Database : HANSEN Search on : LIPOSSOMOS [Subject descriptor] References found : 6 [refine] Displaying: 1 .. 6   in format [Detailed]

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Id: 13666 Author: Bala, Lakshmi; Anand, Sukumar; Sinha, Sudhir Title: Enhancement of human T cell response to a peptide epitope of 38kDa antigen of Mycobacterium tuberculosis by liposomes ..- Source: s.l; s.n; 2002. 9 p. graf. Abstract: Diagnosis of tuberculosis a problem, specially in the regions harboring an abundance of both pathogenic and non-pathogenic mycobacteria. This study was undertaken to assess in such a situation the predictive value of proliferative T cell response to a peptide epitope ('38G') of the 38 kDa membrane protein of Mycobacterium tuberculosis. 3[H]-thymidine incorporation assays were done with peripheral blood mononuclear cells of tuberculoid leprosy and pulmonary tuberculosis patients. The donors were also classified as PPD responders (Stimulation Index, SI> 3) or non-responders (SI < or = 3) on the basis of their T cell response to the 'Purified Protein Derivative (PPD)' of M. tuberculosis. 38G peptide was used in either free or liposome-associated form prepared by the technique of 'Dehydration-rehydration Vesicles' (Kirby and Gregoriadis, 1984). While free peptide failed to induce a positive response in study subjects, its liposomal form was T cell stimulatory and distinguished, to certain extent, between PPD responders (corresponding SI > 3 in 54 per cent subjects) and non-responders (SI > 3 in 29 per cent subjects). However, it did not differentiate between leprosy and tuberculosis. The study supports use of liposomes as adjuvant vehicles for antigenic peptides designed to activate human T cells. (AU). Descriptors: ANTIGENOS DE BACTERIAS/admin ANTIGENOS DE BACTERIAS/quim ANTIGENOS DE BACTERIAS/genet HANSENIASE TUBERCULOIDE/diag HANSENIASE TUBERCULOIDE/imunol EPITOPOS/admin EPITOPOS/quim EPITOPOS/genet DIAGNOSTICO DIFERENCIAL MYCOBACTERIUM TUBERCULOSIS/quim MYCOBACTERIUM TUBERCULOSIS/genet MYCOBACTERIUM TUBERCULOSIS/imunol DADOS DE SEQUÊNCIA MOLECULAR SEQUÊNCIA DE AMINOACIDOS LINFOCITOS T/imunol TESTE TUBERCULINICO TUBERCULOSE PULMONAR/diag TUBERCULOSE PULMONAR/imunol TRANSFORMACAO LINFOCITICA - LIPOSSOMOS  PESO MOLECULAR Limits: ESTUDO COMPARATIVO HUMANO IN VITRO SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 09061/s

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Id: 11325 Author: Medda, S; Das, N; Mahato, S. B; Mahadevan, P. R; Basu, M. K Title: Glycoside-bearing liposomal delivery systems against macrophage-associated disorders involving mycobacterium leprae and mycobacterium tuberculosis ..- Source: s.l; s.n; jun. 1995. 5 p. ilus, graf. Descriptors: PORTADORES DE DROGAS HANSENIASE LIPOSSOMOS MACROFAGOS CAMUNDONGOS MYCOBACTERIUM LEPRAE MYCOBACTERIUM TUBERCULOSIS TRITERPENOS TUBERCULOSE Limits: ESTUDO COMPARATIVO ANIMAL Location: BR191.1; 07264/s

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Id: 10251 Author: Bermudez, Luiz E Title: Use of liposome preparation to treat mycobacterial infections ..- Source: s.l; s.n; 1994. 6 p. . Descriptors: INFECÇOES OPORTUNISTAS RELACIONADAS COM A AIDS INFECÇOES OPORTUNISTAS RELACIONADAS COM A AIDS ANTIINFECCIOSOS ANTITUBERCULOSOS PORTADORES DE DROGAS HANSENIASE LIPOSSOMOS MICOBACTERIOSE MICOBACTERIOSE INFECÇAO POR MYCOBACTERIUM AVIUM-INTRACELLULARE TUBERCULOSE TUBERCULOSE RESISTENTE A MULTIPLAS DROGAS Location: BR191.1; 06961/s

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Id: 10167 Author: Bermudez, Luiz E Title: Use of liposome preparation to treat mycobacterial infections ..- Source: s.l; s.n; 1994. 6 p. . Descriptors: HANSENIASE INFECÇOES OPORTUNISTAS RELACIONADAS COM A AIDS INFECÇOES OPORTUNISTAS RELACIONADAS COM A AIDS ANTIINFECCIOSOS ANTITUBERCULOSOS PORTADORES DE DROGAS LIPOSSOMOS MICOBACTERIOSE INFECÇAO POR MYCOBACTERIUM AVIUM-INTRACELLULARE TUBERCULOSE TUBERCULOSE RESISTENTE A MULTIPLAS DROGAS Location: BR191.1; 07080/s

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Id: 10105 Author: Moura, A. C. N; Modolell, M; Mariano, M Title: Down-regulatory effect of Mycobacterium leprae cell wall lipids on phagocytosis, oxidative respiratory burst and tumour cell killing by mouse bone marrow derived macrophages ..- Source: s.l; s.n; 1997. 6 p. ilus, tab, graf. Descriptors: PAREDE CELULAR DEPRESSAO QUIMICA HANSENIASE LIPIDIOS LIPIDIOS LIPOSSOMOS ATIVAÇAO DE MACROFAGOS MACROFAGOS MACROFAGOS MACROFAGOS CAMUNDONGOS CAMUNDONGOS ENDOGAMICOS BALB C CAMUNDONGOS ENDOGAMICOS C57BL MYCOBACTERIUM LEPRAE FAGOCITOSE EXPLOSAO RESPIRATORIA SUPEROXIDOS CELULAS DA MEDULA OSSEA/*DE/PH CELULAS CULTIVADAS Limits: ANIMAL Location: BR191.1; 07046/s

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Id: 9488 Author: Schauf, Victoria; Holobaugh, Pat; Miller, Pamela; Mittal, Kamal Title: Sensitization in vitro of human peripheral blood mononuclear cells to phenolic glycolipid 1 of Mycobacterium leprae in liposomes ..- Source: s.l; s.n; 1991. 7 p. tab, graf. Descriptors: ANTIGENOS DE BACTÉRIAS POLIIDROXIETIL METACRILATO GLICOLIPIDIOS GLICOLIPIDIOS HEMOCIANINA TOLERANCIA IMUNOLOGICA LEUCOCITOS MONONUCLEARES LIPOSSOMOS TRANSFORMAÇAO LINFOCITICA MYCOBACTERIUM LEPRAE CELULAS CULTIVADAS Limits: IN VITRO Location: BR191.1; 06344/s

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