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| Id: | 16230
| | Author: | Rodriguez, José N. | | Title: | Observations on the leprolin (Mitsuda) reaction.
| | Source: | Int. J. Lepr;6(1):11-32, Jan.-Mar. 1938. ilus, tab.
| | Abstract: | The leprolin (Mitsuda) test in the hands of leprosy workers in different parts of the world has given fairly consistent results along certain lines. However, the mechanism of the reaction is still very imperfectly understood, and for this reason its true significance can not be fully evaluated. The present report covers certain work done in an effort to obtain a further understanding of its nature. The results of this study suggest that a positive reaction depends on the presence of sessile antibodies attached to the cells in the dermis. Efforts either to stimulate or to exhaust these hypothetical antibodies by repeated injections of the test material at varying intervals were unsuccessful, but the experiments in this respect were not entirely satisfactory because of insufficiency of material. A positive leprolin reactive in a case of the cutaneous type of the disease may be considered a favorable prognostic sign, but it is not necessarily a guarantee that the case will improve to the bacillus-free stage within a reasonable time. Among bacteriologically found to relapse. The usual negative result of the leprolin test among cutaneous-type lepers seems to be based on positive or specific anergy, though we have failed to demonstrate the presence of hypothetical substances analogous to the anticutines shown by Picker and Loewenstein to exist in tuberculosis. On the other hand the negative result in infants and young children seems probably to be nonspecific. The leprolin and the tuberculina reactions have some points in common, but they are so dissimilar in certain important respects that in all probabilitty they are fundamentally different. Neither can be transmitted by passive transfer and both are more delayed than the usual cutaneous tests. However, one of their imortant differences lies in the fact that the leprolin reaction has been found to be positive in most normal adults, whether they have been in contact with the leprosy or not, whereas the tuberculin reaction is positive only in those who have acquired an infection. Furthermore, the tuberculin reaction is usually at its maximum and is read at the end of 48 hours; the leprolin reaction is much more delayed and is ordinarily read at the end of the second week...(AU).
| | Descriptors: | HANSENIASE
HANSENIASE/compl
HANSENIASE/diag
ANTIGENO DE MITSUDA/clas
ANTIGENO DE MITSUDA/farmacol
| | Electronic Medium: | http://www.ilsl.br
| | Location: | BR191.1 |
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