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Id: 26724 Autor: Guerra-Infante, Fernando M; López-Hurtado, Marcela; Flores-Medina, Saúl; Zamora-Ruiz, Angélica; Haro-Cruz, Ma. de Jesús. Título: Dettection of a tumor necrosis factor-like activity in culture supernatants of armadillo leukocytes. Fonte: Int. J. Lepr;69(4):354-357, Dec., 2001. ilus, tab. Descritores: Fatores de Necrose Tumoral/fisiol Fatores de Necrose Tumoral/secr Fatores de Necrose Tumoral/tox Leucócitos/imunol Leucócitos/microbiol Meio Eletrônico: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/2001/pdf/v69n4/v69n4cor03.pdf - en. Localização: BR191.1

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Id: 25086 Autor: Kang, Tae Jin; Yeum, Chung Eun; Kim, Byoung Chul; You, Eun-Young; Chae, Gue-Tae Título: Differential production of interleukin-10 and interleukin-12 mononuclear cells from leprosy patients with a Toll-like receptor 2 mutations ..- Fonte: s.l; s.n; 2004. 7 p. tab, graf. Resumo: Toll-like receptor 2 (TLR2) is a key mediator of the immune response to mycobacterial infections, and mutations in TLR2 have been shown to confer susceptibility to infections with mycobacteria. This study investigated the profiles of cytokines, such as interferon (IFN)-gamma, interleukin (IL)-10, IL-12 and tumour necrosis factor (TNF)-alpha in response to Mycobacterium leprae in peripheral blood mononuclear cells (PBMC) with the TLR2 mutation Argo677Trp, a recently reported polymorphism that is associated with lepromatous leprosy. In leprosy patients with the TLR2 mutation, production of IL-2, IL-12, IFN-gamma, and TNF-alpha by M. leprae-stimulated PBMC were significantly decreased compared with that in groups with wild-type TLR2. However, the cells from patients with the TLR2 mutation showed significantly increased production of IL-10. There was no significant difference in Il-4 production between the mutant and wild-type during stimulation. Yhus, these results suggest that the TLR2 signal pathway plays a critical role in the alteration of cytokine profiles in PBMC from leprosy pateints and the TLR2 mutation Arg677Trp provides a mechanism for the poor cellular immune response associated with lepromatous leprosy (AU). Descritores: HANSENIASE VIRCHOWIANA/sangue HANSENIASE VIRCHOWIANA/clas HANSENIASE VIRCHOWIANA/diag HANSENIASE VIRCHOWIANA/imunol HANSENIASE TUBERCULOIDE/sangue HANSENIASE TUBERCULOIDE/clas HANSENIASE TUBERCULOIDE/diag HANSENIASE TUBERCULOIDE/imunol INTERLEUCINA-10/anal INTERLEUCINA-10/sangue INTERLEUCINA-10/imunol INTERLEUCINA-12/anal INTERLEUCINA-12/sangue INTERLEUCINA-12/imunol - LEUCOCITOS MONONUCLEARES/imunol  IMUNOCOMPETÊNCIA/imunol Limites: ESTUDO COMPARATIVO HUMANO Localização: BR191.1; 09194/s

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Id: 23197 Autor: Kang, Tae Jin; Yeum, Chung Eun; Kim, Byoung Chul; You, Eun-Young; Chae, Gue-Tae Título: Differential production of interleukin-10 and interleukin-12 in mononuclear cells from leprosy patients with a Toll-like receptor 2 mutation ..- Fonte: s.l; s.n; 2004. 7 p. ilus, tab, graf. Resumo: Toll-like receptor 2 (TLR2) is a key mediator of the immune response to mycobacterial infections, and mutations in TLR2 have been shown to confer susceptibility to infection with mycobacteria. This study investigated the profiles of cytokines, such as interferon (IFN)-gamma, interleukin (IL)-10, IL-12 and tumour necrosis factor (TNF)-alpha in response to Mycobacterium leprae in peripheral blood mononuclear cells (PBMC) with the TLR2 mutation Arg677Trp, a recently reported polymorphism that is associated with lepromatous leprosy. In leprosy patients with the TLR2 mutation, production of IL-2, IL-12, IFN-gamma, and TNF-alpha by M. leprae-stimulated PBMC were significantly decreased compared with that in groups with wild-type TLR2. However, the cells from patients with the TLR2 mutation showed significantly increased production of IL-10. There was no significant difference in IL-4 production between the mutant and wild-type during stimulation. Thus, these results suggest that the TLR2 signal pathway plays a critical role in the alteration of cytokine profiles in PBMC from leprosy patients and the TLR2 mutation Arg677Trp provides a mechanism for the poor cellular immune response associated with lepromatous leprosy. (AU). Descritores: Sequência de Bases Interleucina-10/*BI Interleucina-12/*BI Hanseníase/GE/*IM Leucócitos Mononucleares/IM Glicoproteínas de Membrana/*GE/ME Camundongos Nus Dados de Sequência Molecular Mutação Puntual/* Receptores da Superfície Celular/*GE/ME Receptor 2 Toll-Like Receptores Toll-Like Fator de Necrose Tumoral alfa/BI Limites: Adulto Idoso Animais Feminino Humanos Masculino Camundongos Research Support, Non-U.S. Gov't Meia-Idade Localização: BR191.1; 09341/s

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Id: 18346 Autor: Nath, Indira; Curtis, Jill; Bhutani, L. K; Talwar, G. P Título: Reduction of subpopulation of T lymphocytes in lepromatous leprosy ..- Fonte: s.l; s.n; 1974. 7 p. tab, graf. Resumo: A reduction in number of a subpopulation of T lymphocytes was noted in lepromatous leprosy cases with high bacillary load. Tuberculoid and treated lepromatous patients, who were bacillary negative had normal levels of these cells. B-cell numbers were high in lepromatous patients of treatment and bacillary load. (AU). Descritores: REACAO DE IMUNO-ADERÊNCIA HANSENIASE/compl HANSENIASE/imunol HANSENIASE/microbiol LINFOCITOS T/imunol FATORES DE TEMPO CONTAGEM DE LEUCOCITOS TUBERCULOSE/compl LINFOCITOS B Limites: HUMANO Localização: BR191.1; 03163/s

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Id: 18270 Autor: Roselle, G. A; Kauffman, C. A Título: Amphotericin B and 5-fluorocytosine: effects on cell-mediated immunity ..- Fonte: s.l; s.n; apr. 1980. 7 p. tab, graf. Resumo: Although single-dose amphotericin B therapy appears to be immunostimulatory in mice, no data are available regarding the effects of chronic anti-fungal drug therapy on the immune system. We studied the effects on the guinea-pig cellular immune system of 4 weeks of treatment with amphotericin B, 5-fluorocytosine, or the combination of both drugs. The in vitro lymphocyte response to phytohaemagglutinin and the specific antigen, picryl human serum albumin (picHSA), were not affected by anti-fungal drug treatment. At 1.5 weeks of therapy with amphotericin B, skin test reactivity to picHSA was significantly reduced but returned toward normal by the end of 3.5 weeks of drug therapy. Macrophage migration inhibitory factor production by guinea-pig peripheral blood lymphocytes was significantly reduced after 4 weeks of amphotericin B therapy. No immunostimulatory properties could be ascribed to amphotericin B. 5-fluorocytosine had no effect on cellular immunity.(AU). Descritores: TESTES CUTÂNEOS FATORES INIBIDORES DA MIGRACAO DE MACROFAGOS/anal CONTAGEM DE LEUCOCITOS LINFOCITOS T/imunol IMUNIDADE CELULAR/ef drogas TRANSFORMACAO LINFOCITICA/ef drogas FLUCITOSINA/farmacol CITOSINA/analog ANFOTERICINA B/farmacol Limites: ANIMAL FEMININO COBAIAS SUPPORT, U.S. GOV'T, NON-P.H.S. Meio Eletrônico: - . Localização: BR191.1; 01306/s

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Id: 18233 Autor: Bach, Marie Anne; Chatenoud, Lucienne; Wallach, D; Phan Dinh Tuy, Françoise; Cottenot, F Título: Studies on T cell subsets and functions in leprosy ..- Fonte: s.l; s.n; jun. 1981. 10 p. tab, graf. Resumo: T cell subsets and T cell functions were explored in 31 leprosy patients with the following methods: determination of the percentages of the different T cell subpopulations defined by monoclonal antibodies directed at total T cells, helper T cells and suppressor/cytotoxic T cells; measurement of the in vitro proliferative responses to mitogens; study of the concanavalin A-induced suppressive activity, assessed on MLC; measurement of delayed-type hypersensitivity by skin testing. The confrontation between immunological lepromatous patients without type-2 reaction (erythema nodosum leprosum), (2) lepromatous patients without ENL (erythema nodosum leprosum), (2) lepromatous patients was recent ENL and (3) tuberculoid patients. Unexpectedly, groups 1 and 3, although differing strongly in their clinical status and their sensitivity to lepromin (absent in group 1 and strong in group 3), showed a similar immunological profile with a normal percentage of T cells and a normal distribution of T cells among the major T cell subset contrasting with a moderate decrease of proliferative responses to mitogens and impaired delayed-type hypersensitivity reactions. Concanavalin A-induced suppressive activity was type-2 reaction) strongly differed from both other groups, showing striking abnormalities other groups, showing striking abnormalities of the repartition of the T cell subsets, with increased percentages of helper T cells and decreased percentages of suppressor T cells, and elevated proliferative responses to mitogens. Concanavalin A-induced suppressive activity was reduced in most patients of this group. It is suggested that this imbalance between T cell subsets contributes to the occurrence of ENL reactions in lepromatous patients.(AU). Descritores: ANTICORPOS MONOCLONAIS/imunol HANSENIASE/imunol TESTES INTRADERMICOS CONTAGEM DE LEUCOCITOS TRANSFORMACAO LINFOCITICA LINFOCITOS T/clas LINFOCITOS T/imunol LINFOCITOS T SUPRESSORES-EFETORES/imunol CONCANAVALINA A/farmacol Limites: HUMANO MASCULINO FEMININO ADULTO MEIA-IDADE IDOSO SUPPORT, NON-U.S. GOV'T ADOLESCENTE Meio Eletrônico: - . Localização: BR191.1; 01450/s

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Id: 18161 Autor: Modlin, R. L; Gebhard, J. F; Taylor, C. R; Rea, T. H Título: In situ characterization of T lymphocyte subsets in the reactional states of leprosy ..- Fonte: s.l; s.n; jul. 1983. 8 p. ilus, tab. Resumo: Using monoclonal antibodies and the immunoperoxidase technique, the numbers and distribution of T lymphocyte subsets in the tissues of reactional states of leprosy (six reversal reaction, nine erythema nodosum leprosum (ENL) and two Lucio's reaction) were determined and compared with those found in stable, non-reactional patients (six tuberculoid, two borderline lepromatous and seven lepromatous). The pattern of segregation of the suppressor/cytotoxic phenotype at the periphery of the granuloma was found in both non-reactional tuberculoid lesions and reversal reactions, but was better developed in the former. In ENL and Lucio's reaction, as well as in non-reactional lepromatous tissue, the helper/inducer and suppressor/cytotoxic phenotypes were both admixed with the aggregated histiocytes. However, the helper/suppressor ratio in ENL (2.1 +/- 0.4) was significantly larger than that in non-reactional lepromatous tissue (0.7 +/- 0.4, P less than 0.001). The immature thymocyte antigen OKT6 was found on scattered large non-lymphoid cells, most commonly in tuberculoid and reversal reaction tissues, less commonly in ENL, but only irregularly in non-reactional lepromatous tissue. The peripheral pattern of the suppressor/cytotoxic phenotype may be an immunohistological reflection of a cell-mediated immune response common to both non-reactional tuberculoid and reversal reaction patients. The reversal of the helper/suppressor ratio in ENL as compared to non-reactional lepromatous disease suggests some role for cell-mediated immunity in the pathogenesis of ENL. The OKT6 positive cell is of unknown origin and function.(AU). Descritores: PELE/patol CONTAGEM DE LEUCOCITOS HANSENIASE/imunol HANSENIASE/patol TECNICAS IMUNOENZIMATICAS LINFOCITOS T/imunol ERITEMA NODOSO/patol LINFOCITOS T AUXILIADORES-INDUTORES/imunol LINFOCITOS T SUPRESSORES-EFETORES/imunol ANTICORPOS MONOCLONAIS/imunol Limites: ESTUDO COMPARATIVO HUMANO SUPPORT, NON-U.S. GOV'T Meio Eletrônico: - . Localização: BR191.1; 01386/s

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Id: 18158 Autor: Narayanan, R. B; Bhutani, L. K; Sharma, A. K; Nath, I Título: T cell subsets in leprosy lesions: in situ characterization using monoclonal antibodies ..- Fonte: s.l; s.n; mar. 1983. 9 p. ilus, tab. Resumo: Cryostat sections of dermal lesions from 30 untreated leprosy patients were studied by indirect immunofluorescence using monoclonal antibodies defining T cell subsets and Ia like antigens. Most lymphocytes in leprosy lesions were positive for OKT3 and Ia like antigens indicating thereby the presence of activated T cells. Maximal numbers of these cells were seen in localized paucibacillary tuberculoid leprosy lesions in close association with epithelioid cells. A decline in their numbers was observed over the leprosy spectrum with a marked reduction in disseminated, multi-bacillary, lepromatous leprosy where only scattered OKT3+ cells were visualized. OKT4 and OKT8 positive cells defining T cell subsets, were frequently found within the OKT3+ lymphocytes throughout the leprosy spectrum. The ratio of OKT4+/OKT8+ cells ranged from 1.2 to 5.0 in tuberculoid and from 0.2 to 1.0 in lepromatous lesions. Macrophages in the granulomas stained intensely with anti-Ia antisera. Ia like antigens were expressed to the same degree on macrophages with or without intracellular acid fast bacilli.(AU). Descritores: GRANULOMA/imunol GRANULOMA/patol CONTAGEM DE LEUCOCITOS PELE/imunol PELE/patol HANSENIASE/imunol HANSENIASE/patol LINFOCITOS T/clas LINFOCITOS T/imunol Limites: HUMANO SUPPORT, NON-U.S. GOV'T Meio Eletrônico: - . Localização: BR191.1; 01382/s

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Id: 18150 Autor: Purtilo, David T; Walsh, Gerald P; Storrs, Eleanor E; Gannon, Carman Título: The immune system of the nine-banded armadillo (Dasypus novemcinctus, Linn) ..- Fonte: s.l; s.n; apr. 1975. 9 p. ilus, tab. Resumo: The armadillo is rapidly emerging as an animal for biomedical research. A morphological study of the immune system of the armadillo was undertaken to try to demonstrate a possible defect in the morphogenesis of the lymphoid organs that could account for their susceptibility to leprosy. Blood from 20 domesticated adult armadillos revealed lymphocytes predominated among circulating leukocytes in the majority of animals, whereas in wild animals neutrophils predominated. Necropsies revealed well-developed thymus glands and the thymus-dependent areas in lymph nodes and spleens contained abundant lymphoid cells. Hence, we conclude that the susceptibility of the armadillo to leprosy cannot be explained on a morphological basis.(AU). Descritores: HANSENIASE/imunol LINFOCITOS/citol LEUCOCITOS/citol MYCOBACTERIUM LEPRAE/patogen HISTIOCITOS/citol NEUTROFILOS/citol TECIDO LINFOIDE/anat LINFONODOS/anat XENARTROS/anat XENARTROS/imunol Limites: ANIMAL Meio Eletrônico: - . Localização: BR191.1; 00495/s

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Id: 18050 Autor: McAdam, K. P; Anders, R. F; Smith, S. R; Russell, D. A; Price, M. A Título: Association of amyloidosis with erythema nodosum leprosum reactions and recurrent neutrophil leucocytosis in leprosy ..- Fonte: s.l; s.n; September 27, 1975. 4 p. tab, graf. Resumo: Rectal biopsy in 190 inpatients at a leprosy hospital in the Highlands of Papua New Guinea disclosed 16 patients with secondary amyloidosis. This represented 20% of the patients who had had polar lepromatous leprosy (L.L.) for more than 2 years. Patients with amyloidosis characteristically had either a history of recurrent attacks of erythema nodosum leprosum (E.NH) reactions or chronic trophic ulcers. Levels of the serum component (protein SAA) antigenically related to the amyloid fibril protein AA were monitored, at varying intervals for three months, in lepromatous patients with E.N.L. reaction. The SAA levels rose during E.N.L. reactions in parallel with the neutrophil count. SAA occurred with greatest frequency among patients with LH, while most non-lepromatous patients with detectable SAA had chronic trophic ulcers. The correlation between raised neutrophil count and elevated SAA concentration, observed in this and other studies, suggests that neutrophils are associated with the production of SAA.(AU). Descritores: AMILOIDOSE/sangue AMILOIDOSE/etiol CONTAGEM DE LEUCOCITOS RECIDIVA HANSENIASE/sangue HANSENIASE/compl LEUCOCITOSE/sangue ERITEMA NODOSO/compl ERITEMA NODOSO/etiol Limites: HUMANO Meio Eletrônico: - . Localização: BR191.1; 01790/s

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Id: 17992 Autor: Rea, T. H; Quismorio, F. P; Harding, B; Nies, K. M; Di Saia, P. J; Levan NE;; Friou GJ Título: Immunologic responses in patients with lepromatous leprosy ..- Fonte: s.l; s.n; jun. 1976. 10 p. tab, graf. Resumo: Immunologic responses were measured in 46 patients with lepromatous leprosy. These patients were not distinguishable from controls on the basis of responses to soluble intradermal antigens, sensitization to contactants, peripheral blood T- and B-cell percentages, in vitro lymphocyte responses to a mitogen, or the prevalence of autoantibodies. Generalized immunologic abnormalities in patients with lepromatous leprosy are neither predisposing causes nor necessary accompaniments of lepromatous leprosy, but are probably remote sequellae of the illness. By implication, the generalized immunologic abnormalities reported in other diseases are likely to be remote sequellae of the particular illness.(AU). Descritores: DERMATITE ATOPICA/ind quim DERMATITE DE CONTATO/etiol LECTINAS/farmacol ANTIGENO DE MITSUDA/farmacol HANSENIASE/clas HANSENIASE/genet HANSENIASE/imunol PELE/imunol LINFOCITOS T/imunol - DINITROCLOROBENZENO  DINITROFLUOROBENZENO  ANTIGENOS  AUTO-ANTICORPOS  LINFOCITOS B/imunol  CONTAGEM DE LEUCOCITOS  TRANSFORMACAO LINFOCITICA Limites: HUMANO MASCULINO FEMININO ADULTO MEIA-IDADE IDOSO Meio Eletrônico: - . Localização: BR191.1; 01265/s

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Id: 17918 Autor: Levine, Peter H; Weintraub, Lewis R Título: Pseudoleukemia during recovery from dapsone-induced agranulocytosis ..- Fonte: s.l; s.n; may 1968. 6 p. ilus, graf. Resumo: The case presented here illustrates how convincingly the recovery from agranulocytosis may mimic acute leukemia in both the peripheral blood and the bone marrow. The development of a leukemia-like syndrome in any patient who has been exposed to a drug known to cause agranulocytosis should raise the question of pseudoleukemia. Repeated bone marrow aspirations and daily observation of changes in peripheral blood parameters will help prevent needless exposure to myelossuppressive agents. The experience with this case makes mandatory an awareness of agranulocytosis as a side effect of dapsone.(AU). Descritores: AGRANULOCITOSE/ind quim AGRANULOCITOSE/diag CONTAGEM DE CELULAS SANGUINEAS CELULAS DA MEDULA OSSEA DAPSONA DIAGNOSTICO DIFERENCIAL CONTAGEM DE LEUCOCITOS DERMATOPATIAS/quimioter Meio Eletrônico: - . Localização: BR191.1; 01860/s

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Id: 17905 Autor: Bach, Marie-Anne; Chatenoud, Lucienne; Wallach, D; Phan Dinh Tuy, F; Cottenot, F Título: Studies on T cell subsets and functions in leprosy ..- Fonte: s.l; s.n; jun. 1981. 10 p. tab, graf. Resumo: T cell subsets and T cell functions were explored in 31 leprosy patients with the following methods: determination of the percentages of the different T cell subpopulations defined by monoclonal antibodies directed at total T cells, helper T cells and suppressor/cytotoxic T cells; measurement of the in vitro proliferative responses to mitogens; study of the concanavalin A-induced suppressive activity, assessed on MLC; measurement of delayed-type hypersensitivity by skin testing. The confrontation between immunological lepromatous patients without type-2 reaction (erythema nodosum leprosum), (2) lepromatous patients without ENL (erythema nodosum leprosum), (2) lepromatous patients was recent ENL and (3) tuberculoid patients. Unexpectedly, groups 1 and 3, although differing strongly in their clinical status and their sensitivity to lepromin (absent in group 1 and strong in group 3), showed a similar immunological profile with a normal percentage of T cells and a normal distribution of T cells among the major T cell subset contrasting with a moderate decrease of proliferative responses to mitogens and impaired delayed-type hypersensitivity reactions. Concanavalin A-induced suppressive activity was type-2 reaction) strongly differed from both other groups, showing striking abnormalities other groups, showing striking abnormalities of the repartition of the T cell subsets, with increased percentages of helper T cells and decreased percentages of suppressor T cells, and elevated proliferative responses to mitogens. Concanavalin A-induced suppressive activity was reduced in most patients of this group. It is suggested that this imbalance between T cell subsets contributes to the occurrence of ENL reactions in lepromatous patients.(AU). Descritores: ANTICORPOS MONOCLONAIS/imunol CONCANAVALINA A/farmacol TESTES INTRADERMICOS HANSENIASE/imunol CONTAGEM DE LEUCOCITOS TRANSFORMACAO LINFOCITICA LINFOCITOS T/clas LINFOCITOS T/imunol LINFOCITOS T SUPRESSORES-EFETORES/imunol Limites: HUMANO MASCULINO FEMININO ADULTO MEIA-IDADE IDOSO SUPPORT, NON-U.S. GOV'T ADOLESCENTE Meio Eletrônico: - . Localização: BR191.1; 01569/s

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Id: 17904 Autor: Modlin, R. L; Hofman, F. M; Meyer, P. R; Sharma, O. P; Taylor, C. R; Rea, T. H Título: In situ demonstration of T lymphocyte subsets in granulomatous inflammation: leprosy, rhinoscleroma and sarcoidosis ..- Fonte: s.l; s.n; mar. 1983. 9 p. ilus. Resumo: T lymphocyte subpopulations in frozen tissue sections of four granulomatous conditions (five patients with tuberculoid leprosy, five with lepromatous leprosy, seven with sarcoidosis and four with rhinoscleroma) were studied using monoclonal antibodies and a modified immunoperoxidase technique. Two immunohistological patterns were observed. In tuberculoid leprosy and sarcoidosis, lymphocytes expressing the helper/inducer phenotype were present within the aggregates of mononuclear phagocytes (epithelioid cells); however, cells with the suppressor/cytotoxic phenotype were predominantly in the lymphocytic mantle surrounding each granuloma. In lepromatous leprosy and rhinoscleroma the helper/inducer T cells and suppressor/cytotoxic T cells were both diffusely distributed among the mononuclear phagocytes (histiocytes) without any discernible mantle. The segregation of the helper/inducer and suppressor/cytotoxic phenotypic subsets was associated with an epithelioid cell differentiation of mononuclear phagocytic cells, bacterial elimination and a delayed type hypersensitivity response. The intimate admixture of helper/inducer and suppressor/cytotoxic subsets was associated with undifferentiated mononuclear phagocytes, bacterial proliferation and the absence of a delayed type hypersensitivity response. Thus the different distributions of T cell subpopulations in granulomas may be associated with differences in the host's immune response in several forms of granulomatous reactions.(AU). Descritores: LINFOCITOS T/imunol LINFOCITOS T AUXILIADORES-INDUTORES/imunol GRANULOMA/imunol HANSENIASE/imunol HANSENIASE/patol CONTAGEM DE LEUCOCITOS RINOSCLEROMA/imunol RINOSCLEROMA/patol PELE/imunol PELE/patol Limites: HUMANO SUPPORT, NON-U.S. GOV'T Meio Eletrônico: - . Localização: BR191.1; 01381/s

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Id: 16371 Autor: Kang, Tae-Jin; Chae, Gue-Tae Título: Detection of toll-like receptor 2 (TLR2) mutation in the lepromatous leprosy patients ..- Fonte: s.l; s.n; 2001. 6 p. ilus, tab. Descritores: SEQUENCIA DE AMINOACIDOS HANSENIASE LEPROMATOSA HANSENIASE LEPROMATOSA HANSENIASE LEPROMATOSA HANSENIASE TUBERCULOIDE HANSENIASE TUBERCULOIDE HANSENIASE TUBERCULOIDE LEUCOCITOS MONONUCLEARES LEUCOCITOS MONONUCLEARES GLICOPROTEINAS DE MEMBRANAS GLICOPROTEINAS DE MEMBRANAS DADOS DE SEQUENCIA MOLECULAR MUTAÇAO MYCOBACTERIUM LEPRAE POLIMORFISMO CONFORMACIONAL DE SIMPLES FITA RECEPTORES DA SUPERFICIE CELULAR RECEPTORES DA SUPERFICIE CELULAR ALINHAMENTO DE SEQUENCIA TRANSDUÇAO DE SINAL Localização: BR191.1; 08630/s

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Id: 16360 Autor: Gwozdz, J. M; Thompson, K. G; Manktelow, B. W Título: Lymphocytic neuritis of the ileum in sheep with naturally acquired and experimental paratuberculosis ..- Fonte: s.l; s.n; 2001. 4 p. ilus. Descritores: ILEO ILEO LEUCOCITOS MONONUCLEARES MYCOBACTERIUM TUBERCULOSIS MYCOBACTERIUM TUBERCULOSIS NEURITE NEURITE PARATUBERCULOSE PARATUBERCULOSE REAÇAO EM CADEIA POR POLIMERASE OVINOS DOENÇAS DOS OVINOS Limites: ANIMAL Localização: BR191.1; 08662/s

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Id: 15776 Autor: Aleman, M; Barrera, S. de la; Fink, S; Finiasz, M; Arinna, M. H; Pizzariello, G; Sasiain, M. del C Título: Interleukin-12 amplifies the M. leprae hsp65-cytotoxic responses in the presence of tumor necrosis factor-alpha and interferon-gamma generating CD56+ effector cells: interleukin-4 downregulates this effect ..- Fonte: s.l; s.n; 2000. 9 p. tab, graf. Descritores: HANSENIASE MYCOBACTERIUM LEPRAE ANTIGENOS CD56 CHAPERONINAS CITOTOXICIDADE IMUNOLOGICA SINERGISMO DE DROGAS SOROS IMUNES INTERFERON TIPO II INTERLEUCINA-10 INTERLEUCINA-12 INTERLEUCINA-12 INTERLEUCINA-12 INTERLEUCINA-4 INTERFASE LEUCOCITOS MONONUCLEARES LEUCOCITOS MONONUCLEARES TRANSFORMAÇAO LINFOCITICA COMPLEXO PRINCIPAL DE HISTOCOMPATIBILIDADE LIGAÇAO PROTÉICA LINFOCITOS T CITOTOXICOS LINFOCITOS T CITOTOXICOS FATOR DE NECROSE DE TUMOR FATOR DE NECROSE DE TUMOR FATOR DE NECROSE DE TUMOR Localização: BR191.1; 07463/s

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Id: 15621 Autor: Pereira, Newton Lindolfo Título: Estudo da migração dos leucócitos na hanseníase. Relação entre a ação da lepromina proveniente do homem e do tatu ?- Fonte: Ribeirão Preto; s.n; 1989. 50 p. tab, graf. Tese: Apresentada a Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto para obtenção do grau de Mestre. Resumo: O autor estudou os leucócitos do sangue de doentes portadores de hanseníase nas formas indeterminada, tuberculóide e lepromatosa e do sangue de pessoas tidas como não leprosas. Fez a coleta do sangue empregando heparina como anticoagulante. Separou os leucócitos presentes em gradiente de Ficoll-Hypaque com posterior centrifugação. Após separação os leucócitos foram lavados em PBSI, colocados em tubos capilares e compactados por centrifugação. Os tubos foram cortados na altura do sedimento de leucócitos formado, fixados com silicone em placas de petri e sobre estes foi vertido meio de crescimento TC 199E, após foi adicionado lepromina de homem e de tatu. Foram incubados durante 24 horas e as áreas migradas foram medidas. Os resultados foram tratados estatíticamente para se conhecer a ação inibidora dos antígenos empregados. Quando se analisou todas as áreas de migração, tanto dos controles, como dos pacientes, verificou-se que as áreas tratadas com lepromina de homem foram, de uma de maneira geral, menores que as áreas não tratadas com antígenos e as tratadas com lepromina de tatu, menores ainda. As áreas de migração obtidas dos controles sadios, demonstraram inibição significante produzida pela lepromina de homem e pela lepromina de tatu. As áreas de migração dos pacientes em geral mostraram inibição significante entre as áreas controles e as tratadas com lepromina de tatu. Não foi observada inibição significante nos pacientes da forma tuberculóide e indeterminada. Já os da forma lepromatosa mostraram inibição significante entre as áreas controle e as tratadas com lepromina de tatu. Os testes de correlação empregados mostraram correlações entre áreas migradas e leucócitos presentes. (AU). Descritores: HANSENIASE INIBIÇAO DE MIGRAÇAO CELULAR HANSENIASE LEPROMATOSA HANSENIASE TUBERCULOIDE LEUCOCITOS Localização: BR191.1; WC335.400, P414e

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HANSEN

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Id: 15506 Autor: afutis-Morris, Mary; Guillén-Vargas, Cecilia M; Navarro-Fierros, Sérgio; Alfaro-Bustamante, Fernando; Zaitzeva-Petrovna, Galina; Daneri-Navarro, Adrian; Santoscoy-Tovar, Luis; Armendariz-Borunda, Juan Título: Addition of anti-CD28 antibodies restores PBMC proliferation and IFN-gamma production in lepromatous leprosy patients ..- Fonte: s.l; s.n; 1999. 7 p. graf. Descritores: HANSENIASE LEPROMATOSA HANSENIASE LEPROMATOSA HANSENIASE LEPROMATOSA ANTICORPOS MONOCLONAIS ANTIGENOS CD28 ANTIGENOS CD80 LINFOCITOS B DIVISAO CELULAR INTERFERON TIPO II LEUCOCITOS MONONUCLEARES LEUCOCITOS MONONUCLEARES FITOHEMAGLUTININAS LINFOCITOS T Localização: BR191.1; 08357/s

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HANSEN

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Id: 15164 Autor: Peng, Nan-Jing; Wang, Jen-Hsian; Hsieh, Shih-Peng; Jao, Gang-Hong; Tsay, Daw-Guey; Liu, Ren-Shyan Título: Ga-67 and Tc-99m HMPAO lebaled WBC imaging in erythema nodosum leprosum reaction of leprosy ..- Fonte: s.l; s.n; apr. 1998. 3 p. ilu. Descritores: HANSENIASE LEPROMATOSA HANSENIASE LEPROMATOSA HANSENIASE LEPROMATOSA ERITEMA NODOSO RADIOISOTOPOS DE GALIO LEUCOCITOS PELE Localização: BR191.1; 07319/s

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