Database : HANSEN Search on : HIDROLASES [Subject descriptor] References found : 8 [refine] Displaying: 1 .. 8   in format [Detailed]

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Id: 19778 Author: Kolhi, Majula; Vaishnavi, Chetana; Garg, Uttam Chand; Ganguly, Nirmal Kumar; Kaur, Surrinder. Title: Urinary excretion of renal brush-border enzymes in lepromatous leprosy - a preliminary investigation. Source: Int J Lep;57(1):20-23, Mar. 1989. ^bgraf. Abstract: Activities of the brush-border enzymes, alkaline phosphatase, maltase, leucine aminopeptidase, and gamma-glutamyl transpeptidase, were measured in urine samples of 25 lepromatous leprosy patients and an equal number of age-matched healthy controls. None of the patients were shown to be suffering from any other systematic disease. The enzymatic activities were shown to be significantly elevated in leprosy patients when compared to controls^ien. Descriptors: Hanseníase Virchowiana/compl Hanseníase Virchowiana/enzimol Hanseníase Virchowiana/urina Nefropatias/urina Monoester Fosfórico Hidrolases/urina Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1989/pdf/v57n1/v57n1a03.pdf / en Location: Br191.1

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Id: 13615 Author: Martinuzzo, M. E; Larrañaga, G. F. de; Forastiero, R. R; Pelegri, Y; Fariña, M. H; Alonso, B. S; Kordich, L. C; Carreras, L. O Title: Markers of platelet, endothelial cell and blood coagulation activation in leprosy patients with antiphospholipid antibodies ..- Source: s.l; s.n; 2002. 7 p. tab, graf. Abstract: OBJECTIVE: To evaluate plasma levels of markers of platelet, endothelial cell and blood coagulation activation in leprosy patients with or without antiphospholipid antibodies (aPL) and to compare them to those found in patients with antiphospholipid syndrome (APS). METHODS: 42 patients with leprosy (35 lepromatous and 7 borderline): 29 aPL(+) and 13 aPL(-), as well as 26 healthy subjects as normal controls (NC) and 79 control aPL patients without leprosy (59 with and 20 without APS) were included in the study. Plasma soluble P and E selectin (sPsel and sEsel), and VCAM-1 (sVCAM-1), prothrombin F1 + 2 fragment (F1 + 2), thrombin-antithrombin complexes (TAT) and D dimer (DD) were measured by ELISA. The protein C pathway was assessed by the ProC global test. RESULTS: Leprosy patients with aPL presented increased median levels of sPsel [ng/ml (82.0 vs 36.0, p smaller 0.001)] and sVCAM-1 [ng/ml (495 vs 335, p smaller 0.001)] compared to NC, as observed in control aPL patients without leprosy. Levels of sPsel in aPL(+) patients with leprosy were significantly higher than in aPL(-) ones (52.5 ng/ml), p = 0.005. However, plasma markers of thrombin generation were increased in control aPL patients without leprosy but not in those with leprosy. ProcC global test was abnormal in 24.1 per cent of leprosy patients with aPL compared to 4.4 per cent of NC (p smaller 0.024), and to 57.2 per cent of control patients with aPL without leprosy (p = 0.005). CONCLUSIONS: We demonstrated that although patients with leprosy present a high prevalence of aPL, and platelet and endothelial cell activation in vivo to the same extent than patients with APS, they do not show a procoagulant state. (AU). Descriptors: ANTICORPOS ANTIFOSFOLIPIDEOS/*BL ANTITROMBINA III MARCADORES BIOLOGICOS/BL COAGULACAO SANGUINEA/*PH PLAQUETAS/*PH MOLECULAS DE ADESAO CELULAR/BL ENDOTELIO VASCULAR/*PH ELISA PRODUTOS DE DEGRADACAO DA FIBRINA E DO FIBRINOGENIO/AN GLICOPROTEINAS/IM IMUNOGLOBULINA G/AN IMUNOGLOBULINA M/AN HANSENIASE DIMORFA/*BL HANSENIASE VIRCHOWIANA/*BL INIBIDOR DE COAGULACAO DO LUPUS/BL FRAGMENTOS DE PEPTIDEOS/BL PEPTIDEO HIDROLASES/BL PROTEINA C/AN PROTROMBINA Limits: HUMANO MASCULINO FEMININO ADULTO MEIA-IDADE IDOSO SUPPORT, NON-U.S. GOV'T ADOLESCENTE Location: BR191.1; 09034/s

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Id: 13443 Author: Kashiwabara, Yoshiko; Nakagawa, Hiroko; Matsuki, Genji Title: Phospholipid deacylating activities in murine leprosy bacilli ..- Source: s.l; s.n; dec. 1980. 8 p. tab, graf. Abstract: 1) The particulate fraction of cultivated murine leprosy bacilli (Mycobacterium lepraemurium, rough colonies of the Hawaiian-Ogawa strain) contained phospholipid deacylating activities with acidic pH optima. It hydrolyzed phosphatidylcholine and phosphatidylethanolamine at similar rates, and phosphatidylinositol oligomannosides more slowly. It also hydrolyzed 1-acyl- and 2-acyl-GPCs (sn-glycerol 3-phosphocholine) more rapidly than phosphatidylcholine. 2) Ca2+ did not stimulate either diacyl- or monoacyl-hydrolase activity. Triton X-100 and Emulgen 913 had little influence on the hydrolysis of phosphatidylcholine, but at rather high concentrations inhibited the hydrolyses of 1-acyl- and 2-acyl-GPCs. Iron ions strongly inhibited the hydrolysis of phosphatidylcholine, but caused little or no inhibition of the deacylations of 1-acyl- and 2-acyl-GPCs. 3) With 1-[stearoyl-14C]phosphatidylcholine and 2-[oleoyl-14C]phosphatidylcholine as substrates, both labeled fatty acid and lysophosphatidylcholine were produced. Labeled fatty acid appeared more rapidly from 2-[oleoyl-14C]phosphatidylcholine than labeled lysophosphatidylcholine, while labeled lysophosphatidylcholine was produced more than labeled fatty acid from 1-[stearoyl-14C]phosphatidylcholine in the early stage of incubation.(AU). Descriptors: FOSFOLIPIDIOS/metab HIDROLISE HIDROLASES/metab CONCENTRACAO DE IONS DE HIDROGÊNIO FERRO/farmacol MYCOBACTERIUM LEPRAEMURIUM/metab DETERGENTES/farmacol FOSFATIDILCOLINAS/metab CALOR Limits: ANIMAL FEMININO CAMUNDONGOS Electronic Medium: http://www.ilsl.br Location: BR191.1; 00689/s

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Id: 11274 Author: Facer, Paul; Mann, Dawn; Mathur, Rajeev; Pandya, Shubha; Ladiwalla, Uma; Singhal, Bhim; Hongo, Jo-Anne; Sinicropi, Dominick V; Terenghi, Giorgio; Anand, Praveen Title: Do nerve growth factor-related mmechanisms contribute to loss of cutaneous nociception in leprosy? ..- Source: s.l; s.n; 2000. 8 p. ilus, graf. Descriptors: AXONIOS CALOR IMUNOHISTOQUIMICA HIBRIDIZAÇAO IN SITU CERATINOCITOS HANSENIASE HANSENIASE HANSENIASE NOCICEPTORES DOR DOR DOR LIMIAR DA DOR ESTIMULAÇAO FISICA RECEPTOR DA PROTEINA TIROSINAQUINASE REFLEXO PELE PELE CANAIS DE SODIO TIOLÉSTER HIDROLASES VASODILATAÇAO FATORES DE CRESCIMENTO NEURAL/ME/*PH Location: BR191.1; 07450/s

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Id: 10063 Author: Facer, P; Mathur, R; Pandya, S. S; Ladiwala, U; Singhal, B. S; Anand, P Title: Correlation of quantitative tests of nerve and target organ dysfunction with skin immunohistology in leprosy ..- Source: s.l; s.n; 1998. 9 p. ilus, tab, graf. Descriptors: HANSENIASE HANSENIASE HANSENIASE SISTEMA NERVOSO AUTONOMO BIOPSIA CALOR IMUNOHISTOQUIMICA FIBRAS NERVOSAS FIBRAS NERVOSAS SISTEMA NERVOSO SISTEMA NERVOSO SENSAÇAO LIMIAR SENSORIAL PELE PELE PELE PELE GLANDULAS SUDORIPARAS TIOLÉSTER HIDROLASES Location: BR191.1; 07028/s

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Id: 9496 Author: Macedo, H. W; Quirico-Santos, T Title: Nonspecific esterase staining of lymphocyte subsets in leprosy ..- Source: s.l; s.n; 1991. 3 p. tab. Descriptors: LINFOCITOS B HIDROLASES DE ÉSTER CARBOXILICO HANSENIASE LINFOCITOS LINFOCITOS LINFOCITOS T AUXILIADORES-INDUTORES Location: BR191.1; 06352/s

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Id: 9450 Author: Dhople, Arvind M Title: Changes in hydrolytic enzyme activities in armadillos infected with Mycobacterium leprae ..- Source: s.l; s.n; 1991. 10 p. tab. Descriptors: TATUS MODELOS ANIMAIS DE DOENÇAS VIRILHA HIDROLASES HANSENIASE FIGADO FIGADO GANGLIOS LINFATICOS GANGLIOS LINFATICOS MYCOBACTERIUM LEPRAE PESO DOS ORGAOS BAÇO BAÇO Location: BR191.1; 06310/s

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Id: 3860 Author: Page, Roy C; Davies, Philip; Allison, A. C Title: Participation of mononuclear phagocytes in chronic inflammatory diseases ..- Source: s.l; s.n; 1974. 25 p. ilus, tab, graf. Descriptors: AMIDOIDROLASES MEMBRANA CELULAR PAREDE CELULAR DOENÇA CRONICA PLACA DENTARIA ENDOCITOSE HIDROLASES INFECÇAO LACTATO DESIDROGENASE LINFOCITOS LISOSSOMOS FAGOCITOS FAGOCITOS COELHOS Location: BR191.1; 02700/s

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