Database : HANSEN Search on : IMUNOGLOBULINA G [Subject descriptor] References found : 15 [refine] Displaying: 1 .. 15   in format [Detailed]

page 1 de 1

1 / 15

HANSEN

select to print Texto Completo-en

Id: 19872 Author: Stefani, Mariane M. A; Martelli, Celina M. T; Morais-Neto, Otaliba L; Martelli, Pierpaolo; Costa, Mauricio B; Andrade, Ana Lucia S. S de. Title: Assessment of anti-PGL-I as a prognostic marker of leprosy reaction. Source: Int. J. Lepr;66(3):356-364, Sept. 1998. tab, graf. Abstract: The anti-phenolic glycolipid-I (PGL-I) assay as currently applied for leprosy is conceived as an early marker of asymptomatic infection, early disease diagnosis and cure monitoring. Its use as a prognostic marker of reaction is still a matter of controversy. We conducted a case-control study to investigate whether IgM and IgG anti-PGL-I antibodies could discriminate patients at increased risk of developing reactions. Eligible cases were untreated leprosy patients at the onset of type 1 and type 2 reactions recruited from among 600 concurrent, newly detected, untreated leprosy patients attending an outpatient clinic in central Brazil. For the patients with reaction, approximately the same number of leprosy cases without reaction matched as to bacterial index (BI), age and gender were randomly selected. Individuals without clinical leprosy were evaluated as healthy controls. Sera from type 1 reaction (N = 43) and type 2 reaction (N = 26) patients were tested by an ELISA using PGL-I synthetic disaccharide-BSA antigen and 1:300 sera dilution (cut-off point > or = 0.2 OD). Antibody profiles were evaluated by exploratory data analysis and reverse cumulative distribution curves. The IgG anti-PGL-I response did not have a defined pattern, being detected only at low levels. Our results indicate that leprosy patients, independently of their reactional status, produce high levels of IgM anti-PGL-I, demonstrating a strong correlation between the magnitude of antibody response and the BI. Patients with a higher BI were at least 3.4 times more prone to produce an antibody response compared to healthy controls. (AU)^ien. Descriptors: Hanseníase/quimioter Hanseníase/imunol ELISA/instrum Imunoglobulina G/sangue Imunoglobulina M/sangue Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1998/pdf/v66n3/v66n3a06.pdf / en Location: BR191.1

2 / 15

HANSEN

select to print Texto Completo-en

Id: 19589 Author: Desforges, Sylvie; Bobin, Pierre; Brethes, Bernard; Huerre, Michel; Moreau, Jean-Paul; Bach, Marie-Ann. Title: Specific anti M. Leprae PHL-1 antibodies and mitsuda reactions in the management of household contacts in New Caledonia. Source: Int. J. Lep;57(4):794-800, dec. 1989. ^btab, ^bgraf. Abstract: Household contacts of leprosy patients have been tested for anti-phenolic glycolipid-I IgM antibodies (anti-PGL-I IgM) by an ELISA using the natural disaccharide (NDO) and natural trisaccharide (NTO) synthetic antigens. A group of healthy subjects without known exposure to Mycobacterium leprae served as controls. The percentages of positivity observed in multibacillary patients, paucibacillary patients, and household contacts were significantly higher than those of the negative controls. The absorbance values using NDO and NTO correlated well (range 0.59-0.91) when analysis of each subject group was performed. As reported here, NDO and NTO antigens seem to be equal in detecting leprosy cases; 100% of multibacillary and 21.43% of paucibacillary cases were detected as seropositive. For the screening of household contacts, NDO appears to be more sensitive and NTO more specific. There were more seropositive cases in the young age groups of household contacts, suggesting a higher rate of transmission of M. leprae infection in those age groups. Lepromin and anti-PGL-I IgG tests were also performed in contacts who were followed. The 2 paucibacillary subjects (1 borderline tuberculoid, 1 indeterminate) were Mitsuda negative. At diagnosis, their anti-PGL-I IgM levels were much higher than those of previous results; their anti-PGL-I IgG levels showed an increase in one and a decrease in the other. However, for the entire group anti-PGL-I IgM and anti-PGL-I IgG levels were positively correlated. The data reported here suggest that an increase in specific anti-M. leprae IgM levels in Mitsuda-negative household contacts could reveal the development of overt disease. Descriptors: Imunoglobulina G/imunol Imunoglobulina M/imunol Glicolipídeos/imunol Mycobacterium leprae/imunol Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1989/pdf/v57n4/v57n4a07.pdf / en Location: Br191.1

3 / 15

HANSEN

select to print Texto Completo-en

Id: 19586 Author: Hasan, Rumina; Dockrell, Hazel M; Chiang, Thomas; Hussain, Rabia. Title: Quantitative antibody ELISA for leprosy. Source: Int. J. Lep;57(4):766-776, dec. 1989. ^btab, ^bgraf. Abstract: Quantitative enzyme-linked immunosorbent assays (ELISAs) were established to measure IgM and IgG antibody levels to soluble Mycobacterium leprae sonicate (CD60) and to the synthetic disaccharide antigen based on the phenolic glycolipid-I antigen of M. leprae coupled to bovine serum albumin in 46 leprosy patients. Separate reference pools for IgM and IgG antibody were established. The reciprocal of the antibody titer was expressed as the number of arbitrary units in the reference pools which was subsequently used as the calibrator for assessment of units in individual test sera. The dose-response relationship for both IgM and IgG was highly specific and reproducible for both isotypes, as indicated by the intra- and inter-assay coefficients of variation. The distribution of antibody levels are in general agreement with the results from previous studies against different M. leprae antigens. The lepromatous group showed 10- to 100-fold higher IgM antibodies to both the soluble sonicate antigen and the disaccharide as compared to the control group. Very low to undetectable levels of IgM antibodies were observed in the tuberculoid group of leprosy patients. IgG antibodies, on the other hand, were not only present but showed considerable overlap with the lepromatous patient group. Optimized ELISAs, such as the one described in this study, would allow one to address issues such as antibody changes with treatment, antigen clearance, and correlation with other immune parameters associated with disease pathogenesis and protection. Descriptors: Anticorpos Antibacterianos/imunol Imunoglobulina G/imunol Imunoglobulina M/imunol Mycobacterium leprae/imunol Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1989/pdf/v57n4/v57n4a04.pdf / en Location: Br191.1

4 / 15

HANSEN

select to print

Id: 18234 Author: Das, Pranab K; Rambukkan, Anura; Baas, J. G; Groothuuis, Dick G; Halperin, Moshe Title: Enzyme-linked immunosorbent assay for distinguishing serological responses of lepromatous and tuberculoid leprosies to the 29/33-kilodalton doublet and 64-kilodalton antigens of Mycobacterium tuberculosis ..- Source: s.l; s.n; Feb. 1990. 4 p. ilus, tab. Abstract: Immunoblot assays for the antibodies to Mycobacterium tuberculosis sonic extracts showed that all serum specimens of 40 lepromatous and 28 tuberculoid leprosy patient reacted in a significant amnner to 29/33-kilodalton (kDa) doublet and 64-kDa antigens, respectively. By using an enzyme-linked immunosorbent assay, we observed a significantly high immunoglobulin G antibody titer to the purified M. tuberculosis 29/33-kDa doublet and 64-kDa antigens in lepromatous and tuberculoid leprosy pateints, respectively, as compared with normal subjects and tuberculosis patients. This enzyme-linked immunosorbent assay serology may be useful for distinguihing two polar types of leprosy and for diagnosing leprosy in general (AU). Descriptors: HANSENIASE VIRCHOWIANA/imunol HANSENIASE TUBERCULOIDE/imunol MYCOBACTERIUM TUBERCULOSIS/imunol ELISA/util IMUNOGLOBULINA G/imunol IMUNOGLOBULINA G/ultraest - HANSENIASE/imunol  MICOBACTERIOSE/imunol Limits: HUMANO Location: BR191.1; 09295/s

5 / 15

HANSEN

select to print

Id: 13500 Author: Mehra, Vijay; Mason, Llewellyn H; Fields, James P; Bloom, Barry R Title: Lepromin-induced suppressor cells in patients with leprosy ..- Source: s.l; s.n; oct. 1979. 5 p. tab, graf. Abstract: The possibility of an active mechanism of immunologic suppression in leprosy was explored by assessing the in vitro lymphocyte responses of 61 leprosy patients and 30 normal individuals to the mitogen Con A in the presence or absence of Dharmendra lepromin. Lepromin-induced suppression of Con A stimulation was found in 32 of 35 lepromatous patients and 15 of 15 borderline patients, but only 2 of 15 tuberculoid patients and 2 of 30 normal controls. Cell fractionation studies indicated at least two cell populations involved in the in vitro lepromin-induced suppressor activity, adherent cells and T gamma-cells.(AU). Descriptors: LINFOCITOS/clas TRANSFORMACAO LINFOCITICA HANSENIASE/imunol FORMACAO DE ROSETA LINFOCITOS T SUPRESSORES-EFETORES/imunol IMUNOGLOBULINA G/imunol ANTIGENO DE MITSUDA/imunol RECEPTORES FC/imunol CONCANAVALINA A/farmacol ADERÊNCIA CELULAR Limits: HUMANO SUPPORT, U.S. GOV'T, P.H.S. Electronic Medium: http://www.ilsl.br Location: BR191.1; 01400/s

6 / 15

HANSEN

select to print

Id: 13431 Author: Melsom, R; Duncan, M. E; Harboe, M; Bjune, G Title: Antibodies against Mycobacterium leprae antigen 7 from birth to 18 months of age: an indicator of intra-uterine infection in leprosy ..- Source: s.l; s.n; oct. 1980. 7 p. tab, graf. Abstract: All babies of three non-leprosy mothers and ten tuberculoid leprosy mothers and four of five babies of mothers with inactive lepromatous leprosy showed a decline in serum concentration of antibodies against M. leprae antigen 7 during the first 4 months of life, as expected from catabolism of maternal IgG. By contrast, ten of twenty babies of mothers with active lepromatous leprosy showed a decline in concentration of anti-M. leprae 7 antibodies considerably less than expected. This indicates that these babies have been stimulated by M. leprae antigen 7, either as free antigen or by viable M. leprae before birth, and thus that leprosy may occur as a congenital infection. Studies of anti-M. leprae antibodies in repeated serum samples obtained during the first 18 months of life indicated that children of mothers with bacilliferous leprosy are frequently exposed to M. leprae to a sufficient extent to stimulate the immune system of the baby to production of anti-M. leprae antibodies during this period. The consequences of this exposure to M. leprae should be ascertained by careful clinical studies.(AU). Descriptors: HANSENIASE/imunol TROCA MATERNO-FETAL MYCOBACTERIUM LEPRAE/imunol IMUNOGLOBULINA G/metab ENVELHECIMENTO SANGUE FETAL/imunol ANTIGENOS DE BACTERIAS/imunol ANTICORPOS ANTIBACTERIAS/anal Limits: HUMANO FEMININO GRAVIDEZ RECÉM-NASCIDO LACTENTE SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 00461/s

7 / 15

HANSEN

select to print

Id: 13423 Author: Wall, J. R; Wright, D. J. M Title: Antibodies against testicular germinal cells in lepromatous leprosy ..- Source: s.l; s.n; may 1974. 9 p. ilus, tab. Abstract: Testicular germinal cell antibodies were found in forty-four out of the fifty-nine patients with lepromatous leprosy and in four out of ten patients with tuberculoid disease. A similar pattern was found in twelve out of 262 control patients and normal subjects. The antibody was found to be of the IgC class and forty out of forty-nine of these antibodies were shown to be complement fixing. Spermatozoal antibodies were detected in twelve patients, but no ovarian antibodies were found in any specimen. There was no close correlation between erythema nodosum leprosum (ENL) and testicular antibodies. it was found that the characteristic of the testicular antibody in leprosy was its ability to be absorbed by Mycobacterium BCG suspension suggesting that this is another antibody induced by infection. A similar fluorescent pattern was seen in some patients who did not have leprosy, but in these cases it could not be abolished with BCG. It is concluded that autoimmunity may be one of the factors involved in the pathogenesis of orchitis in leprosy.(AU). Descriptors: AUTO-ANTICORPOS VACINA BCG IMUNOGLOBULINA G HANSENIASE/imunol MYCOBACTERIUM BOVIS/imunol ESPERMATOGÔNIAS/imunol TESTICULO/citol TESTICULO/imunol Limits: HUMANO MASCULINO FEMININO ADULTO MEIA-IDADE IDOSO ADOLESCENTE Electronic Medium: http://www.ilsl.br Location: BR191.1; 01581/s

8 / 15

HANSEN

select to print

Id: 13404 Author: Faber, W. R; Leiker, D. L Title: Immunofluorescence studies across the leprosy spectrum ..- Source: s.l; s.n; June 29, 1978. 8 p. ilus, tab. Abstract: Forty biopsies from skin lesions of untreated (24) and treated (16) leprosy patients, representing the whole leprosy spectrum, were examined by means of immunofluorescence (IF) methods. Only few or no cells staining with FTC-labelled antihuman immunoglobulin antisera were found in the lesional skin of all patients examined. Sparse IgM-deposits along the basement membrane of the epidermis were observed in a few borderline lepromatous and lepromatous patients. Complement deposits along the basement membrane of the epidermis and in the vessel walls were found in tuberculoïd as well as in lepromatous patients. Complement and in a lesser number IgG-deposits were observed around sweat glands and sometimes around sweat gland ducts and other skin appendages. Autofluorescing macrophages were noted in patients at the lepromatous side of the leprosy spectrum; approximately half of these patients showed complement deposits in an around these cells.(AU). Descriptors: COMPLEMENTO/anal IMUNOFLUORESCÊNCIA IMUNOGLOBULINA G/anal IMUNOGLOBULINA M/anal HANSENIASE/imunol MACROFAGOS/imunol PELE/imunol Limits: HUMANO Electronic Medium: http://www.ilsl.br Location: BR191.1; 00970/s

9 / 15

HANSEN

select to print

Id: 13321 Author: Saha, Kunal; Mittal, Mmdan M; Ray, S. N Title: Consequences of smallpox vaccination in leprosy patients ..- Source: s.l; s.n; sep. 1973. 8 p. tab. Abstract: This study illustrates the consequences of smallpox revaccination in 45 lepromatous, 28 tuberculoid, and 47 normal individuals. Results obtained with leprosy were associated with a relative anergy against the vaccinia virus, the anergy being minimal in the tuberculoid leprosy but marked in the cases with lepromatous leprosy.(AU). Descriptors: HIPERSENSIBILIDADE TARDIA/imunol IMUNIDADE CELULAR IMUNOGLOBULINA A/anal IMUNOGLOBULINA G/anal IMUNOGLOBULINA M/anal INJECOES INTRADERMICAS HANSENIASE/imunol VACINA ANTIVARIOLICA/admin VACINACAO/ef adv VIRUS DA VACÍNIA/imunol - FORMACAO DE ANTICORPOS  CALOR  HEMAGLUTINACAO  IMUNIZACAO SECUNDARIA  INIBICAO (PSICOLOGIA)  MERCAPTOETANOL  COMPLEMENTO/anal  IMUNODIFUSAO Limits: HUMANO ADULTO Electronic Medium: http://www.ilsl.br Location: BR191.1; 01256/s

10 / 15

HANSEN

select to print

Id: 13290 Author: Wager, O; Penttinen, K; Almeida, J. D; Opromolla, Diltor Vladimir Araujo; Godal, T; Kronvall, G Title: Circulating complexes in leprosy studied by the platelet aggregation test. The platelet aggregation test and its relation to the Rubino test and other sero-immunological parameters in 135 patients with leprosy ..- Source: s.l; s.n; dec. 1978. 12 p. ilus, tab, graf. Abstract: Circulating complexes in leprosy studied by the platelet aggregation test. The platelet aggregation test and its relation to the Rubino test and other sero-immunological parameters in 135 patients with leprosy.(AU). Descriptors: IMUNOGLOBULINA G/anal IMUNOGLOBULINA M HANSENIASE/imunol MYCOBACTERIUM LEPRAE/imunol FATOR REUMATOIDE/farmacol Limits: HUMANO Electronic Medium: http://www.ilsl.br Location: BR191.1; 00576

11 / 15

HANSEN

select to print

Id: 13265 Author: Bahr, G. M; Rook, G. A; Moreno, E; Lydyard, P. M; Modabber, F. Z; Stanford, J. L Title: Use of the ELISA to screen for anti-thymocyte and anti-beta 2-microglobulin antibodies in leprosy and SLE ..- Source: s.l; s.n; dec. 1980. 9 p. graf. Abstract: A report is given of the use of the enzyme-linked immunosorbent assay to measure antibody to preparations of human thymocyte membranes (HTMA) and to beta 2-microglobulin. The assay described is simple and rapid, and requires only small quantities of an easily stored membrane preparation. The advantages of this technique over conventional methods involving cytotoxicity are discussed. Raised levels of IgM antibody to beta 2-microglobulin were detected in sera from SLE patients. Raised levels of IgG and IgM antibody to HTMA were found in sera from most active lepromatous cases. Two of eight sera from SLE patients showed raised IgG anti-HMTA, but not raised IgM. An attempt was made to study the subclass of the IgG antibodies found, but when checked against purified human IgG myeloma proteins, the available anti-subclass sera were found to lack the necessary degree of specificity in this assay. (AU). Descriptors: AUTO-ANTICORPOS/anal BETA-GLOBULINAS/imunol ELISA IMUNOGLOBULINA G/anal IMUNOGLOBULINA G/clas IMUNOGLOBULINA M/anal HANSENIASE/imunol LUPUS ERITEMATOSO SISTÊMICO/imunol LINFOCITOS T/imunol MICROGLOBULINA-2 BETA/imunol Limits: HUMANO SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 0713/s

12 / 15

HANSEN

select to print

Id: 13227 Author: Volc-Platzer, B; Wolff, K Title: Behandlung eines subakut-kutanen Lupus erythematodes mit Thalidomid Treatment of subacute cutaneous lupus erythematosus with thalidomide- Source: s.l; s.n; apr. 1983. 4 p. ilus. Abstract: A patient with subacute-cutaneous lupus erythematosus showed no response to corticosteroids and azathioprine. Treatment with thalidomide resulted in a dramatic clearing of skin lesions but failed to improve pathological laboratory tests.(AU). Descriptors: IMUNOFLUORESCÊNCIA AZATIOPRINA/uso terap IMUNOGLOBULINA G/metab IMUNOGLOBULINA M/metab RIM/patol LUPUS ERITEMATOSO SISTÊMICO/quimioter LUPUS ERITEMATOSO SISTÊMICO/patol METILPREDNISOLONA/uso terap TALIDOMIDA/uso terap Limits: RELATO DE CASO HUMANO MASCULINO MEIA-IDADE RESUMO EM INGLES Electronic Medium: http://www.ilsl.br Location: BR191.1; 02129/s

13 / 15

HANSEN

select to print

Id: 13219 Author: Wall, J. R; Wright, D. J Title: Antibodies against testicular germinal cells in lepromatous leprosy ..- Source: s.l; s.n; May 1974. 9 p. ilus, tab. Abstract: Testicular germinal cell antibodies were found in forty-four out of the fifty-nine patients with lepromatous leprosy and in four out of ten patients with tuberculoid disease. A similar pattern was found in twelve out of 262 control patients and normal subjects.The antibody was found to be of the IgC class and forty out of forty-nine of these antibodies were shown to be complement fixing. Spermatozoal antibodies were detected in twelve patients, but no ovarian antibodies were found in any specimen. There was no close correlation between erythema nodosum leprosum (ENL) and testicular antibodies. It was found that the characteristic of the testicular antibody in leprosy was its ability to be absorberd by Mycobacterium BCG suspension suggesting that this is another antibody induced by infection. A similar fluorescent pattern was seen in some patients who did not have leprosy, but in these cases it could not be abolished with BCG. It is concluded that autoimmunity may be one of the factors involved in the pathogenesis of orchitis in leprosy.(AU). Descriptors: VACINA BCG REACOES CRUZADAS IMUNOGLOBULINA G HANSENIASE/imunol MYCOBACTERIUM BOVIS/imunol ESPERMATOCITOS/imunol ESPERMATOGÔNIAS/imunol TESTICULO/citol TESTICULO/imunol Limits: HUMANO MASCULINO FEMININO ADULTO MEIA-IDADE IDOSO ADOLESCENTE Electronic Medium: http://www.ilsl.br Location: BR191.1; 01581/s

14 / 15

HANSEN

select to print

Id: 9621 Author: Launois, Pascal; N'Diaye, M'Bayame; Sarthou, Jean-Louis; Millan, Jacques; Bach, Marie-Anne Title: Anti-peripheral nerve antibodies in leprosy patients recognize an epitope shared by the M. leprae 65 kDa heat shock protein ..- Source: s.l; s.n; 1992. 13 p. ilus, tab. Descriptors: ANTICORPOS ANTIBACTÉRIAS ANTIGENOS DE BACTÉRIAS AUTO-ANTICORPOS AUTO-ANTIGENOS REAÇOES CRUZADAS EPITOPOS COBAIAS PROTEINAS DO CHOQUE TÉRMICO HANSENIASE CAMUNDONGOS MYCOBACTERIUM LEPRAE NERVOS PERIFÉRICOS COELHOS ESPECIFICIDADE DE ESPÉCIES IMUNOGLOBULINA G Limits: ANIMAL IN VITRO Location: BR191.1; 06571/s

15 / 15

HANSEN

select to print

Id: 9202 Author: Lima, Edimo Garcia de; Borras, Maria Rosa Losanao Title: Linfocitos em hanseniase: I. linfocitos B do sangue periferico de portadores de Mal de Hansen ?- Source: s.l; s.n; 1985. 10 p. tab. Descriptors: HANSENIASE LINFOCITOS B HANSENIASE TUBERCULOIDE FICOLL SEPARAÇAO CELULAR LEUCOCITOS MONONUCLEARES FORMAÇAO DE ROSETA LINFOCITOS T CAMUNDONGOS IMUNOGLOBULINA G IMUNOGLOBULINA M Location: BR191.1; 06181/s

---

page 1 de 1

Refine the search

Database : HANSEN

Advanced form

Search for : Free form

		Search	in field
1			WordsTitle wordsAbstract wordsAuthorInstitutional authorSubject descriptorLimitsLanguageCountry, year publicationJournalType of literatureBibliographic levelMonography in seriesPublication typeConferenceUnique identifierLocationElectronic supportEntry dateRecord type
2	and or and not		WordsTitle wordsAbstract wordsAuthorInstitutional authorSubject descriptorLimitsLanguageCountry, year publicationJournalType of literatureBibliographic levelMonography in seriesPublication typeConferenceUnique identifierLocationElectronic supportEntry dateRecord type
3	and or and not		WordsTitle wordsAbstract wordsAuthorInstitutional authorSubject descriptorLimitsLanguageCountry, year publicationJournalType of literatureBibliographic levelMonography in seriesPublication typeConferenceUnique identifierLocationElectronic supportEntry dateRecord type

Search engine: iAH powered by WWWISIS

IAH - © BIREME/PAHO/WHO Latin American and Caribbean Center on Health Sciences Information