Database : HANSEN Search on : INFECCOES POR HIV/IMUNOL [Subject descriptor] References found : 7 [refine] Displaying: 1 .. 7   in format [Detailed]

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Id: 13938 Author: Dredge, Keith; Marriott, J. Blake; Dalgleish, Angus G Title: Immunological effects of thalidomide and its chemical and functional analogs ..- Source: s.l; s.n; 2002. 13 p. ilus, tab. Abstract: Thalidomide has recently shown considerable promise in the treatment of a number of conditions, such as leprosy and cancer. Its effectiveness in the clinic has been ascribed to wide-ranging properties, including anti-TNF-alpha, T-cell costimulatory and antiangiogenic activity. Novel compounds with improved immunomodulatory activity and side effect profiles are also being evaluated. These include selective cytokine inhibitory drugs (SelCIDs), with greatly improved TNF-alpha inhibitory activity, and immunomodulatory drugs (IMiDs) that are structural analogs of thalidomide, with improved properties. A third group recently identified within the SelCID group, with phosphodiesterase type 4-independent activity, is in the process of being characterized in laboratory studies. This review describes the emerging immunological properties of thalidomide, from a historical context to present-day clinical applications, most notably in multiple myeloma but also in other cancers, inflammatory disease, and HIV. We also describe the laboratory studies that have led to the characterization and development of SelCIDs and IMiDs into potentially clinically relevant drugs. Early trial data suggest that these novel immunomodulatory compounds may supercede thalidomide to become established therapies, particularly in certain cancers. Further evidence is required, however, to correlate the clinical efficacy of these compounds with their known immunomodulatory, antiangiogenic, and antitumor properties. (AU). Descriptors: TALIDOMIDA/analog TALIDOMIDA/imunol TALIDOMIDA/farmacol SISTEMA IMUNE/ef drogas NEOPLASIAS/quimioter NEOPLASIAS/imunol INFECCOES POR HIV/quimioter INFECCOES POR HIV/imunol ADJUVANTES IMUNOLOGICOS/farmacol INIBIDORES DE ANGIOGÊNESE/imunol INIBIDORES DE ANGIOGÊNESE/farmacol ANTIVIRAIS/imunol ANTIVIRAIS/farmacol Limits: HUMANO Electronic Medium: http://www.ilsl.br Location: BR191.1; 04731/s

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Id: 13734 Author: Lawn, S. D; Wood, C; Lockwood, D. N Title: Borderline tuberculoid leprosy: an immune reconstitution phenomenon in a human immunodeficiency virus-infected person ..- Source: s.l; s.n; 2003. 2 p. ilus. Abstract: Two months after starting highly active antiretroviral treatment (HAART), an individual with human immunodeficiency virus type 1 (HIV-1) infection and profound CD4+ T lymphocytopenia developed several erythematous plaques on his face, which were due to borderline tuberculoid leprosy with reversal reaction. The temporal association between the development of these lesions and changes in blood CD4+ lymphocyte count and plasma HIV-1 load observed during HAART strongly suggests that the presentation of leprosy resulted from immune reconstitution. (AU). Descriptors: INFECCOES OPORTUNISTAS RELACIONADAS COM A AIDS/imunol AGENTES ANTI-HIV/uso terap TERAPIA ANTI-RETROVIRAL DE ALTA ATIVIDADE/ef adv CONTAGEM DE LINFOCITO CD4 INFECCOES POR HIV/compl INFECCOES POR HIV/quimioter INFECCOES POR HIV/imunol HANSENIASE TUBERCULOIDE/etiol HANSENIASE TUBERCULOIDE/imunol IMUNIDADE/ef drogas Limits: RELATO DE CASO HUMANO MASCULINO ADULTO Electronic Medium: http://www.ilsl.br Location: BR191.1; 09026/s

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Id: 13540 Author: Lawn, S. D; Wood, C; Lockwood, D. N Title: Borderline tuberculoid leprosy: an immune reconstitution phenomenon in a human immunodeficiency virus-infected person ..- Source: s.l; s.n; Jan. 2003. 3 p. ilus. Abstract: Two months after starting highly active antiretroviral treatment (HAART), an individual with human immunodeficiency virus type 1 (HIV-1) infection and profound CD4+ T lymphocytopenia developed several erythematous plaques on his face, which were due to borderline tuberculoid leprosy with reversal reaction. The temporal association between the development of these lesions and changes in blood CD4+ lymphocyte count and plasma HIV-1 load observed during HAART strongly suggests that the presentation of leprosy resulted from immune reconstitution. (AU). Descriptors: HANSENIASE TUBERCULOIDE/etiol HANSENIASE TUBERCULOIDE/imunol INFECCOES POR HIV/compl INFECCOES POR HIV/quimioter INFECCOES POR HIV/imunol CONTAGEM DE LINFOCITO CD4 INFECCOES OPORTUNISTAS RELACIONADAS COM A AIDS/imunol AGENTES ANTI-HIV/uso terap TERAPIA ANTI-RETROVIRAL DE ALTA ATIVIDADE/ef adv IMUNIDADE/ef drogas Limits: RELATO DE CASO HUMANO MASCULINO ADULTO Location: BR191.1; 09166/s

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Id: 10246 Author: Bwire, Robert; Kawuma, H. J. S Title: Type 1 reactions in leprosy, neuritis and steroid therapy: the impact of the human immunodeficiency virus ..- Source: s.l; s.n; 1994. 2 p. tab. Descriptors: INFECÇOES POR HIV INFECÇOES POR HIV HANSENIASE HANSENIASE NEURITE NEURITE ESTEROIDES ESTEROIDES Location: BR191.1; 06956/s

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Id: 9774 Author: Sampaio, Elizabeth P; Caneshi, Jaqueline R. T; Nery, Jose A. C; Duppre, Nadia C; Pereira, Geraldo M. B; Vieira, Leila M. M; Moreira, Andre L; Kaplan, Gilla; Sarno, Euzenir N Title: Cellular immune response to Mycobacterium leprae infection in human immunodeficiency virus-infected individuals ..- Source: s.l; s.n; 1995. 7 p. ilus, tab, graf. Descriptors: CITOCINAS CITOCINAS EXPRESSAO GENICA INFECÇOES POR HIV INFECÇOES POR HIV HIV-1 ANTIGENO DE MITSUDA LEUCOCITOS MONONUCLEARES TRANSFORMAÇAO LINFOCITICA RNA MENSAGEIRO PELE Location: BR191.1. 6774/s

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Id: 9703 Author: Dohms, John E Title: Mechanisms of immunosuppression ..- Source: s.l; s.n; 1991. 12 p. tab. Descriptors: HANSENIASE MYCOBACTERIUM LEPRAE AVES ANTIGENOS HIV INFECÇOES POR HIV HIV-1 HIV-1 TOLERANCIA IMUNOLOGICA Location: BR191.1; 06647/s

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Id: 9328 Author: Serme, Abdel K Title: L'infection par le virus de l'immunodeficience humaine et lepre ..- Source: s.l; s.n; 1992. 6 p. tab. Descriptors: AFRICA ASIA SUDESTE COMORBILIDADE INFECÇOES POR HIV INFECÇOES POR HIV INFECÇOES POR HIV SOROPREVALENCIA DE HIV HIV-1 INCIDENCIA INDIA HANSENIASE HANSENIASE HANSENIASE MACACA MULATTA Limits: ANIMAL Location: BR191.1; 06473/s

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