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| Id: | 25870
| | Autor: | Hadler, W. A. | | Título: | Estudo comparado das lesões provocadas por suspensões de "M. leprae" e de "M. tuberculosis, injetadas por via intradêrmica, em cobaios préviamente vacinados pelo BCG / Comparative study of injuries caused by suspensions of "M. leprae" and of "M. tuberculosis, injected intradermally in guinea pigs previously vaccinated with BCG
| | Fonte: | Rev. bras. Leprol;22(2):109-123, jun. 1954. ^btab.
| | Resumo: | The lesions suspensions by intracutaneous injections of M. tuberculosis and M. leprosy suspensions, in BCG vaccinated guinea pigs, are cytologically alike; the cells of the inflmmatory tissue are morphologically and physiologically indicals and constitute lesions of a same type, with a central abscess surrounded by the tuberculosis inflammatory tissue. This cytological and histological identity makes easy the comparative study of the lesions by these two mycobacteria in vaccinated guinea pigs. In opposition in normal guinea pigs the same comparison is difficulted by the presence of the abscess observed only animals injected with M. tuberculosis. Ninety eight normal guinea pigs were innoculated with 33.0 mg of BCG, by peritoneal or intramuscular route. Fourt days after 58 guineas pigs were injected intracutaneously with 0,05 ml of a M. tuberculosis (BCG) suspension, containing 0.165 mg of bacilli; 22 guinea pigs were injected by this same via with 0, 1 ml of lepromin contaning nearly 0.074 mg of M. leprae; the other 20 guinea pigs were injected by this same route with 0.165 mg of BCG on a side and with 0,1 ml of lepromin containing 0.170 mg of M. leprae on the other side. The macroscopic and microscopic lesions suscitated by the intracutaneous injection of these two mycobacteria were observed during 50 days. The macroscopic examination shows: a) the reaction provoked by 0.165 mg of BCG is stronger but disappears at the 30th day after innoculation; b) the reaction suscitated by approximately 0.074 mg of M. leprae is weaker but vanishes only 40days after innoculation. The histological study of the lesions shows: a) the injection of 0.165 mg of BCG induces stronger reactions which have shorter evolutive course, with complete cicatrization of the 50th day; b) the injection of nearly 0.170 mg of M. leprae produces weaker lesions which have longer evolutive course, without complete cicatrization at the 50th day after innoculation. The evolutive speed of the... (AU)^ien.
| | Descritores: | Mycobacterium leprae/genet
Mycobacterium leprae/fisiol
Mycobacterium leprae/patogen
Mycobacterium tuberculosis/genet
Mycobacterium tuberculosis/fisiol
Mycobacterium tuberculosis/patogen
Pele/citol
Pele/les
| | Limites: | Animais
| | Meio Eletrônico: | http://hansen.bvs.ilsl.br/textoc/revistas/brasleprol/1954/PDF/v22n2/v22n2a01.pdf - pt.
| | Localização: | BR191.1 |
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