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| Id: | 18486
| | Autor: | Plancoulaine, S; Alcaïs, A; Abel, L; Casanova, J. L
| | Título: | Infections mycobactériennes humaines: im´pact des facteurs génetiques de l'hôte
Human mycobacterial infections: impact of host genetic factors-
| | Fonte: | s.l; s.n; 2002. 6 p. ilus.
| | Resumo: | Humans are exposed worldwide to a variety of environmental mycobacteria (EM) and most children are inoculated with live Bacille Calmette-Guérin (BCG) vaccine. Although rarely pathogenic, poorly virulent mycobacteria, including BCG and most EM, may cause a variety of clinical diseases. M. tuberculosis and M. leprae are more virulent, causing tuberculosis, and leprosy, respectively. Remarkably, only a minority of individuals develop clinical disease, even if infected with virulent mycobacteria. There is now accumulating evidence that the large interindividual variability of clinical outcome results in part from variability in the human genes that control host defense. We review here in current knowledge about genetic predisposition to common (leprosy and tuberculosis) and rare (BCG and EM infections) mycobacterial infections. (AU).
| | Descritores: | PREDISPOSICAO GENETICA PARA DOENÇA
HANSENIASE/etiol
HANSENIASE/genet
MYCOBACTERIUM/patogen
MICOBACTERIOSE/etiol
MICOBACTERIOSE/genet
TUBERCULOSE PULMONAR/etiol
TUBERCULOSE PULMONAR/genet
VARIACAO (GENETICA)
| | Limites: | HUMANO
RESUMO EM INGLES
| | Meio Eletrônico: | - .
| | Localização: | BR191.1; 09052/s |
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