1 DE ADESAO INTERCELULAR INTERFERON TIPO II HANSENIASE HANSENIASE HANSENIASE ANTIGENO-1 LINFOCITARIO ASSOCIADO A FUNÇAO HIBRIDIZAÇAO DE ACIDO NUCLÉICO RECEPTORES IMUNOLOGICOS LINFOCITOS T LINFOTOXINA Location: BR191.1; 06211/s

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