Database : HANSEN Search on : INTERLEUCINA-2/IMUNOL [Subject descriptor] References found : 8 [refine] Displaying: 1 .. 8   in format [Detailed]

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Id: 19599 Author: Kaur, Surrinder; Kumar, Bhushan. Title: Interleukin-2 receptors in the sera of leprosy patients. Source: Int. J. Lep;57(4):870-872, dec. 1989. ^btab. Descriptors: Interleucina-2/imunol Interleucina-2/fisiol Interleucina-2/uso terap Hanseníase/imunol Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1989/pdf/v57n4/v57n4cor04.pdf / en Location: Br191.1

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Id: 13501 Author: Haregewoin, Abebe; Godal, Tore; Mustafa, Abu Salim; Belehu, Ayele; Yemaneberhan, Tabebe Title: T-cell conditioned media reverse T-cell unresponsiveness in lepromatous leprosy ..- Source: s.l; s.n; May 26, 1983. 3 p. . Abstract: In some subjects the infective agent of leprosy, Mycobacterium leprae, causes disseminated (lepromatous) disease. Such subjects have a major role in the transmission of the disease and show deficient T-cell responses both in vivo and in vitro to M. leprae, but not to other antigens. Numerous studies have recently shown that T cells with functional capabilities after initial triggering with antigen can be maintained in a state of continuous proliferation in vitro when cultured in medium containing interleukin 2 (IL-2). Here we have studied the effect of IL-2 rich T-cell conditioned medium on lepromatous peripheral blood mononuclear cells. Our results show that although lepromatous T cells fail to produce IL-2 after exposure to M. leprae they can respond by proliferation to M. leprae in the presence of T-cell conditioned medium, suggesting that the unresponsiveness in lepromatous leprosy results from a deficiency in the production of IL-2 or related factors and not a lack of M. leprae-reactive T cells.(AU). Descriptors: MEIOS DE CULTURA TOLERÂNCIA IMUNOLOGICA INTERLEUCINA-2/imunol HANSENIASE/imunol TRANSFORMACAO LINFOCITICA LINFOCITOS T/imunol Limits: HUMANO SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 01401/s

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Id: 13450 Author: Modlin, Robert L; Hofman, Florence M; Horwitz, David A; Husmann, Linda A; Gillis, Steven; Taylor, Clive R; Rea, Thomas H Title: In situ identification of cells in human leprosy granulomas with monoclonal antibodies to interleukin 2 and its receptor ..- Source: s.l; s.n; Jun. 1984. 6 p. ilus, tab, graf. Abstract: Leprosy is a chronic granulomatous disease with an immunologic spectrum in which lepromatous leprosy patients have defective cell-mediated immune responses, in comparison to tuberculoid leprosy patients. Immunoregulatory aspects of this spectrum were investigated by using monoclonal antibodies to interleukin 2 (IL 2), IL 2 receptors (Tac), and T lymphocyte subpopulations with immunoperoxidase techniques on frozen sections of skin biopsy specimens from 10 tuberculoid and 10 lepromatous patients. A comparison of IL 2+ cells revealed markedly fewer IL 2+ cells in lepromatous specimens (lep. 0.028% +/- 0.02 vs tub. 0.46% +/- 0.28, p less than 0.001). These IL 2+ cells were large, exhibited cytoplasmic staining, and on double immunostaining were Leu-4+, Leu-3a+, Leu-2a-, Tac-, and OKT6-, consistent with the fact they are IL 2 producers. Equivalent numbers of Tac+ cells were observed in both lepromatous and tuberculoid granulomas (lep. 1.5% +/- 0.5 vs tub. 2.1% +/- 0.7, p, NS), suggesting that the responder cells are present in both conditions. The tuberculoid granuloma was highly organized, composed of a central core of mature macrophages, Leu-3a+ and Tac+ cells with a surrounding mantle of Leu-2a+, Leu-3a+, IL 2+, Tac+, and OKT6+ cells. In lepromatous granulomas, Leu-2a+, Leu-3a+, Tac+, and rare IL 2+ cells were randomly admixed with bacilli-laden macrophages. The defective cell-mediated immune responses in lepromatous leprosy appears to be associated with diminished IL 2 production and disorganization of the granuloma.(AU). Descriptors: GRANULOMA/imunol GRANULOMA/metab HISTOCITOQUIMICA INTERLEUCINA-2/bios INTERLEUCINA-2/imunol HANSENIASE/imunol HANSENIASE/metab LINFOCITOS T/clas LINFOCITOS T/imunol LINFOCITOS T/metab Limits: HUMANO SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 01415/s

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Id: 13315 Author: Haregewoin, Abebe; Godal, Tore; Mustafa, Abu Salim; Belehu, Ayele; Yemaneberhan, Tabebe Title: T-cell conditioned media reverse T-cell unresponsiveness in lepromatous leprosy ..- Source: s.l; s.n; may 1983. 3 p. ilus, tab. Abstract: In some subjects the infective agent of leprosy, Mycobacterium leprae, causes disseminated (lepromatous) disease. Such subjects have a major role in the transmission of the disease and show deficient T-cell responses both in vivo and in vitro to M. leprae, but not to other antigens. Numerous studies have recently shown that T cells with functional capabilities after initial triggering with antigen can be maintained in a state of continuous proliferation in vitro when cultured in medium containing interleukin 2 (IL-2). Here we have studied the effect of IL-2 rich T-cell conditioned medium on lepromatous peripheral blood mononuclear cells. Our results show that although lepromatous T cells fail to produce IL-2 after exposure to M. leprae they can respond by proliferation to M. leprae in the presence of T-cell conditioned medium, suggesting that the unresponsiveness in lepromatous leprosy results from a deficiency in the production of IL-2 or related factors and not a lack of M. leprae-reactive T cells.(AU). Descriptors: MEIOS DE CULTURA TOLERÂNCIA IMUNOLOGICA INTERLEUCINA-2/imunol HANSENIASE/imunol LINFOCITOS T/imunol - TRANSFORMACAO LINFOCITICA Limits: HUMANO SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 01176/s

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Id: 12551 Author: Seitzer, Ulrike; Kayser, Klaus; Höhn, Hanni; Entzian, Peter; Wacker, Hans-Heinrich; Ploetz, Sabine; Flad, Hans-Dieter; Gerdes, Johannes; maeurer, Markus J Title: Reduced T-cell receptor CD3zeta-chain protein and sustained CD3epsilon expression at the site of mycobacterial infection ..- Source: s.l; s.n; 2001. 9 p. ilus. Descriptors: IMUNOFLUORESCENCIA GRANULOMA TÉCNICAS IMUNOENZIMATICAS INTERLEUCINA-2 HANSENIASE LEPROMATOSA PROTEINA-TIROSINA QUINASE PROTEINAS DA MEMBRANA MICOBACTERIOSE PROTEINAS PROTO-ONCOGENICAS RECEPTORES DE ANTIGENO DA CÉLULA-T SARCOIDOSE PULMONAR TRANSDUÇAO DE SINAL TONSILA TUBERCULOSE PULMONAR Location: BR191.1; 08657/s

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Id: 10189 Author: De Jong, Rolien; Janson, Anneke A. M; Faber, William R; Naafs, Ben; Ottenhoff, Tom H. M Title: IL-2 and IL-12 act in synergy to overcome antigen-specific T cell unresponsiveness in mycobacterial disease ..- Source: s.l; s.n; 1997. 8 p. tab, graf. Descriptors: SINERGISMO DE DROGAS IMUNIDADE CELULAR INTERLEUCINA-12 INTERLEUCINA-12 INTERLEUCINA-2 INTERLEUCINA-2 TRANSFORMAÇAO LINFOCITICA PROTEINAS RECOMBINANTES LINFOCITOS T Location: BR191.1; 07102/s

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Id: 9438 Author: Scollard, David M Title: Inside the skin: the local immune and inflammatory milieu in leprosy ..- Source: s.l; s.n; 1991. 7 p. ilus, graf. Descriptors: ERITEMA NODOSO ERITEMA NODOSO INTERLEUCINA-2 INTERLEUCINA-2 HANSENIASE HANSENIASE HANSENIASE DIMORFA HANSENIASE DIMORFA HANSENIASE LEPROMATOSA HANSENIASE LEPROMATOSA HANSENIASE TUBERCULOIDE HANSENIASE TUBERCULOIDE MACROFAGOS RECEPTORES DA INTERLEUCINA 2 PROTEINAS RECOMBINANTES PELE PELE SUB-POPULAÇOES DE LINFOCITOS T Location: BR191.1; 06322/s

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Id: 3610 Author: Brett, Sara J Title: Limiting dilution analysis of the human T cell response to mycobacterial antigens from BCG vaccinated individuals and leprosy patients ..- Source: s.l; s.n; 1987. 11 p. tab, graf. Descriptors: HANSENIASE ANTIGENOS DE BACTÉRIAS VACINA BCG REAÇOES CRUZADAS CONTAGEM DE LEUCOCITOS TRANSFORMAÇAO LINFOCITICA MYCOBACTERIUM LEPRAE LINFOCITOS LINFOCITOS T INTERLEUCINA-2 Location: BR191.1; 02448/s

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