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Id: 24187 Autor: Arruda, M. S.M; Astolfi, C. S. Título: Algumas consideraçoes a respeito da reaçao de Rubino / ver / Some considerations regarding the reaction of Rubino Fonte: Hansen. int;10(1/2):5-9, Jan-Dez. 1985. tab. Resumo: Sao comentados alguns aspectos relativos a reaçao de Rubino, visando tanto uma melhor identificaçao dos elementos envolvidos como despertar o interesse dos pesquisadores para esta prova. Os seguintes aspectos sao discutidos: 1) influencia da temperatura sobre os elementos da reaçao; 2) correlaçao entre a reaçao de Rubino e: a) alteraçao humorais observadas na hanseniase, b) imunidade mediata por celulas; 3) variaçoes na reatividade sorologica; 4) valor prognostico e crerio de cura.(AU). Descritores: HANSENIASE/compl HANSENIASE/diag HANSENIASE/imunol IMUNIDADE CELULAR/imunol IMUNIDADE CELULAR/fisiol MYCOBACTERIUM LEPRAE/imunol MYCOBACTERIUM LEPRAE/fisiol Limites: ESTUDO COMPARATIVO HUMANO Meio Eletrônico: http://hansen.bvs.ilsl.br/textoc/hansenint/v01aov20/1985/PDF/v10n1-2a02.pdf - Pt. Localização: BR191.1

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Id: 23973 Autor: Scollard, D. M; Adams, L. B; Gillis, T. P; Krahenbuhl, J. L; Truman, R. W; Williams, D. L Título: The continuing challenges of leprosy ..- Fonte: s.l; s.n; 2006. 44 p. ilus, tab. Resumo: Leprosy is best understood as two conjoined diseases. The first is a chronic mycobacterial infection that elicits an extraordinary range of cellular immune responses in humans. The second is a peripheral neuropathy that is initiated by the infection and the accompanying immunological events. The infection is curable but not preventable, and leprosy remains a major global health problem, especially in the developing world, publicity to the contrary notwithstanding. Mycobacterium leprae remains noncultivable, and for over a century leprosy has presented major challenges in the fields of microbiology, pathology, immunology, and genetics; it continues to do so today. This review focuses on recent advances in our understanding of M. leprae and the host response to it, especially concerning molecular identification of M. leprae, knowledge of its genome, transcriptome, and proteome, its mechanisms of microbial resistance, and recognition of strains by variable-number tandem repeat analysis. Advances in experimental models include studies in gene knockout mice and the development of molecular techniques to explore the armadillo model. In clinical studies, notable progress has been made concerning the immunology and immunopathology of leprosy, the genetics of human resistance, mechanisms of nerve injury, and chemotherapy. In nearly all of these areas, however, leprosy remains poorly understood compared to other major bacterial diseases. (AU). Descritores: Antiinfecciosos/TU Proteínas de Bactérias/ME Vacinas Bacterianas Modelos Animais de Doenças Suscetibilidade à Doença/IM Resistência Bacteriana a Drogas Genes Bacterianos/GE Predisposição Genética para Doença Genoma Bacteriano Imunidade Celular Imunidade Natural/GE Hansenostáticos/PD/TU Hanseníase/*/DI/MI/TH Mycobacterium leprae/*/CH/DE/IP/PH Nervos Periféricos/MI Doenças do Sistema Nervoso Periférico/MI/PA Reação em Cadeia da Polimerase Research Support, N.I.H., Extramural Células de Schwann/IM/MI Limites: HUMANO ANIMAL CAMUNDONGOS SUPPORT, NON-U.S. GOV'T Localização: BR191.1; 09365/S

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Id: 23188 Autor: Bottasso, O. A; Morini, J. C Título: Imunopatologia de la lepra Immunopathology of leprosy- Fonte: s.l; s.n; 1989. 3 p. . Resumo: Se comentan los estudios en convivientes íntimos de enfermos de Lepra, donde se observó una relación inversa entre grado y tiempo de exposición al Mycobacterium leprae (MI) y la magnitud de la respuesta inmune in vivo hacia el bacilo (reacción de Mitsuda); esta variable por otro lado, se halla influenciada por un importante grado de determinación genética. En un modelo murino experimental, la artritis por adyuvante, también se comprobó que el tratamiento con MI inducia una población de células esplénicas supresoras, con actividad regulatoria sobre la respuesta inmune celular. Se plantean además, las posible alteraciones inmunorregulatorias involucradas con la excesiva respuesta humoral que sirve de sustrato para la generación del episodio de eritema nudoso leproso (ENL) (AU). Descritores: Imunidade Celular Formação de Anticorpos HANSENIASE/genet HANSENIASE/imunol ARTRITE EXPERIMENTAL/terap TRANSFORMACAO LINFOCITICA ANTIGENO DE MITSUDA/imunol MYCOBACTERIUM LEPRAEMURIUM/imunol Limites: HUMANO ANIMAL RATOS Localização: BR191.1; 09332/s

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Id: 22688 Autor: Schmutzhard, E; Fuchs, D; Hausen, A; Reibnegger, G; Wachter, H Título: Is neopterin - a marker of cellmediated immune response - helpful in classifying leprosy? ..- Fonte: s.l; s.n; 1986. 4 p. . Resumo: The urinary excretion of neopterin, an indicator of cellular immune response, was measured in patients suffering from leprosy. No difference was found between the BT+T group and BL + L group. All age groups presented with similar urinary neopterin excretion. There was no correlation apparent batween the duration of disease and urinary neopterin excretion. Whether the most recent skin smear was positive or negative, did not make any difference. Similary, prior medication did not play any role in influencing urinary neopterin excretion. Urinary neopterin excretion is of little value in classifying leprosy, but it might be of some value in long-term follow-up and in determining the activity of the disease and the efficacy of therapy. (AU). Descritores: Biopterina/*AA/UR Imunidade Celular/* Hanseníase/*CL/IM/UR Neopterina Limites: HUMANO MASCULINO FEMININO CRIANÇA ADULTO MEIA-IDADE IDOSO Adolescente Localização: BR191.1; 09185/s

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Id: 22674 Autor: Bleharski, Joshua R; Li, Huiying; Meinken, Cristoph; Graeber, Thomas G; Ochoa, Maria-Teresa; Yamamura, Masahiro; Burdick, Anne; Sarno, Euzenir N; Wagner, Manfred; Röllinghoff, Martin; Rea, Thomas H; Colonna, Marco; Stenger, Steffen; Bloom, Barry R; Eisenberg, David; Modlin, Robert L Título: Use of genetic profiling in leprosy to discriminate clinical forms of the disease ..- Fonte: s.l; s.n; 2003. 4 p. . Resumo: Leprosy presents as a clinical and immunological spectrum of disease. With the use of gene expression profiling, we observed that a distinction in gene expression correlates with and accurately classifies the clinical form of the disease. Genes belonging to the leukocyte immunoglobulin-like receptor (LIR) family were significantly up-regulated in lesions of lepromatous patients suffering from the disseminated form of the infection. In functional studies, LIR-7 suppressed innate host defense mechanisms by shifting monocyte production from interleukin-12 toward interleukin-10 and by blocking antimicrobial activity triggered by Toll-like receptors. Gene expression profiles may be useful in defining clinical forms of disease and providing insights into the regulation of immune responses to pathogens. (AU). Descritores: Algoritmos Análise por Conglomerados Contagem de Colônia Microbiana Citocinas/GE/ME Perfilação da Expressão Gênica/* Regulação da Expressão Gênica/* Genes de Imunoglobulinas Imunidade Celular Imunidade Natural Hanseníase Virchowiana/*CL/*GE/IM/PP Hanseníase Tuberculóide/*CL/*GE/IM/PP Macrófagos Alveolares/MI Glicoproteínas de Membrana/IM Mycobacterium tuberculosis/GD/IM Análise de Sequência com Séries de Oligonucleotídeos Reação em Cadeia da Polimerase Análise de Componente Principal Receptores da Superfície Celular/IM Receptores Imunológicos/GE/ME Limites: Humano Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. Regulação para Cima Localização: BR191.1; 09174/s

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Id: 18986 Autor: Krutzik, Stephan R; Ochoa, Maria Teresa; Sieling, Peter A; Uematsu, Satoshi; Ng, Yolanda W; Legaspi, Annaliza; Liu, Philip T; Cole, Stewart T; Godowski, Paul J; Maeda, Yumi; Sarno, Euzenir N; Norgard, Michael V; Brennan, Patrick J; Akira, Shizuo; Rea, Thomas H; Modlin, Robert L Título: Activation and regulation of toll-like receptors 2 and 1 in human leprosy ..- Fonte: s.l; s.n; 2003. 8 p. ilus, graf. Resumo: The expression and activation of Toll-like receptors (TLRs) was investigated in leprosy, a spectral disease in which clinical manifestations correlate with the type of immune response mounted toward Mycobacterium leprae. TLR2-TLR1 heterodimers mediated cell activation by killed M. leprae, indicating the presence of triacylated lipoproteins. A genome-wide scan of M. leprae detected 31 putative lipoproteins. Synthetic lipopeptides representing the 19-kD and 33-kD lipoproteins activated both monocytes and dendritic cells. Activation was enhanced by type-1 cytokines and inhibited by type-2 cytokines. In addition, interferon (IFN)-gamma and granulocyte-macrophage colony-stimulating factor (GM-CSF) enhanced TLR1 expression in monocytes and dendritic cells, respectively, whereas IL-4 downregulated TLR2 expression. TLR2 and TLR1 were more strongly expressed in lesions from the localized tuberculoid form (T-lep) as compared with the disseminated lepromatous form (L-lep) of the disease. These data provide evidence that regulated expression and activation of TLRs at the site of disease contribute to the host defense against microbial pathogens. (AU). Descritores: CITOCINAS/fisiol HANSENIASE/imunol IMUNIDADE NATURAL LIPOPROTEINAS/anal GLICOPROTEINAS DE MEMBRANA/anal GLICOPROTEINAS DE MEMBRANA/fisiol RECEPTORES DA SUPERFICIE CELULAR/anal RECEPTORES DA SUPERFICIE CELULAR/fisiol Limites: HUMANO ANIMAL CAMUNDONGOS SUPPORT, NON-U.S. GOV'T SUPPORT, U.S. GOV'T, P.H.S. Meio Eletrônico: - . Localização: BR191.1; 09113/s

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Id: 18953 Autor: Bochud, Pierre-Yves; Hawn, Thomas R; Aderem, Alan Título: Cutting edge: a toll-like receptor 2 polymorphism that is associated with lepromatous leprosy is unable to mediate mycobacterial signaling ..- Fonte: s.l; s.n; 2003. 4 p. graf. Resumo: Toll-like receptors (TLRs) are key mediators of the innate immune response to microbial pathogens. We investigated the role of TLRs in the recognition of Mycobacterium leprae and the significance of TLR2Arg(677)Trp, a recently discovered human polymorphism that is associated with lepromatous leprosy. In mice, TNF-alpha production in response to M. leprae was essentially absent in TLR2-deficient macrophages. Similarly, human TLR2 mediated M. leprae-dependent activation of NF-kappaB in transfected Chinese hamster ovary and human embryonic kidney 293 cells, with enhancement of this signaling in the presence of CD14. In contrast, activation of NF-kappaB by human TLR2Arg(677)Trp was abolished in response to M. leprae and Mycobacterium tuberculosis. The impaired function of this TLR2 variant provides a molecular mechanism for the poor cellular immune response associated with lepromatous leprosy and may have important implications for understanding the pathogenesis of other mycobacterial infections. (AU). Descritores: CELULAS CHO LINHAGEM CELULAR IMUNIDADE NATURAL/genet ARGININA/genet HANSENIASE VIRCHOWIANA/genet HANSENIASE VIRCHOWIANA/imunol HANSENIASE VIRCHOWIANA/microbiol GLICOPROTEINAS DE MEMBRANA/defic GLICOPROTEINAS DE MEMBRANA/genet GLICOPROTEINAS DE MEMBRANA/fisiol CAMUNDONGOS ENDOGÂMICOS C57BL CAMUNDONGOS KNOCKOUT MYCOBACTERIUM LEPRAE/imunol MYCOBACTERIUM TUBERCULOSIS/imunol POLIMORFISMO DE UM UNICO NUCLEOTIDIO/imunol TRANSDUCAO DE SINAL/imunol TRIPTOFANO/genet RECEPTORES DA SUPERFICIE CELULAR/defic RECEPTORES DA SUPERFICIE CELULAR/genet RECEPTORES DA SUPERFICIE CELULAR/fisiol Limites: HUMANO ANIMAL HAMSTERS CAMUNDONGOS SUPPORT, NON-U.S. GOV'T SUPPORT, U.S. GOV'T, P.H.S. Meio Eletrônico: - . Localização: BR191.1; 09085/s

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Id: 18582 Autor: Lawn, S. D; Wood, C; Lockwood, D. N Título: Borderline tuberculoid leprosy: an immune reconstitution phenomenon in a human immunodeficiency virus-infected person ..- Fonte: s.l; s.n; 2003. 2 p. ilus. Resumo: Two months after starting highly active antiretroviral treatment (HAART), an individual with human immunodeficiency virus type 1 (HIV-1) infection and profound CD4+ T lymphocytopenia developed several erythematous plaques on his face, which were due to borderline tuberculoid leprosy with reversal reaction. The temporal association between the development of these lesions and changes in blood CD4+ lymphocyte count and plasma HIV-1 load observed during HAART strongly suggests that the presentation of leprosy resulted from immune reconstitution. (AU). Descritores: INFECCOES OPORTUNISTAS RELACIONADAS COM A AIDS/imunol AGENTES ANTI-HIV/uso terap TERAPIA ANTI-RETROVIRAL DE ALTA ATIVIDADE/ef adv CONTAGEM DE LINFOCITO CD4 INFECCOES POR HIV/compl INFECCOES POR HIV/quimioter INFECCOES POR HIV/imunol HANSENIASE TUBERCULOIDE/etiol HANSENIASE TUBERCULOIDE/imunol IMUNIDADE/ef drogas Limites: RELATO DE CASO HUMANO MASCULINO ADULTO Meio Eletrônico: - . Localização: BR191.1; 09026/s

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Id: 18580 Autor: Oliveira, Rosane B; Ochoa, Maria T; Sieling, Peter A; Rea, Thomas H; Rambukkana, Anura; Sarno, Euzenir N; Modlin, Robert L Título: Expression of toll-like receptor 2 on human Schwann cells: a mechanism of nerve damage in leprosy ..- Fonte: s.l; s.n; 2003. 7 p. ilus, graf. Resumo: Nerve damage is a clinical hallmark of leprosy and a major source of patient morbidity. We investigated the possibility that human Schwann cells are susceptible to cell death through the activation of Toll-like receptor 2 (TLR2), a pattern recognition receptor of the innate immune system. TLR2 was detected on the surface of human Schwann cell line ST88-14 and on cultured primary human Schwann cells. Activation of the human Schwann cell line and primary human Schwann cell cultures with a TLR2 agonist, a synthetic lipopeptide comprising the N-terminal portion of the putative Mycobacterium leprae 19-kDa lipoprotein, triggered an increase in the number of apoptotic cells. The lipopeptide-induced apoptosis of Schwann cells could be blocked by an anti-TLR2 monoclonal antibody. Schwann cells in skin lesions from leprosy patients were found to express TLR2. It was possible to identify in the lesions Schwann cells that had undergone apoptosis in vivo. The ability of M. leprae ligands to induce the apoptosis of Schwann cells through TLR2 provides a mechanism by which activation of the innate immune response contributes to nerve injury in leprosy. (AU). Descritores: APOPTOSE CELULAS CULTIVADAS DANO DO DNA IMUNIDADE NATURAL HANSENIASE/imunol HANSENIASE/patol LIPOPROTEINAS/fisiol CELULAS DE SCHWANN/patol GLICOPROTEINAS DE MEMBRANA/anal GLICOPROTEINAS DE MEMBRANA/fisiol RECEPTORES DA SUPERFICIE CELULAR/anal RECEPTORES DA SUPERFICIE CELULAR/fisiol Limites: HUMANO SUPPORT, NON-U.S. GOV'T SUPPORT, U.S. GOV'T, P.H.S Meio Eletrônico: - . Localização: BR191.1; 09028/s

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Id: 18504 Autor: Bleharski, Joshua R; Li, Huiying; Meinken, Christoph; Graeber, Thomas G; Ochoa, Maria-Teresa; Yamamura, Masahiro; Burdick, Anne; Sarno, Euzenir N; Wagner, Manfred; Röllinghoff, Martin; Rea, Thomas H; Colonna, Marco; Stenger, Steffen; Bloom, Barry R; Eisenberg, David; Modlin, Robert L Título: Use of genetic profiling in leprosy to discriminate clinical forms of the disease ..- Fonte: s.l; s.n; Sep. 2003. 4 p. graf. Resumo: Leprosy presents as a clinical and immunological spectrum of disease. With the use of gene expression profiling, we observed that a distinction in gene expression correlates with and accurately classifies the clinical form of the disease. Genes belonging to the leukocyte immunoglobulin-like receptor (LIR) family were significantly up-regulated in lesions of lepromatous patients suffering from the disseminated form of the infection. In functional studies, LIR-7 suppressed innate host defense mechanisms by shifting monocyte production from interleukin-12 toward interleukin-10 and by blocking antimicrobial activity triggered by Toll-like receptors. Gene expression profiles may be useful in defining clinical forms of disease and providing insights into the regulation of immune responses to pathogens. (AU). Descritores: HANSENIASE VIRCHOWIANA/clas HANSENIASE VIRCHOWIANA/genet HANSENIASE VIRCHOWIANA/imunol HANSENIASE VIRCHOWIANA/fisiopatol HANSENIASE TUBERCULOIDE/clas HANSENIASE TUBERCULOIDE/genet HANSENIASE TUBERCULOIDE/imunol HANSENIASE TUBERCULOIDE/fisiopatol CITOCINAS/genet CITOCINAS/metab PERFILACAO DA EXPRESSÃO GÊNICA ANALISE POR CONGLOMERADOS CONTAGEM DE COLÔNIA MICROBIANA REGULACAO DA EXPRESSÃO GÊNICA IMUNIDADE CELULAR IMUNIDADE NATURAL MACROFAGOS ALVEOLARES/microbiol GLICOPROTEINAS DE MEMBRANA/imunol MYCOBACTERIUM TUBERCULOSIS/cresc MYCOBACTERIUM TUBERCULOSIS/imunol REACAO EM CADEIA DA POLIMERASE RECEPTORES IMUNOLOGICOS/genet RECEPTORES IMUNOLOGICOS/metab RECEPTORES DA SUPERFICIE CELULAR/imunol - REGULACAO PARA CIMA  Análise de Componente Principal  ALGORITMOS  GENES DE IMUNOGLOBULINAS  ANALISE DE SEQUÊNCIA COM SERIES DE OLIGONUCLEOTIDIOS Limites: SUPPORT, NON-U.S. GOV'T HUMANO SUPPORT, U.S. GOV'T, P.H.S. Meio Eletrônico: - . Localização: BR191.1; 09142/s; BR191.1; 09145/s

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Id: 18467 Autor: Kang, Tae Jin; Lee, Seong-Beom; Chae, Gue-Tae Título: A polymorphism in the toll-like receptor 2 is associated with IL-12 production from monocyte in lepromatous leprosy ..- Fonte: s.l; s.n; Oct. 2002. 7 p. graf. Resumo: Toll-like receptor 2 (TLR2) is critical in the immune response to mycobacterial infections, and the mutations in the TLR2 have been shown to confer the susceptibility to infection with mycobacteria. We previously reported the detection of TLR2 Arg677Trp mutation in lepromatous leprosy. Here, the events triggered by TLR2 in response to cell lysate of Mycobacterium leprae(MLL), the causative agent of leprosy, were investigated. Upon stimulation with MLL, monocytes produced TNF-alpha and Interleukin-12 (IL-12), which play a role in the innate immune response to infection. Anti-TLR2 mAb blocked greater than 50 per cent of the MLL-induced production of IL-12. We also performed the functional study on TLR2 by measurement of IL-12 production in serum and monocytes from leprosy patients with TLR2 mutation (Arg677Trp). The monocytes obtained from patients with the TLR2 mutation, in comparison to the wild-type TLR2, is significantly less responsive to MLL. It was also confirmed that patients with TLR2 mutation showed significantly lower serum levels of IL-12, in comparing with TLR2 wild-type. Our results reveal that innate immune response of monocytes against M. lepraeis mediated by TLR2, and suggest that the mutation in the intracellular domain of TLR2 gene is associated with IL-12 production in lepromatous leprosy. (AU). Descritores: SEQUÊNCIA DE AMINOACIDOS SEQUÊNCIA DE BASES ESTUDOS DE CASOS E CONTROLES DNA COMPLEMENTAR/genet IMUNIDADE NATURAL INTERLEUCINA-12/bios HANSENIASE VIRCHOWIANA/genet HANSENIASE VIRCHOWIANA/imunol GLICOPROTEINAS DE MEMBRANA/quim GLICOPROTEINAS DE MEMBRANA/genet MONOCITOS/imunol MYCOBACTERIUM LEPRAE/imunol MUTACAO PUNTUAL POLIMORFISMO (GENETICA) ESTRUTURA TERCIARIA DE PROTEINA RECEPTORES DA SUPERFICIE CELULAR/quim RECEPTORES DA SUPERFICIE CELULAR/genet FATOR DE NECROSE TUMORAL/bios Limites: HUMANO SUPPORT, NON-U.S. GOV'T HUMANO IN VITRO Meio Eletrônico: - . Localização: BR191.1; 09004/s

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Id: 18421 Autor: Godal, Tore; Negassi, Kesete Título: Subclinical infection in leprosy ..- Fonte: s.l; s.n; September 15, 1973. 3 p. tab. Resumo: Lymphocyte transformation has been used to study the immune response to Mycobacterium leprae aomng contacts and non-contacts of leprosy patients. Of 26 subjects living a leprosy endemic area for less than two months none responded to M. leprae; 24% of subjects who had lived in an endemic area for more than a year gave a positive response to M. leprae; more than 50% of individuals with occupational contact of leprosy for more than a year responded; and about 50% of caontacts of tuberculoid and treated lepromatous patients responded to M. leprae, while only 22% (4/18) of contacts of leproamtous patients treated for less than six months responded. It seems that leprosy is more highly infectious than is indicated by the prevalence of the disease and that a subclinical infection commonly follows exposure to M. leprae. The relatively low response found in contacts of active lepromatous patients suggests that in these contacts "superexposure" to M. leprae can bring about a decrease in host resistance.(AU). Descritores: TRANSFORMACAO LINFOCITICA ETIOPIA HABITACAO IMUNIDADE HANSENIASE/genet HANSENIASE/imunol HANSENIASE/microbiol MYCOBACTERIUM BOVIS/imunol MYCOBACTERIUM LEPRAE/imunol - FATORES DE TEMPO  DOENCAS OCUPACIONAIS Limites: HUMANO Meio Eletrônico: - . Localização: BR191.1; 00624

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Id: 18416 Autor: Storrs, Eleanor E; Walsh, G. P; Burchfield, H. P Título: Development of leprosy in another species of armadillo Dasypus hybridus (L): genetic and immunologic implications ..- Fonte: s.l; s.n; Oct-Nov. 1975. 3 p. ilus. Resumo: The leprosy bacillus (Mycobacterium leprae) was discovered in 1873 and was the first bacterium to be associated with a human disease; yet leprosy is one of the least understood of all bacterial diseases.(AU). Descritores: XENARTROS/microbiol TEMPERATURA CORPORAL IMUNIDADE CELULAR TATUS/microbiol HANSENIASE/imunol HANSENIASE/microbiol HANSENIASE/vet MYCOBACTERIUM LEPRAE/cresc MYCOBACTERIUM LEPRAE/imunol Limites: ANIMAL Meio Eletrônico: - . Localização: BR191.1; 01408/s

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Id: 18409 Autor: Varkey, Basil; Rose, Harold D; Lohaus, Gerhard; Sohnle, Peter G Título: Blastomycosis: clinical and immunologic aspects ..- Fonte: s.l; s.n; jun. 1980. 7 p. ilus, tab. Resumo: Dr. Basil Varkey: Blastomycosis was first described by Gilchrist in 1894. For some 50 years thereafter, progress in the understanding of the various aspects of this disease evolved very slowly.(AU). Descritores: IMUNIDADE CELULAR DERMATOMICOSES/diag PNEUMOPATIAS FUNGICAS/diag PNEUMOPATIAS FUNGICAS/quimioter PNEUMOPATIAS FUNGICAS/imunol BLASTOMICOSE/diag BLASTOMICOSE/quimioter BLASTOMICOSE/imunol BLASTOMYCES ANFOTERICINA B/uso terap Limites: RELATO DE CASO HUMANO MASCULINO ADULTO MEIA-IDADE Meio Eletrônico: - . Localização: BR191.1; 00489/s

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Id: 18390 Autor: Rees, R. J; Waters, M. F; Weddell, A. G; Palmer, E Título: Experimental lepromatous leprosy ..- Fonte: s.l; s.n; August 5, 1967. 4 p. ilus, tab, graf. Resumo: LEPROSY is the result of infection by Mycobacterium leprae-bacilli which are closely realted to those responsible for tuberculosis. Myco. leprae, however, unlike Myco. tuberculosis, cannot as yet gown in vitro, and to such a limited extent in vivo that progress in the aetiology and treatment of the disease is making little headway.(AU). Descritores: HANSENIASE/patol IMUNIDADE/ef rad MYCOBACTERIUM LEPRAE/cresc TIMECTOMIA Limites: ANIMAL FEMININO CAMUNDONGOS Meio Eletrônico: - . Localização: BR191.1; 00492/s

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Id: 18366 Autor: Freiberger, Harley F; Fudenberg, H. Hugh Título: An appetite for armadillo ..- Fonte: s.l; s.n; jun. 1981. 8 p. ilus. Resumo: In October 1979, a 70-year-old man was referred and admitted to the Medical University of South Carolina Hospital. Three or four years earlier, he had begun to notice the appearance of raised, nontender lumps on his arms and legs.(AU). Descritores: DOENCAS DO COMPLEXO IMUNE/imunol IMUNIDADE CELULAR HANSENIASE/imunol PLASMAFERESE LINFOCITOS T/imunol Limites: RELATO DE CASO HUMANO MASCULINO IDOSO Meio Eletrônico: - . Localização: BR191.1; 01472/s

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Id: 18358 Autor: Convit, Jacinto; Ulrich, Marian Título: Recent advances in the immunology of leprosy ..- Fonte: s.l; s.n; apr. 1976. 14 p. ilus. Resumo: For many decades, interest in leprosy has been largely limited to those areas of the tropical and subtropical world where the disease constitutes an important public health problem.(AU). Descritores: ANTICORPOS ANTIBACTERIAS COMPLEXO ANTIGENO-ANTICORPO REACOES ANTIGENO-ANTICORPO TECNICAS IMUNOLOGICAS HANSENIASE/quimioter HANSENIASE/imunol HANSENIASE/patol LINFOCITOS/imunol MACROFAGOS/imunol MYCOBACTERIUM LEPRAE/imunol - IMUNIZACAO PASSIVA  SINDROMES DE DEFICIÊNCIA IMUNOLOGICA/imunol  IMUNOTERAPIA  VACINACAO  IMUNIDADE  IMUNIDADE CELULAR  TATUS/imunol  MODELOS ANIMAIS DE DOENCAS Limites: HUMANO ANIMAL Meio Eletrônico: - . Localização: BR191.1; 00578/s

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Id: 18350 Autor: Lawn, S. D; Wood, C; Lockwood, D. N Título: Borderline tuberculoid leprosy: an immune reconstitution phenomenon in a human immunodeficiency virus-infected person ..- Fonte: s.l; s.n; Jan. 2003. 3 p. ilus. Resumo: Two months after starting highly active antiretroviral treatment (HAART), an individual with human immunodeficiency virus type 1 (HIV-1) infection and profound CD4+ T lymphocytopenia developed several erythematous plaques on his face, which were due to borderline tuberculoid leprosy with reversal reaction. The temporal association between the development of these lesions and changes in blood CD4+ lymphocyte count and plasma HIV-1 load observed during HAART strongly suggests that the presentation of leprosy resulted from immune reconstitution. (AU). Descritores: HANSENIASE TUBERCULOIDE/etiol HANSENIASE TUBERCULOIDE/imunol INFECCOES POR HIV/compl INFECCOES POR HIV/quimioter INFECCOES POR HIV/imunol CONTAGEM DE LINFOCITO CD4 INFECCOES OPORTUNISTAS RELACIONADAS COM A AIDS/imunol AGENTES ANTI-HIV/uso terap TERAPIA ANTI-RETROVIRAL DE ALTA ATIVIDADE/ef adv IMUNIDADE/ef drogas Limites: RELATO DE CASO HUMANO MASCULINO ADULTO Localização: BR191.1; 09166/s

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Id: 18344 Autor: Alcaïs, A; Sanchez, F. O; Thuc, N. V; Lap, V. D; Oberti, J; Lagrange, P. H; Schurr, E; Abel, L Título: Granulomatous reaction to intradermal injection of lepromin (Mitsuda reaction) is linked to the human NRAMP1 gene in Vietnamese leprosy ..- Fonte: s.l; s.n; 2000. 7 p. tab, graf. Resumo: The Mitsuda test, which measures the specific immune response against intradermally injected lepromin, has a high prognostic value for susceptibility or resistance to the lepromatous form of leprosy. A sib-pair linkage analysis between the Mitsuda response and the NRAMP1 gene was done among 20 nuclear families with leprosy (totaling 118 sibs) from Ho Chi Minh City, Vietnam. All family subjects were genotyped for several intragenic and flanking NRAMP1 markers, leading to the definition of a fully informative NRAMP1 haplotype. Significant linkage was observed between NRAMP1 and Mitsuda reaction when considered either as a quantitative (P<.002) or as a categorical (P=.001) trait. Separate analyses among healthy and affected sibs showed evidence for linkage in both subsamples, indicating that linkage between the Mitsuda reaction and NRAMP1 is independent of leprosy status. These results support the view that NRAMP1 plays a regulatory role for the development of acquired antimycobacterial immune responses as determined by in vivo Mitsuda test reaction. (AU). Descritores: HANSENIASE/imunol ANTIGENO DE MITSUDA/imunol HANSENIASE VIRCHOWIANA/imunol HANSENIASE TUBERCULOIDE/imunol PELE/imunol VIETNA GRANULOMA CHINA/etnol - HAPLOTIPOS  IMUNIDADE NATURAL  INJECOES INTRADERMICAS  LINHAGEM  NUCLEO FAMILIAR  FENOTIPO  LINFOCITOS T AUXILIADORES-INDUTORES Limites: HUMANO MASCULINO FEMININO SUPPORT, NON-U.S. GOV'T Localização: BR191.1; 08991/s

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Id: 18327 Autor: Meyers, Wayne M; Kvernes, Staffan; Staple, Edna M Título: Failure of levamisole to alter the lepromin reaction ..- Fonte: s.l; s.n; sep. 1975. 3 p. tab. Resumo: In a study of 37 leprosy patients, the oral administration of levamisole failed to provoke an increase in both the Fernandez and Mitsuda reactions to lepromins of human and armadillo origin. We interpret this as evidence against an effective specific immunostimulatory capability of levamisole in leprosy patients under the conditions of the study. Current knowledge of the mechanism of levamisole action supports the concept that the fundamental immunologic defect in lepromatosus leprosy may reside in the lymphocyte and not the macrophage, or the respective related functions of these two cell forms.(AU). Descritores: LINFOCITOS/imunol MYCOBACTERIUM LEPRAE/isol LEVAMISOL/admin LEVAMISOL/farmacol HANSENIASE/imunol ANTIGENO DE MITSUDA/imunol IMUNIDADE CELULAR/ef drogas TATUS Limites: HUMANO ANIMAL ADULTO MEIA-IDADE IDOSO CAMUNDONGOS SUPPORT, U.S. GOV'T, NON-P.H.S. Meio Eletrônico: - . Localização: BR191.1; 01921/s

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