Database : HANSEN Search on : PESO MOLECULAR [Subject descriptor] References found : 29 [refine] Displaying: 1 .. 20   in format [Detailed]

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Id: 13722 Author: Maeda, Yumi; Makino, Masahiko; Crick, Dean C; Mahapatra, Sebabrata; Srisungnam, Sopa; Takii, Takemasa; Kashiwabara, Yoshiko; Brennan, Patrick J Title: Novel 33-kilodalton lipoprotein from Mycobacterium leprae ..- Source: s.l; s.n; 2002. 6 p. tab, graf. Abstract: A novel Mycobacterium leprae lipoprotein LpK (accession no. ML0603) was identified from the genomic database. The 1,116-bp open reading frame encodes a 371-amino-acid precursor protein with an N-terminal signal sequence and a consensus motif for lipid conjugation. Expression of the protein, LpK, in Escherichia coli revealed a 33-kDa protein, and metabolic labeling experiments and globomycin treatment proved that the protein was lipidated. Fractionation of M. leprae demonstrated that this lipoprotein was a membrane protein of M. leprae. The purified lipoprotein was found to induce production of interleukin-12 in human peripheral blood monocytes. The studies imply that M. leprae LpK is involved in protective immunity against leprosy and may be a candidate for vaccine design. (AU). Descriptors: SEQUENCIA DE AMINOACIDOS ANTIGENOS DE BACTERIAS/GE/*IM/IP PROTEINAS DE BACTERIAS/GE/*IM/IP CLONAGEM MOLECULAR ESCHERICHIA COLI EXPRESSAO GENICA GENES BACTERIANOS INTERLEUCINA-12/*BI LIPOPROTEINAS/GE/*IM/IP PROTEINAS DE MEMBRANA/GE/*IM/IP DADOS DE SEQUENCIA MOLECULAR PESO MOLECULAR MONOCITOS/IM MYCOBACTERIUM LEPRAE/GE/*IM/IP PRECURSORES DE PROTEINAS/GE/*IM/IP ANALISE DE SEQUENCIA DE DNA Limits: HUMANO SUPPORT, NON-U.S. GOV'T SUPPORT, U.S. GOV'T, P.H.S. Location: BR191.1; 09059/s

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Id: 13666 Author: Bala, Lakshmi; Anand, Sukumar; Sinha, Sudhir Title: Enhancement of human T cell response to a peptide epitope of 38kDa antigen of Mycobacterium tuberculosis by liposomes ..- Source: s.l; s.n; 2002. 9 p. graf. Abstract: Diagnosis of tuberculosis a problem, specially in the regions harboring an abundance of both pathogenic and non-pathogenic mycobacteria. This study was undertaken to assess in such a situation the predictive value of proliferative T cell response to a peptide epitope ('38G') of the 38 kDa membrane protein of Mycobacterium tuberculosis. 3[H]-thymidine incorporation assays were done with peripheral blood mononuclear cells of tuberculoid leprosy and pulmonary tuberculosis patients. The donors were also classified as PPD responders (Stimulation Index, SI> 3) or non-responders (SI < or = 3) on the basis of their T cell response to the 'Purified Protein Derivative (PPD)' of M. tuberculosis. 38G peptide was used in either free or liposome-associated form prepared by the technique of 'Dehydration-rehydration Vesicles' (Kirby and Gregoriadis, 1984). While free peptide failed to induce a positive response in study subjects, its liposomal form was T cell stimulatory and distinguished, to certain extent, between PPD responders (corresponding SI > 3 in 54 per cent subjects) and non-responders (SI > 3 in 29 per cent subjects). However, it did not differentiate between leprosy and tuberculosis. The study supports use of liposomes as adjuvant vehicles for antigenic peptides designed to activate human T cells. (AU). Descriptors: ANTIGENOS DE BACTERIAS/admin ANTIGENOS DE BACTERIAS/quim ANTIGENOS DE BACTERIAS/genet HANSENIASE TUBERCULOIDE/diag HANSENIASE TUBERCULOIDE/imunol EPITOPOS/admin EPITOPOS/quim EPITOPOS/genet DIAGNOSTICO DIFERENCIAL MYCOBACTERIUM TUBERCULOSIS/quim MYCOBACTERIUM TUBERCULOSIS/genet MYCOBACTERIUM TUBERCULOSIS/imunol DADOS DE SEQUÊNCIA MOLECULAR SEQUÊNCIA DE AMINOACIDOS LINFOCITOS T/imunol TESTE TUBERCULINICO TUBERCULOSE PULMONAR/diag TUBERCULOSE PULMONAR/imunol TRANSFORMACAO LINFOCITICA - LIPOSSOMOS  PESO MOLECULAR Limits: ESTUDO COMPARATIVO HUMANO IN VITRO SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 09061/s

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Id: 13661 Author: Rajesh, Mohanraj; Sulochana, Konerirajapuram Natarajan; Sundaram, Amritha Lakshmi; Krishnakumar, Subramanian; Biswas, Jyotirmay; Ramakrishnan, Sivaramakrishnan Title: Presence of a 88 kDa Eales protein in uveitis, tuberculosis, leprosy and rheumatoid arthritis ..- Source: s.l; s.n; 2003. 5 p. ilus, tab. Abstract: BACKGROUND: Eales disease (ED) is an idiopathic retinal vasculitis affecting young adult males. We have earlier reported the identification, purification and partial characterization of a novel 88 kDa protein found in the serum of patients with ED. The aim of the present study was to look for the 88 kDa protein in serum samples obtained from cases of retinal vasculitis mimicking ED and in other systemic inflammatory diseases. MATERIAL/METHODS: Serum samples from healthy volunteers and from patients with ED, uveitis, parsplanitis ocular sarcoidosis, toxoplasmosis, leprosy, diabetic retinopathy, viral hepatitis, and rheumatoid arthritis were analyzed for the presence of the 88 kDa protein by polyacralymide gel electrophoresis (PAGE). The immunological identity of the 88 kDa protein found in ED and in other diseases was investigated by Western blot. Immunohistochemistry was performed on epiretinal membranes (ERM) obtained from ED patients to localize the 88 kDa protein. RESULTS: 88 kDa protein were detected in serum samples obtained from patients with posterior uveitis, tuberculosis, leprosy and rheumatoid arthritis. The 88 kDa protein found in serum from patients with ED is immunologically identical to that found in other systemic inflammatory conditions. 88 kDa protein was localized in inflammatory cells and in nonvascular endothelium in ERMs obtained from patients with ED. CONCLUSIONS: We have identified a novel acute phase reactant, which is elaborated in ocular and systemic inflammatory conditions other than Eales disease. Further work is necessary to decipher the precise role of the 88 kDa protein in the pathophysiology of these inflammatory diseases. (AU). Descriptors: ARTRITE REUMATOIDE/sangue MEMBRANA EPIRRETINIANA/metab MEMBRANA EPIRRETINIANA/patol HANSENIASE/sangue PROTEINAS/quim PROTEINAS/metab VASCULITE TUBERCULOSE/sangue UVEITE/sangue - PESO MOLECULAR Limits: HUMANO MASCULINO FEMININO ADULTO MEIA-IDADE SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 09134/s

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Id: 11939 Author: Meada, Yumi; Makino, Masahiko; Crick, Dean C; Mahapatra, Sebabrata; Srisungnam, Sopa; Takii, Takemasa; Kashiwabara, Yoshiko; Brennan, Partrick J Title: Novel 33-kilodalton lipoprotein from Mycobacterium leprae ..- Source: s.l; s.n; 2002. 6 p. ilus, graf. Descriptors: MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE MONOCITOS ANTIGENOS DE BACTÉRIAS ANTIGENOS DE BACTÉRIAS ANTIGENOS DE BACTÉRIAS PROTEINAS DE BACTÉRIAS PROTEINAS DE BACTÉRIAS PROTEINAS DE BACTÉRIAS CLONAGEM MOLECULAR ESCHERICHIA COLI EXPRESSAO GENICA GENES BACTERIANOS INTERLEUCINA-12 PESO MOLECULAR ANALISE SEQUENCIAL PRECURSORES DE PROTEINAS PRECURSORES DE PROTEINAS PRECURSORES DE PROTEINAS Location: BR191.1; 08605/s

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Id: 11759 Author: Brahmbhatt, S; Hussain, R; Zafar, S; Dawood, G; Ottenhoff, Tom H. M; Drijfhout, J. W; Bothamley, G; Smith, S; Lopez, F. V; Dockrell, H. M Title: Human T cell responses to peptides of the Mycobacterium leprae 45-KD serine-rich antigen ..- Source: s.l; s.n; 2002. 9 p. tab, graf. Descriptors: SEQUENCIA DE AMINOACIDOS ANTIGENOS DE BACTÉRIAS ANTIGENOS DE BACTÉRIAS LINHAGEM CELULAR EPITOPOS DE LINFOCITO T EPITOPOS DE LINFOCITO T REINO UNIDO ANTIGENOS HLA-DR EPITOPOS IMUNODOMINANTES EPITOPOS IMUNODOMINANTES INTERFERON TIPO II HANSENIASE TUBERCULOIDE DADOS DE SEQUENCIA MOLECULAR PESO MOLECULAR MYCOBACTERIUM LEPRAE PAQUISTAO PEPTIDIOS HOMOLOGIA DE SEQUENCIA DE AMINOACIDOS SERINA LINFOCITOS T TUBERCULOSE PULMONAR CELULAS CULTIVADAS Limits: ESTUDO COMPARATIVO Location: BR191.1; 08519/s

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Id: 11316 Author: Shimoji, Yoshihiro; Ng, Vincent; Matsumura, Kiichiro; Fischetti, Vincent A; Rambukkana, Anura Title: A 21-kDa surface protein of mycobacterium leprae binds peripheral nerve laminin-2 and mediates Schwann cell invasion ..- Source: s.l; s.n; 1999. 6 p. tab, graf. Descriptors: SEQUENCIA DE AMINOACIDOS ADESINAS BACTERIANAS ADESINAS BACTERIANAS SEQUENCIA DE BASES ELETROFORESE EM GEL DE POLIACRILAMIDA LAMININA HANSENIASE CAMUNDONGOS CAMUNDONGOS ENDOGAMICOS BALB C MICROSCOPIA IMUNOELETRONICA DADOS DE SEQUENCIA MOLECULAR PESO MOLECULAR MYCOBACTERIUM LEPRAE SISTEMA NERVOSO PERIFÉRICO SISTEMA NERVOSO PERIFÉRICO CÉLULAS DE SCHWANN PROPRIEDADES DE SUPERFICIE CELULAS CULTIVADAS Limits: ANIMAL Location: BR191.1; 07255/s

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Id: 11034 Author: Yadava, Anjali; Mukherjee, Rama Title: An immunodominant 30-kDa antigen of a candidate anti-leprosy vaccine, mycobacterium w, shares T and B cell determinants with m. leprae and m. tuberculosis ..- Source: s.l; s.n; 1993. 11 p. ilus, graf. Descriptors: HANSENIASE MYCOBACTERIUM LEPRAE MYCOBACTERIUM TUBERCULOSIS ANTIGENOS DE BACTÉRIAS ANTIGENOS DE BACTÉRIAS LINFOCITOS B VACINAS BACTERIANAS COBAIAS HIPERSENSIBILIDADE TARDIA PESO MOLECULAR LINFOCITOS T Location: BR191.1; 07213/s

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Id: 10301 Author: Thole, Jelle E. R; Janson, Anneke A. M; Cornelisse, Yolanthe; Schreuder, Geziena M. T; Wieles, Brigitte; Naafs, Ben; Vries, Rene R. P. de; Ottenhoff, Tom H. M Title: HLA-class II-associated control of antigen recognition by T cells in leprosy: a prominent role for the 30/31-kDa antigens ..- Source: s.l; s.n; 1999. 7 p. ilus, tab. Descriptors: ANTIGENOS DE BACTÉRIAS ANTIGENOS DE BACTÉRIAS MAPEAMENTO DE EPITOPOS EPITOPOS DE LINFOCITO T EPITOPOS DE LINFOCITO T ANTIGENOS HLA-DR ANTIGENO HLA-DR3 IMUNOFENOTIPAGEM HANSENIASE TRANSFORMAÇAO LINFOCITICA PESO MOLECULAR MYCOBACTERIUM LEPRAE LINFOCITOS T LINFOCITOS T Location: BR191.1; 07404/s

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Id: 10298 Author: Weir, R. E; Brennan, P. J; Butlin, C. R; Dockrell, H. M Title: Use of a whole blood assay to evaluate in vitro T cell responses to new leprosy skin test antigens in leprosy patients and healthy subjects ..- Source: s.l; s.n; 1999. 7 p. tab. Descriptors: ANTIGENOS DE BACTÉRIAS PROTEINAS DE BACTÉRIAS INTERFERON TIPO II HANSENIASE HANSENIASE TRANSFORMAÇAO LINFOCITICA PESO MOLECULAR MYCOBACTERIUM LEPRAE TESTES CUTANEOS ESTERILIZAÇAO LINFOCITOS T Location: BR191.1; 07400/s

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Id: 10294 Author: Mehrotra, J; Mittal, A; Rastogi, A. K; Jaiswal, A. K; Bhandari, N. K; Sinha, S Title: Antigenic definition of plasma membrane proteins of bacillus Calmette-Guerin: predominant activation of human T cells by low-molecular-mass integral proteins ..- Source: s.l; s.n; 1999. 9 p. ilus, tab, graf. Descriptors: ANTICORPOS MONOCLONAIS ANTIGENOS DE BACTÉRIAS ANTIGENOS DE BACTÉRIAS VACINA BCG VACINA BCG LINFOCITOS T CD4-POSITIVOS EPITOPOS IMUNODOMINANTES HANSENIASE TUBERCULOIDE TRANSFORMAÇAO LINFOCITICA PROTEINAS DA MEMBRANA PROTEINAS DA MEMBRANA PESO MOLECULAR MYCOBACTERIUM BOVIS SUB-POPULAÇOES DE LINFOCITOS T LINFOCITOS T TUBERCULOSE PULMONAR Location: BR191.1; 07396/s

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Id: 10268 Author: Gilburd, B; Ziporen, L; Zharhary, D; Blank, M; Zurgil, N; Scheinberg, M. A; Guedes, L. H; Gershwin, M. E; Shoenfeld, Y Title: Antimitochondrial (pyruvate dehydrogenase) antibodies in leprosy ..- Source: s.l; s.n; 1994. 6 p. tab, graf. Descriptors: AUTO-ANTICORPOS AUTO-ANTIGENOS ELETROFORESE EM GEL DE POLIACRILAMIDA ELISA IMMUNOBLOTTING HANSENIASE LEPROMATOSA CIRROSE HEPATICA BILIAR MITOCONDRIA HEPATICA MITOCONDRIA HEPATICA PESO MOLECULAR COMPLEXO PIRUVATO DESIDROGENASE Location: BR191.1; 07163/s

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Id: 10094 Author: Winter, Nathalie; Triccas, James A; Rivoire, Becky; Pessolani, Maria Cristina V; Eiglmeier, Karin; Lim, Eng-Mong; Hunter, Shirley W; Brennan, Patrick J; Britton, Warwick J Title: Characterization of the gene encoding the immunodominant 35 kDa protein of Mycobacterium leprae ..- Source: s.l; s.n; 1995. 12 p. ilus, tab, graf. Descriptors: HANSENIASE MYCOBACTERIUM MYCOBACTERIUM MYCOBACTERIUM LEPRAE SEQUENCIA DE AMINOACIDOS ANTICORPOS MONOCLONAIS ANTIGENOS DE BACTÉRIAS ANTIGENOS DE BACTÉRIAS ANTIGENOS DE BACTÉRIAS SEQUENCIA DE BASES COSMIDIOS PRIMERS DO DNA BIBLIOTECA DE GENES GENES BACTERIANOS GENES DOMINANTES DADOS DE SEQUENCIA MOLECULAR PESO MOLECULAR REAÇAO EM CADEIA POR POLIMERASE REGIOES PROMOTORAS (GENÉTICA) PROTEINAS RECOMBINANTES MAPEAMENTO POR RESTRIÇAO HOMOLOGIA DE SEQUENCIA DE AMINOACIDOS LINFOCITOS T Location: BR191.1; 07153/s

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Id: 10093 Author: Deshpande, Rajashri G; Khan, Mahfuz B; Bhat, Deepashree A; Navalkar, R. G Title: Immunoaffinity chromatographic isolation of a high molecular weight seroreactive protein from Mycobacterium leprae cell sonicate ..- Source: s.l; s.n; 1995. 7 p. ilus, tab. Descriptors: HANSENIASE MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE MYCOBACTERIUM PARATUBERCULOSIS ANTICORPOS MONOCLONAIS ANTIGENOS DE BACTÉRIAS ANTIGENOS DE BACTÉRIAS ANTIGENOS DE BACTÉRIAS PROTEINAS DE BACTÉRIAS PROTEINAS DE BACTÉRIAS PROTEINAS DE BACTÉRIAS CITOCROMO B FERRITINA DADOS DE SEQUENCIA MOLECULAR PESO MOLECULAR HOMOLOGIA DE SEQUENCIA DE AMINOACIDOS Limits: ANIMAL HUMANO COELHOS Location: BR191.1; 07152/s

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Id: 9869 Author: Bisht, Deepa; Mehrotra,, Jyoti; Dhindsa, M. S; Singh, N. B; Sinha, Sudhir Title: A major T-cell-inducing cytosolic 23 kDa protein antigen of the vaccine candidate Mycobacterium habana is superoxide dismutase ..- Source: s.l; s.n; 1996. 9 p. ilus, tab. Descriptors: MYCOBACTERIUM LEPRAE SEQUENCIA DE AMINOACIDOS ANTIGENOS DE BACTÉRIAS ANTIGENOS DE BACTÉRIAS PROTEINAS DE BACTÉRIAS PROTEINAS DE BACTÉRIAS VACINAS BACTERIANAS HANSENIASE TUBERCULOIDE TRANSFORMAÇAO LINFOCITICA CAMUNDONGOS ENDOGAMICOS BALB C DADOS DE SEQUENCIA MOLECULAR PESO MOLECULAR FITOHEMAGLUTININAS SUPEROXIDO DISMUTASE SUPEROXIDO DISMUTASE LINFOCITOS T Location: BR191.1; 06808/s

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Id: 9844 Author: Hussain, R; Menz, B; Dockrell, H. M; Chiang, T. J Title: Recognition of Mycobacterium leprae recombinant 18000 MW epitopes by IgG subclasses in leprosy ..- Source: s.l; s.n; 1995. 8 p. tab, graf. Descriptors: HANSENIASE HANSENIASE LEPROMATOSA HANSENIASE TUBERCULOIDE MYCOBACTERIUM LEPRAE ANTICORPOS ANTIBACTÉRIAS ESPECIFICIDADE DE ANTICORPOS REAÇOES ANTIGENO-ANTICORPO ELISA MAPEAMENTO DE EPITOPOS EPITOPOS SWITCHING DE IMUNOGLOBULINA PESO MOLECULAR PEPTIDIOS LIGAÇAO PROTÉICA PROTEINAS RECOMBINANTES Location: BR191.1; 06825/s

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Id: 9818 Author: Triccas, James A; Roche, Paul W; Winter, Nathalie; Feng, Carl G; Butlin, C. Ruth; Britton, Warwick J Title: A 35-kilodalton protein is a major target of the human immune response to Mycobacterium leprae ..- Source: s.l; s.n; 1996. 7 p. ilus, tab, graf. Descriptors: HANSENIASE MYCOBACTERIUM LEPRAE ANTIGENOS DE BACTÉRIAS PESO MOLECULAR PROTEINAS RECOMBINANTES LINFOCITOS LINFOCITOS Location: BR191.1; 06730/s

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Id: 9754 Author: Deshpande, R. G; Khan, M. B; Navalkar, R. G Title: Immunological evaluation of a 12-kilodalton protein of Mycobacterium tuberculosis by enzyme-linked immunosorbent assay ..- Source: s.l; s.n; 1993. 6 p. ilus. Descriptors: HANSENIASE MYCOBACTERIUM LEPRAE ANTIGENOS DE BACTÉRIAS ANTIGENOS DE BACTÉRIAS PROTEINAS DE BACTÉRIAS PROTEINAS DE BACTÉRIAS WESTERN BLOTTING ELISA COBAIAS HIPERSENSIBILIDADE TARDIA PESO MOLECULAR PROTEINAS RECOMBINANTES TUBERCULOSE PULMONAR Limits: ANIMAL HUMANO Location: BR191.1; 06695/s

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Id: 9731 Author: Sela, S; Thole, J. E. R; Ottenhoff, Tom H. M; Clark-Curtiss, J. E Title: Identification of mycobacterium leprae antigens from a cosmid library: characterization of a 15-kilodalton antigen that is recognized by both the humoral and cellular immune systems in leprosy patients ..- Source: s.l; s.n; 1991. 8 p. ilus, tab, graf. Descriptors: SEQUENCIA DE AMINOACIDOS ANTICORPOS ANTIBACTÉRIAS ANTIGENOS DE BACTÉRIAS ANTIGENOS DE BACTÉRIAS SEQUENCIA DE BASES WESTERN BLOTTING DNA BACTERIANO BIBLIOTECA GENOMICA HANSENIASE HANSENIASE TUBERCULOIDE TRANSFORMAÇAO LINFOCITICA DADOS DE SEQUENCIA MOLECULAR PESO MOLECULAR MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE HIBRIDIZAÇAO DE ACIDO NUCLÉICO OLIGONUCLEOTIDIOS HOMOLOGIA DE SEQUENCIA DO ACIDO NUCLÉICO FASES DE LEITURA REAÇAO EM CADEIA POR POLIMERASE MAPEAMENTO POR RESTRIÇAO Location: BR191.1; 06530/s

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Id: 9697 Author: Rinke de Wit, Tobias F; Clark-Curtiss, Josephine E; Abebe, Feseha; Kolk, Arend H. J; Janson, Anneke A. M; Van Agterveld, Miranda; Thole, Jelle E. R Title: A Mycobacterium leprae-specific gene enconding an immunological recognized 45 kDa protein ..- Source: s.l; s.n; 1993. 10 p. ilus, tab. Descriptors: HANSENIASE DIMORFA HANSENIASE LEPROMATOSA MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE MYCOBACTERIUM TUBERCULOSIS MYCOBACTERIUM TUBERCULOSIS SEQUENCIA DE AMINOACIDOS ANTICORPOS ANTIBACTÉRIAS ANTIGENOS DE BACTÉRIAS ANTIGENOS DE BACTÉRIAS PROTEINAS DE BACTÉRIAS PROTEINAS DE BACTÉRIAS PROTEINAS DE BACTÉRIAS SEQUENCIA DE BASES CLONAGEM MOLECULAR DNA BACTERIANO GENES BACTERIANOS FERTILIZAÇAO IN VITRO DADOS DE SEQUENCIA MOLECULAR PESO MOLECULAR LINFOCITOS T Location: BR191.1; 06653/s

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Id: 9681 Author: Adams, E; Britton, W. J; Morgan, A; Goodsall, A. L; Basten, A Title: Identification of human T cell epitopes in the Mycobacterium leprae heat shock protein 70-kD antigen ..- Source: s.l; s.n; 1993. 7 p. ilus, tab. Descriptors: SEQUENCIA DE AMINOACIDOS ANTIGENOS DE BACTÉRIAS VACINA BCG EPITOPOS PROTEINAS DO CHOQUE TÉRMICO PROTEINAS DO CHOQUE TÉRMICO HANSENIASE TRANSFORMAÇAO LINFOCITICA DADOS DE SEQUENCIA MOLECULAR PESO MOLECULAR MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE MYCOBACTERIUM TUBERCULOSIS MYCOBACTERIUM TUBERCULOSIS PEPTIDIOS PEPTIDIOS PEPTIDIOS PROTEINAS RECOMBINANTES HOMOLOGIA DE SEQUENCIA DE AMINOACIDOS LINFOCITOS T TUBERCULOSE PULMONAR Location: BR191.1; 06669/s

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