Database : HANSEN Search on : ANTIMALARICOS [Subject descriptor] References found : 5 [refine] Displaying: 1 .. 5   in format [Detailed]

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Id: 13927 Author: Halim, N. K. D; Ogbeide, E Title: Haematological alterations in leprosy patients treated with dapsone ..- Source: s.l; s.n; Feb. 2002. 3 p. tab. Abstract: OBJECTIVE: To evaluate the haemoglobin concentration (Hb); total white blood cell count (WBC), differential WBC count; platelet count and reticulocyte count in leprosy patients already treated with dapsone. DESIGN: A case-control study. SETTING: Specialist Hospital Ossiomo, which is a Leprosarium and Haematology laboratory, University of Benin Teaching Hospital (UBTH), Nigeria. SUBJECTS: Seventy six leprosy patients (forty males and thirty six females) age range 13-40 years on single dose dapsone. RESULTS: The haemoglobin concentration showed a marked decrease while the reticulocyte count was markedly elevated which was suggestive of haemolytic anaemia. There was also lymphocytosis in patients during pre and post dapsone therapy. CONCLUSION: Leprosy patients on a dosage of 100 mg dapsone, are prone to haemolytic anaemia. Leprosy patients should routinely have their Hb, WBC, platelet count and reticulocyte count determined, while on dapsone therapy in order to ascertain the presence of haemolysis. (AU). Descriptors: ANTIMALARICOS/uso terap CONTAGEM DE CELULAS SANGUINEAS ESTUDOS DE CASOS E CONTROLES DAPSONA/uso terap HEMOGLOBINAS/anal HANSENIASE/sangue HANSENIASE/quimioter CONTAGEM DE RETICULOCITOS Limits: HUMANO MASCULINO FEMININO ADULTO SUPPORT, NON-U.S. GOV'T ADOLESCENTE Electronic Medium: http://www.ilsl.br Location: BR191.1; 09103/s

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Id: 13439 Author: Shepard, Charles C; Walker, Laura L; Van Landingham, Rosalind M; Redus, Martha A Title: Kinetic testing of drugs against Mycobacterium leprae in mice. Activity of cephaloridine, rifampin, streptovaricin, vadrine, and viomycin ..- Source: s.l; s.n; jul. 1971. 5 p. tab, graf. Abstract: A series of drugs that had been found active against Mycobacterium leprae in mice by the continous method of drug administration was tested by the kinetic method. Vadrine and vyomivin were found inactive. Cephaloridine, streptovaricin, and rifampin gave bactericidal-type results. In a second experiment, rifampin was found to have distinct bactericidal effect when given for only 2 days. The plasma levels of rifampin that were associated with bactericidal effect in mice were in the range reported for man receiving acceptable dosages of rifampin. Cephaloridine and, especially, rifampin merit further investigation in clinical trials in leprosy patients, either as single drugs or in combination with other active drugs. The combination of rifampin and dapsone (DDS) or acedapsone (DADDS) appear to provide the advantages of tboth drugs.(AU). Descriptors: ANTIMALARICOS/admin DAPSONA/admin INJECOES SUBCUTÂNEAS HANSENIASE/quimioter MYCOBACTERIUM LEPRAE/ef drogas MYCOBACTERIUM LEPRAE/cresc RIFAMPINA/admin RIFAMPINA/sangue VIOMICINA/admin - DIETA  ESTUDOS DE AVALIACAO  CINETICA  MALARIA/sangue  OXIDIAZOIS/admin  PIRIDINAS/admin  ACIDOS SALICILICOS/admin  ESTREPTOVARICINA/admin Limits: ANIMAL CAMUNDONGOS Electronic Medium: http://www.ilsl.br Location: BR191.1; 02305/s

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Id: 11329 Author: Cook, Gordon C Title: Adverse effects of chemotherapeutic agents used in tropical medicine ..- Source: s.l; s.n; 1995. 15 p. . Descriptors: ANTI-HELMINTICOS VACINAS ANTIMALARICAS ANTIMALARICOS QUIMIOTERAPIA HANSENIASE METRONIDAZOL MEDICINA TROPICAL Location: BR191.1; 07268/s

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Id: 10151 Author: Birdi, Tannaz J; D'Souza, Sushila; Antia, Noshir H Title: Expression of mycobacterial antigens on murine dissociated Schwann cells infected with Mycobacterium leprae ..- Source: s.l; s.n; 1997. 5 p. graf. Descriptors: ANTICORPOS ANTIBACTÉRIAS ANTIMICOTICOS ANTIGENOS DE BACTÉRIAS ANTIGENOS DE BACTÉRIAS ANTIMALARICOS MEMBRANA CELULAR CLOROQUINA ELISA INTERFERON RECOMBINANTE GAMA CINÉTICA HANSENIASE HANSENIASE CAMUNDONGOS MONENSIN MYCOBACTERIUM LEPRAE CÉLULAS DE SCHWANN Limits: ANIMAL Location: BR191.1; 07116/s

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Id: 10122 Author: Roul-Bouriat, S; Leaute-Labreze, C; Bobin, P; Tamisier, J. M; Vernhes, P; Geniaux, M Title: Lepre revelee par une polyarthrite ..- Source: s.l; s.n; 1998. 3 p. ilus. Descriptors: ANTIMALARICOS ARTRITE ARTRITE DOENÇAS DO TECIDO CONJUNTIVO DIAGNOSTICO DIFERENCIAL GLUCOCORTICOIDES SINTÉTICOS HIDROXICLOROQUINA LEPROSTATICOS LEPROSTATICOS HANSENIASE LEPROMATOSA HANSENIASE LEPROMATOSA PREDNISOLONA Limits: RELATO DE CASO Location: BR191.1; 07063/s

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