Database : HANSEN Search on : COMBINACAO DE MEDICAMENTOS [Subject descriptor] References found : 8 [refine] Displaying: 1 .. 8   in format [Detailed]

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Id: 13461 Author: Waters, M. F; Rees, R. J; Pearson, J. M; Laing, A. B; Helmy, H. S; Gelber, R. H Title: Rifampicin for lepromatous leprosy: nine years' experience ..- Source: s.l; s.n; January 21, 1978. 4 p. tab. Abstract: Over 100 patients with lepromatous leprosy were treated with rifampicin in a series of pilot, uncontrolled, and controlled trials in 1968-77. The rapid bactericidal effect of rifampicin on Mycobacterium leprae was confirmed. Clinical improvement became apparent sometimes as early as 14 days after the start of treatment. Nevertheless, a few persisting viable M leprae were detected as long as five years after the start of treatment with rifampicin either by itself or in combination with the bacteriostatic drug thiambutosine. Treatment with rifampicin and dapsone for six months reduced the number of persisting leprosy bacteria more than treatment with dapsone alone. Although rifampicin proved more effective than dapsone, it is unlikely that used by itself if can significantly shorten the length of treatment in lepromatous leprosy. Therefore initial intensive combined treatment with two or more bactericidal drugs (including rifampicin) warrants further investigation in both untreated leprosy and lepromatous leprosy resistant to dapsone.(AU). Descriptors: MYCOBACTERIUM LEPRAE/ef drogas HANSENIASE/quimioter ENSAIOS CLINICOS COMBINACAO DE MEDICAMENTOS DAPSONA/uso terap FENILTIOUREIA/analog FENILTIOUREIA/uso terap RIFAMPINA/admin RIFAMPINA/farmacol RIFAMPINA/uso terap Limits: HUMANO ANIMAL CAMUNDONGOS Electronic Medium: http://www.ilsl.br Location: BR191.1; 01449/s

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Id: 13295 Author: Freerksen, Enno; Rosenfeld, Magdalena; Bonnici, Edgar; Depasquale, George; Kriiger-Thiemer, Malwine Title: Combined therapy in leprosy. Background and findings ..- Source: s.l; s.n; 1978. 5 p. tab. Abstract: This report is based on data obtained from 64 lepromatous cases. Despite many years of DDS monotherapy, the homogenates from biopsies of these patients revealed 10(4) or more bacteria. From the beginning of combination therapy with synergistic-acting substances (rifampicin + isoprodian (INH + PTH + DDS) the logarithms of the number of bacteria in the homogenates decreased, both during treatment period and during treatment-free observation period (Figs. 3--8). During the whole time biopsies were taken almost monthly. A considerable regression of the bacterial mass or even negativity could be observed within a relatively short time. Once started, the process of reduction of bacteria continued also after termination of therapy. To be able to evaluate a medication, therapy-free observation periods (for a minimum of 5 years) are indispensable.(AU). Descriptors: COMBINACAO DE MEDICAMENTOS QUIMIOTERAPIA COMBINADA ISONIAZIDA/uso terap HANSENOSTATICOS/uso terap HANSENIASE/clas HANSENIASE/quimioter HANSENIASE/imunol PROTIONAMIDA/uso terap DAPSONA/uso terap RIFAMPINA/uso terap Limits: HUMANO Electronic Medium: http://www.ilsl.br Location: BR191.1; 00599/s

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Id: 13275 Author: Prabhakaran, K; Harris, E. B; Kirchheimer, W. F Title: A possible method for improving the efficacy of dapsone ..- Source: s.l; s.n; December 15, 1980. 2 p. tab. Abstract: The antileprosy drug dapsone is unable to penetrate intact Mycobacterium leprae in vitro, as determined by its effect on o-diphenoloxidase in the bacilli. When combined with the peptide polylysine, the sulfone drug passes through the bacterial cell membranes, and penetrates the enzyme protein, resulting in a 100% inhibition of its activity. Descriptors: CATECOL OXIDASE/antag PERMEABILIDADE DA MEMBRANA CELULAR/ef drogas COMBINACAO DE MEDICAMENTOS CONCENTRACAO DE IONS DE HIDROGÊNIO MYCOBACTERIUM LEPRAE/enzimol PEPTIDIOS/uso terap DAPSONA/admin DAPSONA/farmacol POLILISINA/farmacol POLILISINA/uso terap Electronic Medium: http://www.ilsl.br Location: BR191.1; 00684/s

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Id: 13233 Author: Dey, S. K; Chanda, M; Chowdhury, A; Panja, S. K Title: Treatment of paucibacillary leprosy by WHO regimen ..- Source: s.l; s.n; jan. 1987. 3 p. . Abstract: 50 Cases of paucibacillary leprosy was selected for study multi-drug therapy recommended by W.H.O. for sixth months. At the end of six months, 46 cases showed "no clinical activity" and 4 cases showed increased clinical activityweth flaring up of the lesions during treatment.(AU). Descriptors: DAPSONA/admin DAPSONA/uso terap COMBINACAO DE MEDICAMENTOS HANSENIASE/quimioter RIFAMPINA/admin RIFAMPINA/uso terap ORGANIZACAO MUNDIAL DA SAUDE Limits: HUMANO MASCULINO FEMININO CRIANÇA ADULTO MEIA-IDADE ADOLESCENTE Electronic Medium: http://www.ilsl.br Location: BR191.1; 02084/s

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Id: 10283 Author: Jacobson, Robert R; Krahenbuhl, James L Title: Leprosy ..- Source: s.l; s.n; 1999. 6 p. ilus. Descriptors: HANSENIASE HANSENIASE HANSENIASE HANSENIASE HANSENIASE LEPROSTATICOS LEPROSTATICOS ESQUEMA DE MEDICAÇAO COMBINAÇAO DE MEDICAMENTOS PREVISOES ACESSO AOS SERVIÇOS DE SAUDE INCIDENCIA SAUDE MUNDIAL ORGANIZAÇAO MUNDIAL DA SAUDE Location: BR191.1; 07422/s

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Id: 10216 Author: Sehgal, Virendra N Title: Leprosy ..- Source: s.l; s.n; 1994. 16 p. ilus. Descriptors: DIAGNOSTICO DIFERENCIAL COMBINAÇAO DE MEDICAMENTOS LEPROSTATICOS LEPROSTATICOS HANSENIASE HANSENIASE HANSENIASE HANSENIASE HANSENIASE HANSENIASE DERMATOPATIAS CLIMA TROPICAL Location: BR191.1; 06917/s

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Id: 9983 Author: Jacobs, Jean M; Shetty, Vanaja P; Antia, Noshia H Title: A morphological study of nerve biopsies from cases of multibacillary leprosy given multidrug therapy ..- Source: s.l; s.n; 1993. 9 p. ilus, tab, graf. Descriptors: AXONIOS COMBINAÇAO DE MEDICAMENTOS CÉLULAS ESPUMOSAS LEPROSTATICOS HANSENIASE LEPROMATOSA HANSENIASE LEPROMATOSA HANSENIASE LEPROMATOSA FIBRAS NERVOSAS FIBRAS NERVOSAS MIELINIZADAS REGENERAÇAO NERVOSA TECIDO NERVOSO Location: BR191.1; 06627/s

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Id: 9815 Author: Baohong, J. I; Perani, Evelyne G; Petinom, Corinne; Grosset, Jacques H Title: Bactericidal activities of combinations of new drugs against Mycobacterium leprae in nude mice ..- Source: s.l; s.n; 1996. 7 p. tab. Descriptors: HANSENIASE MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE LEPROSTATICOS LEPROSTATICOS AGENTES ANTIINFECCIOSOS DE FLUOROQUINOLONA AGENTES ANTIINFECCIOSOS DE FLUOROQUINOLONA ANTIBIOTICOS COMBINADOS ANTIBIOTICOS MACROLIDIOS ANTIBIOTICOS MACROLIDIOS ANTIBIOTICOS TETRACICLINICOS ANTIBIOTICOS TETRACICLINICOS CLARITROMICINA CONTAGEM DE COLONIA MICROBIANA ESQUEMA DE MEDICAÇAO COMBINAÇAO DE MEDICAMENTOS CAMUNDONGOS MINOCICLINA RIFAMPINA RIFAMPINA Location: BR191.1; 06733/s

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