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| Id: | 25223
| | Autor: | Naafs, Bernard; Kolk, Arend H. J; Lien, Roel A. M Chin A; Faber, William R; Van Dijk, Grietje; Kuijper Sjoukje, M. T; Stolz Ernst, M. T; Van Joost, Theodoor
| | Título: | Anti-Mycobacterium leprae monoclonal antibodies cross-react with human skin: an alternative explanation for the immune reponses in leprosy
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| | Fonte: | s.l; s.n; May 1990. 4 p. ilus, tab.
| | Resumo: | A panel of 17 mouse monoclonal antibodies (MoAb) raised against Mycobacterium leprae (M. leprae) antigens was used to detect antigenic determinants in normal human skin. An indirect immunoperoxidase technique was used. Eight of the MoAb detected epidermal antigens similar to patterns well known for human sera. Five of these MoAb detected determinants in the dermis, too. These observations may indicate a certain degree of similarity between the antigenic determinants occurring in M. leprae and in the human host. We propose that such a similarity on the one hand may facilitate the survical of M. leprae in the human host when the antigens are not recognized as "non-self", a situation which seems to ocuur in lepromatous leprosy, when the patients' tissues are loaded with bacteria virtually without any immune response. On the other hand, M. leprae antigens which mimic host antigens may induce an auto-immune reaction against the host's own antigens, which could explain the immune reaction in tuberculod leprosy and during a "reversal reaction" when M. leprae is not observed in the host tissues, but extensive granuloma formation occurs (AU).
| | Descritores: | MYCOBACTERIUM LEPRAE/citol
MYCOBACTERIUM LEPRAE/genet
MYCOBACTERIUM LEPRAE/imunol
MYCOBACTERIUM LEPRAE/fisiol
HANSENIASE/imunol
HANSENIASE/fisiopatol
PELE/imunol
PELE/microbiol
| | Limites: | ESTUDO COMPARATIVO
| | Localização: | BR191.1; 09269/s |
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