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| Id: | 18503
| | Author: | Pineda, E. V; Pineda, E. R
| | Title: | Studies on the serology of leprosy, I. The Wassermann reaction in leprosy (1)^ien
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| | Source: | S„o Paulo; s.n; 1940. 35 p. .
| | Abstract: | The Wassermann reaction was made, using Kolmer´s method, on the sera of five hundred lepers and, for comparison, about one hundred fifty of these were also tested by an ordinary method, using both plain and cholesterinized antigens. In the latter method it was found necessary to adjust the antigen dose closely, as an increase from the dose used, two and one-half antigenic units to four, resulted in an increased number of weakly positive or doubtful reactions.The five hundred cases considered include sixty-six untreated new admissions, and cases that were under treatment at the time or that had been treated. Among the latter fifty-none were negative and eighty-two were cases of lepra reaction.Of the total group eighty-five, or 17 per cent, gave reactions that were positive in some degree, the doubtful plus-minus reactions being included. Of these, fifty-eighty were in the group of sixty-seven cases that were under suspicious of yaws (42 cases) or syphilis (25 cases). In the remaining twenty-seven positive cases neither history nor signs of yaws or syphilis could be elicite Data on the clinically framboesial and syphilitic groups are givenThe particularly interesting group without clinical evidence of treponematous infection us subdivised into those without and those with lepra reaction, eleven and sixteen cases, respectively. Of the former, eight gave strongly positive Wassermann reactions of the former group were in cases of slight leprous involvement, and the reactions were negative on retest. The one strong reaction in the latter group was in a Moro, particularly liable yaws. These facts, and the results of antitreponematous treatment, strongly suggest that positive reactions were due to unrecognized syphilis or yaws. The remaining fifiteen waakly positive reactions in cases of lepra reaction were probably due to serum changes that occur in this condition, either peculiar to it or, more probably, particularly marked in it.Our findings incidentally agree wit...(AU)^ien.
| | Descriptors: | HANSENIASE/imunol
HANSENIASE/metab
HANSENIASE/enf
HANSENIASE/fisiopatol
HANSENIASE/virol
| | Location: | BR191.1; 01073/d.a |
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