Database : HANSEN Search on : INTERLEUCINAS [Subject descriptor] References found : 8 [refine] Displaying: 1 .. 8   in format [Detailed]

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Id: 18227 Author: Quiroga, Maria F; Martinez, Gustavo J; Pasquinelli, Virginia; Costas, Monica A; Bracco, Maria M; Malbran, Aleajndro; Olivares, Liliana M; Sieling, Peter A; Garcia, Veronica E Title: Activation of signaling lymphocytic activation molecule triggers a signaling cascade that enhances Th1 responses in human intracellular infection ..- Source: s.l; s.n; 2004. 10 p. graf. Abstract: T cell production of IFN-gamma contributes to host defense against infections by intracellular pathogens, including mycobacteria. Lepromatous leprosy, the dissminated from of infection caused by Mycobacterium leprae, is characterized by loss of cellular response against the pathogen and diminished Th1 cytokine production. Relieving bacterial burden in Ag-unresponsive patients might be achieved through alternative receptors that stimulate IFN-gamma production. We have previously shown that ligation of signaling lymphocytic activation molecule (SLAM) enhances IFN-gamma in mycobacterial infection; therefore, we investigated molecular pathways leading from SLAM activation to IFN-gamma production in human leprosy. The expression of the SLAM-associated protein (an inhibitory factor for IFN-gamma induction) on M. leprae-stimulated cells from leprosy patients was inversely correlated to IFN-gamma production. Howevwe, SLAM ligation or exposure of cell from lepromatous patients to a proinflammatory microenvironment down-regulated SLAM-associated protein expression. Moreover. SALAM activation induced a sequence of signaling proteins, including activation of the NF-kB complex, phosphorylation of Stat1, and induction of T-bet expression, resulting in the promotion a cascade of molecular events during signaling through SLAM in leprosy that cooperate to induce INF-gamma production and strongly suggest that SLAM might be a focal point for therapeutic modulation of the cell cytokine responses in diseases characterized by dysfunctional Th2 responses (AU). Descriptors: HANSENIASE/imunol HANSENIASE/microbiol LINFOCITOS T/imunol LINFOCITOS T/microbiol INTERLEUCINAS/sangue INTERLEUCINAS/imunol - LINFOCITOS/imunol  LINFOCITOS/microbiol  MYCOBACTERIUM LEPRAE/imunol  MYCOBACTERIUM LEPRAE/patogen Limits: HUMANO Location: BR191.1; 09192/s

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Id: 17305 Author: Leal, Angela M. O; Magalhaes, Patricia K. R; Souza, Cacilda S; Foss, Norma T Title: Adrenocortical hormones and interleukin patterns in leprosy ..- Source: s.l; s.n; 2003. 5 p. graf. Abstract: The functional status of adrenocortical hormones and their relationship to the pattern of inflammatory cytokines in the lepromatous and tuberculoid poles of leprosy were investigated. Interleukin (IL)-1beta, IL-6 and tumour necrosis factor (TNF)-alpha plasma levels, C-reactive protein (CRP) concentrations and erythrocyte sedimentation rates (ESR) were significantly higher in LL/BL (lepromatous) leprosy patients than in control subjects. There was a significant positive correlation between IL-6 and TNF-alpha plasma levels and ESR and CRP concentrations. IL-1beta was positively correlated with ESR but not with CRP. Both baseline and stimulated adrenocorticotropic hormone and cortisol plasma levels were not different between patients and control subjects. In contrast, adrenal androgen dehydroepiandrosterone sulphate (DHEA-S) plasma levels were significantly lower in leprosy patients than in sex-matched control subjects. There was a significant inverse correlation between DHEA-S and IL-6, TNF-alpha, and CRP concentrations. This finding may be of pathogenetic significance in this disease and in other inflammatory states. (AU). Descriptors: Corticosteróides/*BL Sedimentação Sanguínea Proteína C-Reativa/AN Corticotropina/BL Sulfato de Desidroepiandrosterona/BL Hidrocortisona/BL Interleucina-1/BL Interleucina-6/BL Interleucinas/*BL Hanseníase/*BL/*IM Hanseníase Dimorfa/BL/IM Hanseníase Virchowiana/BL/IM Hanseníase Tuberculóide/BL/IM Fator de Necrose Tumoral/AN Limits: Adulto Estudos de Casos e Controles Humano Masculino Location: BR191.1. 0357/s

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Id: 11085 Author: Jullien, Denis; Sieling, Peter A; Uyemura, Koichi; Mar, Natalie D; Rea, Thomas H; Modlin, Robert L Title: IL-15, an immunomodulator of T cell responses in intracellular infection ..- Source: s.l; s.n; 1997. 7 p. ilus, tab, graf. Descriptors: HANSENIASE HANSENIASE HANSENIASE INTERLEUCINAS INTERLEUCINAS INTERLEUCINAS INTERLEUCINAS MONOCITOS MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE RNA MENSAGEIRO LINFOCITOS T LINFOCITOS T Location: BR191.1; 07382/s

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Id: 11031 Author: Sieling, Peter A; Modlin, Robert L Title: Regulation of cytokine patterns in leprosy ..- Source: s.l; s.n; 1994. 11 p. . Descriptors: RELAÇAO CD4-CD8 CITOCINAS EXPRESSAO GENICA INTERLEUCINA-10 INTERLEUCINA-12 INTERLEUCINA-7 INTERLEUCINAS HANSENIASE RNA MENSAGEIRO RECEPTORES PARA ANTIGENOS DE CÉLULAS T ALFA-BETA RECEPTORES PARA ANTIGENOS DE CÉLULAS T GAMA-DELTA SUB-POPULAÇOES DE LINFOCITOS T LINFOCITOS T AUXILIADORES-INDUTORES LINFOCITOS T SUPRESSORES-EFETORES Location: BR191.1; 07209/s

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Id: 10045 Author: Libraty, Daniel H; Airan, Lisa E; Uyemura, Koichi; Jullien, Denis; Spellberg, Brad; Rea, Thomas H; Modlin, Robert L Title: Interferon-y differentially regulates interleukin-12 interleukin-10 production in leprosy ..- Source: s.l; s.n; 1997. 6 p. graf. Descriptors: DOWN-REGULATION (FISIOLOGIA) REGULAÇAO DE EXPRESSAO GENICA INTERFERON TIPO II INTERLEUCINA-10 INTERLEUCINA-12 INTERLEUCINAS HANSENIASE LEUCOCITOS MONONUCLEARES UP-REGULATION (FISIOLOGIA) Location: BR191.1; 07010/s

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Id: 9665 Author: Kaufmann, Stefan H. E; Follows, George A; Munk, Martin E Title: Immunity to intracellular bacteria ..- Source: s.l; s.n; 1992. 4 p. . Descriptors: BACTÉRIAS TUBERCULOSE HANSENIASE MACROFAGOS LINFOCITOS T CD4-POSITIVOS INTERLEUCINAS Location: BR191.1; 06502/s

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Id: 9574 Author: Salgame, Padmini; Abrams, John S; Clayberger, Carol; Goldstein, Harris; Convit, Jacinto; Modlin, Robert L; Bloom, Barry R Title: Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones ..- Source: s.l; s.n; 1991. 4 p. ilus, tab. Descriptors: HANSENIASE FORMAÇAO DE ANTICORPOS ANTIGENOS CD4 ANTIGENOS CD8 LINFOCITOS T CD4-POSITIVOS CÉLULAS CLONAIS INTERFERON TIPO II INTERLEUCINA-4 INTERLEUCINAS LINFOCINAS LINFOCITOS T SUB-POPULAÇOES DE LINFOCITOS T Location: BR191.1; 06289/s

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Id: 9280 Author: Kaufmann, Stefan H. E Title: The macrophage in tuberculosis: sinner or saint? The T cell decides ..- Source: s.l; s.n; 1991. 3 p. ilus. Descriptors: INTERLEUCINAS HANSENIASE MACROFAGOS RECEPTORES DE ANTIGENO DA CÉLULA-T SUB-POPULAÇOES DE LINFOCITOS SUB-POPULAÇOES DE LINFOCITOS T TUBERCULOSE Location: BR191.1; 06239/s

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