Database : HANSEN Search on : DAPSONA/METAB [Subject descriptor] References found : 5 [refine] Displaying: 1 .. 5   in format [Detailed]

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Id: 13195 Author: George, Joseph; Balakrishnan, S; Bhatia, V. N Title: Drug interaction during multidrug regimens for treatment of leprosy ..- Source: s.l; s.n; feb. 1988. 6 p. tab. Abstract: The influence of concurrently rifampicin and clofazimine on the metabolism of 4,4'-diaminodiphenyl sulfone (dapsone, DDS) has been studied in 30 subjects on multidrug regimens for treatment of leprosy. Plasma and urinary levels of drugs were determined on days 2,8 and 15 after administration of the drug, while cretinine levels in urine were also determined to overcome the effect of diuresis. During concurrent administration of rifampicin the plasma levels of DDS gradually fell from day 2 to day 15 of rifampicin administration and the decrease was most significant on day 15. Clofazimine did not exert any such influence on DDS metabolism. A comparison of urine and plasma levels of DDS during the course of treatment. The findings suggest that during concurrent administration of DDS and rifampicin, the intake of DDS shoud be regular and uninterrupted.(AU). Descriptors: HANSENIASE/quimioter QUIMIOTERAPIA COMBINADA ESQUEMA DE MEDICACAO DAPSONA/admin DAPSONA/metab INTERACOES DE MEDICAMENTOS CLOFAZIMINA/uso terapeutico RIFAMPINA/uso terapeutico Limits: HUMANO SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 02088/s

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Id: 9606 Author: Illet, Kenneth F; Chiswell, Gregory M; Spargo, Randolph M; Platt, Elanor; Minchin, Rodney F Title: Acetylation phenotype and genotype in Aboriginal leprosy patients from the north-west region of Western Australia ..- Source: s.l; s.n; 1993. 6 p. tab, graf. Descriptors: ABORIGENES ACETILAÇAO ADOLESCENCIA AUSTRALIA RAÇA AUSTRALOIDE DAPSONA DAPSONA GENOTIPO HANSENIASE HANSENIASE FENOTIPO POLIMORFISMO (GENÉTICA) ARILAMINA N-ACETILTRANSFERASE/*GE/*ME Location: BR191.1; 06586/s

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Id: 475 Author: Peters, J. H; Gordon, G. R; Gelber, R; Levy, L. Title: Studies on the metabolism of dapsona in rabbits and man. Source: In: Annual Leprosy Research Conference, 4.Annual Leprosy Research Conference, 4/Abstracts of papers. San Francisco, U.S. Public Health Service Hospital, 1969. p.463. Conference: Present in: Annual Leprosy Research Conference, 4, San Francisco, 26-28 May 1969. Descriptors: DAPSONA TERAPEUTICA Limits: COELHOS HUMANO ESTUDO COMPARATIVO Location: BR191.1; WC335.3, A78a

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Id: 448 Author: Peters, J. H; Gordon, G. R; Karat, A. B. A; Meyers, W. M. Title: Metabolic disposition of dapsone in Indian and African subjects. Source: In: Annual Leprosy Research Conference, 7.Annual Leprosy Research Conference, 7/Abstracts. California, National Institute of Health, 1972. p.26-7. Conference: Present in: Annual Leprosy Research Conference, 7, California, 29 Feb.-01 Mar. 1972. Descriptors: HANSENIASE METABOLISMO DAPSONA INDIA AFRICA Location: BR191.1; WC335.3, 78a

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Id: 412 Author: Biggs, John T; Levy, Louis. Title: Renal and biliary clearance of dapsone (DDS) in the dog. Source: In: Annual Leprosy Research Conference, 6.Annual Leprosy Research Conference, 6/Abstracts. Atlanta, Center for Disease Control, 1971. p.14. Conference: Present in: Annual Leprosy Research Conference, 6, Atlanta, 10-12 March 1971. Descriptors: DAPSONA DAPSONA DAPSONA FIGADO FIGADO RIM RIM RIM Limits: CAES Location: BR191.1; WC335.3, A78a

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