Database : HANSEN Search on : LEUCOCITOS MONONUCLEARES/IMUNOL [Subject descriptor] References found : 17 [refine] Displaying: 1 .. 17   in format [Detailed]

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Id: 18204 Author: Kang, Tae Jin; Yeum, Chung Eun; Kim, Byoung Chul; You, Eun-Young; Chae, Gue-Tae Title: Differential production of interleukin-10 and interleukin-12 mononuclear cells from leprosy patients with a Toll-like receptor 2 mutations ..- Source: s.l; s.n; 2004. 7 p. tab, graf. Abstract: Toll-like receptor 2 (TLR2) is a key mediator of the immune response to mycobacterial infections, and mutations in TLR2 have been shown to confer susceptibility to infections with mycobacteria. This study investigated the profiles of cytokines, such as interferon (IFN)-gamma, interleukin (IL)-10, IL-12 and tumour necrosis factor (TNF)-alpha in response to Mycobacterium leprae in peripheral blood mononuclear cells (PBMC) with the TLR2 mutation Argo677Trp, a recently reported polymorphism that is associated with lepromatous leprosy. In leprosy patients with the TLR2 mutation, production of IL-2, IL-12, IFN-gamma, and TNF-alpha by M. leprae-stimulated PBMC were significantly decreased compared with that in groups with wild-type TLR2. However, the cells from patients with the TLR2 mutation showed significantly increased production of IL-10. There was no significant difference in Il-4 production between the mutant and wild-type during stimulation. Yhus, these results suggest that the TLR2 signal pathway plays a critical role in the alteration of cytokine profiles in PBMC from leprosy pateints and the TLR2 mutation Arg677Trp provides a mechanism for the poor cellular immune response associated with lepromatous leprosy (AU). Descriptors: HANSENIASE VIRCHOWIANA/sangue HANSENIASE VIRCHOWIANA/clas HANSENIASE VIRCHOWIANA/diag HANSENIASE VIRCHOWIANA/imunol HANSENIASE TUBERCULOIDE/sangue HANSENIASE TUBERCULOIDE/clas HANSENIASE TUBERCULOIDE/diag HANSENIASE TUBERCULOIDE/imunol INTERLEUCINA-10/anal INTERLEUCINA-10/sangue INTERLEUCINA-10/imunol INTERLEUCINA-12/anal INTERLEUCINA-12/sangue INTERLEUCINA-12/imunol - LEUCOCITOS MONONUCLEARES/imunol  IMUNOCOMPETÊNCIA/imunol Limits: ESTUDO COMPARATIVO HUMANO Location: BR191.1; 09194/s

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Id: 17562 Author: Kang, Tae Jin; Yeum, Chung Eun; Kim, Byoung Chul; You, Eun-Young; Chae, Gue-Tae Title: Differential production of interleukin-10 and interleukin-12 in mononuclear cells from leprosy patients with a Toll-like receptor 2 mutation ..- Source: s.l; s.n; 2004. 7 p. ilus, tab, graf. Abstract: Toll-like receptor 2 (TLR2) is a key mediator of the immune response to mycobacterial infections, and mutations in TLR2 have been shown to confer susceptibility to infection with mycobacteria. This study investigated the profiles of cytokines, such as interferon (IFN)-gamma, interleukin (IL)-10, IL-12 and tumour necrosis factor (TNF)-alpha in response to Mycobacterium leprae in peripheral blood mononuclear cells (PBMC) with the TLR2 mutation Arg677Trp, a recently reported polymorphism that is associated with lepromatous leprosy. In leprosy patients with the TLR2 mutation, production of IL-2, IL-12, IFN-gamma, and TNF-alpha by M. leprae-stimulated PBMC were significantly decreased compared with that in groups with wild-type TLR2. However, the cells from patients with the TLR2 mutation showed significantly increased production of IL-10. There was no significant difference in IL-4 production between the mutant and wild-type during stimulation. Thus, these results suggest that the TLR2 signal pathway plays a critical role in the alteration of cytokine profiles in PBMC from leprosy patients and the TLR2 mutation Arg677Trp provides a mechanism for the poor cellular immune response associated with lepromatous leprosy. (AU). Descriptors: Sequência de Bases Interleucina-10/*BI Interleucina-12/*BI Hanseníase/GE/*IM Leucócitos Mononucleares/IM Glicoproteínas de Membrana/*GE/ME Camundongos Nus Dados de Sequência Molecular Mutação Puntual/* Receptores da Superfície Celular/*GE/ME Receptor 2 Toll-Like Receptores Toll-Like Fator de Necrose Tumoral alfa/BI Limits: Adulto Idoso Animais Feminino Humanos Masculino Camundongos Research Support, Non-U.S. Gov't Meia-Idade Location: BR191.1; 09341/s

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Id: 12278 Author: Kang, Tae-Jin; Chae, Gue-Tae Title: Detection of toll-like receptor 2 (TLR2) mutation in the lepromatous leprosy patients ..- Source: s.l; s.n; 2001. 6 p. ilus, tab. Descriptors: SEQUENCIA DE AMINOACIDOS HANSENIASE LEPROMATOSA HANSENIASE LEPROMATOSA HANSENIASE LEPROMATOSA HANSENIASE TUBERCULOIDE HANSENIASE TUBERCULOIDE HANSENIASE TUBERCULOIDE LEUCOCITOS MONONUCLEARES LEUCOCITOS MONONUCLEARES GLICOPROTEINAS DE MEMBRANAS GLICOPROTEINAS DE MEMBRANAS DADOS DE SEQUENCIA MOLECULAR MUTAÇAO MYCOBACTERIUM LEPRAE POLIMORFISMO CONFORMACIONAL DE SIMPLES FITA RECEPTORES DA SUPERFICIE CELULAR RECEPTORES DA SUPERFICIE CELULAR ALINHAMENTO DE SEQUENCIA TRANSDUÇAO DE SINAL Location: BR191.1; 08630/s

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Id: 11720 Author: Aleman, M; Barrera, S. de la; Fink, S; Finiasz, M; Arinna, M. H; Pizzariello, G; Sasiain, M. del C Title: Interleukin-12 amplifies the M. leprae hsp65-cytotoxic responses in the presence of tumor necrosis factor-alpha and interferon-gamma generating CD56+ effector cells: interleukin-4 downregulates this effect ..- Source: s.l; s.n; 2000. 9 p. tab, graf. Descriptors: HANSENIASE MYCOBACTERIUM LEPRAE ANTIGENOS CD56 CHAPERONINAS CITOTOXICIDADE IMUNOLOGICA SINERGISMO DE DROGAS SOROS IMUNES INTERFERON TIPO II INTERLEUCINA-10 INTERLEUCINA-12 INTERLEUCINA-12 INTERLEUCINA-12 INTERLEUCINA-4 INTERFASE LEUCOCITOS MONONUCLEARES LEUCOCITOS MONONUCLEARES TRANSFORMAÇAO LINFOCITICA COMPLEXO PRINCIPAL DE HISTOCOMPATIBILIDADE LIGAÇAO PROTÉICA LINFOCITOS T CITOTOXICOS LINFOCITOS T CITOTOXICOS FATOR DE NECROSE DE TUMOR FATOR DE NECROSE DE TUMOR FATOR DE NECROSE DE TUMOR Location: BR191.1; 07463/s

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Id: 11478 Author: afutis-Morris, Mary; Guillén-Vargas, Cecilia M; Navarro-Fierros, Sérgio; Alfaro-Bustamante, Fernando; Zaitzeva-Petrovna, Galina; Daneri-Navarro, Adrian; Santoscoy-Tovar, Luis; Armendariz-Borunda, Juan Title: Addition of anti-CD28 antibodies restores PBMC proliferation and IFN-gamma production in lepromatous leprosy patients ..- Source: s.l; s.n; 1999. 7 p. graf. Descriptors: HANSENIASE LEPROMATOSA HANSENIASE LEPROMATOSA HANSENIASE LEPROMATOSA ANTICORPOS MONOCLONAIS ANTIGENOS CD28 ANTIGENOS CD80 LINFOCITOS B DIVISAO CELULAR INTERFERON TIPO II LEUCOCITOS MONONUCLEARES LEUCOCITOS MONONUCLEARES FITOHEMAGLUTININAS LINFOCITOS T Location: BR191.1; 08357/s

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Id: 11036 Author: Machado, Paulo; Abrams, John; Santos, Silvane; Brennan, Patrick; Barral, Aldina; Barral-Netto, Manoel Title: Production of host-protective (INF-gamma), host-impairing (IL-10, IL-13) and inflammatory (TNF-alpha) cytokines by PBMC from leprosy patients stimulated with mycobacterial antigens ..- Source: s.l; s.n; 1998. 6 p. tab, graf. Descriptors: HANSENIASE LEPROMATOSA HANSENIASE TUBERCULOIDE ANTIGENOS DE BACTÉRIAS INTERFERON TIPO II INTERFERON TIPO II INTERLEUCINA-10 INTERLEUCINA-10 INTERLEUCINA-13 INTERLEUCINA-13 LEUCOCITOS MONONUCLEARES TRANSFORMAÇAO LINFOCITICA MYCOBACTERIUM BOVIS MYCOBACTERIUM LEPRAE FATOR DE NECROSE DE TUMOR FATOR DE NECROSE DE TUMOR Location: BR191.1; 07206/s

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Id: 11016 Author: Triccas, James A; Winter, Nathalie; Roche, Paul W; Gilpin, Andrea; Kendrick, Kathleen E; Britton, Warwick J Title: Molecular and immunological analyses of the mycobacterium avium homolog of the immunodominant mycobacterium leprae 35-kilodalton protein ..- Source: s.l; s.n; 1998. 7 p. ilus, tab, graf. Descriptors: HANSENIASE MYCOBACTERIUM AVIUM MYCOBACTERIUM AVIUM MYCOBACTERIUM LEPRAE SEQUENCIA DE AMINOACIDOS SEQUENCIA DE BASES CLONAGEM MOLECULAR GENES BACTERIANOS COBAIAS PROTEINAS DO CHOQUE TÉRMICO PROTEINAS DO CHOQUE TÉRMICO HIPERSENSIBILIDADE TARDIA EPITOPOS IMUNODOMINANTES EPITOPOS IMUNODOMINANTES LEUCOCITOS MONONUCLEARES TRANSFORMAÇAO LINFOCITICA DADOS DE SEQUENCIA MOLECULAR PROTEINAS RECOMBINANTES HOMOLOGIA DE SEQUENCIA DE AMINOACIDOS TUBERCULOSE PULMONAR Location: BR191.1; 07286/s

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Id: 11001 Author: Schlienger, Katia; Uyemura, Koichi; Jullien, Denis; Sieling, Peter A; Rea, Thomas H; Linsley, Peter S; Modlin, Robert L Title: B7-1, but not CD28, is crucial for the maintenance of the CD4+ T cell responses in human leprosy ..- Source: s.l; s.n; 1998. 7 p. tab, graf. Descriptors: HANSENIASE LEPROMATOSA HANSENIASE LEPROMATOSA HANSENIASE TUBERCULOIDE HANSENIASE TUBERCULOIDE MYCOBACTERIUM LEPRAE ANTICORPOS BLOQUEADORES ANTIGENOS CD ANTIGENOS CD28 ANTIGENOS CD28 ANTIGENOS DE DIFERENCIAÇAO ANTIGENOS CD80 ANTIGENOS CD80 ANTIGENOS CD80 LINFOCITOS T CD4-POSITIVOS LINFOCITOS T CD4-POSITIVOS CÉLULAS CLONAIS SOROS IMUNES LEUCOCITOS MONONUCLEARES TRANSFORMAÇAO LINFOCITICA GLICOPROTEINAS DE MEMBRANAS TRANSDUÇAO DE SINAL PELE PELE Location: BR191.1; 07275/s

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Id: 10979 Author: de la Barrera, Silvia; Fink, Susana; Finiasz, Marta; Aleman, Mercedes; Farina, Maria Helena; Pizzariello, Graciela; Sasiain, Maria del Carmen Title: Lysis of autologous macrophages pulsed with hsp10 from mycobacterium leprae is associated to the absence of bacilli in leprosy ..- Source: s.l; s.n; 2001. 8 p. tab, graf. Descriptors: HANSENIASE HANSENIASE LEUCOCITOS MONONUCLEARES MYCOBACTERIUM LEPRAE ANTIGENOS CD56 CHAPERONINA 10 CHAPERONINA 10 TESTES IMUNOLOGICOS DE CITOTOXICIDADE INTERFERON TIPO II TRANSFORMAÇAO LINFOCITICA MACROFAGOS RECEPTORES DE IGG LINFOCITOS T CITOTOXICOS LINFOCITOS T CITOTOXICOS FATOR DE NECROSE DE TUMOR Location: BR191.1; 07348/s

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Id: 10373 Author: Gupta, Anu; Sharma, V. K; Vohra, Harpreet; Ganguly, N. K Title: Spontaneous apoptosis in peripheral blood mononuclear cells of leprosy patients: role of cytokines ..- Source: s.l; s.n; 1999. 7 p. tab, graf. Descriptors: ANTICORPOS ESPECIFICIDADE DE ANTICORPOS ANTIGENOS CD28 APOPTOSE CITOCINAS CITOCINAS INTERLEUCINA-1 INTERLEUCINA-6 INTERLEUCINA-6 IONOMICINA HANSENIASE HANSENIASE LEUCOCITOS MONONUCLEARES LEUCOCITOS MONONUCLEARES ZINCO CELULAS CULTIVADAS FATOR DE NECROSE TUMORAL/AI/PH Location: BR191.1; 07501/s

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Id: 10308 Author: Stewart, G. R; Boussinesq, M; Coulson, T; Elson, L; Nutman, T; Bradley, J. E Title: Onchocerciasis modulates the immune response to mycobacterial antigens ..- Source: s.l; s.n; 1999. 7 p. graf. Descriptors: ADOLESCENCIA ANTIGENOS DE HELMINTOS CRIANÇA PRÉ-ESCOLAR INTERFERON TIPO II INTERLEUCINA-4 HANSENIASE HANSENIASE LEUCOCITOS MONONUCLEARES MYCOBACTERIUM LEPRAE MYCOBACTERIUM TUBERCULOSIS ONCHOCERCA VOLVULUS ONCOCERCIASE ONCOCERCIASE TUBERCULINA TUBERCULOSE TUBERCULOSE CELULAS CULTIVADAS Limits: ANIMAL Location: BR191.1; 07413/s

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Id: 10045 Author: Libraty, Daniel H; Airan, Lisa E; Uyemura, Koichi; Jullien, Denis; Spellberg, Brad; Rea, Thomas H; Modlin, Robert L Title: Interferon-y differentially regulates interleukin-12 interleukin-10 production in leprosy ..- Source: s.l; s.n; 1997. 6 p. graf. Descriptors: DOWN-REGULATION (FISIOLOGIA) REGULAÇAO DE EXPRESSAO GENICA INTERFERON TIPO II INTERLEUCINA-10 INTERLEUCINA-12 INTERLEUCINAS HANSENIASE LEUCOCITOS MONONUCLEARES UP-REGULATION (FISIOLOGIA) Location: BR191.1; 07010/s

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Id: 10008 Author: Adams, E; Britto, W; Morgan, A; Sergeantson, S; Basten, A Title: Individuals from different populations identify multiple and diverse T-cell determinants on mycobacterial HSP70 ..- Source: s.l; s.n; 1994. 9 p. tab, graf. Descriptors: SEQUENCIA DE AMINOACIDOS VACINA BCG PROTEINAS DE BACTÉRIAS RAÇA CAUCASOIDE EPITOPOS ANTIGENOS HLA-DR PROTEINAS DO CHOQUE TÉRMICO HANSENIASE LEUCOCITOS MONONUCLEARES DADOS DE SEQUENCIA MOLECULAR MYCOBACTERIUM LEPRAE NEPAL FRAGMENTOS DE PEPTIDIOS PROTEINAS RECOMBINANTES LINFOCITOS T TUBERCULOSE Location: BR191.1; 06904/s

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Id: 9949 Author: De la Barrera, S; Fink, S; Finiasz, M; Minnucci, F; Valdez, R; Balina, L. M; Sasiain, M. C Title: Lack of cytotoxic activity agaisnt Mycobacterium leprae 65-kD heat shock protein (hsp) in multibacillary leprosy patients ..- Source: s.l; s.n; 1995. 8 p. tab, graf. Descriptors: MYCOBACTERIUM LEPRAE MYCOBACTERIUM TUBERCULOSIS PROTEINAS DO CHOQUE TÉRMICO LEUCOCITOS MONONUCLEARES LEUCOCITOS MONONUCLEARES TRANSFORMAÇAO LINFOCITICA MACROFAGOS LINFOCITOS T CITOTOXICOS Location: BR191.1; 06842/s

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Id: 9774 Author: Sampaio, Elizabeth P; Caneshi, Jaqueline R. T; Nery, Jose A. C; Duppre, Nadia C; Pereira, Geraldo M. B; Vieira, Leila M. M; Moreira, Andre L; Kaplan, Gilla; Sarno, Euzenir N Title: Cellular immune response to Mycobacterium leprae infection in human immunodeficiency virus-infected individuals ..- Source: s.l; s.n; 1995. 7 p. ilus, tab, graf. Descriptors: CITOCINAS CITOCINAS EXPRESSAO GENICA INFECÇOES POR HIV INFECÇOES POR HIV HIV-1 ANTIGENO DE MITSUDA LEUCOCITOS MONONUCLEARES TRANSFORMAÇAO LINFOCITICA RNA MENSAGEIRO PELE Location: BR191.1. 6774/s

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Id: 9711 Author: Launois, Pascal; Niang, M'Bayang; Dieye, Alioune; Sarthou, Jean-Louis Title: TNF-alpha failed to reverse the M.leprae-induced defective chemiluminescence response of human mononuclear cells ..- Source: s.l; s.n; 1992. 6 p. tab, graf. Descriptors: HANSENIASE LEUCOCITOS MONONUCLEARES LEUCOCITOS MONONUCLEARES LEUCOCITOS MONONUCLEARES LUMINESCENCIA MYCOBACTERIUM BOVIS MYCOBACTERIUM LEPRAE FAGOCITOSE PROTEINAS RECOMBINANTES EXPLOSAO RESPIRATORIA FATOR DE NECROSE DE TUMOR Location: BR191.1; 06509/s

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Id: 9488 Author: Schauf, Victoria; Holobaugh, Pat; Miller, Pamela; Mittal, Kamal Title: Sensitization in vitro of human peripheral blood mononuclear cells to phenolic glycolipid 1 of Mycobacterium leprae in liposomes ..- Source: s.l; s.n; 1991. 7 p. tab, graf. Descriptors: ANTIGENOS DE BACTÉRIAS POLIIDROXIETIL METACRILATO GLICOLIPIDIOS GLICOLIPIDIOS HEMOCIANINA TOLERANCIA IMUNOLOGICA LEUCOCITOS MONONUCLEARES LIPOSSOMOS TRANSFORMAÇAO LINFOCITICA MYCOBACTERIUM LEPRAE CELULAS CULTIVADAS Limits: IN VITRO Location: BR191.1; 06344/s

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